GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca 2+ /CREB pathway
    Wiley ; 2015
    In:  Aging Cell Vol. 14, No. 3 ( 2015-06), p. 409-420
    Details
    In: Aging Cell, Wiley, Vol. 14, No. 3 ( 2015-06), p. 409-420
    Abstract: Increased fat mass and fat redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens and oestrogens have been observed, the exact mechanism of fat accumulation and redistribution during aging remains obscure. In this study, the receptor of follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply and persistently with aging in both males and females, is functionally expressed in human and mouse fat tissues and adipocytes. Follicle‐stimulating hormone was found to promote lipid biosynthesis and lipid droplet formation; FSH could also alter the secretion of leptin and adiponectin, but not hyperplasia, in vitro and in vivo . The effects of FSH are mediated by FSH receptors coupled to the Gαi protein; as a result, Ca 2+ influx is stimulated, c AMP ‐response‐element‐binding protein is phosphorylated, and an array of genes involved in lipid biosynthesis is activated. The present findings depict the potential of FSH receptor‐mediated lipodystrophy of adipose tissues in aging. Our results also reveal the mechanism of fat accumulation and redistribution during aging of males and females.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.2015.14.issue-3
    DOI: 10.1111/acel.12331
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2099130-7
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Interactions of several genetic polymorphisms and alcohol consumption on blood pressure levels
    Wiley ; 2015
    In:  BioFactors Vol. 41, No. 5 ( 2015-09-10), p. 339-351
    Details
    In: BioFactors, Wiley, Vol. 41, No. 5 ( 2015-09-10), p. 339-351
    Abstract: This study aimed to detect the interactions of several single nucleotide polymorphisms (SNPs) and alcohol consumption on blood pressure levels. Genotypes of 10 SNPs in the ATP‐binding cassette transporter A1 ( ABCA‐1 ), acyl‐CoA:cholesterol acyltransferase‐1 ( ACAT‐1 ), low density lipoprotein receptor ( LDLR ), hepatic lipase gene ( LIPC ), endothelial lipase gene ( LIPG ), methylenetetrahydrofolate reductase ( MTHFR ), the E3 ubiquitin ligase myosin regulatory light chain‐interacting protein ( MYLIP ), proprotein convertase subtilisin‐like kexin type 9 ( PCSK9 ), peroxisome proliferator‐activated receptor delta ( PPARD ), and Scavenger receptor class B type 1 ( SCARB1 ) genes were determined in 616 nondrinkers and 608 drinkers. The genotypic frequencies of LDLR rs5925, LIPC rs2070895, MTHFR rs1801133, and MYLIP rs3757354 SNPs were significantly different between nondrinkers and drinkers. The levels of systolic blood pressure ( ABCA‐1 rs2066715 and rs2070895), diastolic blood pressure (rs2070895), and pulse pressure (PP) (rs2066715, ACAT‐1 rs1044925, and rs1801133) in nondrinkers, and systolic blood pressure (rs1044925 and SCARB1 rs5888), diastolic blood pressure (rs1044925 and LIPG rs2000813), and PP ( PCSK9 rs505151 and rs5888) in drinkers were different among the genotypes ( P   〈  0.005–0.001). The interactions of several SNPs and alcohol consumption on systolic blood pressure (rs2066715, rs1044925, rs5925, rs2070895, rs1801133, rs3757354, PPARD rs2016520, and rs5888), diastolic blood pressure (rs2066715, rs1044925, rs5925, rs2000813, rs3757354, and rs2016520), and PP (rs1044925, rs2070895, rs1801133, rs3757354, rs505151, and rs5888) were observed ( P   〈  0.005–0.001). The differences in blood pressure levels between the nondrinkers and drinkers might be partially attributed to the interactions of these SNPs and alcohol consumption. © 2015 BioFactors, 41(5):339–351, 2015
    Type of Medium: Online Resource
    ISSN: 0951-6433 , 1872-8081
    URL: Issue
    URL: Article
    DOI: 10.1002/biof.v41.5
    DOI: 10.1002/biof.1234
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2011592-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Comparative proteomic analysis of human placenta derived from assisted reproductive technology
    Wiley ; 2008
    In:  PROTEOMICS Vol. 8, No. 20 ( 2008-10), p. 4344-4356
    Details
    In: PROTEOMICS, Wiley, Vol. 8, No. 20 ( 2008-10), p. 4344-4356
    Abstract: The aim of this study was to use proteomics‐based approach to examine differences in protein expression in placenta derived from assisted reproductive technology (ART) and normal pregnancy. Using 2‐DE we found that, compared with the control group, 12 spots in standard in vitro fertilization group and 18 spots in intracytoplasmic sperm injection group were identified as significantly differentially expressed proteins. Among them, six spots were differentially expressed in both standard IVF and ICSI groups with the same change tendency. Totally, 20 proteins were successfully identified by MALDI TOF/TOF MS, including proteins involved in the membrane traffic, metabolism, nucleic acid processing, stress response and cytoskeleton. Notably, five proteins detected to be differentially expressed in both ART groups were identified as annexin A3, hnRNP C1/C2, α‐SNAP, FTL and ATP5A. Some of the proteins were confirmed by Western blot and immunohistochemistry analysis. Our study allowed for the initial identification of these proteins related to various functions in placentation with significantly altered abundance in ART groups. The present results reveal that abnormal protein profiles are involved in ART placenta and these differentially expressed proteins may be valuable for the evaluation of potential association between ART treatment and offspring outcome.
