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  • 1
    Online Resource
    Online Resource
    Efficacy and safety of adalimumab in Chinese patients with moderate‐to‐severe plaque psoriasis: results from a phase 3, randomized, placebo‐controlled, double‐blind study
    Wiley ; 2017
    In:  Journal of the European Academy of Dermatology and Venereology Vol. 31, No. 1 ( 2017-01), p. 89-95
    Details
    In: Journal of the European Academy of Dermatology and Venereology, Wiley, Vol. 31, No. 1 ( 2017-01), p. 89-95
    Abstract: This phase 3 trial is the first to evaluate the efficacy and safety of treatment with the systemic TNF ‐α inhibitor, adalimumab, for Chinese patients with moderate‐to‐severe plaque psoriasis. Methods In the 12‐week, double‐blind, placebo‐controlled Period A, patients were randomized 4 : 1 to receive adalimumab 40 mg every‐other‐week (following a single 80 mg dose), or placebo every‐other‐week. In the subsequent 12‐week, open‐label, Period B, all patients received adalimumab 40 mg every‐other‐week starting at week 13, following a single, blinded dose at week 12 of adalimumab 80 mg or matching placebo (for patients receiving placebo or adalimumab in Period A respectively). In Period A, efficacy was analysed for all randomized patients and safety for all patients receiving ≥1 dose of the study drug. Results For the 425 patients in this study (87 placebo; 338 adalimumab), a higher percentage randomized to adalimumab achieved the primary endpoint of ≥75% improvement from baseline in PASI score ( PASI 75) at week 12: placebo 11.5% (10/87); adalimumab 77.8% (263/338; P 〈 0.001). Physician's Global Assessment of clear to minimal was achieved at week 12 by 14.9% placebo (13/87) and 80.5% adalimumab (272/338; P 〈 0.001). For patients who received adalimumab at any time during the study (All‐adalimumab Population), treatment‐emergent adverse events ( AE s) were reported by 63.4%; the most common was upper respiratory infection (16.1%). Serious AE s were reported by 3.5% of the All‐adalimumab Population, and serious infectious AE s by 1.2%, which include lung infection, pneumonia and tuberculosis [2 (0.5%) patients each] . There was one death (chronic heart failure). Conclusion In these Chinese patients with moderate‐to‐severe psoriasis, a significantly greater percentage treated with adalimumab compared with placebo achieved efficacy endpoints at week 12 and efficacy was sustained to week 24. Safety results were consistent with the known adalimumab safety profile; no new safety signals were identified in the 24 weeks of treatment.
    Type of Medium: Online Resource
    ISSN: 0926-9959 , 1468-3083
    URL: Issue
    URL: Article
    DOI: 10.1111/jdv.2017.31.issue-1
    DOI: 10.1111/jdv.13746
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2022088-1
    detail.hit.zdb_id: 1128828-0
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  • 2
    Online Resource
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    Huntingtin gene CAG repeat numbers in C hinese patients with H untington's disease and controls
    Wiley ; 2014
    In:  European Journal of Neurology Vol. 21, No. 4 ( 2014-04), p. 637-642
    Details
    In: European Journal of Neurology, Wiley, Vol. 21, No. 4 ( 2014-04), p. 637-642
    Abstract: Huntington's disease is due to a CAG triplet repeat elongation in the huntingtin gene. Boundaries in CAG numbers have been found between healthy people with and without risk to pass the disorder to the next generation, and between people without, with a mild, or with a fully penetrant phenotype. These data have been generated in western populations and it is not clear whether they are also valid amongst Chinese. Methods In order to establish normative data in the huntingtin gene for Chinese people, 966 chromosomes from normal controls were tested. Further, the range of CAG repeats was examined in a cohort from six centres and a total of 368 patients with the disease were included. Results The CAG triplet repeat range in normal controls was between 9 and 35 (mean 18.9, SD 2.57). Triplets in the range between 26 and 35 were found in 2.5%. In the patient cohort, triplet repeats in the shorter allele were between 8 and 37 (mean 17.7, SD 1.6). In the longer allele, a range between 36 and 120 was found. There was a negative correlation (−0.65, r  = 0.42) between age at onset and the number of triplet repeats in the larger allele. The mean age at onset was 38 years, with a range between 2 and 70 years. In 23 patients (6%) a childhood or juvenile onset was noted. Conclusion These data show comparable ranges of huntingtin gene CAG triplet repeats in normal people and in patients with Huntington's disease as in western populations.
