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  • 1
    Online Resource
    Online Resource
    SCARF1 promotes M2 polarization of Kupffer cells via calcium‐dependent PI3K‐AKT‐STAT3 signalling to improve liver transplantation
    Wiley ; 2021
    In:  Cell Proliferation Vol. 54, No. 4 ( 2021-04)
    Details
    In: Cell Proliferation, Wiley, Vol. 54, No. 4 ( 2021-04)
    Abstract: This study aimed to investigate the protective effect of SCARF1 on acute rejection (AR), phagocytic clearance of Kupffer cells (KCs), M2 polarization and the exact mechanism underlying these processes. Methods AAV was transfected into the portal vein of rats, and AR and immune tolerance (IT) models of liver transplantation were established. Liver tissue and blood samples were collected. The level of SCARF1 was detected via WB and immunohistochemical staining. Pathological changes in liver tissue were detected using HE staining. Apoptotic cells were detected using TUNEL staining. KC polarization was assessed via immunohistochemical staining. Primary KCs were isolated and co‐cultured with apoptotic T lymphocytes. Phagocytosis of apoptotic cells and polarization of KCs were both detected using immunofluorescence. Calcium concentration was determined using immunofluorescence and a fluorescence microplate reader. The levels of PI3K, p‐AKT and P‐STAT3 were assessed via WB and immunofluorescence. Results Compared to the IT group, the level of SCARF1 was significantly decreased in the AR group. Overexpression of SCARF1 in KCs improved AR and liver function markers. Enhanced phagocytosis mediated by SCARF1 is beneficial for improving the apoptotic clearance of AR and promoting M2 polarization of KCs. SCARF1‐mediated enhancement of phagocytosis promotes increased calcium concentration in KCs, thus further activating the PI3K‐AKT‐STAT3 signalling pathway. Conclusions SCARF1 promotes the M2 polarization of KCs by promoting phagocytosis through the calcium‐dependent PI3K‐AKT‐STAT3 signalling pathway.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.v54.4
    DOI: 10.1111/cpr.13022
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Coupling of Cu(100) and (110) Facets Promotes Carbon Dioxide Conversion to Hydrocarbons and Alcohols
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 9 ( 2021-02-23), p. 4929-4935
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 9 ( 2021-02-23), p. 4929-4935
    Abstract: Copper can efficiently electro‐catalyze carbon dioxide reduction to C 2+ products (C 2 H 4 , C 2 H 5 OH, n‐propanol). However, the correlation between the activity and active sites remains ambiguous, impeding further improvements in their performance. The facet effect of copper crystals to promote CO adsorption and C−C coupling and consequently yield a superior selectivity for C 2+ products is described. We achieve a high Faradaic efficiency (FE) of 87 % and a large partial current density of 217 mA cm −2 toward C 2+ products on Cu(OH) 2 ‐D at only −0.54 V versus the reversible hydrogen electrode in a flow‐cell electrolyzer. With further coupled to a Si solar cell, record‐high solar conversion efficiencies of 4.47 % and 6.4 % are achieved for C 2 H 4 and C 2+ products, respectively. This study provides an in‐depth understanding of the selective formation of C 2+ products on Cu and paves the way for the practical application of electrocatalytic or solar‐driven CO 2 reduction.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.9
    DOI: 10.1002/ange.202015159
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
    Online Resource
    Online Resource
    Age‐dependent alteration in metabolism of vitamin B 6 , neurotransmitters, and amino acids after 4′‐ O ‐methylpyridoxine administration in rats
    Wiley ; 2022
    In:  Journal of Food Science Vol. 87, No. 1 ( 2022-01), p. 466-480
    Details
    In: Journal of Food Science, Wiley, Vol. 87, No. 1 ( 2022-01), p. 466-480
    Abstract: 4′‐ O ‐methylpyridoxine (MPN), a recognized antivitamin B 6 compound, is a potentially poisonous substance found in Ginkgo biloba L. In this work, the effects of MPN on the metabolism of vitamin B 6 , neurotransmitters, and amino acids were compared in the plasma and brain of young and adult rats under various administration times. Results showed that the contents of MPN residues in the plasma and brain of young rats were 12.72 and 14.76 µM higher than adult rats, respectively. Moreover, the levels of 5‐hydroxytryptamine and dopamine in the brain of young rats have decreased by 13.78% and 7.19%, respectively, compared with the control group, at 2 h after MPN administration. Furthermore, the principal component analysis revealed that MPN was an important contributor to the amino acid composition in the brain of young rats. These results suggest that age may lead to different toxic effects of MPN. Practical Application 4ʹ‐ O ‐methylpyridoxine is primarily responsible for poisoning due to overconsumption of Ginkgo biloba seeds. This study will provide an exploratory understanding of the age‐dependent toxicity of 4ʹ‐ O ‐methylpyridoxine.
