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  • 1
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    Online Resource
    Near work, screen time, outdoor time and myopia in schoolchildren in the Sunflower Myopia AEEC Consortium
    Wiley ; 2022
    In:  Acta Ophthalmologica Vol. 100, No. 3 ( 2022-05), p. 302-311
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 100, No. 3 ( 2022-05), p. 302-311
    Abstract: To examine the association between near work, screen time including TV and outdoor time with myopia in children from the Sunflower Myopia Asian Eye Epidemiology Consortium (AEEC). Methods We analysed AEEC cross‐sectional data (12 241 children) on risk factors (near work, screen time including TV and outdoor time) and myopia of six population‐based studies (China, Hong Kong and Singapore). Cycloplegic refraction and axial length (AL) measurements were included. Risk factors were determined using questionnaires. Data were pooled from each study, and multivariable regression analysis was performed to evaluate the associations between risks factors and myopia, spherical equivalent (SE) and AL. Results Among the included children, 52.1% were boys, 98.1% were Chinese and 69.7% lived in urban areas. Mean±standard deviation (SD) for age was 8.8 ± 2.9 years, for SE was −0.14 ± 1.8 D and for AL was 23.3 ± 1.1 mm. Myopia prevalence was 30.6%. In multivariate analysis, more reading and writing (OR = 1.17; 95% CI, 1.11–1.24), more total near work (OR = 1.05; 95% CI, 1.02–1.09) and less outdoor time (OR = 0.82, 95% CI, 0.75–0.88) were associated with myopia (p’s  〈  0.05). These factors were similarly associated with SE and AL (p’s  〈  0.05), except for total near work and AL (p = 0.15). Screen time including TV was not significantly associated with myopia (p = 0.49), SE (p = 0.49) or AL (p = 0.83). Conclusion In this study, increased reading and writing and decreased outdoor time were associated with myopia. Screen time may be a surrogate factor of near work or outdoor time, but further research is needed to assess its role as an independent risk factor for myopia.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v100.3
    DOI: 10.1111/aos.14942
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2466981-7
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  • 2
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    Temperature dependence of molecular conformation in uniaxially deformed isotactic polypropylene investigated by combination of polarized FTIR spectroscopy and 2D correlation analysis
    Wiley ; 2015
    In:  Journal of Polymer Science Part B: Polymer Physics Vol. 53, No. 9 ( 2015-05-01), p. 673-684
    Details
    In: Journal of Polymer Science Part B: Polymer Physics, Wiley, Vol. 53, No. 9 ( 2015-05-01), p. 673-684
    Type of Medium: Online Resource
    ISSN: 0887-6266
    URL: Article
    DOI: 10.1002/polb.23683
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1473448-5
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  • 3
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    Stabilizing RbPbBr 3 Perovskite Nanocrystals through Cs + Substitution
    Wiley ; 2019
    In:  Chemistry – A European Journal Vol. 25, No. 10 ( 2019-02-18), p. 2597-2603
    Details
    In: Chemistry – A European Journal, Wiley, Vol. 25, No. 10 ( 2019-02-18), p. 2597-2603
    Abstract: ABX 3 ‐type halide perovskite nanocrystals (NCs) have been a hot topic recently due to their fascinating optoelectronic properties. It has been demonstrated that A‐site ions have an impact on their photophysical and chemical properties, such as the optical band gap and chemical stability. The pursuit of halide perovskite materials with diverse A‐site species would deepen the understanding of the structure–property relationship of the perovskite family. In this work we have attempted to synthesize rubidium‐based perovskite NCs. We have discovered that the partial substitution of Rb + by Cs + help to stabilize the orthorhombic RbPbBr 3 NCs at low temperature, which otherwise can only be obtained at high temperature. The inclusion of Cs + into the RbPbBr 3 lattice results in highly photoluminescent Rb 1− x Cs x PbBr 3 NCs. With increasing amounts of Cs + , the band gaps of the Rb 1− x Cs x PbBr 3 NCs decrease, leading to a redshift of the photoluminescence peak. Also, the Rb 1− x Cs x PbBr 3 NCs ( x =0.4) show good stability under ambient conditions. This work demonstrates the high structural flexibility and tunability of halide perovskite materials through an A‐site cation substitution strategy and sheds light on the optimization of perovskite materials for application in high‐performance optoelectronic devices.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    URL: Article
