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  • Wiley  (12)
  • 1
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    Online Resource
    Protective Effects of Total Flavonoids from Epimedium on the Male Mouse Reproductive System Against Cyclophosphamide‐Induced Oxidative Injury by Up‐Regulating the Expressions of SOD3 and GPX1
    Wiley ; 2014
    In:  Phytotherapy Research Vol. 28, No. 1 ( 2014-01), p. 88-97
    Details
    In: Phytotherapy Research, Wiley, Vol. 28, No. 1 ( 2014-01), p. 88-97
    Abstract: Total flavonoids of Epimedium (TFE) is the main active composition of Epimedium that has been used to treat male reproductive problems. The present aim was to investigate the protective effects of TFE on male mice reproductive system against cyclophosphamide (CP)‐induced oxidative injury. The animals were treated with CP to make testicular injury model and the protective effects of TFE were observed. In the CP‐treated group, testicular and epididymal weights, sperm count and motility significantly decreased relative to the control group ( P   〈  0.05 and P   〈  0.01, respectively). Compared with the CP‐treated group, TFE (200 and 400 mg/kg) treated mice increased testicular weights by 21.6% and 28.4% ( P   〈  0.05), sperm counts by 81.7% and 148.3% ( P   〈  0.01) and sperm motility by 47.2% and 61.3% ( P   〈  0.01). Meanwhile, the CP‐treated group showed enhancement of lipid peroxidation leading to testicular reproductive toxicity. TFE restored these oxidative damages by up‐regulating the expression of antioxidant enzymes, especially SOD3 and GPX1. TUNEL assay and histopathological observations provided supportive evidence for above results, and when the dose of TFE increased, the aforesaid improvement became more and more strong. These results demonstrated that TFE exerted beneficially protective effects on the structural and functional damage of male mice reproductive system and reduced apoptosis in spermatogenic cells by inhibiting CP‐induced oxidative stress. Copyright © 2013 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v28.1
    DOI: 10.1002/ptr.4956
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Efficacy of telitacicept in patients with lupus‐ and antiphospholipid syndrome‐associated refractory thrombocytopenia
    Wiley ; 2023
    In:  Rheumatology & Autoimmunity Vol. 3, No. 2 ( 2023-06), p. 120-124
    Details
    In: Rheumatology & Autoimmunity, Wiley, Vol. 3, No. 2 ( 2023-06), p. 120-124
    Abstract: Telitacicept may be a safe and effective treatment for refractory thrombocytopenia in lupus and antiphospholipid syndrome patients.
    Type of Medium: Online Resource
    ISSN: 2767-1429 , 2767-1429
    URL: Issue
    URL: Article
    DOI: 10.1002/rai2.v3.2
    DOI: 10.1002/rai2.12073
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3100945-1
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  • 3
    Online Resource
    Online Resource
    Risk factors for cancer‐associated myositis: A large‐scale multicenter cohort study
    Wiley ; 2021
    In:  International Journal of Rheumatic Diseases Vol. 24, No. 2 ( 2021-02), p. 268-273
    Details
    In: International Journal of Rheumatic Diseases, Wiley, Vol. 24, No. 2 ( 2021-02), p. 268-273
    Abstract: The aim of this study was to identify the risk factors and prognosis of patients with cancer‐associated myositis (CAM). Method Four hundred and eighty‐seven patients with dermatomyositis (DM), clinical amyopathic dermatomyositis (CADM) and polymyositis (PM) from 3 clinical centers were enrolled retrospectively in this study. Clinical and laboratory data of CAM and non‐CAM patients were compared. Logistic regression analysis was used to identify risk factors of CAM. Results Out of the 487 patients with DM/CADM/PM, 7.0% (34/487) of patients were classified as CAM. Older age (53.91 ± 13.32 vs. 48.76 ± 14.34 years), heliotrope rash (61.8% vs. 41.9%), shawl sign (41.2% vs. 22.1%), V sign (58.8% vs. 38.6%) were observed significantly more commonly in patients with CAM than those without CAM (all P   〈  .05). Fever (17.7% vs. 37.8%), arthralgia/arthritis (23.5% vs. 45.7%), interstitial lung disease (ILD, 38.2% vs 68.9%) were significantly less common in the CAM group than the non‐CAM group. Age at onset (odds ratio [OR] 1.036, 95% CI 1.001‐1.072, P  = .042), shawl sign (OR 2.748, 95% CI 1.107‐6.822, P  = .029), anti‐transition initiation factor (TIF)‐1γ antibody (OR 4.012, 95% CI 1.268‐12.687, P  = .018) were identified as the initial risk factors for the onset of CAM, and ILD was identified as a protective factor for CAM (OR 0.292, 95% CI 0.115‐0.739, P  = .009). All‐cause mortality was significantly higher in CAM patients compared with non‐CAM patients ( P  = .001). Conclusion The mortality of patients with CAM was higher than DM/CADM/PM patients without cancer. Malignancy should be screened in DM/CADM/PM patients especially with risk factors, including older age, shawl sign, anti‐TIF‐1γ antibody, and lack of ILD.
