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  • Wiley  (6)
  • 1
    Online Resource
    Online Resource
    Precise evaluation of blood flow patterns in human carotid bifurcation based on high‐frame‐rate vector flow imaging
    Wiley ; 2023
    In:  Journal of Clinical Ultrasound Vol. 51, No. 6 ( 2023-07), p. 1070-1077
    Details
    In: Journal of Clinical Ultrasound, Wiley, Vol. 51, No. 6 ( 2023-07), p. 1070-1077
    Abstract: To investigate the feasibility of high‐frame‐rate vector flow imaging (HiFR‐VFI) compared to ultrasound color Doppler flow imaging (CDFI) for precisely evaluating flow characteristics in the carotid bifurcation (CB) of presumed healthy adults. Methods Forty‐three volunteers were assessed for flow characteristics and their extensions using HiFR‐VFI and CDFI in CBs. The flow patterns were classified according to the streamlines in HiFR‐VFI and quantitatively measured using an innovative turbulence index (Tur‐value). Interobserver agreement was also assessed. Results HiFR‐VFI was consistent with CDFI in detecting laminar and nonlaminar flow in 81.4% of the cases; however, in 18.6% of the cases, only HiFR‐VFI identified the nonlaminar flow. HiFR‐VFI showed a larger extension of complex flow (0.37 ± 0.26 cm 2 ) compared to CDFI (0.22 ± 0.21 cm 2 ; p   〈  0.05). The flow patterns were classified into four types: 3 type‐I (laminar flow), 35 type‐II (rotational flow), 27 type‐III (reversed flow), and 5 type‐IV (complex flow). The Tur‐value of type‐IV (50.03 ± 14.97)% is larger than type‐III (44.57 ± 8.89)%, type‐II (16.30 ± 8.16)%, and type‐I (1.48 ± 1.43)% ( p   〈  0.05). Two radiologists demonstrated almost perfect interobserver agreement on recognizing the change of streamlines (κ = 0.81, p   〈  0.001). The intraclass correlation coefficient of the Tur‐value was 0.98. Conclusion HiFR‐VFI can reliably characterize complex hemodynamics with quantitative turbulence measurement and may be an auxiliary diagnostic tool for assessing atherosclerotic arterial disease.
    Type of Medium: Online Resource
    ISSN: 0091-2751 , 1097-0096
    URL: Issue
    URL: Article
    DOI: 10.1002/jcu.v51.6
    DOI: 10.1002/jcu.23489
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492376-2
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  • 2
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    An outbreak of acute respiratory disease caused by HAdV‐55 in Beijing, China, 2020
    Wiley ; 2022
    In:  Journal of Medical Virology Vol. 94, No. 12 ( 2022-12), p. 6111-6115
    Details
    In: Journal of Medical Virology, Wiley, Vol. 94, No. 12 ( 2022-12), p. 6111-6115
    Abstract: Human adenoviruses (HAdVs) can cause acute respiratory diseases (ARDs) worldwide, and HAdV‐55 is a reemergent pathogen in recent years. In the study, we investigated an outbreak of ARD at a school due to HAdV‐55 in Beijing, China, during the early outbreak of coronavirus disease 2019 (COVID‐19). The epidemic prevention team was dispatched to the school to collect epidemiologic data and nasopharyngeal samples. Then, real‐time reverse transcription polymerase chain reaction (PCR) and multiplex PCR assays were used to detect severe acute respiratory syndrome coronavirus 2 and other respiratory pathogens, respectively. One representative HAdV‐55 isolate was selected and submitted for whole‐genome sequencing using a MiSeq system and the whole‐genome phylogenetic tree was conducted based on the maximum likelihood method. The outbreak lasted from January 27 to February 6, 2020, and 108 students developed fever, among whom 60 (55.56%) cases were diagnosed with HAdV‐55 infection in the laboratory using real‐time PCR and 56 cases were hospitalized. All the confirmed cases had a fever and 11 cases (18.33%) presented with a fever above 39°C. Other main clinical symptoms included sore throat (43.33%) and headache (43.33%). We obtained and assembled the full genome of one isolate, BJ‐446, with 34 761 nucleotides in length. HAdV‐55 isolate BJ‐446 was 99.85% identical to strain QS‐DLL, which was the first HAdV‐55 strain in China isolated from an ARD outbreak in Shanxi in 2006. One and four amino acid mutations were observed in the hexon gene and the coding region of L2 pV 40.1 kDa protein, respectively. We identified the first HAdV‐55 infection associated with the ARD outbreak in Beijing since the emergence of COVID‐19. The study suggests that improved surveillance of HAdV is needed, although COVID‐19 is still prevalent in the world.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v94.12