    DOI: 10.1002/chem.v25.10
    DOI: 10.1002/chem.201805032
    RVK:
    VA 1120 ; VA 3507
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478547-X
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  • 4
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    The difference between cycloplegic and non‐cycloplegic autorefraction and its association with progression of refractive error in Beijing urban children
    Wiley ; 2017
    In:  Ophthalmic and Physiological Optics Vol. 37, No. 4 ( 2017-07), p. 489-497
    Details
    In: Ophthalmic and Physiological Optics, Wiley, Vol. 37, No. 4 ( 2017-07), p. 489-497
    Abstract: To investigate the difference between cycloplegic and non‐cycloplegic autorefraction and its association with the progression of refractive error in Beijing urban children. Methods A total of 386 children aged 6–17 years were enrolled in the baseline investigation of the Beijing Myopia Progression Study in 2010. They were invited for follow‐up vision examinations in the years 2011, 2012, and 2013, including cycloplegic (cyclopentolate 1%, three times) autorefraction. We investigated the difference between the cycloplegic spherical equivalent ( SE ) and the non‐cycloplegic SE ( DSE ) provided by autorefraction and its association with refractive error progression. The progression of refractive error was defined as the difference between the cycloplegic SE at follow‐up and at baseline. Results Two hundred and nineteen children (57%) with completed refractive data (mean ± standard deviation: −1.36 ± 2.44 D at baseline) were ultimately enrolled. The DSE reduced from 0.51 ± 0.72 D at baseline to 0.19 ± 0.43 D in the third year of follow‐up ( p = 0.01). The baseline DSE was positively associated with the children's baseline cycloplegic refraction (β = 0.193 dioptre dioptre −1 , p 〈 0.001). After further divided by refractive status, the DSE was consistently higher in the hyperopic group than in either the emmetropic or myopic groups at each follow‐up (all p 〈 0.001). In the multivariate regression analysis, the myopic children with larger baseline DSE (β = −0.404 dioptre dioptre −1 , p = 0.01) exhibited more myopic refractive change. However, baseline DSE was not found to be a significant risk factor (relative risk, 95% confidence interval: 1.06, 0.79–1.41) for those with newly developed myopia. Conclusion In this sample, the children's DSE was found to be increased as the hyperopic refraction increased. Furthermore, greater the DSE was associated with the progression of refractive error among the myopic children, but not with the onset of myopia.
    Type of Medium: Online Resource
    ISSN: 0275-5408 , 1475-1313
    URL: Issue
    URL: Article
    DOI: 10.1111/opo.2017.37.issue-4
    DOI: 10.1111/opo.12381
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008422-5
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  • 5
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    Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase‐2 activation through the FAK/Src and ERK pathways
    Wiley ; 2019
    In:  Environmental Toxicology Vol. 34, No. 10 ( 2019-10), p. 1085-1093
    Details
    In: Environmental Toxicology, Wiley, Vol. 34, No. 10 ( 2019-10), p. 1085-1093
    Abstract: Geraniin has been reported to have numerous biological activities, including antiviral, antihypertensive, antihyperglycaemic, liver protective, antidiabetic, and apoptotic activities. However, the anti‐migration effects of geraniin on oral cancer remain elusive. In this study, we revealed the potential antitumor mechanisms of geraniin through the inhibition of the migration and invasion of human oral cancer cell lines SCC‐9 and SCC‐14. The results of gelatin zymography and Western blot assays revealed that geraniin significantly reduced the activity and expression of matrix metalloproteinase‐2 (MMP‐2) of oral cancer cells in a concentration‐dependent manner. Furthermore, geraniin potently suppressed the phosphorylation of focal adhesion kinase (FAK), Src, and extracellular signal‐regulated kinase (ERK)1/2 but did not affect the phosphorylation of p38 mitogen‐activated protein kinase (MAPK) and c‐Jun N‐terminal kinase 1/2. Moreover, blocking the MAPK/ERK1/2 pathway significantly enhanced the anti‐migration ability of geraniin in oral cancer cells. In conclusion, we demonstrated that geraniin inhibits the motility of SCC‐9 and SCC‐14 cells in vitro through a molecular mechanism that involves the attenuation of MMP‐2 expression and activity mediated by decreased FAK/Src and ERK1/2 pathways.
