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  • 1
    Online Resource
    Online Resource
    Wiley ; 2005
    In:  Oxford Bulletin of Economics and Statistics Vol. 67, No. 4 ( 2005-08), p. 497-516
    In: Oxford Bulletin of Economics and Statistics, Wiley, Vol. 67, No. 4 ( 2005-08), p. 497-516
    Abstract: Monetary policy reaction functions are estimated for the UK over three periods – 1985–90, 1992–97 and 1997–2003 – in order to disentangle two effects: the switch from an emphasis on exchange rate stabilization to inflation targeting, and the introduction of instrument‐independence in 1997. The external factors considered include US as well as German interest rates, and this leads to the identification of ‘domestic’ and ‘international’ models of the reaction function. The results suggest that it is the changes in the institutional arrangements rather than those in the targeting regime which have been decisive in the development of policy in this period.
    Type of Medium: Online Resource
    ISSN: 0305-9049 , 1468-0084
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 1473788-7
    detail.hit.zdb_id: 215159-5
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  • 2
    In: International Journal of Cancer, Wiley, Vol. 132, No. 8 ( 2013-04-15), p. 1842-1850
    Type of Medium: Online Resource
    ISSN: 0020-7136
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 3
    In: Journal of Biogeography, Wiley, Vol. 44, No. 6 ( 2017-06), p. 1268-1279
    Abstract: Wildfire activity is projected to increase under global warming in many parts of the world. Knowledge of the role of these disturbances in shaping the composition of boreal forests is needed to better anticipate their future impacts. Here, we investigate the incidence of wildfire activity (burned biomass, frequency and size) on multi‐millennia vegetation trajectories in two coniferous boreal forest regions that display different types of vegetation composition and relief. We hypothesize that this difference in vegetation results from dissimilar wildfire activity during the Holocene. Location Conifer‐dominated boreal forests in Quebec‐Labrador, eastern North America. Methods Fire and vegetation histories during the last 8000 years were reconstructed and compared through analyses of charcoal and pollen records extracted from nine lacustrine deposits located in two spruce‐moss forests: the western region, co‐dominated by Pinus banksiana, and the eastern region, co‐dominated by Abies balsamea . Results Between 7000 and 2000 cal. yr  bp , the western region experienced fewer fires than the eastern region, but they were larger in size. The main species adapted to fire, P. banksiana and Alnus viridis ssp. crispa, progressively co‐dominated with Picea sp.. Conversely, in the eastern region, P. banksiana and A. viridis ssp. crispa were very rare, and Picea sp. co‐dominated with non‐fire‐adapted A. balsamea and Betula sp.. Then, around 2000 cal. yr  bp , fires decreased in frequency but were larger in size in the eastern region than in the western one, thus allowing densification of P. banksiana and A. viridis ssp. crispa in these landscapes. Main conclusions In the coniferous boreal forests of eastern North America, fire size was relatively more important in determining the long‐term vegetation trajectories in comparison with fire frequency. Changes in the rate of occurrence of large‐fire episodes will have significant impacts on vegetation dynamics over the next decades under continuing warming.
    Type of Medium: Online Resource
    ISSN: 0305-0270 , 1365-2699
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020428-0
    detail.hit.zdb_id: 188963-1
    SSG: 12
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  • 4
    In: International Journal of Cancer, Wiley, Vol. 143, No. 8 ( 2018-10-15), p. 2008-2016
    Abstract: What's new? The infiltration of T cells into the tumors of colorectal cancer (CRC) patients is associated with disease outcome. While in some cases, improved outcome is observed, populations of T cells impact tumor growth differently and prognosis may decline. In this study, the authors confirm that the infiltration of IFNγ‐producing T cells is associated with positive outcome and show that two other markers of activated T cells, CD69 and IL‐2, are associated with poor outcome. The findings could impact the development of immune therapies and markers and facilitate new insight into the role of CD69 + and IL‐2‐producing T‐cell populations in CRC.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 5
    In: Ecosphere, Wiley, Vol. 9, No. 6 ( 2018-06)
    Abstract: The North American boreal forest has been developing since the end of the last glaciation approximately 10,000 yr ago. With climate warming and human occupation, it is anticipated that fire danger, ignition, and activity will be increasing, compromising forests’ benefits for generations to come. In this study, we show, however, that a century of rapid climate changes and human densification has had the opposite effect in the boreal eastern interior of the North American continent, reducing biomass burning to values below two millennia of historical levels. A multi‐millennial fire history was reconstructed for eight forested landscapes from the Lake of the Woods Ecoregion ( LWE ) located at the boreal–prairie ecotone. Fire history was reconstructed using a combination of archival (period 1920–2010), tree‐ring (stand initiations and fire scars: period 1690–2010), and lake sediment charcoal (2500 BP to present) records. The archival record revealed recent large fires ( 〉 200 ha) in 1948, 1980, and 1988. An additional 19 fires were identified by the fire‐scar record. Fire events in 1805, 1840, 1863, and the 1890s were identified in numerous locations around multiple lakes suggesting that they were of large extents. In accordance with the tree‐ring record, the charcoal accumulation rate ( CHAR ) peak record generally identified the major fires but tended to lag from the tree‐ring records by several decades. Within LWE , the long‐term charcoal record revealed that CHAR was higher for each lake in the earlier portion of the record including the warm Medieval Climate Anomaly ( AD −900 to AD 1000), followed by a progressive decrease toward the cool Little Ice Age period. This decline was abruptly interrupted in the mid‐ to late 19th century with large synchronized fires, also reported over western and central North America, and resumed approximately four decades later. Fire disturbance level is today below the historical range, despite the accentuated climate warming. Aging of the forest landscape may create biodiversity loss notably in fire‐adapted species while at the same time setting the tone for major fires in upcoming decades if no action is taken for managing fuels.