    Type of Medium: Online Resource
    ISSN: 1351-5101 , 1468-1331
    URL: Issue
    URL: Article
    DOI: 10.1111/ene.2014.21.issue-4
    DOI: 10.1111/ene.12366
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2020241-6
    detail.hit.zdb_id: 1280785-0
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  • 3
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    Size effect on efficiency droop of blue light emitting diode
    Wiley ; 2012
    In:  physica status solidi c Vol. 9, No. 3-4 ( 2012-03), p. 616-619
    Details
    In: physica status solidi c, Wiley, Vol. 9, No. 3-4 ( 2012-03), p. 616-619
    Abstract: In this paper, the size effects on the efficiency droop (ED) in blue InGaN/GaN quantum well light emitting diode are investigated. The smaller size LEDs can work well under much higher power density, especially when the size is reduced to under 40 micro‐meters. It shows a weaker ED in these small LEDs. Time correlated single photon counting (TCSPC) measurements show a longer electroluminescence lifetime for smaller size LEDs, which implicates the nonradiative recombination is reduced. It is likely due to Aguer recombination reduction by quantum well (QW) band flatened with the device size decreasing. Cathodoluminescence results indicates that the strain in QWs is relaxed both in the whole pillar and along radial direction of the pillar. The better performance of the smaller size LED is likely attributed to strain relaxation (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
    Type of Medium: Online Resource
    ISSN: 1862-6351 , 1610-1642
    URL: Issue
    URL: Article
    DOI: 10.1002/pssc.v9.3/4
    DOI: 10.1002/pssc.201100483
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2105580-4
    detail.hit.zdb_id: 2102966-0
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  • 4
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    Effects of vascular endothelial cells on osteogenic differentiation of noncontact co‐cultured periodontal ligament stem cells under hypoxia
    Wiley ; 2013
    In:  Journal of Periodontal Research Vol. 48, No. 1 ( 2013-02), p. 52-65
    Details
    In: Journal of Periodontal Research, Wiley, Vol. 48, No. 1 ( 2013-02), p. 52-65
    Abstract: Background and Objective:  During periodontitis or orthodontic tooth movement, the periodontal vasculature is severely impaired by chronic inflammation or excessive mechanical force. This leads to a hypoxic microenvironment of the periodontal cells and enhances the expression of various cytokines and growth factors that may regulate angiogenesis and alveolar bone remodeling. However, the role of hypoxia in regulating the communication between endothelial cells (ECs) and osteoblast progenitors during the remodeling and repair of periodontal tissue is still poorly defined. The aim of this study was to investigate the effects of vascular ECs on osteogenic differentiation, mineralization and the paracrine function of noncontact co‐cultured periodontal ligament stem cells (PDLSCs) under hypoxia, and further reveal the involvement of MEK/ERK and p38 MAPK pathways in the process. Material and Methods:  First, PDLSCs were obtained and a noncontact co‐culture system of PDLSCs and human umbilical vein endothelial cells was established. Second, the effects of different time‐periods of hypoxia (2% O 2 ) on the osteogenic potential, mineralization and paracrine