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  • 1
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    Online Resource
    Progressive hypofractionated carbon‐ion radiotherapy for hepatocellular carcinoma: Combined analyses of 2 prospective trials
    Wiley ; 2017
    In:  Cancer Vol. 123, No. 20 ( 2017-10-15), p. 3955-3965
    Details
    In: Cancer, Wiley, Vol. 123, No. 20 ( 2017-10-15), p. 3955-3965
    Abstract: Sequential phase 1/2 and phase 2 prospective trials including 133 lesions in 124 patients with histologically proven hepatocellular carcinoma have been performed to evaluate the safety and efficacy of carbon‐ion radiotherapy hypofractionation with 12, 8, and 4 fractions. Few severe adverse effects have been found, and the 3‐year local‐control rate is 91.4% for all lesions with a 3‐year local‐control rate of 95.5% in the phase 2 trial.
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Article
    DOI: 10.1002/cncr.v123.20
    DOI: 10.1002/cncr.30816
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 2
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    The impact of endoscopic sphincterotomy incision size on common bile duct stone recurrence: A propensity score matching analysis
    Wiley ; 2022
    In:  Journal of Hepato-Biliary-Pancreatic Sciences Vol. 29, No. 12 ( 2022-12), p. 1274-1282
    Details
    In: Journal of Hepato-Biliary-Pancreatic Sciences, Wiley, Vol. 29, No. 12 ( 2022-12), p. 1274-1282
    Abstract: The aim of this study is to clarify the relation between the incision size for endoscopic sphincterotomy (EST) and common bile duct stone (CBDS) recurrence. Methods Patients who underwent elective endoscopic treatment for CBDS between January 2013 and December 2017 were enrolled, excluding those who met the exclusion criteria. The clinical characteristics were investigated using propensity score matching analysis. Results A total of 243 patients were investigated. Propensity scores were calculated using multinomial logistic regression with five relevant variables (age, gender, follow‐up time, maximum stone size, and bile duct diameter), which led to extraction of 188 cases to compose cohorts of the small and medium EST incision groups. The CBDS recurrence rate was 17.0% in the small incision group and 6.4% in the medium incision group. Multivariate analysis identified the medium incision as an independent predictor of CBDS recurrence (hazard ratio 0.350, 95% confidence interval 0.133‐0.922, P  = .034). The CBDS non‐recurrence rate of the medium incision group was significantly higher than that of the small incision group (log‐rank test P  = .019). Conclusions Our findings suggest that the CBDS recurrence rate was lower in EST with medium incision size than with small incision size.
    Type of Medium: Online Resource
    ISSN: 1868-6974 , 1868-6982
    URL: Issue
    URL: Article
    DOI: 10.1002/jhbp.v29.12
    DOI: 10.1002/jhbp.1083
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2536390-6
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  • 3
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    Zonisamide effects on sleep problems and depressive symptoms in Parkinson’s disease
    Wiley ; 2021
    In:  Brain and Behavior Vol. 11, No. 3 ( 2021-03)
    Details
    In: Brain and Behavior, Wiley, Vol. 11, No. 3 ( 2021-03)
    Abstract: We aimed to evaluate the effect of zonisamide (ZNS) on motor symptoms and nonmotor symptoms such as depressive symptoms and sleep problems in Parkinson’s disease (PD) patients with or without tremor. Methods We conducted a 3‐month, open‐label study to assess the effects of ZNS on motor symptoms, depressive symptoms and sleep problems. Twenty levodopa‐treated PD patients with motor fluctuation completed the study. Patients received 25–50 mg/day of ZNS and were assessed for the Japanese version of the Movement Disorder Society Revision of the Unified PD Rating Scale (MDS‐UPDRS) parts I, III, and IV, PD Sleep Scale (PDSS)‐2, Beck depression inventory‐2 (BDI‐II), and PD Questionnaire (PDQ‐8) at baseline and after 1, 2 and 3 months of treatment. Patients were categorized into the tremor group and nontremor group to assess changes in clinical parameters. Results At 3 months, the scores on the MDS‐UPDRS parts I, III and IV significantly improved and off‐time reduced compared to baseline. Additionally, the PDSS‐2 total score significantly decreased at 3 months. Although there were no significant differences in changes in UPDRS part I, III, or IV between the groups after ZNS treatment, the tremor group had significant improvements in PDSS‐2 at 3 months and BDI‐II at 1, 2 and 3 months compared with the nontremor group. Conclusion We showed the beneficial effects of ZNS on motor symptoms and sleep problems in levodopa‐treated PD patients with motor fluctuation. ZNS may be more effective for several nonmotor symptoms in PD patients with tremor compared with those without tremor.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v11.3