    Type of Medium: Online Resource
    ISSN: 0022-1147 , 1750-3841
    URL: Issue
    URL: Article
    DOI: 10.1111/jfds.v87.1
    DOI: 10.1111/1750-3841.15997
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2006705-7
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  • 4
    Online Resource
    Online Resource
    In situ Observation of the Photochromism in the Langmuir Monolayer of a Non-typical Amphiphilic Spiropyran Derivative at the Air/Water Interface
    Wiley ; 2010
    In:  Chinese Journal of Chemistry Vol. 21, No. 4 ( 2010-08-26), p. 387-391
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 21, No. 4 ( 2010-08-26), p. 387-391
    Type of Medium: Online Resource
    ISSN: 1001-604X
    URL: Article
    DOI: 10.1002/cjoc.20030210407
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2144352-X
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  • 5
    Online Resource
    Online Resource
    Coupling of Cu(100) and (110) Facets Promotes Carbon Dioxide Conversion to Hydrocarbons and Alcohols
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 9 ( 2021-02-23), p. 4879-4885
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 9 ( 2021-02-23), p. 4879-4885
    Abstract: Copper can efficiently electro‐catalyze carbon dioxide reduction to C 2+ products (C 2 H 4 , C 2 H 5 OH, n‐propanol). However, the correlation between the activity and active sites remains ambiguous, impeding further improvements in their performance. The facet effect of copper crystals to promote CO adsorption and C−C coupling and consequently yield a superior selectivity for C 2+ products is described. We achieve a high Faradaic efficiency (FE) of 87 % and a large partial current density of 217 mA cm −2 toward C 2+ products on Cu(OH) 2 ‐D at only −0.54 V versus the reversible hydrogen electrode in a flow‐cell electrolyzer. With further coupled to a Si solar cell, record‐high solar conversion efficiencies of 4.47 % and 6.4 % are achieved for C 2 H 4 and C 2+ products, respectively. This study provides an in‐depth understanding of the selective formation of C 2+ products on Cu and paves the way for the practical application of electrocatalytic or solar‐driven CO 2 reduction.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.9
    DOI: 10.1002/anie.202015159
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 6
    Online Resource
    Online Resource
    Promoting Syngas to Olefins with Isolated Internal Silanols‐Enriched Al‐IDM‐1 Aluminosilicate Nanosheets
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 52 ( 2023-12-21)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 52 ( 2023-12-21)
    Abstract: Selective conversion of syngas to value‐added olefins has attracted considerable research interest. Regulating product distribution remains challenging, such as achieving higher olefin selectivity, propylene/ethylene ( P/E ) and olefin/paraffin ( O/P ) ratios. A new pentasil zeolite Al‐IDM‐1 with recently approved − ION structure, composed of 17‐membered‐ring (MR) extra‐large lobed pores and intersected 10‐MR medium pores, shows a C 2–6 = selectivity up to 85 % and a high O/P value of 14 in the conversion of syngas when being combined with Zn a Al b O x oxide. Moreover, for the high‐silica Al‐IDM‐1 with Si/Al ratio of 400, the selectivity of propylene and butene accounts for 88 % in C 2–4 = , resulting in high P/E ( 〉 4) and butene/ethylene ( B/E 〉 3) ratios. The high C 3–4 = selectivity is contributed by two main reasons, that is, the relatively weak acidity of Al‐IDM‐1 zeolite enhances the olefin‐based cycle revealed by the probe reactions of methanol‐to‐propylene (MTP) and 1‐hexene cracking, and the rich isolated internal SiOH groups in Al‐IDM‐1 promote the desorption of C 3–4 = , once they are formed inside zeolite pores.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.52
    DOI: 10.1002/anie.202313785
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 7
    Online Resource
    Online Resource
    Promoting Syngas to Olefins with Isolated Internal Silanols‐Enriched Al‐IDM‐1 Aluminosilicate Nanosheets
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 52 ( 2023-12-21)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 52 ( 2023-12-21)
