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  • 1
    Online Resource
    Online Resource
    UV‐Curable Polyurethane Elastomer with UV‐Irradiation/Thermo Dual‐Activated Self‐Healability
    Wiley ; 2022
    In:  Macromolecular Materials and Engineering Vol. 307, No. 6 ( 2022-06)
    Details
    In: Macromolecular Materials and Engineering, Wiley, Vol. 307, No. 6 ( 2022-06)
    Abstract: Self‐healable polyurethane elastomers have potential applications in many fields, however, their use is limited by single self‐healing mechanism, intricate preparation process, and long curing time. Herein, a UV‐irradiation/thermo dual‐induced self‐healing polyurethane elastomer is prepared by UV‐curing two kinds of acrylates, where one includes a quadruple hydrogen bond (PU‐UPy‐HEA) and the other contains a disulfide bond (SS‐MA). UV‐curing kinetics indicate that the conversion of acrylates is significantly improved by tuning the irradiation intensity, photoinitiator dosage, and SS‐MA content. A maximum conversion of 80% is achieved within 10 s under 200 mW cm −2 in the case of the 1.5 wt% photoinitiator. The tensile strength of UV‐cured polyurethane elastomer is notably improved by SS‐MA, whereas its elongation at break decreases. Tensile shear tests demonstrates that the bisected samples can be re‐bonded when they are repaired at 100 °C for 15 min, or under 200 mW cm −2 irradiation for 1 h. After that, ≈90% of shear strength is recovered and the strength is only slightly reduced after two healing cycles. Self‐healing mainly relies on thermally reversible hydrogen bonding interactions and UV‐induced disulfide metathesis. This UV‐cured self‐healable polyurethane elastomer can be used in smart coatings as well as in other fields.
    Type of Medium: Online Resource
    ISSN: 1438-7492 , 1439-2054
    URL: Issue
    URL: Article
    DOI: 10.1002/mame.v307.6
    DOI: 10.1002/mame.202100874
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    Short‐term function and immune‐protection of microencapsulated adult porcine islets with alginate incorporating CXCL12 in healthy and diabetic non‐human primates without systemic immune suppression: A pilot study
    Wiley ; 2023
    In:  Xenotransplantation
    Details
    In: Xenotransplantation, Wiley
    Abstract: Replacement of insulin‐producing pancreatic beta‐cells by islet transplantation offers a functional cure for type‐1 diabetes (T1D). We recently demonstrated that a clinical grade alginate micro‐encapsulant incorporating the immune‐repellent chemokine and pro‐survival factor CXCL12 could protect and sustain the integrity and function of autologous islets in healthy non‐human primates (NHPs) without systemic immune suppression. In this pilot study, we examined the impact of the CXCL12 micro encapsulant on the function and inflammatory and immune responses of xenogeneic islets transplanted into the omental tissue bilayer sac (OB; n = 4) and diabetic ( n = 1) NHPs. Changes in the expression of cytokines after implantation were limited to 2–6‐fold changes in blood, most of which did not persist over the first 4 weeks after implantation. Flow cytometry of PBMCs following transplantation showed minimal changes in IFNγ or TNFα expression on xenoantigen‐specific CD4 +  or CD8 +  T cells compared to unstimulated cells, and these occurred mainly in the first 4 weeks. Microbeads were readily retrievable for assessment at day 90 and day 180 and at retrieval were without microscopic signs of degradation or foreign body responses (FBR). In vitro and immunohistochemistry studies of explanted microbeads indicated the presence of functional xenogeneic islets at day 30 post transplantation in all biopsied NHPs. These results from a small pilot study revealed that CXCL12‐microencapsulated xenogeneic islets abrogate inflammatory and adaptive immune responses to the xenograft. This work paves the way toward future larger scale studies of the transplantation of alginate microbeads with CXCL12 and porcine or human stem cell‐derived beta cells or allogeneic islets into diabetic NHPs without systemic immunosuppression.