    DOI: 10.1002/brb3.2026
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2623587-0
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  • 4
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    Survey on the use of personal protective equipment and COVID ‐19 testing of pregnant women in Japan
    Wiley ; 2020
    In:  Journal of Obstetrics and Gynaecology Research Vol. 46, No. 10 ( 2020-10), p. 1933-1939
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 46, No. 10 ( 2020-10), p. 1933-1939
    Abstract: To clarify the status of personal protective equipment (PPE) and coronavirus disease 2019 (COVID‐19) tests for pregnant women, we conducted an urgent survey. Methods The survey was conducted online from April 27 to May 1, 2020. Questionnaires were sent to core facilities and affiliated hospitals of the obstetrics and gynecology training program and to hospitals of the national perinatal medical liaison council. Results A total of 296 institutions participated in our survey; however, 2 institutions were excluded. Full PPE was used by doctors in 7.1% of facilities and by midwives in 6.8%. Our study also determined that around 65.0% of facilities for doctors and 73.5% of facilities for midwives used PPE beyond the “standard gown or apron, surgical mask, goggles or face shield” during labor of asymptomatic women. N95 masks were running out of stock at 6.5% of the facilities and goggles and face shields at 2.7%. Disposable N95 masks and goggles or face shields were re‐used after re‐sterilization in 12% and 14% of facilities, respectively. Polymerase chain reaction (PCR) testing of asymptomatic patients was performed for 9% of vaginal deliveries, 14% of planned cesarean sections and 17% of emergency cesarean sections. The number of PCR tests for obstetrics and gynecology per a week ranged from zero to five in 92% of facilities. Conclusion The shortage of PPE in Japan is alarming. Sufficient stockpiling of PPE is necessary to prevent unnecessary disruptions in medical care. Appropriate guidelines for PPE usage and COVID‐19 testing of pregnant women at delivery are needed in Japan.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.v46.10
    DOI: 10.1111/jog.14382
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2079101-X
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  • 5
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    Psychological stress among pregnant and puerperal women in Japan during the coronavirus disease 2019 pandemic
    Wiley ; 2021
    In:  Journal of Obstetrics and Gynaecology Research Vol. 47, No. 9 ( 2021-09), p. 2990-3000
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 47, No. 9 ( 2021-09), p. 2990-3000
    Abstract: To evaluate psychological stress among pregnant and puerperal women in Japan during the coronavirus disease 2019 (COVID‐19) pandemic. Methods In this cross‐sectional study, we recruited pregnant women and puerperal women who delivered between January and September 2020 in Japan, using an online questionnaire. Participants were divided into low, middle, and high groups according to the degree of the epidemic in their region of residence. Related factors were analyzed using the chi‐squared test. The relationship between COVID‐19 epidemic regions and depression risks and anxiety using the Edinburgh Postnatal Depression Scale (EPDS) and Kessler 6 scale (K6) was evaluated using a univariate and multivariable logistic regression model. Results Overall, 7775 cases, including 4798 pregnant and 2977 puerperal women, were analyzed. The prevalence of high EPDS and K6 scores was significantly increased in pregnant women in the high than those in the low epidemic regions (EPDS: adjusted odds ratio [aOR] 1.453, 95% confidence interval [CI] 1.205–1.753; K6: aOR 1.601, 95% CI 1.338–1.918). There was no difference in EPDS score, but the prevalence of high K6 scores was significantly increased in puerperal women in the high than those in the low epidemic regions (aOR 1.342, 95% CI 1.066–1.690). Further, restriction on going to their hometown for delivery increased the prevalence of high EPDS scores among pregnant (aOR 1.663, 95% CI 1.296–2.133) and puerperal women (aOR 1.604, 95% CI 1.006–2.557). Conclusions Decreased support due to the COVID‐19 pandemic affected the psychological status of pregnant and puerperal women; hence, investing medical resources in their healthcare essential.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.v47.9
    DOI: 10.1111/jog.14877