function of co‐cultured PDLSCs were investigated. Third, ERK1/2 and p38 MAPK activities of PDLSCs under hypoxia were measured by western blotting. Finally, we employed specific MAPK inhibitors (PD98059 and SB20350) to investigate the involvement of ERK1/2 and p38 MAPK in PDLSC osteogenesis under hypoxia. Results:  We observed further increased osteogenic differentiation of co‐cultured PDLSCs, manifested by markedly enhanced alkaline phosphatase (ALP) activity and prostaglandin E 2 (PGE 2 ) levels, vascular endothelial growth factor (VEGF) release, runt‐related transcription factor 2 (Runx2) and Sp7 transcriptional and protein levels and mineralized nodule formation, compared with PDLSCs cultured alone. ERK1/2 was phosphorylated in a rapid but transient manner, whereas p38 MAPK was activated in a slow and sustained way under hypoxia. Furthermore, hypoxia‐stimulated transcription and expression of osteogenic regulators (hypoxia‐inducible factor‐1α, ALP, Runx2, Sp7, PGE 2 and VEGF) were also inhibited by PD98059 and SB203580 to different degrees. Conclusion:  Further increased osteogenic differentiation and mineralization of co‐cultured PDLSCs under hypoxia were regulated by MEK/ERK and p38 MAPK pathways. And the ECs‐mediated paracrine of PGE 2 and VEGF may facilitate the unidirectional PDLSC‐EC communication and promote PDLSCs osteogenesis.
    Type of Medium: Online Resource
    ISSN: 0022-3484 , 1600-0765
    URL: Issue
    URL: Article
    DOI: 10.1111/jre.2012.48.issue-1
    DOI: 10.1111/j.1600-0765.2012.01503.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 390953-0
    detail.hit.zdb_id: 2025633-4
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  • 5
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    Characterization and application of two novel monoclonal antibodies against human OX40: costimulation of T cells and expression on tumor as well as normal gland tissues
    Wiley ; 2006
    In:  Tissue Antigens Vol. 67, No. 4 ( 2006-04), p. 307-317
    Details
    In: Tissue Antigens, Wiley, Vol. 67, No. 4 ( 2006-04), p. 307-317
    Abstract: OX40, a membrane‐bound molecule of the tumor‐necrosis‐factor‐receptor superfamily, is a critical costimulatory receptor during the immune response. Here, we newly generated two specific mouse antihuman OX40 monoclonal antibodies (mAbs) (2G2 and 1F7), whose specificities are quite different from the available OX40 mAb (ACT35) by competition assay. It was also found that both mAbs could enhance the proliferation, activation and differentiation of T lymphocytes primed by anti‐CD3 mAb. These results evidenced that both were functional antihuman OX40 mAbs. Furthermore, stained by 2G2 and 1F7, FCM and immunohistochemistry detected the constitutive expression of OX40 on tumor cell lines from epithelium, breast cancer and glioma tissues. Meanwhile, the non‐tumor tissues (thyroid gland, stomach gland) were also found OX40 expression. These results suggested that OX40 is not only expressed in activated T cells, but also in some tumors as well as normal gland tissues. Such expression pattern indicated that OX40 may be a valuable surface antigen in unveiling its expression and function outside the immune system. Briefly, these novel antibodies may contribute to the evaluation of the mechanism of tumor metastasis and eventually shed light on further study of tumor immunotherapy and autoimmune diseases.