    Type of Medium: Online Resource
    ISSN: 0908-665X , 1399-3089
    URL: Article
    DOI: 10.1111/xen.12826
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011995-1
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  • 3
    Online Resource
    Online Resource
    Protein‐Framed Multi‐Porphyrin Micelles for a Hybrid Natural–Artificial Light‐Harvesting Nanosystem
    Wiley ; 2016
    In:  Angewandte Chemie Vol. 128, No. 28 ( 2016-07-04), p. 8084-8089
    Details
    In: Angewandte Chemie, Wiley, Vol. 128, No. 28 ( 2016-07-04), p. 8084-8089
    Abstract: A micelle‐like hybrid natural–artificial light‐harvesting nanosystem was prepared through protein‐framed electrostatic self‐assembly of phycocyanin and a four‐armed porphyrin star polymer. The nanosystem has a special structure of pomegranate‐like unimolecular micelle aggregate with one phycocyanin acceptor in the center and multiple porphyrin donors in the shell. It can inhibit donor self‐quenching effectively and display efficient transfer of excitation energy (about 80.1 %) in water. Furthermore, the number of donors contributing to a single acceptor could reach as high as about 179 in this nanosystem.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v128.28
    DOI: 10.1002/ange.201601516
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 4
    Online Resource
    Online Resource
    Non‐Covalent Interaction of Atomically Dispersed Cu and Zn Pair Sites for Efficient Oxygen Reduction Reaction
    Wiley ; 2022
    In:  Advanced Functional Materials Vol. 32, No. 32 ( 2022-08)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 32, No. 32 ( 2022-08)
    Abstract: Dual–single‐atom catalysts with synergistic effect of adjacent atomic metal sites show a great potential for oxygen reduction reaction (ORR). Herein, a dynamical synthetic strategy is demonstrated for the rational design of dual‐atom catalyst ((Zn, Cu) − NC) with non‐covalent Cu and Zn sites as nitrogen‐doped carbon as support. Owing to the non‐covalent interaction of Zn and Cu atomic pair sites, (Zn, Cu) − NC exhibits significant performances for ORR, surpassing the catalysts with individual Zn or Cu site. The theoretical calculations reveal that (Zn, Cu) − NC can highly activate the linear O 2 molecule via the non‐covalent interaction between Zn and Cu pairs, providing the more effective overlap between the metal 3d orbitals and O 2p orbital. Therefore, the ORR activity is optimized with the improvement of the adsorption configuration and adsorption energy of O 2 . Further, both liquid and quasi‐solid zinc − air batteries with (Zn, Cu) − NC as air cathodes achieve remarkable energy density and stability. This research proposes a facile synthetic strategy to construct single‐atom catalysts and presents an insightful understanding of the non‐covalent interplay between heteronuclear metal atoms in dual‐atom catalysts.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v32.32
    DOI: 10.1002/adfm.202203471
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 5
    Online Resource
    Online Resource
    A Multi‐Bioactive Nanomicelle‐Based “One Stone for Multiple Birds” Strategy for Precision Therapy of Abdominal Aortic Aneurysms
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 44 ( 2022-11)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 44 ( 2022-11)
    Abstract: Abdominal aortic aneurysm (AAA) remains a lethal aortic disease in the elderly. Currently, no effective drugs can be clinically applied to prevent the development of AAA. Herein, a “one stone for multiple birds” strategy for AAA therapy is reported. As a proof of concept, three bioactive conjugates are designed and synthesized, which can assemble into nanomicelles. Cellularly, these nanomicelles significantly inhibit migration and activation of inflammatory cells as well as protect vascular smooth muscle cells (VSMCs) from induced oxidative stress, calcification and apoptosis, with the best effect for nanomicelles (TPTN) derived from a conjugate defined as TPT. After intravenous delivery, TPTN efficiently accumulates in the aneurysmal tissue of AAA rats, showing notable distribution in neutrophils, macrophages and VSMCs, all relevant to AAA pathogenesis. Whereas three examined nanomicelles effectively delay expansion of AAA in rats, TPTN most potently prevents AAA growth by simultaneously normalizing the pro‐inflammatory microenvironment and regulating multiple pathological cells. TPTN is effective even at 0.2 mg kg −1 . Besides, TPTN can function as a bioactive nanoplatform for site‐specifically delivering and triggerably releasing anti‐aneurysmal drugs, affording synergistic therapeutic effects. Consequently, TPTN is a promising multi‐bioactive nanotherapy and bioresponsive targeting delivery nanocarrier for effective therapy of AAA and other inflammatory vascular diseases.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.44
    DOI: 10.1002/adma.202204455
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 6
    Online Resource
    Online Resource