    Abstract: Selective conversion of syngas to value‐added olefins has attracted considerable research interest. Regulating product distribution remains challenging, such as achieving higher olefin selectivity, propylene/ethylene ( P/E ) and olefin/paraffin ( O/P ) ratios. A new pentasil zeolite Al‐IDM‐1 with recently approved − ION structure, composed of 17‐membered‐ring (MR) extra‐large lobed pores and intersected 10‐MR medium pores, shows a C 2–6 = selectivity up to 85 % and a high O/P value of 14 in the conversion of syngas when being combined with Zn a Al b O x oxide. Moreover, for the high‐silica Al‐IDM‐1 with Si/Al ratio of 400, the selectivity of propylene and butene accounts for 88 % in C 2–4 = , resulting in high P/E ( 〉 4) and butene/ethylene ( B/E 〉 3) ratios. The high C 3–4 = selectivity is contributed by two main reasons, that is, the relatively weak acidity of Al‐IDM‐1 zeolite enhances the olefin‐based cycle revealed by the probe reactions of methanol‐to‐propylene (MTP) and 1‐hexene cracking, and the rich isolated internal SiOH groups in Al‐IDM‐1 promote the desorption of C 3–4 = , once they are formed inside zeolite pores.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.52
    DOI: 10.1002/ange.202313785
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
    Online Resource
    Online Resource
    Symmetry in Paraspinal Muscles as a Predictor of the Development of Pregnancy‐Related Low Back and Pelvic Pain: A Prospective Study
    Wiley ; 2021
    In:  Orthopaedic Surgery Vol. 13, No. 8 ( 2021-12), p. 2255-2262
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 13, No. 8 ( 2021-12), p. 2255-2262
    Abstract: To determine the asymmetry in the paraspinal muscle before pregnancy and evaluate its association with pregnancy‐associated lumbopelvic pain (LPP). Methods This was a prospective case–control study conducted from January 2017 and December 2018. A total of 171 subjects (mean age ± SD, 27.4 ± 5.8 years) were finally divided into the LBP group, PGP group, and no LPP group. Each subject was asked to follow a standardized clinical imaging protocol before the pregnancy. The area of muscles (multifidus, erector spinae, and psoas muscles) on the axial slice at mid‐disc of L 4 –L 5 and L 5 –S 1 were segmented and then the cross‐sectional area (CSA) of a particular muscle was measured by outlining the innermost fascial border surrounding each muscle. The mean value of F‐CSA's ratio to T‐CSA (F/T CSA) was used to determine whether the bilateral paraspinal muscle was asymmetrical. Total muscle CSA (T‐CSA) represents the sum of CSA of interested three muscles. The signal intensity can distinguish fat and muscle tissue in a different range. Based on this, functional CSA (F‐CSA), represented by fat‐free area, was evaluated quantitively by excluding the signal of the deposits of intramuscular fat. Total muscle CSA (T‐CSA), functional CSA (F‐CSA), and the ratio of F‐CSA to T‐CSA (F/T CSA) were measured unilaterally and compared between groups. Logistic regression was performed to determine the risk factors for pregnancy‐associated LPP. The Pearson correlation coefficient was performed to test the relationship between asymmetry in F/T‐CSA and pain rating. Results A total of 124 subjects (72.5%) (28.5 ± 5.2 years) had LPP during pregnancy. Forty‐eight (38.7%) individuals had low back pain (LBP) and 76 (61.3%) had pelvic girdle pain (PGP). Seventy‐six women (44.4%) were determined to have asymmetry in paraspinal muscle according to the definition in this methods section. The duration of follow‐up was 24 months postpartum. A total of 39 (31.5%) women unrecovered from LPP. F/T‐CSA was significantly decreased for LBP in the PGP group than in the and control group (0.03 ± 0.02 vs 0.05 ± 0.03 vs 0.12 ± 0.05, P 〈  0.001). Meanwhile, significant differences were detected in both groups (all P 〈  0.001). In patients with LBP, the level of paraspinal asymmetry, represented by the difference in F/T‐CSA, was positively correlated with pain scores ( r  = 0.52, P 〈  0.01). However, no statistically significant correlation between pain scores and paraspinal asymmetry was found in PGP ( r  = 0.42, P 〉  0.05). Asymmetry in the paraspinal muscle (adjusted OR  = 1.5), LBP (adjusted OR  = 1.6), LPP in a previous pregnancy (adjusted OR  = 1.4), sick leave ≥90 days (adjusted OR  = 1.2), and heavy labor (adjusted OR  = 1.2) were risk factors for the unrecovered LPP during pregnancy. Conclusions Asymmetrical muscular compositions could lead to abnormal biomechanics for the segmental motions. Lateral‐directed physical training and stretching may help decrease the occurrence and severity of this condition.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v13.8
