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  • 1
    Online Resource
    Online Resource
    Successful control of Candida auris transmission in a German COVID‐19 intensive care unit
    Wiley ; 2022
    In:  Mycoses Vol. 65, No. 6 ( 2022-06), p. 643-649
    Details
    In: Mycoses, Wiley, Vol. 65, No. 6 ( 2022-06), p. 643-649
    Abstract: Candida auris a frequently multidrug‐resistant yeast species that poses a global health threat due to its high potential for hospital outbreaks. While C .  auris has become endemic in parts of Asia and Africa, transmissions have so far rarely been reported in Western Europe except for Great Britain and Spain. We describe the first documented patient‐to‐patient transmission of C .  auris in Germany in a COVID‐19 intensive care unit (ICU) and infection control measures implemented to prevent further spread of the pathogen. Methods Identification of C .  auris was performed by MALDI‐TOF and confirmed by internal transcribed spacer (ITS) sequencing. Antifungal susceptibility testing was carried out. We conducted repeated cross‐sectional examinations for the presence of C .  auris in the patients of the affected ICU and investigated possible routes of transmission. Results The index patient had been transferred to Germany from a hospital in Northern Africa and was found to be colonised with C .  auris . The contact patient developed C .  auris sepsis. Infection prevention and control (IPC) measures included strict isolation of the two C .  auris patients and regular screening of non‐affected patients. No further case occurred during the subsequent weeks. Reusable blades used in video laryngoscope‐guided intubation were considered as the most likely vehicle of transmission. Conclusions In view of its high risk of transmission, vigilance regarding C .  auris colonisation in patients referred from endemic countries is crucial. Strict and immediate IPC measures may have the potential to prevent C .  auris outbreaks.
    Type of Medium: Online Resource
    ISSN: 0933-7407 , 1439-0507
    URL: Issue
    URL: Article
    DOI: 10.1111/myc.v65.6
    DOI: 10.1111/myc.13443
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 392487-7
    detail.hit.zdb_id: 2020780-3
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  • 2
    Online Resource
    Online Resource
    Expert recommendations for prevention and management of Candida auris transmission
    Wiley ; 2022
    In:  Mycoses Vol. 65, No. 6 ( 2022-06), p. 590-598
    Details
    In: Mycoses, Wiley, Vol. 65, No. 6 ( 2022-06), p. 590-598
    Abstract: Candida auris was first described as a yeast pathogen in 2009. Since then, the species has emerged worldwide. In contrast to most other Candida spp., C. auris frequently exhibits multi‐drug resistance and is readily transmitted in hospital settings. While most detections so far are from colonised patients, C. auris does cause superficial and life‐threatening invasive infections. During management of the first documented C. auris transmission in a German hospital, experts from the National Reference Centers for Invasive Fungal Infections (NRZMyk) and the National Reference Center for Surveillance of Nosocomial Infections screened available literature and integrated available knowledge on infection prevention and C. auris epidemiology and biology to enable optimal containment. Relevant recommendations developed during this process are summarised in this guidance document, intended to assist in management of C. auris transmission and potential outbreak situations. Rapid and effective measures to contain C. auris spread require a multi‐disciplinary approach that includes clinical specialists of the affected unit, nursing staff, hospital hygiene, diagnostic microbiology, cleaning staff, hospital management and experts in diagnostic mycology / fungal infections. Action should be initiated in a step‐wise process and relevant interventions differ between management of singular C. auris colonised / infected patients and detection of potential C. auris transmission or nosocomial outbreaks.
    Type of Medium: Online Resource
    ISSN: 0933-7407 , 1439-0507
    URL: Issue
    URL: Article
    DOI: 10.1111/myc.v65.6
    DOI: 10.1111/myc.13445
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 392487-7
    detail.hit.zdb_id: 2020780-3
    Location Call Number Limitation Availability
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  • 3
    Online Resource
    Online Resource
    Deep transcriptome profiling of clinical K lebsiella pneumoniae isolates reveals strain and sequence type‐specific adaptation
    Wiley ; 2015
    In:  Environmental Microbiology Vol. 17, No. 11 ( 2015-11), p. 4690-4710
    Details
    In: Environmental Microbiology, Wiley, Vol. 17, No. 11 ( 2015-11), p. 4690-4710
    Abstract: Health‐care‐associated infections by multi‐drug‐resistant bacteria constitute one of the greatest challenges to modern medicine. Bacterial pathogens devise various mechanisms to withstand the activity of a wide range of antimicrobial compounds, among which the acquisition of carbapenemases is one of the most concerning. In K lebsiella pneumoniae , the dissemination of the K. pneumoniae carbapenemase is tightly connected to the global spread of certain clonal lineages. Although antibiotic resistance is a key driver for the global distribution of epidemic high‐risk clones, there seem to be other adaptive traits that may explain their success. Here, we exploited the power of deep transcriptome profiling ( RNA ‐seq) to shed light on the transcriptomic landscape of 37 clinical K . pneumoniae isolates of diverse phylogenetic origins. We identified a large set of 3346 genes which was expressed in all isolates. While the core‐transcriptome profiles varied substantially between groups of different sequence types, they were more homogenous among isolates of the same sequence type. We furthermore linked the detailed information on differentially expressed genes with the clinically relevant phenotypes of biofilm formation and bacterial virulence. This allowed for the identification of a diminished expression of biofilm‐specific genes within the low biofilm producing ST 258 isolates as a sequence type‐specific trait.
    Type of Medium: Online Resource
    ISSN: 1462-2912 , 1462-2920
    URL: Issue
    URL: Article
    DOI: 10.1111/emi.2015.17.issue-11
    DOI: 10.1111/1462-2920.13016
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1436752-X
    detail.hit.zdb_id: 2020213-1
    SSG: 12
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