    Type of Medium: Online Resource
    ISSN: 1756-1841 , 1756-185X
    URL: Issue
    URL: Article
    DOI: 10.1111/apl.v24.2
    DOI: 10.1111/1756-185X.14046
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2427877-4
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  • 4
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    Online Resource
    GhARF16‐1 modulates leaf development by transcriptionally regulating the GhKNOX2‐1 gene in cotton
    Wiley ; 2021
    In:  Plant Biotechnology Journal Vol. 19, No. 3 ( 2021-03), p. 548-562
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 19, No. 3 ( 2021-03), p. 548-562
    Abstract: The leaf is a crucial organ evolved with remarkable morphological diversity to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis, flowering rates, disease resistance and yield. Although many genes regulating leaf development have been identified in the past years, the precise regulatory architecture underlying the generation of diverse leaf shapes remains to be elucidated. We used cotton as a reference model to probe the genetic framework underlying divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16‐1 and GhKNOX2‐1 genes might be potential regulators of leaf shape. We functionally characterized the auxin‐responsive factor ARF16‐1 acting upstream of GhKNOX2‐1 to determine leaf morphology in cotton. The transcription of GhARF16‐1 was significantly higher in lobed‐leaved cotton than in smooth‐leaved cotton. Furthermore, the overexpression of GhARF16‐1 led to the up‐regulation of GhKNOX2‐1 and resulted in more and deeper serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing GhKNOX2‐1 . We found that GhARF16‐1 specifically bound to the promoter of GhKNOX2‐1 to induce its expression. The heterologous expression of GhARF16‐1 and GhKNOX2‐1 in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed that GhKNOX2‐1 is epistatic to GhARF16‐1 in Arabidopsis , suggesting that the GhARF16‐1 and GhKNOX2‐1 interaction paradigm also functions to regulate leaf shape in Arabidopsis . To our knowledge, our results uncover a novel mechanism by which auxin, through the key component ARF16‐1 and its downstream‐activated gene KNOX2‐1 , determines leaf morphology in eudicots.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.v19.3
    DOI: 10.1111/pbi.13484
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2136367-5
    SSG: 12
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  • 5
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    Resequencing core accessions of a pedigree identifies derivation of genomic segments and key agronomic trait loci during cotton improvement
    Wiley ; 2019
    In:  Plant Biotechnology Journal Vol. 17, No. 4 ( 2019-04), p. 762-775
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 17, No. 4 ( 2019-04), p. 762-775
    Abstract: Upland cotton ( Gossypium hirsutum ) is the world's largest source of natural fibre and dominates the global textile industry. Hybrid cotton varieties exhibit strong heterosis that confers high fibre yields, yet the genome‐wide effects of artificial selection that have influenced Upland cotton during its breeding history are poorly understood. Here, we resequenced Upland cotton genomes and constructed a variation map of an intact breeding pedigree comprising seven elite and 19 backbone parents. Compared to wild accessions, the 26 pedigree accessions underwent strong artificial selection during domestication that has resulted in reduced genetic diversity but stronger linkage disequilibrium and higher extents of selective sweeps. In contrast to the backbone parents, the elite parents have acquired significantly improved agronomic traits, with an especially pronounced increase in the lint percentage. Notably, identify by descent ( IBD ) tracking revealed that the elite parents inherited abundant beneficial trait segments and loci from the backbone parents and our combined analyses led to the identification of a core genomic segment which was inherited in the elite lines from the parents Zhong 7263 and Ejing 1 and that was strongly associated with lint percentage. Additionally, SNP correlation analysis of this core segment showed that a non‐synonymous SNP (A‐to‐G) site in a gene encoding the cell wall‐associated receptor‐like kinase 3 (Gh WAKL 3) protein was highly correlated with increased lint percentage. Our results substantially increase the valuable genomics resources available for future genetic and functional genomics studies of cotton and reveal insights that will facilitate yield increases in the molecular breeding of cotton.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.2019.17.issue-4
    DOI: 10.1111/pbi.13013
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2136367-5
    SSG: 12
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  • 6
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    Auxin‐mediated statolith production for root gravitropism
    Wiley ; 2019
    In:  New Phytologist Vol. 224, No. 2 ( 2019-10), p. 761-774
    Details
    In: New Phytologist, Wiley, Vol. 224, No. 2 ( 2019-10), p. 761-774
    Abstract: See also the Commentary on this article by Su & Masson, 224 : 543–546 .