    DOI: 10.1002/jmv.28074
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 3
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    Intermediate phase assisted sequential deposition of reverse‐graded quasi‐ 2D alternating cation perovskites for MA‐free perovskite solar cells
    Wiley ; 2023
    In:  InfoMat Vol. 5, No. 3 ( 2023-03)
    Details
    In: InfoMat, Wiley, Vol. 5, No. 3 ( 2023-03)
    Abstract: One‐step deposition approaches have been widely applied and developed in the fabrication of quasi‐2D perovskites. However, the regulation of quantum wells (QWs) and crystalline orientation is difficult and complicated when using this methodology. Sequential deposition is another widespread synthetic approach for preparing perovskite films and perovskite dimension engineering. In this article, δ ‐CsPbI 3 intermediate phase assisted sequential (IPAS) deposition is successfully carried out to fabricate MA‐free quasi‐2D ACI perovskites. The amount of the δ ‐CsPbI 3 intermediate phase in the PbI 2 layer and the concentration of GAI molecule in the IPA solution both play important roles in the production of MA‐free quasi‐2D ACI perovskite films. The n value of the MA‐free quasi‐2D ACI perovskites can be adjusted, which affects the photovoltaic performance and device stability. Compared with one‐step deposition, the MA‐free quasi‐2D ACI perovskites prepared via IPAS deposition have opposite reverse‐graded QW distribution and improved vertical orientation, leading to a remarkable PEC of up to 18.86% and allowing the preparation of unpackaged devices with prominent working stability (80%, ~400 h). The underlying mechanism and crystallization pathway of IPAS deposition confirm that sequential deposition has unique superiority in regulating the QW distribution and crystalline orientation of quasi‐2D perovskites. image
    Type of Medium: Online Resource
    ISSN: 2567-3165 , 2567-3165
    URL: Issue
    URL: Article
    DOI: 10.1002/inf2.v5.3
    DOI: 10.1002/inf2.12396
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2902931-4
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  • 4
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    Online Resource
    SMAD3/SP1 complex‐mediated constitutive active loop between lncRNA PCAT7 and TGF‐β signaling promotes prostate cancer bone metastasis
    Wiley ; 2020
    In:  Molecular Oncology Vol. 14, No. 4 ( 2020-04), p. 808-828
    Details
    In: Molecular Oncology, Wiley, Vol. 14, No. 4 ( 2020-04), p. 808-828
    Abstract: Bone metastasis is associated with cancer‐related death in patients with prostate cancer (PCa). Long noncoding RNAs (lncRNAs) play critical roles in tumor progression of PCa. Nevertheless, the biological function of lncRNAs in PCa bone metastasis remains unclear. PCAT7 was identified as a bone metastasis‐related lncRNA via analyzing TCGA dataset. Meanwhile, PCAT7 was found to be elevated in primary PCa tissues with bone metastasis and associated with bone metastasis status and poor prognosis of patients with PCa. Functionally, our results reveal that PCAT7 overexpression promotes PCa bone metastasis in vivo , as well as migration, invasion, and EMT of PCa cells in vitro ; on the contrary, PCAT7 knockdown has an inverse effect. Mechanistically, PCAT7 activates TGF‐β/SMAD signaling by upregulating TGFBR1 expression via sponging miR‐324‐5p. In turn, TGF‐β signaling forms a positive feedback loop with PCAT7 via SMAD3/SP1 complex‐induced PCAT7 upregulation. Finally, the clinical positive correlation between PCAT7 and TGFBR1 and TGF‐β signaling activity, and the negative association with miR‐324‐5p are further demonstrated in PCa tissues and clinical primary PCa cells. This study reveals a novel mechanism that is responsible for the constitutive activation of TGF‐β signaling in PCa bone metastasis, implying that PCAT7 can act as a potential therapeutic target against bone metastasis of PCa via disrupting the constitutive active loop between PCAT7 and TGF‐β signaling.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.v14.4
    DOI: 10.1002/1878-0261.12634
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2322586-5
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  • 5
    Online Resource
    Online Resource
    Blood Flow Turbulence Quantification of Carotid Artery With a High‐Frame Rate Vector Flow Imaging
    Wiley ; 2023
    In:  Journal of Ultrasound in Medicine Vol. 42, No. 2 ( 2023-02), p. 427-436
    Details
    In: Journal of Ultrasound in Medicine, Wiley, Vol. 42, No. 2 ( 2023-02), p. 427-436
