In:
Otolaryngology–Head and Neck Surgery, Wiley, Vol. 136, No. 2 ( 2007-02), p. 205-210
Abstract:
Laryngopharyngeal reflux (LPR) is generally treated with twice‐daily proton‐pump inhibitor (PPI) therapy. In this study, the efficacy of esomeprazole 40 mg once‐daily together with lifestyle modifications was determined by repeated 24‐hour pH monitoring. Study Design and Setting A prospective study. Fortynine patients with suspected LPR underwent 24‐hour pH monitoring. Twenty‐seven of 49 patients with measurable abnormal proximal reflux reflected by a reflux area index (RAI) 〉 6.3 were treated with esomeprazole 40 mg every day, and a second pH study was performed. Results In 22 of 27 patients, everyday PPI treatment reduced the RAI. Four of 5 patients with no RAI reduction reported on symptomatic relief. Conclusion In a considerable number of patients with suspected LPR, pH monitoring reveals no abnormal proximal reflux. Esomeprazole 40 mg every day together with lifestyle modifications could reach adequate acid suppression in a large number of patients. Symptom improvement is also reported by patients without measurable effects of therapy.
Type of Medium:
Online Resource
ISSN:
0194-5998
,
1097-6817
DOI:
10.1016/j.otohns.2006.10.011
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
2008453-5
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