    Type of Medium: Online Resource
    ISSN: 0001-2815 , 1399-0039
    URL: Issue
    URL: Article
    DOI: 10.1111/tan.2006.67.issue-4
    DOI: 10.1111/j.1399-0039.2006.00584.x
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1498140-3
    detail.hit.zdb_id: 120440-3
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  • 6
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    Online Resource
    Application of allele-specific RNAi in hepatitis B virus lamivudine resistance : Application of ASP-RNAi in HBV
    Wiley ; 2011
    In:  Journal of Viral Hepatitis Vol. 18, No. 10 ( 2011-10), p. e491-e498
    Details
    In: Journal of Viral Hepatitis, Wiley, Vol. 18, No. 10 ( 2011-10), p. e491-e498
    Type of Medium: Online Resource
    ISSN: 1352-0504
    URL: Issue
    URL: Article
    DOI: 10.1111/jvh.2011.18.issue-10
    DOI: 10.1111/j.1365-2893.2011.01483.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1212497-7
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  • 7
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    Online Resource
    Comparison of micro RNA s in adipose and muscle tissue from seven indigenous Chinese breeds and Yorkshire pigs
    Wiley ; 2019
    In:  Animal Genetics Vol. 50, No. 5 ( 2019-10), p. 439-448
    Details
    In: Animal Genetics, Wiley, Vol. 50, No. 5 ( 2019-10), p. 439-448
    Abstract: Elucidation of the pig micro RNA ome is essential for interpreting functional elements of the genome and understanding the genetic architecture of complex traits. Here, we extracted small RNA s from skeletal muscle and adipose tissue, and we compared their expression levels between one Western breed (Yorkshire) and seven indigenous Chinese breeds. We detected the expression of 172 known porcine micro RNA s (mi RNA s) and 181 novel mi RNA s. Differential expression analysis found 92 and 12 differentially expressed mi RNA s in adipose and muscle tissue respectively. We found that different Chinese breeds shared common directional mi RNA expression changes compared to Yorkshire pigs. Some mi RNA s differentially expressed across multiple Chinese breeds, including ssc‐miR‐129‐5p, ssc‐miR‐30 and ssc‐miR‐150, are involved in adipose tissue function. Functional enrichment analysis revealed that the target genes of the differentially expressed mi RNA s are associated mainly with signaling pathways rather than metabolic and biosynthetic processes. The mi RNA –target gene and mi RNA –phenotypic traits networks identified many hub mi RNA s that regulate a large number of target genes or phenotypic traits. Specifically, we found that intramuscular fat content is regulated by the greatest number of mi RNA s in muscle tissue. This study provides valuable new candidate mi RNA s that will aid in the improvement of meat quality and production.
    Type of Medium: Online Resource
    ISSN: 0268-9146 , 1365-2052
    URL: Issue
    URL: Article
    DOI: 10.1111/age.v50.5
    DOI: 10.1111/age.12826
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 632766-7
    detail.hit.zdb_id: 1472889-8
    SSG: 22
    SSG: 12
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  • 8
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    Comparison of long non‐coding RNAs in adipose and muscle tissues between seven indigenous Chinese and the Yorkshire pig breeds
    Wiley ; 2021
    In:  Animal Genetics Vol. 52, No. 5 ( 2021-10), p. 645-655
    Details
    In: Animal Genetics, Wiley, Vol. 52, No. 5 ( 2021-10), p. 645-655
    Abstract: lncRNAs play crucial roles in fat metabolism in animals. Previously, we have compared the mRNA transcriptome profiles between seven fat‐type Chinese pig breeds and one lean‐type Western breed (Yorkshire, YY). The associations between differentially expressed (DE) genes and phenotypical traits were investigated. In the present study, to further explore the underlying regulatory mechanisms, lncRNAs were sequenced and compared between YY and Chinese indigenous breeds. The results showed 9114 and 7538 DE lncRNAs between at least one Chinese breed and the YY breed in the adipose and muscle tissue respectively. KEGG enrichment analysis revealed that the target genes of these DE lncRNAs mainly influenced the glucolipid metabolism, which is an important process affecting meat quality. Correlation analyses between the DE lncRNA and DE mRNA genes related to meat quality and growth traits were performed. The results showed that LTCONS_00073280 was associated with intramuscular fat content. Four lncRNAs (LTCONS_00101781, LTCONS_00037879, LTCONS_00088260 and LTCONS‐00128343) might mediate backfat thickness. Overall, this study provides candidate lncRNAs that potentially affect meat quality, which might be useful for molecular breeding of pig breeds in future.