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2079101-X
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  • 6
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    The vaccination status and adverse effects of COVID ‐19 vaccine among pregnant women in Japan in 2021
    Wiley ; 2022
    In:  Journal of Obstetrics and Gynaecology Research Vol. 48, No. 7 ( 2022-07), p. 1561-1569
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 48, No. 7 ( 2022-07), p. 1561-1569
    Abstract: To investigate the vaccination status and adverse reactions to the COVID‐19 vaccine among pregnant women in Japan, we conducted an online questionnaire survey from October 5 to November 22, 2021. The number of participants in the online survey was 6576. Of the participants, 4840 (73.6%) were vaccinated twice, and 557 (8.5%) were vaccinated once. A total of 1179 (17.9%) responders had never been vaccinated against COVID‐19. The most frequent adverse reaction was local pain at the injection site. The incidence of local adverse reactions was almost identical after the first and the second vaccinations, while systemic reactions, such as fever and fatigue/malaise, and adverse reactions outside the vaccination site such as headache and arthralgia, were more frequent after the second vaccination than after the first vaccination. Regarding the obstetrical complications, uterine tension and/or contraction was observed in 1.65% of the pregnant women after the first vaccination and in 2.98% after the second vaccination, and uterine pain appeared in 1.06% of the pregnant women after the second vaccination. However, serious symptoms, such as hemorrhage, decreased fetal movement, edema, increased blood pressure, and amniorrhexis, were seen in less than 1% of vaccinated women after both the first and second vaccinations. This study clarified the characteristics of vaccination, adverse reactions, and obstetrical symptoms in pregnant women in Japan who had the COVID‐19 vaccine up to the second dose. As a booster vaccination is currently underway, further study is needed to improve the management of pregnant women during the current pandemic.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.v48.7
    DOI: 10.1111/jog.15285
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 7
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    Exploring the contributing factors to multiple chemical sensitivity in patients with migraine
    Wiley ; 2022
    In:  Journal of Occupational Health Vol. 64, No. 1 ( 2022-01)
    Details
    In: Journal of Occupational Health, Wiley, Vol. 64, No. 1 ( 2022-01)
    Abstract: Multiple chemical sensitivity (MCS) is a form of chemical intolerance in which various systemic symptoms are triggered by exposure to a variety of chemical substances. Although migraine has been associated with central sensitivity syndrome, the relationship between MCS and migraine has not been studied. We assessed the frequency of MCS and its related factors in patients with migraine. Methods We performed a cross‐sectional study that included 95 patients (14 M/81 F; age, 45.4 ± 12.4 years) out of 100 consecutive patients with migraine from our outpatient headache clinic. MCS was defined as having a combination of Q1 ≥ 30, Q3 ≥ 13, and Q5 ≥ 17 on the quick environment exposure sensitivity inventory (QEESI; Japanese version). Central sensitization inventory‐A scores 〉 40 were considered an indication of central sensitization. Headache‐related disability and psychological distress were evaluated with the Migraine Disability Assessment score (MIDAS) and Kessler Psychological Distress Scale (K6), respectively. Results MCS was identified in 20% of patients with migraine; however, none had previously been diagnosed with MCS. The MCS‐positive group had higher rates of photophobia, osmophobia, visual aura, sensory aura, and central sensitization and higher MIDAS and K6 scores than the MCS‐negative group. A logistic regression analysis showed that osmophobia, sensory aura, and central sensitization were significant contributors to MCS. Conclusion We showed that MCS was observed in 20% of patients with migraine, and our study results may indicate a possible association of MCS with central sensitization and hypersensitivity‐related symptoms in patients with migraine.
    Type of Medium: Online Resource
    ISSN: 1341-9145 , 1348-9585
    URL: Article
    DOI: 10.1002/1348-9585.12328
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1340985-2
    detail.hit.zdb_id: 2075956-3
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  • 8
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    Determination of the origin of oral squamous cell carcinoma by microarray analysis: Squamous epithelium or minor salivary gland?
