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  • Wiley  (54)
  • 1
    In: Advanced Science, Wiley
    Abstract: Blood vessels play a role in osteogenesis and osteoporosis; however, the role of vascular metabolism in these processes remains unclear. The present study finds that ovariectomized mice exhibit reduced blood vessel density in the bone and reduced expression of the endothelial glycolytic regulator pyruvate kinase M2 (PKM2). Endothelial cell (EC)‐specific deletion of Pkm2 impairs osteogenesis and worsens osteoporosis in mice. This is attributed to the impaired ability of bone mesenchymal stem cells (BMSCs) to differentiate into osteoblasts. Mechanistically, EC‐specific deletion of Pkm2 reduces serum lactate levels secreted by ECs, which affect histone lactylation in BMSCs. Using joint CUT & Tag and RNA sequencing analyses, collagen type I alpha 2 chain (COL1A2), cartilage oligomeric matrix protein (COMP), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), and transcription factor 7 like 2 (TCF7L2) as osteogenic genes regulated by histone H3K18la lactylation are identified. PKM2 overexpression in ECs, lactate addition, and exercise restore the phenotype of endothelial PKM2‐deficient mice. Furthermore, serum metabolomics indicate that patients with osteoporosis have relatively low lactate levels. Additionally, histone lactylation and related osteogenic genes of BMSCs are downregulated in patients with osteoporosis. In conclusion, glycolysis in ECs fuels BMSC differentiation into osteoblasts through histone lactylation, and exercise partially ameliorates osteoporosis by increasing serum lactate levels.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 2
    In: ChemistrySelect, Wiley, Vol. 7, No. 3 ( 2022-01-21)
    Abstract: The ketones and benzoic acids are very useful chemicals as the precursors and intermediates in both laboratory and synthetic industrial applications, which are usually obtained by selective catalytic oxidation of alcohols using a amount of certain expensive oxidants or metal catalysts. Here, an efficient and practical oxidation the aryl secondary and primary alcohols to corresponding carbonyl compounds using NaO t Bu in open air at room temperature has been developed. And utilizing NaO t Bu/air/ toluene, a series of ketones or benzoic acids were obtained from secondary and primary alcohols in high yields, respectively. More importantly, most of the substrates with electron‐withdrawing or electron‐donating groups could be converted to the corresponding products in high to excellent yields. Furthermore, the practicality of the reaction was demonstrated through 1.0 gram‐scale reaction with excellent yield.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2844262-3
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  • 3
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Macromolecular Rapid Communications Vol. 44, No. 17 ( 2023-09)
    In: Macromolecular Rapid Communications, Wiley, Vol. 44, No. 17 ( 2023-09)
    Abstract: Polymeric bowl‐shaped nanoparticles (BNPs) are anisotropic hollow structures with large openings on the surface, which have shown advantages such as high specific area and efficient encapsulation, delivery and release of large‐sized cargoes on demand compared to solid nanoparticles or closed hollow structures. Several strategies have been developed to prepare BNPs based on either template or template‐free methods. For instance, despite the widely used self‐assembly strategy, alternative methods including emulsion polymerization, swelling and freeze‐drying of polymeric spheres, and template‐assisted approaches have also been developed. It is attractive but still challenging to fabricate BNPs due to their unique structural features. However, there is still no comprehensive summary of BNPs up to now, which significantly hinders the further development of this field. In this review, the recent progress of BNPs will be highlighted from the perspectives of design strategies, preparation methods, formation mechanisms, and emerging applications. Moreover, the future perspectives of BNPs will also be proposed.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1475027-2
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  • 4
    In: The Structural Design of Tall and Special Buildings, Wiley, Vol. 32, No. 2 ( 2023-02-10)
    Abstract: In order to improve the co‐working performance between the core concrete and steel tube for large‐section rectangular concrete‐filled steel tubular (LSCFT) columns when a vertical load is directly applied to the steel tube, a distributive beam is proposed as a load transferring measure. Four scaled LSCFT column specimens with different details were tested under axial compression to investigate the mechanical behavior and load transferring mechanism of the LSCFT columns with a distributive beam. The experimental results indicated that the bearing capacity of the LSCFT columns without a distributive beam was close to the yield capacity of the steel tube and the load shared by the core concrete was negligible. In contrast, the specimen with a distributive beam and inner stiffeners could bear a much higher load. In addition, refined nonlinear finite element models were developed to further analyze the load‐transferring mechanism of LSCFT columns with different details. The numerical results showed that the ultimate load of the specimen with a distributive beam and inner stiffeners was much closer to the theoretical value calculated from Chinese code CECS159:2004. Setting a distributive beam and inner stiffeners simultaneously in LSCFT columns could ensure the cooperation between the core concrete and steel tube.