    Type of Medium: Online Resource
    ISSN: 1615-9853 , 1615-9861
    URL: Issue
    URL: Article
    DOI: 10.1002/pmic.v8:20
    DOI: 10.1002/pmic.200800294
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2037674-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Extracellular ATP promotes angiogenesis and adhesion of TNBC cells to endothelial cells via upregulation of CTGF
    Wiley ; 2022
    In:  Cancer Science Vol. 113, No. 7 ( 2022-07), p. 2457-2471
    Details
    In: Cancer Science, Wiley, Vol. 113, No. 7 ( 2022-07), p. 2457-2471
    Abstract: Our previous works have indicated that extracellular ATP is an important prometastasis factor. However, the molecular mechanism involved needs to be further studied. We demonstrated that extracellular ATP treatment could upregulate the expression of connective tissue growth factor (CTGF) in both triple‐negative breast cancer (TNBC) cells and endothelial cells (ECs). Extracellular ATP stimulated the migration of TNBC cells and ECs, and angiogenesis of ECs via the P2Y2––YAP‐CTGF axis. Furthermore, we demonstrated that adenosine triphosphate (ATP) stimulated TNBC cell adhesion to ECs and transmigration through the EC layer via CTGF by upregulation of integrin β1 on TNBC cells and VCAM‐1 on ECs. Both apyrase (ATP‐diphosphohydrolase) and CTGF shRNA treatments could inhibit the metastasis of inoculated tumors to lung and liver in a mouse model, and these treated tumors had fewer blood vessels. Collectively, our data indicated that extracellular ATP promotes tumor angiogenesis and the interactions between TNBC cells and ECs through upregulation of CTGF, thereby stimulating TNBC metastasis. The pleiotropic effects of ATP in angiogenesis and cell adhesion suggest that extracellular ATP or CTGF could be an effective target for TNBC therapy.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v113.7
    DOI: 10.1111/cas.15375
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Retracted : Effects of RNA interference‐mediated silencing of toll‐like receptor 4 gene on proliferation and apoptosis of human breast cancer MCF‐7 and MDA‐MB‐231 cells: An in vitro study
    Wiley ; 2019
    In:  Journal of Cellular Physiology Vol. 234, No. 1 ( 2019-01), p. 433-442
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 234, No. 1 ( 2019-01), p. 433-442
    Abstract: Breast cancer is known as the most prevalent cancer in women worldwide, and has an undeniable negative impact on public health, both physically, and mentally. This study aims to investigate the effects of toll‐like receptor 4 (TLR4) gene silencing on proliferation and apoptosis of human breast cancer cells to explore for a new theoretical basis for its treatment. TLR4 small interference RNA (siRNA) fragment recombinant plasmids were constructed, including TLR4 siRNA‐1, TLR4 siRNA‐2, and TLR4 siRNA‐3. Human breast cancer MCF‐7 and MDA‐MB‐231 cells were assigned into blank, negative control (NC), TLR4 siRNA‐1, TLR4 siRNA‐2, and TLR4 siRNA‐3 groups. MCF‐7 and MDA‐MB‐231 cell growth was detected by MTT assay. Apoptosis and cell cycle were determined by flow cytometry. Reverse transcription quantitative polymerase chain reaction (RT‐qPCR) and Western blot analysis were conducted to determine the expression of TLR4, CDK4, cyclin D1, Livin, Bcl‐2, p53, c‐FLIP, and caspase‐3. In comparison with the NC and blank groups, the TLR4 siRNA‐1, TLR4 siRNA‐2, and TLR4 siRNA‐3 groups showed decreased the expression of TLR4, inhibited proliferation of MCF‐7 and MDA‐MB‐231 cells and promoted MCF‐7 and MDA‐MB‐231 cell apoptosis, and the cells were blocked in G1 phase. In comparison with the NC and blank groups, in the TLR4 siRNA‐1, TLR4 siRNA‐2, and TLR4 siRNA‐3 groups, siRNA‐TLR4 significantly increased expression of p53 and caspase‐3 in MCF‐7 and MDA‐MB‐231 cells, while it decreased the expressions of CDK4, cyclinD1, Livin, Bal‐2, and c‐FLIP. The study demonstrates that TLR4 gene silencing inhibits proliferation and induces apoptosis of MCF‐7 and MDA‐MB‐231 cells.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v234.1
    DOI: 10.1002/jcp.26573
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1478143-8
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    A new type of unsaturated polyester resin with epoxy functionalized nano‐silica and dimer fatty acid: Preparation and property
    Wiley ; 2022
    In:  Polymers for Advanced Technologies Vol. 33, No. 8 ( 2022-08), p. 2459-2469
    Details
    In: Polymers for Advanced Technologies, Wiley, Vol. 33, No. 8 ( 2022-08), p. 2459-2469