    Wiley ; 2018
    In:  International Journal of Cancer Vol. 143, No. 10 ( 2018-11-15), p. 2551-2560
    Details
    In: International Journal of Cancer, Wiley, Vol. 143, No. 10 ( 2018-11-15), p. 2551-2560
    Abstract: What's new? In spite of several past attempts, no distinct factors controlling the biological aggressiveness of oral squamous cell carcinoma (SCC) have been identified. Determining the origin of the cancer cells could help predict biological aggressiveness, however. Here, the authors provide evidence that oral SCC has two different origins, as mucosal or salivary SCC. Furthermore, they identify nine genes able to reveal the origin of oral SCC. Based on their expression levels, the authors determined that twelve of the 66 oral SCCs in their sample originated from minor salivary glands. Salivary SCC tumors showed high metastatic potential and poor event‐free survival rate.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v143.10
    DOI: 10.1002/ijc.31811
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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    detail.hit.zdb_id: 1474822-8
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  • 9
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    Cancer‐specific mortality of high‐risk prostate cancer after carbon‐ion radiotherapy plus long‐term androgen deprivation therapy
    Wiley ; 2017
    In:  Cancer Science Vol. 108, No. 12 ( 2017-12), p. 2422-2429
    Details
    In: Cancer Science, Wiley, Vol. 108, No. 12 ( 2017-12), p. 2422-2429
    Abstract: The treatment outcomes of patients with high‐risk localized prostate cancer ( PC ) after carbon‐ion radiotherapy ( CIRT ) combined with long‐term androgen deprivation therapy ( LTADT ) were analyzed, and compared with those of other treatment modalities, focusing on PC ‐specific mortality ( PCSM ). A total of 1247 patients were enrolled in three phase  II clinical trials of fixed‐dose CIRT between 2000 and 2013. Excluding patients with T4 disease, 608 patients with high‐risk or very‐high‐risk PC , according to the National Comprehensive Cancer Network classification system, who received CIRT with LTADT were evaluated. The median follow‐up time was 88.4 months, and the 5‐/10‐year PCSM rates were 1.5%/4.3%, respectively. T3b disease, Gleason score of 9–10 and percentage of positive biopsy cores 〉 75% were associated with significantly higher PCSM on univariate and multivariate analyses. The 10‐year PCSM rates of patients having all three ( n  = 16), two ( n  = 74) or one of these risk factors ( n  = 217) were 27.1, 11.6 and 5.7%, respectively. Of the 301 patients with none of these factors, only 1 PCSM occurred over the 10‐year follow‐up (10‐year PCSM rate, 0.3%), and significant differences were observed among the four stratified groups ( P   〈 0.001). CIRT combined with LTADT yielded relatively favorable treatment outcomes in patients with high‐risk PC and very favorable results in patients without any of the three abovementioned factors for PCSM . Because a significant difference in PCSM among the high‐risk PC patient groups was observed, new categorization and treatment intensity adjustment may be required for high‐risk PC patients treated with CIRT .
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.2017.108.issue-12
    DOI: 10.1111/cas.13402
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 10
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    Updated long‐term outcomes after carbon‐ion radiotherapy for primary renal cell carcinoma
    Wiley ; 2018
    In:  Cancer Science Vol. 109, No. 9 ( 2018-09), p. 2873-2880
    Details
    In: Cancer Science, Wiley, Vol. 109, No. 9 ( 2018-09), p. 2873-2880
    Abstract: Long‐term oncological outcomes for primary renal cell carcinoma ( RCC ) treated with carbon‐ion radiotherapy ( CIRT ) are poorly understood. Patients with primary RCC were treated with 12 or 16‐fraction CIRT at The Hospital of the National Institute of Radiological Sciences outside of clinical trials. Outcome data were pooled and retrospectively analyzed for toxicity, local control, and disease‐free, cancer‐specific, and overall survival. From 1997 to 2014, 19 RCC patients (11 with T1aN0M0, 4 with T1bN0M0, and 4 with inoperable advanced stage [T4N0M0, T3aN1M0, and T1aN0M1]) were treated with CIRT and followed up for a median of 6.6 (range, 0.7‐16.5) years; 9 of these patients were inoperable because of comorbidities or advanced‐stage disease. Diagnoses were confirmed by imaging in 11 patients and by biopsy in the remaining 8. In 4 of 5 patients with definitive renal comorbidities, including diabetic nephropathy, sclerotic kidney or solitary kidney pre‐ CIRT progressed to grade 4 chronic kidney disease ( CKD ). In contrast, the remaining 14 patients without definitive renal comorbidities did not progress to grade 3 or higher CKD . Furthermore, although 1 case of grade 4 dermatitis was observed, there were no other grade 3 or higher non‐renal adverse events. Local control rate, and disease‐free, cancer‐specific, and overall survival rates at 5 years of all 19 patients were 94.1%, 68.9%, 100%, and 89.2%, respectively. This updated retrospective analysis based on long‐term follow‐up data suggests that CIRT is a safe treatment for primary RCC patients without definitive renal comorbidities pre‐ CIRT , and yield favorable treatment outcomes, even in inoperable cases.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.2018.109.issue-9
    DOI: 10.1111/cas.13727
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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