    Protein‐Framed Multi‐Porphyrin Micelles for a Hybrid Natural–Artificial Light‐Harvesting Nanosystem
    Wiley ; 2016
    In:  Angewandte Chemie International Edition Vol. 55, No. 28 ( 2016-07-04), p. 7952-7957
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 55, No. 28 ( 2016-07-04), p. 7952-7957
    Abstract: A micelle‐like hybrid natural–artificial light‐harvesting nanosystem was prepared through protein‐framed electrostatic self‐assembly of phycocyanin and a four‐armed porphyrin star polymer. The nanosystem has a special structure of pomegranate‐like unimolecular micelle aggregate with one phycocyanin acceptor in the center and multiple porphyrin donors in the shell. It can inhibit donor self‐quenching effectively and display efficient transfer of excitation energy (about 80.1 %) in water. Furthermore, the number of donors contributing to a single acceptor could reach as high as about 179 in this nanosystem.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v55.28
    DOI: 10.1002/anie.201601516
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 7
    Online Resource
    Online Resource
    Endoplasmic Reticulum–Targeted Fluorescent Nanodot with Large Stokes Shift for Vesicular Transport Monitoring and Long‐Term Bioimaging
    Wiley ; 2018
    In:  Small Vol. 14, No. 25 ( 2018-06)
    Details
    In: Small, Wiley, Vol. 14, No. 25 ( 2018-06)
    Abstract: Herein, a highly stable aggregation‐induced emission (AIE) fluorescent nanodot assembled by an amphiphilic quinoxalinone derivative‐peptide conjugate, namely Quino‐1‐Fmoc‐RACR (also termed as Q1‐PEP), which exhibits large Stokes shift and an endoplasmic reticulum (ER)‐targeting capacity for bioimaging is reported. It is found that the resulting nanodot can effectively enter the ER with high fluorescent emission. As the ER is mainly involved in the transport of synthesized proteins in vesicles to the Golgi or lysosomes, the Q1‐PEP nanodot with ER‐targeting capacity can be used to monitor vesicular transport inside the cells. Compared to conventional fluorescent dyes with small Stokes shifts, the self‐assembled fluorescent nanodot shows superior resistance to photobleaching and aggregation‐induced fluorescence quenching, and elimination of the spectra overlap with autofluorescence of biosubstrate owning to their AIE‐active and red fluorescence emission characteristics. All these optical properties make the fluorescent nanodot suitable for noninvasive and long‐term imaging both in vitro and in vivo.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v14.25
    DOI: 10.1002/smll.201800223
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2168935-0
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  • 8
    Online Resource
    Online Resource
    Distinctive patterns of soil microbial community during forest ecosystem restoration in southwestern China
    Wiley ; 2023
    In:  Land Degradation & Development Vol. 34, No. 14 ( 2023-08-30), p. 4181-4194
    Details
    In: Land Degradation & Development, Wiley, Vol. 34, No. 14 ( 2023-08-30), p. 4181-4194
    Abstract: Microorganisms are essential in soil biogeochemical processes and vegetation establishment. Nonetheless, investigating predictable patterns in the microbial structure during forest restoration damaged by natural or human factors in southwestern China is still limited. Hence, the study intended to explore the effects of forest restoration damaged by illegal construction, abandoned mines, and meteorological disasters on the microbial structure and its consequence on ecosystem functioning. The results uncovered that soil and plant attributes in the restoration forests damaged by illegal construction were similar to the natural community. Furthermore, the alpha diversity indexes were higher in the restoration forests damaged by human factors than in the natural community. Co‐occurrence network analysis identified hub bacterial (e.g., Roseiarcus and Comamonas ) and fungal (e.g., Exophiala and Botryotrichum ) taxa, proving densely connected interactions with other microorganisms. Restoration forests damaged by illegal construction harbored beneficial genera belonging to Proteobacteria ( Nordella , Xanthobacteraceae , and Sphingomonas ) and Basidiomycota ( Panaeolus , Psilocybe , and Sebacina ), whereas restoration forests damaged by abandoned mines presented specialized bacteria involved in dark sulfur oxidation and ureolysis. Correlation analysis showed that soil properties, especially water content and pH, were the dominant factors affecting the microbial communities. Tree and shrub alpha diversities were significantly related to Chloroflexi in the natural community, and herbaceous richness was remarkably related to Proteobacteria and Mortierellomycota in the restoration forest damaged by human factors. Collectively, this comprehensive analysis generates novel insights to explore the contrasting responses of microbial communities during the process of restoration and provides essential microbial indicators for habitat restoration in southwestern China.