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v224.2
    DOI: 10.1111/nph.15932
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 7
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    Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies
    Wiley ; 2016
    In:  International Journal of Cancer Vol. 138, No. 4 ( 2016-02-15), p. 866-874
    Details
    In: International Journal of Cancer, Wiley, Vol. 138, No. 4 ( 2016-02-15), p. 866-874
    Abstract: What's new? Evidence suggests that lifestyle and dietary factors play an important role in the etiology of prostate cancer. However, the association between adult weight gain and risk of prostate cancer has not been widely studied and remains unclear. The meta‐analysis presented here quantitatively assesses the dose‐response relationship between adult weight gain and risk of prostate cancer. The results suggest that adult weight gain is associated with an increased risk of high‐risk and fatal prostate cancer, but only low weight gain is positively associated with low‐intermediate‐risk prostate cancer. Recognition of this risk is of great importance for clinical and public health practices.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v138.4
    DOI: 10.1002/ijc.29846
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 8
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    Mitochondrial Calcium Ion Nanogluttons Alleviate Periodontitis via Controlling mPTPs
    Wiley ; 2023
    In:  Advanced Healthcare Materials Vol. 12, No. 15 ( 2023-06)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 12, No. 15 ( 2023-06)
    Abstract: The mitochondrial permeability transition (mPT) directly affects mitochondrial function in macrophages. Under inflammatory conditions, mitochondrial calcium ion (mitoCa 2+ ) overload triggers the persistent opening of mPT pores (mPTPs), further aggravating Ca 2+ overload and increasing reactive oxygen species (ROS) to form an adverse cycle. However, there are currently no effective drugs targeting mPTPs to confine or unload excess Ca 2+ . It is novelly demonstrated that the initiation of periodontitis and the activation of proinflammatory macrophages depend on the persistent overopening of mPTPs, which is mainly triggered by mitoCa 2+ overload and facilitates further mitochondrial ROS leakage into the cytoplasm. To solve the above problems, mitochondrial‐targeted “nanogluttons” with PEG‐TPP conjugated to the surface of PAMAM and BAPTA‐AM encapsulated in the core are designed. These nanogluttons can efficiently “glut” Ca 2+ around and inside mitochondria to effectively control the sustained opening of mPTPs. As a result, the nanogluttons significantly inhibit the inflammatory activation of macrophages. Further studies also unexpectedly reveal that the alleviation of local periodontal inflammation in mice is accompanied by diminished osteoclast activity and reduced bone loss. This provides a promising strategy for mitochondria‐targeted intervention in inflammatory bone loss in periodontitis and can be extended to treat other chronic inflammatory diseases associated with mitoCa 2+ overload.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v12.15
    DOI: 10.1002/adhm.202203106
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 9
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    Arsenic exposure and pruritus: Evidence from observational, interventional, and mendelian randomization studies
    Wiley ; 2023
    In:  Allergy Vol. 78, No. 6 ( 2023-06), p. 1585-1594
    Details
    In: Allergy, Wiley, Vol. 78, No. 6 ( 2023-06), p. 1585-1594