    Abstract: To assess the feasibility and performance of Turbulence (Tur) index as a quantitative tool for carotid artery flow turbulence; to detect and compare the blood flow patterns of common carotid artery (CCA) and carotid bulb (CB) at different ages and cardiac phases in healthy adults, and thus interpret the evolvement of etiology difference between CCA and CB. Methods Carotid flow characteristics of 40 healthy volunteers were evaluated quantitatively by a high‐frame rate vector flow imaging. Three types of flow patterns were defined depending on the distributive range of complex flow during systole in CB. Comparison of mean Tur value in CCA and CB at different age groups and cardiac phases was performed. And the correlation between Tur value and the diameter ratio of proximal internal carotid artery to common carotid artery (DRpro‐ica/cca) was tested. Results Mean Tur values in CB were remarkably higher than that in CCA, whether during systole or diastole ( P   〈  .001). Meanwhile Tur values in CB during systole were significantly higher than that during diastole ( P   〈  .001). Flow complexity of CB showed variations among 40 participants especially in systole, whereas the flow pattern of CCA was relatively consistent. Mean Tur values were positively correlated with DRpro‐ica/cca in CB ( ρ  = 0.69, P   〈  .05). Conclusions V Flow imaging provided a reliable method—Tur, for quantitative analysis of carotid blood flow. It had potential to be further applied in distinguishing complex hemodynamic characteristics in high‐risk people of carotid diseases for the risk stratification of cardiovascular events.
    Type of Medium: Online Resource
    ISSN: 0278-4297 , 1550-9613
    URL: Issue
    URL: Article
    DOI: 10.1002/jum.v42.2
    DOI: 10.1002/jum.16039
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2067124-6
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  • 6
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    Online Resource
    Assessing habitat quality at Poyang Lake based on InVEST and Geodetector modeling
    Wiley ; 2023
    In:  Ecology and Evolution Vol. 13, No. 12 ( 2023-12)
    Details
    In: Ecology and Evolution, Wiley, Vol. 13, No. 12 ( 2023-12)
    Abstract: Poyang Lake is an essential natural wetland in the Yangtze River basin and plays a vital role in maintaining the ecosystem function and ecological security in the middle and lower reaches of the Yangtze River. However, the relative importance and spatial heterogeneity of the impacts of human activities and land use changes on ecological security needs to be further explored. Here, we analyzed the habitat quality level around Poyang Lake in 2022 and explored the factors of habitat quality change from a geographical perspective. The land use structure changes around the Poyang Lake basin from 2000 to 2022 were quantitatively analyzed, and then the relative importance and spatial heterogeneity of each factor on ecological security changes were investigated using geographic probes. The results show that (1) The worst quality habitat (0–0.1) consists mainly of construction land (1624.9 km 2 ) with an area of 1634.64 km 2 ; (2) Construction land continues to increase with the most significant change, and the dynamic land use attitude is 0.47. Grassland and mudflats have the greatest decrease. The increase in cultivated land in different periods is mainly due to the shift of water surface and forest land; (3) The drivers of habitat quality in Poyang Lake were significantly influenced by the interaction of socioeconomic factors. The explanatory power of population density interacting with the total year‐end population and population density interacting with administrative area exceeded 0.84. These values were higher than the explanatory power of each individual factor, indicating that habitat quality was primarily associated with population density, total year‐end population, and administrative area. These results suggest that human activities contribute to the degradation of wetlands around Poyang Lake. This study has significant reference value for coordinating human–land relationships in Poyang Lake, optimizing land management policy, and improving the sustainable development of cities.
    Type of Medium: Online Resource
    ISSN: 2045-7758 , 2045-7758
    URL: Issue
    URL: Article
    DOI: 10.1002/ece3.v13.12
    DOI: 10.1002/ece3.10759
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2635675-2
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