    Abstract: The surface of reactive nano‐silica coated with a silage coupling agent containing the epoxy group (denoted as E‐SiO 2 ) and dimer fatty acids (DFA) were allowed to participate in the in‐situ polycondensation reaction of unsaturated polyester resin (UPR), thus obtaining E‐SiO 2 /DFA/UPR hybrid material. Fourier transform infrared spectrometer, scanning electron microscope, and X‐ray energy dispersive spectrometer were used to analyze the structure of the material, morphology of tensile section, and the element composition of the section. It was found that E‐SiO 2 grafted onto the DFA/UPR backbone by chemical bonds, and the material exhibited ductile fracture with Si element on the fracture surface. Thermogravimetric analysis, differential scanning calorimetry, stress–strain test, tensile test, bending test, hardness test, and water resistance test, the influence of the content of E‐SiO 2 on the thermal stability, mechanical properties, and water resistance of the materials was studied. The results show that E‐SiO 2 has a good reinforcing and toughening effect for the in‐situ polymerized E‐SiO 2 /DFA/UPR composite due to the chemical reaction between the epoxy group of E‐SiO 2 and the hydroxyl group (carboxyl group) of DFA/UPR. A heterogeneous network structure was formed in the cured E‐SiO 2 /DFA/UPR composites. The mechanical properties and thermal properties of E‐SiO 2 nanocomposites were improved. When 0.8 wt% E‐SiO 2 was added, the tensile strength, Young's modulus, flexural strength, flexural stress, elongation at break, and Shore A hardness increased by 37.03%, 69.18%, 86.81%, 86.80%, 14.0%, and 14.71%, respectively, compared to DFA/UPR. At the same time, the addition of E‐SiO 2 also improved the water resistance of hybrid materials.
    Type of Medium: Online Resource
    ISSN: 1042-7147 , 1099-1581
    URL: Issue
    URL: Article
    DOI: 10.1002/pat.v33.8
    DOI: 10.1002/pat.5701
    RVK:
    VA 6586
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1481102-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Prenatal diagnosis and appearance of nasal chondromesenchymal hamartoma in a fetus: A case report
    Wiley ; 2024
    In:  Journal of Obstetrics and Gynaecology Research Vol. 50, No. 4 ( 2024-04), p. 751-757
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 50, No. 4 ( 2024-04), p. 751-757
    Abstract: We report a case of fetal nasal chondromesenchymal hamartoma (NCMH) first noted on prenatal ultrasound at 34 weeks. A solid‐cystic mass which predominantly hyperechoicgenic and relatively clear margin, was located on the left nasal cavity and pharynx, with anterior extension and moderate blood flow. Further follow‐up ultrasound examination depicted an enlargement of the tumor. Fetal magnetic resonance imaging (MRI) showed an inhomogeneous signal lesion involving the ethmoid sinuses, nasal cavity, and pharynx. The infant, delivered via cesarean section at 37 + 5 weeks, required urgent neonatology intervention due to respiratory difficulties. Neonatal MRI and computer tomography were subsequently performed at 1 day after birth. Surgical excision occurred at 7 days, confirming NCMH via histological examination. Awareness of this entity, is essential to avoid potentially harmful therapies, especially in prenatal period. Considered NCMH in diagnosis when fetal nasal masses presenting with predominantly high‐level echo, well‐defined margins and moderate vascularity.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.v50.4
    DOI: 10.1111/jog.15892
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2079101-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    TADF Regulation by Tuning Keto‐Energy Levels, ISC/RISC Equilibrium in Coordination Polymers with Excited State Intramolecular Proton Transfer (ESIPT)
    Wiley ; 2024
    In:  Advanced Optical Materials
    Details
    In: Advanced Optical Materials, Wiley
    Abstract: Thermally activated delayed fluorescence (TADF) and long persistent luminescence (LPL) are emerging photophysical hotspots, which involve the singlet/triplet excited states and two‐way energy transfer processes between them via intersystem crossing (ISC) or reverse intersystem crossing (RISC). Herein, a new tactic is reported for the regulation of keto‐energy levels and ISC/RISC equilibrium via the introduction of electron‐withdrawing fluorine in a series of excited state intramolecular proton transfer (ESIPT) ligands and corresponding Cd(II) coordination polymers. Among them, the fluorine p‐substituted to the hydroxy group along the nodal plane on the phenol site improves the thermodynamic stability of the keto‐isomers of the ligand, thereby lowering the keto‐energy level and promoting the ESIPT process effectively. Uniquely, the lower‐energy keto excited state makes the ISC/RISC equilibrium shift to the direction of RISC progress, and thus arousing efficient TADF in the constructed coordination polymer. A comprehensive transient photophysical and theoretical study verifies the greatly promoted RISC progress, rather than suppressed ISC is aroused in the p‐substituted system, suggesting a clear‐cut strategy in the design of coordination polymers with good TADF performance.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Article