    Abstract: Pruritus is identified as an adverse drug reaction to arsenic trioxide, but the association of arsenic exposure with pruritus has not been investigated. Methods A cross‐sectional study was conducted in Shimen, China. A Mendelian randomization analysis was conducted to confirm the causal relationship between genetically predicted percentages of monomethylated arsenic (MMA%) and dimethylated arsenic (DMA%) in urine with chronic pruritus in UK Biobank. A case–control study was then conducted to determine the biomarker for pruritus. Arsenite‐treated mice were used to confirm the biomarker, and von Frey test was used to induce scratching bouts. Last, a randomized, double‐blind, placebo‐controlled trial was conducted to test the efficacy of naloxone in arsenic‐exposed patients with pruritus in Shimen. Results Hair arsenic (μg/g) showed a dose–response relationship with the intensity of itch in 1079 participants, with odds ratios (OR) of 1.11 for moderate‐to‐severe itch ( p  = 0.012). The Mendelian randomization analysis confirmed the causal relationship, with ORs of 1.043 for MMA% ( p  = 0.029) and 0.904 for DMA% ( p  = 0.077) above versus under median. Serum β‐endorphin was identified as a significant biomarker for the intensity of itch ( p   〈  0.001). Consistently, treatment with arsenite upregulated the level of β‐endorphin ( p  = 0.002) and induced scratching bouts ( p   〈  0.001) in mice. The randomized controlled trial in 126 participants showed that treatment with sublingual naloxone significantly relieved the intensity of itch in arsenic‐exposed participants in 2 weeks ( β  = −0.98, p  = 0.04). Conclusion Arsenic exposure is associated with pruritus, and β‐endorphin serves as a biomarker of pruritus. Naloxone relieves pruritus in patients with arseniasis.
    Type of Medium: Online Resource
    ISSN: 0105-4538 , 1398-9995
    URL: Issue
    URL: Article
    DOI: 10.1111/all.v78.6
    DOI: 10.1111/all.15758
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2003114-2
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  • 10
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    Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three‐dose immunization regimen of CoronaVac
    Wiley ; 2023
    In:  Immunology Vol. 168, No. 1 ( 2023-01), p. 184-197
    Details
    In: Immunology, Wiley, Vol. 168, No. 1 ( 2023-01), p. 184-197
    Abstract: Given increased acceptance of the CoronaVac, there is an unmet need to assess the safety and immunogenic changes of CoronaVac in patients with rheumatic diseases (RD). Here we comprehensively analysed humoral and cellular responses in patient with RD after a three‐dose immunization regimen of CoronaVac. RD patients with stable condition and/or low disease activity ( n  = 40) or healthy controls ( n  = 40) were assigned in a 1:1 ratio to receive CoronaVac (Sinovac). The prevalence of anti‐receptor binding domain (RBD) antibodies and neutralizing antibodies was similar between healthy control (HC) and RD patients after the second and the third vaccination. However, the titers of anti‐RBD IgG and neutralizing antibodies were significantly lower in RD patients compared to HCs ( p   〈  0.05), which was associated with an impaired T follicular helper (Tfh) cell response. Among RD patients, those who generated an antibody response displayed a significantly higher Tfh cells compared to those who failed after the first and the second vaccination ( p   〈  0.05). Interestingly, subjects with a negative serological response displayed a similar Tfh memory response to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐derived peptides as their anti‐RBD IgG positive counterpart, and all (4/4) of the non‐responders in HCs, and 62.5% (5/8) of the non‐responders in patients with RD displayed a positive serological response following the third dose. No serious adverse events were observed. In conclusion, our findings support SARS‐CoV‐2 vaccination in patients with RD with stable and/or low disease activity. The impaired ability in generating vaccine‐specific antibodies in patients with RD was associated with a reduction in Tfh cells induction. The window of vaccination times still needs to be explored in future studies. Clinical trial registration: This trial was registered with ChiCTR2100049138.
    Type of Medium: Online Resource
    ISSN: 0019-2805 , 1365-2567
    URL: Issue
    URL: Article
    DOI: 10.1111/imm.v168.1
    DOI: 10.1111/imm.13572
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006481-0
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