    Type of Medium: Online Resource
    ISSN: 1085-3278 , 1099-145X
    URL: Issue
    URL: Article
    DOI: 10.1002/ldr.v34.14
    DOI: 10.1002/ldr.4768
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2021787-0
    detail.hit.zdb_id: 1319202-4
    SSG: 14
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  • 9
    Online Resource
    Online Resource
    CircPDE4B inhibits retinal pathological angiogenesis via promoting degradation of HIF ‐1α though targeting miR ‐181c
    Wiley ; 2020
    In:  IUBMB Life Vol. 72, No. 9 ( 2020-09), p. 1920-1929
    Details
    In: IUBMB Life, Wiley, Vol. 72, No. 9 ( 2020-09), p. 1920-1929
    Abstract: Retinopathy of prematurity is a major cause of childhood blindness worldwide. Hence, exploring the proper treatment methods is a must in tacking this disease. qRT‐PCR and western blot were used to detect the expression of genes and proteins, respectively. The proliferation of human retinal vascular endothelial cells (HRECs) was ensured by MTT assay. The luciferase activity was measured through luciferase assay. The inverted phase‐contrast light microscope was used to observe the formation of a vascular tube. In the present study, our data demonstrated that circPDE4B was downregulated, while hypoxia‐inducible factor‐1α (HIF‐1α) and VEGFA were upregulated in the retinopathy of prematurity model in vitro and in vivo. CircPDE4B increasing remarkably inhibited the expression of HIF‐1α and VEGFA in hypoxia‐induced HRECs and subsequent repressed cell proliferation and pathological angiogenesis. We further found that miR‐181c suppressed the expression of von Hippel–Lindau (VHL), while circPDE4B could promote VHL expression via binding to miR‐181c. Finally, our results revealed that circPDE4B inhibited the expression of VEGFA and pathological angiogenesis via facilitating VHL‐mediated ubiquitin degradation of HIF‐1α. In conclusion, circPDE4B suppressed the expression of VEGFA and pathological angiogenesis via promoting VHL‐mediated ubiquitin degradation of HIF‐1α through binding to miR‐181c. Our study indicated that circPDE4B might be an effective therapeutic target of retinopathy of prematurity.
    Type of Medium: Online Resource
    ISSN: 1521-6543 , 1521-6551
    URL: Issue
    URL: Article
    DOI: 10.1002/iub.v72.9
    DOI: 10.1002/iub.2307
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2009952-6
    detail.hit.zdb_id: 2485214-4
    SSG: 12
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  • 10
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    Online Resource
    Effects of Renal Sympathetic Denervation on the Atrial Electrophysiology in Dogs with Pacing‐Induced Heart Failure
    Wiley ; 2014
    In:  Pacing and Clinical Electrophysiology Vol. 37, No. 10 ( 2014-10), p. 1357-1366
    Details
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 37, No. 10 ( 2014-10), p. 1357-1366
    Abstract: Heart failure (HF) and atrial fibrillation (AF) are associated with sympathetic activation. Renal sympathetic denervation (RSD) can suppress AF vulnerability. The impact of RSD on atrial electrophysiology in experimental HF is unclear. Methods Twenty‐two beagles were randomized into control, HF, and HF + RSD groups. Control dogs were implanted cardiac pacemakers without pacing. Dogs in the HF group underwent right ventricular pacing for 3 weeks at 240 beats/min to induce HF. The dogs in the HF + RSD group received RSD and underwent the same HF‐inducing procedure. Results The P‐wave dispersion was higher in HF dogs than in the control and HF + RSD dogs (19 ± 3.1 ms vs 13 ± 2.3 ms, 15 ± 2.9 ms, P = 0.04). Conduction time within the interatrium was significantly longer in the HF dogs than that in the control and HF + RSD dogs (39 ± 4 ms vs 31 ± 3 ms, 33 ± 4 ms; P = 0.03). Window of vulnerability (WOV) of AF was widened in the HF dogs than in the HF + RSD dogs (37 ± 5 ms vs 14 ± 3 ms; P 〈 0.01), while AF could not be induced (WOV = 0) in the control dogs during S 1 S 2 stimulation. The voltage in the threshold for AF inducibility was lower during ganglionated plexi stimulation in the HF dogs than in the control and HF + RSD dogs (1.8 ± 0.6 V vs 2.5 ± 0.6 V, 2.4 ± 0.4 V; P = 0.04). Conclusions RSD could reverse the atrial electrical remodeling and decrease AF inducibility in dogs with pacing‐induced HF.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    URL: Article
    DOI: 10.1111/pace.2014.37.issue-10
    DOI: 10.1111/pace.12429
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2037547-5
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