    DOI: 10.1002/adom.202303025
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2708158-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    TRPV4 is involved in levonorgestrel‐induced reduction in oviduct ciliary beating
    Wiley ; 2019
    In:  The Journal of Pathology Vol. 248, No. 1 ( 2019-05), p. 77-87
    Details
    In: The Journal of Pathology, Wiley, Vol. 248, No. 1 ( 2019-05), p. 77-87
    Abstract: Previous studies revealed the increasing risk of tubal pregnancy following failure of levonorgestrel (LNG)‐induced emergency contraception, which was attributed to the reduced ciliary motility in response to LNG. However, understanding of the mechanism of LNG‐induced reduction in the ciliary beat frequency (CBF) is limited. The transient receptor potential vanilloid (TRPV) 4 channel is located widely in the female reproductive tract and generates an influx of Ca 2+ following its activation under normal physiological conditions, which regulates the CBF. The present study aimed to explore whether LNG reduced the CBF in the Fallopian tubes by modulating TRPV4 channels, leading to embryo retention in the Fallopian tubes and subsequent tubal pregnancy. The study provided evidence that the expression of TRPV4 was downregulated in the Fallopian tubes among patients with tubal pregnancy and negatively correlated with the serum level of progesterone. LNG downregulated the expression of TRPV4, limiting the calcium influx to reduce the CBF in mouse oviducts. Furthermore, the distribution of ciliated cells and the morphology of cilia did not change following the administration of LNG. LNG‐induced reduction in the CBF and embryo retention in the Fallopian tubes and in mouse oviducts were partially reversed by the progesterone receptor antagonist RU486 or the TRPV4 agonist 4α‐phorbol 12,13‐didecanoate (4α‐PDD). The results indicated that LNG could downregulate the expression of TRPV4 to reduce the CBF in both humans and mice, suggesting the possible mechanism of tubal pregnancy. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
    Type of Medium: Online Resource
    ISSN: 0022-3417 , 1096-9896
    URL: Issue
    URL: Article
    DOI: 10.1002/path.2019.248.issue-1
    DOI: 10.1002/path.5233
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1475280-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Microencapsulation of capsanthin by soybean protein isolate‐chitosan coacervation and microcapsule stability evaluation
    Wiley ; 2014
    In:  Journal of Applied Polymer Science Vol. 131, No. 1 ( 2014-01-05)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 131, No. 1 ( 2014-01-05)
    Abstract: Although capsanthin possesses excellent coloring performance and healthcare functions, its application in the food industry is limited due to its susceptibility to humidity, heat, and light. The purpose of this research was to microencapsulate capsanthin by soybean protein isolate (SPI)‐chitosan coacervation and evaluate whether the microencapsulation improved the stability of capsanthin against the adverse conditions mentioned above. The results indicated that the optimum conditions for capsanthin microencapsulation were emulsification speed 10,000 rpm, emulsification temperature 45°C, wall concentration 15 g/L and core to wall ratio 1:2 (w/w). Under these conditions, the droplets in the emulsion were even in size distribution without agglomeration and the microencapsulation efficiency and microencapsulation yield reached 90.46% and 86.69%, respectively. Microencapsulation increased the stability of capsanthin against low/medium moisture, heat, and especially light, but was less effective in protecting capsanthin microcapsules in high moisture. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 39671.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v131.1
    DOI: 10.1002/app.39671
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1491105-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...