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  • 1
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Pediatrics International Vol. 65, No. 1 ( 2023-01)
    In: Pediatrics International, Wiley, Vol. 65, No. 1 ( 2023-01)
    Abstract: Developing continuous and labor‐saving sedation/agitation monitoring methods in ventilated children is important to avoid undesirable events such as unplanned extubation. The existing scales are often challenging to use. We therefore aimed to evaluate the feasibility of sedation/agitation monitoring using a wearable device with a built‐in accelerometer for ventilated children. Methods This prospective observational pilot study included children aged 15 years or less, admitted to the pediatric intensive care unit on mechanical ventilation after cardiac catheterization between December 2021 and April 2022. The wearable device with a built‐in accelerometer was attached to either of the upper limbs, and accelerations due to upper limb movements were measured for 2 h after admission or until extubation, whichever was earliest. Accelerations were measured at 0.02 s intervals, with the mean acceleration calculated for each 1 min interval. The State Behavioral Scale (SBS) was completed at 1 min intervals, with the SBS score (−1, 0, 1, or 2) compared with the mean acceleration. Results The study included 20 children with a median age of 12 months. The mean accelerations and SBS scores were positively correlated (Kendall's τ , 0.22; p 〈 0.001), with an increase in the median (interquartile range) acceleration from an SBS score of −1 through 2, as follows: SBS −1, 0.200 (0.151–0.232) m/s 2 ; SBS 0, 0.202 (0.190–0.235) m/s 2 ; SBS, 1, 0.312 (0.236–0.427) m/s 2 ; SBS 2, 0.455 (0.332–0.517) m/s 2 . No adverse events were observed. Conclusions This study showed that continuous, labor‐saving sedation/agitation monitoring of ventilated children was feasible using a wearable device with a built‐in accelerometer.
    Type of Medium: Online Resource
    ISSN: 1328-8067 , 1442-200X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008621-0
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  • 2
    In: Thoracic Cancer, Wiley, Vol. 13, No. 22 ( 2022-11), p. 3217-3224
    Abstract: As the number of genetic mutations that must be tested increases, the Oncomine Dx Target test (ODxTT), which can simultaneously detect multiple cancer‐related genes is becoming the main test used in preference to single‐molecule testing. In this study, we evaluated the performance of ODxTT and cobas EGFR mutation test v2 (cobas EGFR), one of the single‐molecule tests, in detecting EGFR mutations. Methods Samples from 211 patients diagnosed with NS‐NSCLC were tested simultaneously or sequentially with the cobas EGFR mutation test and ODxTT. We compared the success and detection rates of both tests and evaluated their equivalence by determining the concordance rate and k‐coefficient of both tests. Results The success rate in detecting EGFR mutations was 95.7% for ODxTT and 100% for cobas EGFR. EGFR mutations were detected in 26.5% of samples with ODxTT and in 28.0% with cobas EGFR. For the 200 samples successfully analyzed with both tests, the concordance rate and k‐coefficient were 97.5% and 0.938, respectively. ODxTT failed to detect two exon 19 deletion mutations (p.E746_P753delinsVS and p.E746_P753delinsLS), and cobas EGFR failed to detect three instances of an exon 19 deletion (p.L747_P753delinsS), L861R, and an exon 20 insertion. Discussion The success rate of ODxTT is slightly inferior to that of cobas EGFR. ODxTT shared a high concordance rate and k‐coefficient with cobas EGFR in detecting EGFR mutations, but discordant results between the two tests were observed in a few cases, mainly due to the difference of detectable EGFR variants.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2559245-2
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