    DOI: 10.1111/os.13126
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2483883-4
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  • 9
    Online Resource
    Online Resource
    The effects of different levels of superoxide dismutase in Modena on boar semen quality during liquid preservation at 17°C
    Wiley ; 2017
    In:  Animal Science Journal Vol. 88, No. 1 ( 2017-01), p. 55-62
    Details
    In: Animal Science Journal, Wiley, Vol. 88, No. 1 ( 2017-01), p. 55-62
    Abstract: This study was conducted to investigate the influence of superoxide dismutase (SOD) on the quality of boar semen during liquid preservation at 17°C. Semen samples from 10 Duroc boars were collected and pooled, divided into five equal parts and diluted with Modena containing different concentrations (0, 100, 200, 300 and 400 U/mL) of SOD. During the process of liquid preservation at 17°C, sperm motility, acrosome integrity, membrane integrity, total antioxidant capacity (T‐AOC) activity, malondialdehyde (MDA) content and hydrogen peroxide (H 2 O 2 ) content were measured and analyzed every 24 h. Meanwhile, effective survival time of boar semen during preservation was evaluated and analyzed. The results indicated that different concentrations of SOD in Modena showed different protective effects on boar sperm quality. Modena supplemented with SOD decreased the effects on reactive oxygen species on boar sperm quality during liquid preservation compared with that of the control group. The added 200 U/mL SOD group showed higher sperm motility, membrane integrity, acrosome integrity, effective survival time and T‐AOC activity. Meanwhile, the added 200 U/mL SOD group showed lower MDA content and H 2 O 2 content. In conclusion, addition of SOD to Modena improved the boar sperm quality by reducing oxidative stress during liquid preservation at 17°C and the optimum concentration was 200 U/mL.
    Type of Medium: Online Resource
    ISSN: 1344-3941 , 1740-0929
    URL: Issue
    URL: Article
    DOI: 10.1111/asj.2017.88.issue-1
    DOI: 10.1111/asj.12574
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2095161-9
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  • 10
    Online Resource
    Online Resource
    Design, synthesis, and antifungal activity of novel cinnamon–pyrazole carboxamide derivatives
    Wiley ; 2018
    In:  Drug Development Research Vol. 79, No. 6 ( 2018-09), p. 307-312
    Details
    In: Drug Development Research, Wiley, Vol. 79, No. 6 ( 2018-09), p. 307-312
    Abstract: Hit, Lead & Candidate Discovery To discover succinate dehydrogenase inhibitors with a novel structure, we introduced cinnamic acid structure to optimize the lead structure 1 and synthesized four series of cinnamon–pyrazole carboxamide derivatives. The bioassay data showed that compounds (E)‐N‐(1‐[4‐chlorophenyl]‐4‐cyano‐1H‐pyrazol‐5‐yl)‐3‐(2‐fluorophenyl) acrylamide ( 5III‐d) and (E)‐3‐(2‐chlorophenyl)‐N‐(1‐[4‐chlorophenyl]‐4‐cyano‐1H‐pyrazol‐5‐yl) acrylamide ( 5III‐f) showed the significant antifungal activity against three fungi. In addition, 5III‐d and 5III‐f exhibited the excellent inhibitory effect against succinate dehydrogenase (SDH) enzymes with IC 50 values ranging from 19.4 to 28.7 μM. The study demonstrates that the chlorine substituent group is present on both the phenyl and pyrazole rings that have a very good effect on the antifungal effect, and the compounds 5III‐d and 5III‐f can act as potential SDH inhibitors (SDHI) and throw a sprat for a new generation of SDHI.
    Type of Medium: Online Resource
    ISSN: 0272-4391 , 1098-2299
    URL: Issue
    URL: Article
    DOI: 10.1002/ddr.v79.6
    DOI: 10.1002/ddr.21469
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1500191-X
    SSG: 15,3
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