    Type of Medium: Online Resource
    ISSN: 1520-4081 , 1522-7278
    URL: Issue
    URL: Article
    DOI: 10.1002/tox.v34.10
    DOI: 10.1002/tox.22809
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2027534-1
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  • 6
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    Upregulation of PRMT6 by LPS suppresses Klotho expression through interaction with NF‐κB in glomerular mesangial cells
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 4 ( 2018-04), p. 3404-3416
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 4 ( 2018-04), p. 3404-3416
    Abstract: Lipopolysaccharide (LPS) released from gram‐negative bacteria stimulates immune responses in infected cells. Epigenetic modifications such as DNA methylation and protein methylation modulate LPS‐induced innate immune gene expressions. Expression of the Klotho protein decreased with LPS treatment in rats. In a cellular model, information regarding the effect of LPS on Klotho expression was meager. In the present study, we demonstrated that LPS triggered global DNA and protein methylation in glomerular mesangial MES‐13 cells. LPS upregulated protein expressions of enzymes central to cellular methylation reactions, especially protein arginine methyltransferase 6 (PRMT6) in MES‐13 cells. Expression of the Klotho protein was diminished by LPS and was restored by 5‐Aza‐2′‐deoxycytidine (5‐Aza‐2′‐dc), AMI‐1, and ammonium pyrrolidinedithiocarbamate (PDTC), but not adenosine aldehyde (AdOx). NF‐κB was identified as a substrate for arginine methylation and interacted with PRMT6 in MES‐13 cells. Inhibition of PRMT activity by AMI‐1 blocked LPS‐induced NF‐κB nuclear translocation in MES‐13 cells. Our data indicate that NF‐κB negatively regulated Klotho expression with an interaction with PRMT6, which was upregulated by LPS in MES‐13 cells.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.4
    DOI: 10.1002/jcb.26511
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 7
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    Visualization of Macroscopic Ising Superconducting State in Superconductor‐Graphene Junctions
    Wiley ; 2023
    In:  Advanced Quantum Technologies Vol. 6, No. 7 ( 2023-07)
    Details
    In: Advanced Quantum Technologies, Wiley, Vol. 6, No. 7 ( 2023-07)
    Abstract: Graphene‐based two‐dimensional van der Waals Josephson junctions with superconductors are hopeful for realizing versatile quantum devices. However, research on the junctions with Ising superconductors in atomic‐layer transition metal dichalcogenides, whose superconductivity is resilient to strong in‐plane magnetic fields, has remained elusive. Here the scanning tunneling microscopy study of Ising superconductivity in single‐layer (SL) NbSe 2 island and its long‐range proximity effect to the adjacent graphene with high spatial and energy resolution is reported. It is found that SL NbSe 2 island manifests as an Ising superconductor while the island area is larger than about 800 nm 2 . Moreover, the superconducting proximity effect from the NbSe 2 island generates a superconducting gap in graphene, which can extend to over several tens of nanometers without obvious decay. Such a long‐range proximity effect makes the intrinsically non‐superconducting graphene as a superconductor. More intriguingly, such a superconducting gap can survive under strong in‐plane magnetic fields, following the Ising behavior of that in SL NbSe 2 . This work reveals a brand‐new macroscopic Ising superconducting regime, opening perspectives for superconductor‐based quantum devices with outstanding functionality.
    Type of Medium: Online Resource
    ISSN: 2511-9044 , 2511-9044
    URL: Issue
    URL: Article
    DOI: 10.1002/qute.v6.7
    DOI: 10.1002/qute.202300087
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2885525-5
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  • 8
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    Quantitative proteomics reveals the regulatory networks of circular RNA BTBD7_hsa_circ_0000563 in human coronary artery
    Wiley ; 2020
    In:  Journal of Clinical Laboratory Analysis Vol. 34, No. 11 ( 2020-11)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 11 ( 2020-11)
    Abstract: BTBD7_hsa_circ_0000563, which is located on chromosome 14, contains conserved binding sites with miR‐155/130a and RNA‐binding proteins according to bioinformatic prediction. We investigated the association of BTBD7_hsa_circ_0000563 expression in coronary artery segments with atherosclerotic stenosis and identified the proteome‐wide BTBD7_hsa_circ_0000563‐regulated proteins in human coronary artery. Methods The atherosclerotic grade and extent in coronary artery segments were determined by hematoxylin and eosin staining. BTBD7_hsa_circ_0000563 expression in eight coronary artery segments from one patient was quantified by RT‐qPCR assay. A proteomic approach was adopted to reveal significant differences in protein expression between among four groups differing in their BTBD7_hsa_circ_0000563 expression levels. Results The RT‐qPCR assay revealed that coronary artery segments with severe atherosclerotic stenosis had significantly low BTBD7_hsa_circ_0000563 levels. The proteomic analysis identified 49 differentially expressed proteins among the segment groups with different BTBD7_hsa_circ_0000563 expression levels, of which 10 were downregulated and 