    Type of Medium: Online Resource
    ISSN: 0268-9146 , 1365-2052
    URL: Issue
    URL: Article
    DOI: 10.1111/age.v52.5
    DOI: 10.1111/age.13123
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 632766-7
    detail.hit.zdb_id: 1472889-8
    SSG: 22
    SSG: 12
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  • 9
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    Characterizations of palace lantern tassels preserved in The Palace Museum, Beijing, by UPLC‐ESI‐Q‐TOF
    Wiley ; 2020
    In:  Archaeometry Vol. 62, No. 3 ( 2020-06), p. 660-676
    Details
    In: Archaeometry, Wiley, Vol. 62, No. 3 ( 2020-06), p. 660-676
    Abstract: Palace lanterns were important and highly visible decorations in the imperial palace in Beijing, China, during the Qing dynasty (1636–1912). Most lanterns had colourful tassels made of fibres. The study performed a comprehensive investigation of the materials and dyes used for palace lantern tassels preserved in The Palace Museum, Beijing. Eight samples with different colours, including yellow, green and red, from five palace lanterns were analysed. By using ultra‐performance liquid chromatography combined with time‐of‐flight mass spectrometry, the compositions of the dyes were identified quickly, and thus the dyes' origins were explored. A X‐ray fluorescence spectrometer assisted in the detection of whether a mordant was used during the dyeing process. As a result, the tassels were all made of silk, discovered through the use of microscopic observation and micro‐Fourier transform infrared spectrometry analysis. Different dyeing techniques were found in these tassels: yellow tassels were dyed by cork tree or turmeric by a direct dyeing method; greens were dyed by pagoda bud with an iron mordant, or by the combination of cork tree and indigo using multi‐dyeing method; and red tassels were coloured with different acid red industrial dyes. These results provide valuable data for the conservation of ancient textile tassels and contribute to the investigation of other hanging tags.
    Type of Medium: Online Resource
    ISSN: 0003-813X , 1475-4754
    URL: Issue
    URL: Article
    DOI: 10.1111/arcm.v62.3
    DOI: 10.1111/arcm.12538
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2043768-7
    detail.hit.zdb_id: 301612-2
    SSG: 6,14
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  • 10
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    Serum micro RNA s as potential biomarkers of mandibular prognathism
    Wiley ; 2014
    In:  Oral Diseases Vol. 20, No. 1 ( 2014-01), p. 55-61
    Details
    In: Oral Diseases, Wiley, Vol. 20, No. 1 ( 2014-01), p. 55-61
    Abstract: The aim of the study was to determine whether the expression levels of specific circulating serum micro RNA s (mi RNA s) are associated with mandibular prognathism ( MP ). Methods Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty‐eight normal control subjects in the early permanent dentition stage and 24 in the mixed dentition stage were recruited for comparison. According to the microarray‐based expression profiling, four serum mi RNA s (let‐7i‐3p, mi R ‐595, mi R ‐16‐2‐3p, and mi R ‐367‐5p) were validated. Results In the MP groups, let‐7i‐3p was significantly over‐expressed in subjects in the early permanent ( P  〈   0.0005) and mixed ( P  〈   0.001) dentitions, and mi R ‐595 was significantly under‐expressed ( P  〈   0.004) in subjects in the early permanent ( P  〈   0.004) and mixed ( P  〈   0.0005) dentitions, compared with normal control groups. Multiple logistic regression analysis and receiver operating characteristic curve analysis revealed that let‐7i‐3p and mi R ‐595 were able to significantly discriminate MP subjects from normal controls. Conclusion Let‐7i‐3p and mi R ‐595 could be potential, non‐invasive biomarkers for the accurate early detection and diagnosis of MP , which may result in improved clinical management.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Issue
    URL: Article
    DOI: 10.1111/odi.2013.20.issue-1
    DOI: 10.1111/odi.12073
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2008428-6
    detail.hit.zdb_id: 1290529-X
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