    Type of Medium: Online Resource
    ISSN: 2150-8925 , 2150-8925
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2572257-8
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  • 6
    In: Ecosphere, Wiley, Vol. 13, No. 7 ( 2022-07)
    Abstract: Fire regimes in North American forests are diverse and modern fire records are often too short to capture important patterns, trends, feedbacks, and drivers of variability. Tree‐ring fire scars provide valuable perspectives on fire regimes, including centuries‐long records of fire year, season, frequency, severity, and size. Here, we introduce the newly compiled North American tree‐ring fire‐scar network (NAFSN), which contains 2562 sites, 〉 37,000 fire‐scarred trees, and covers large parts of North America. We investigate the NAFSN in terms of geography, sample depth, vegetation, topography, climate, and human land use. Fire scars are found in most ecoregions, from boreal forests in northern Alaska and Canada to subtropical forests in southern Florida and Mexico. The network includes 91 tree species, but is dominated by gymnosperms in the genus Pinus . Fire scars are found from sea level to 〉 4000‐m elevation and across a range of topographic settings that vary by ecoregion. Multiple regions are densely sampled (e.g., 〉 1000 fire‐scarred trees), enabling new spatial analyses such as reconstructions of area burned. To demonstrate the potential of the network, we compared the climate space of the NAFSN to those of modern fires and forests; the NAFSN spans a climate space largely representative of the forested areas in North America, with notable gaps in warmer tropical climates. Modern fires are burning in similar climate spaces as historical fires, but disproportionately in warmer regions compared to the historical record, possibly related to under‐sampling of warm subtropical forests or supporting observations of changing fire regimes. The historical influence of Indigenous and non‐Indigenous human land use on fire regimes varies in space and time. A 20th century fire deficit associated with human activities is evident in many regions, yet fire regimes characterized by frequent surface fires are still active in some areas (e.g., Mexico and the southeastern United States). These analyses provide a foundation and framework for future studies using the hundreds of thousands of annually‐ to sub‐annually‐resolved tree‐ring records of fire spanning centuries, which will further advance our understanding of the interactions among fire, climate, topography, vegetation, and humans across North America.
    Type of Medium: Online Resource
    ISSN: 2150-8925 , 2150-8925
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2572257-8
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  • 7
    In: Global Change Biology, Wiley, Vol. 15, No. 11 ( 2009-11), p. 2751-2769
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2015
    In:  Immunology & Cell Biology Vol. 93, No. 7 ( 2015-08), p. 634-640
    In: Immunology & Cell Biology, Wiley, Vol. 93, No. 7 ( 2015-08), p. 634-640
    Abstract: CD8 + T cells are important in the control of viral infections and cancers because of their cytolytic activity. A vaccine able to generate these cells could be beneficial in the prevention or treatment of these diseases. Chitosan hydrogel is a promising vaccine formulation that has previously been shown to generate effector CD8 + T cells in a mouse model. This vaccine promotes sustained release of antigen and adjuvant, which generates a robust effector response. For longer lasting immunity, a memory population of these CD8 + T cells is required to control further disease. We found that vaccination with chitosan hydrogel or dendritic cells using ovalbumin protein as a model antigen and Quil‐A adjuvant provided protection in a subcutaneous melanoma challenge 30 days later. Ovalbumin‐specific memory CD8 + T cells were detectable following vaccination with the chitosan hydrogel but not the dendritic cell vaccine and an in vivo cytotoxicity assay demonstrated specific lysis of target cells in chitosan hydrogel vaccinated mice but not those receiving dendritic cell vaccination. These results demonstrate that vaccination with chitosan hydrogel is equally effective as dendritic cell vaccination in tumour protection but has more readily detectable immune correlates of protection. This may be advantageous in predetermining protection in vaccinated individuals.
    Type of Medium: Online Resource
    ISSN: 0818-9641 , 1440-1711
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2011707-3
    SSG: 12
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  • 9
    In: New Phytologist, Wiley, Vol. 199, No. 4 ( 2013-09), p. 1001-1011
    Abstract: Strategic introduction of less flammable broadleaf vegetation into landscapes was suggested as a management strategy for decreasing the risk of boreal wildfires projected under climatic change. However, the realization and strength of this offsetting effect in an actual environment remain to be demonstrated. Here we combined paleoecological data, global climate models and wildfire modelling to assess regional fire frequency (Reg FF , i.e. the number of fires through time) in boreal forests as it relates to tree species composition and climate over millennial time‐scales. Lacustrine charcoals from northern landscapes of eastern boreal Canada indicate that Reg FF during the mid‐Holocene (6000–3000 yr ago) was significantly higher than pre‐industrial Reg FF ( ad c . 1750). In southern landscapes, Reg FF was not significantly higher than the pre‐industrial Reg FF in spite of the declining drought severity. The modelling experiment indicates that the high fire risk brought about by a warmer and drier climate in the south during the mid‐Holocene was offset by a higher broadleaf component. Our data highlight an important function for broadleaf vegetation in determining boreal Reg FF in a warmer climate. We estimate that its feedback may be large enough to offset the projected climate change impacts on drought conditions.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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