39 were upregulated with increases in the BTBD7_hsa_circ_0000563 level. The 10 downregulated proteins were P61626 (LYSC_HUMAN), P02760 (AMBP_HUMAN), Q02985 (FHR3_HUMAN), P01701 (LV151_HUMAN), P06312(KV401_HUMAN), P01624 (KV315_HUMAN), P13671 (CO6_HUMAN), P01700(LV147_HUMAN), Q9Y287(ITM2B_HUMAN), and A0A075B6I0 (LV861_HUMAN). The top 10 upregulated proteins were Q92552 (RT27_HUMAN), Q9UJY1(HSPB8_HUMAN), Q9Y235(ABEC2_HUMAN), P19022 (CADH2_HUMAN), O43837(IDH3B_HUMAN), Q9H479(FN3K_HUMAN), Q9UM22(EPDR1_HUMAN), P48681(NEST_HUMAN), Q9NRP0(OSTC_HUMAN), and Q15628(TRADD_HUMAN). Conclusion BTBD7_hsa_circ_0000563 is involved in the atherosclerotic changes in human coronary artery segments. Verification, mechanistic, and function studies are needed to confirm whether patients with coronary artery disease would benefit from such personalized medicine in the future.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.v34.11
    DOI: 10.1002/jcla.23495
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001635-9
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  • 9
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    Multicenter prospective study to validate a new transient elastography device for staging liver fibrosis in patients with chronic hepatitis B
    Wiley ; 2020
    In:  Journal of Digestive Diseases Vol. 21, No. 9 ( 2020-09), p. 519-525
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 21, No. 9 ( 2020-09), p. 519-525
    Abstract: To validate the operational and diagnostic performances of a new device for transient elastography (TE), FibroTouch, for liver fibrosis in patients with chronic hepatitis B (CHB). Methods In this prospective multicenter study, adult patients with CHB and valid liver pathological results were recruited to validate the operational and diagnostic performance of a TE device by FibroTouch for staging liver fibrosis. Results In total, 517 patients with histologically proven CHB were enrolled. All had achieved at least 10 successful liver stiffness measurements (LSM), resulting in a success rate of 99.1% and reliable evaluations of 95.2%. Altogether 412 patients were included to analyze the diagnostic performance of FibroTouch. The area under the receiver operating characteristic curve for the LSM was 0.846 (95% confidence interval [CI] 0.808‐0.880) for fibrosis stage ≥ F1, 0.850 (95% CI 0.811‐0.883) for ≥ F2, 0.908 (95% CI 0.876‐0.934) for ≥ F3 and 0.874 (95% CI 0.836‐0.903) for F4. The diagnostic accuracy of LSM was superior to that of gamma‐glutamyl transpeptidase‐to‐platelet ratio (GPR), aminotransferase‐to‐platelet ratio index (APRI), or fibrosis index based on 4 factors (FIB‐4) index in staging fibrosis F2‐F4 ( P = 0.007 to  〈  0.0001). Optimal LSM cut‐off values for diagnosing fibrosis stage ≥ F1, ≥ F2, ≥ F3, and F4 were 5.5 kPa, 7.85 kPa, 10.0 kPa, and 12.7 kPa, respectively. Conclusion FibroTouch has a high success rate and good reliability in staging liver fibrosis in patients with CHB.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v21.9
    DOI: 10.1111/1751-2980.12924
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2317117-0
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  • 10
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    Ocean air masses from the East Asian monsoon dominate the land‐surface atmospheric water cycles in the coastal areas of Liaodong Bay, Northeast China
    Wiley ; 2024
    In:  Hydrological Processes Vol. 38, No. 1 ( 2024-01)
    Details
    In: Hydrological Processes, Wiley, Vol. 38, No. 1 ( 2024-01)
    Abstract: Long‐term atmospheric water vapour hydrogen ( δ 2 H), oxygen ( δ 18 O) and deuterium excess ( d‐excess ) can provide unique insights into the land‐atmosphere coupling processes. The in‐situ measurements of atmospheric water vapour δ 2 H, δ 18 O and d‐excess were conducted above a reed wetland of Liaodong Bay (2019–2020). We found significant inter‐annual variations in atmospheric water vapour isotopes between the two growing (May–September) seasons. The δ 2 H, δ 18 O and d‐excess of atmospheric water vapour exhibited different seasonal and diurnal cycles concerning the vertical measurement heights, especially in 2019. The isotopic differences of atmospheric water vapour among vertical measurement heights were more evident in the daytime. Rainfall events directly impacted the diurnal patterns of water vapour isotopes, and the influences depended on rainfall intensities. However, only weak correlations existed between water vapour isotopes and local meteorological factors ( R 2 = 0.01–0.16, p 〈 0.001), such as water vapour concentration ( w ), Relative Humidity (RH) and surface air temperature ( T a ). Based on the back‐air trajectory analyses, the spatial–temporal dynamics of atmospheric water vapour isotopes are highly synchronized with monsoon activities. Different water vapour sources influence the water vapour isotope in this region and the higher d‐excess value is related to the intense convection brought by the monsoon. High‐resolution measurements of atmospheric water vapour isotopes will improve our understanding of the hydrological cycles in coastal areas.
    Type of Medium: Online Resource
    ISSN: 0885-6087 , 1099-1085
    URL: Issue
    URL: Article
    DOI: 10.1002/hyp.v38.1
    DOI: 10.1002/hyp.15070
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1479953-4
    SSG: 14
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