    Type of Medium: Online Resource
    ISSN: 1541-7794 , 1541-7808
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2133303-8
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  • 5
    In: Clinical and Translational Medicine, Wiley, Vol. 10, No. 7 ( 2020-11)
    Abstract: Long noncoding RNAs (lncRNA) represent significant factors of the mammalian transcriptome that mediates varied biological and pathological processes. The liver is the most common site for gallbladder cancer (GBC) distant metastasis and contributes to the majority of GBC‐related death. How lncRNA affects GBC metastasis is not completely understood. Results A novel lncRNA termed lncGALM (lncRNA in GBC associated with liver metastasis) was discovered to be highly expressed in cancer patients and xenografted tumors with liver metastasis. Elevated lncGALM in GBC patients also correlated to decreased survival. Invasion and migration of GBC cells were enhanced through lncGALM, both in vitro and in vivo. lncGALM functioned as sponges by competitively binding to and inactivating miR‐200 family members, which increase epithelial‐mesenchymal transition‐associated transcription factor ZEB1 and ZEB2, leading to a fibroblastic phenotype and increased expression of N‐cadherin. In addition, lncGALM bound to IL‐1β mRNA and stabilized the IL‐1β gene that mediates liver sinusoidal endothelial cell (LSECs) apoptosis. lncGALM‐expressing LiM2‐NOZ cells acquired a strong ability to migrate and adhere to LSECs, promoting LSECs apoptosis and therefore facilitating tumor cell extravasation and dissemination. Conclusions lncGALM promotes GBC liver metastasis by facilitating GBC cell migration, invasion, liver arrest, and extravasation via the invasion‐metastasis cascade. Targeting lncGALM may be protective against the development of liver metastasis in GBC patients.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2697013-2
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  • 6
    In: Cancer Medicine, Wiley, Vol. 12, No. 2 ( 2023-01), p. 1791-1800
    Abstract: This study investigated the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese. We sought to help provide more data to support ESCC screenings. Methods This study was based on an existing Screening Program in Feicheng, China. Esophageal precancerous lesions were identified in 1753 cases, diagnosed from esophageal cancer screenings from 2006 to 2016. We followed up with them through endoscopic screening until October 1, 2017. Pathology results from various grades of precancerous lesions were recorded and the annual transition probabilities and incidence density of ESCC were calculated. Results As of October 1, 2017, a total of 4055.8 person‐years has been observed. The ESCC incidence density of mild, moderate, and severe dysplasia (SD) was 0.17, 0.79, and 1.77 per 100 person‐years, respectively. The median follow‐up time of mild, moderate, and SD was 3.5, 2.3, and 2.2 years, respectively. The annual transition probability of mild, moderate, and SD to the next pathological level was 0.025, 0.038, and 0.016, respectively. The ESCC incidence density of males was 2.6 times higher than females (0.58 vs. 0.22), and the older age group (56–69 age group) had a ESCC incidence density 1.2 times higher than the younger group (40–55 age group) (0.45 vs. 0.39). Conclusions The higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening of esophageal cancer in males and the elderly should be strengthened. It is recommended to reinforce follow‐up management for untreated patients with SD/carcinoma in situ. For patients with mild and moderate dysplasia in high‐risk rural Chinese populations, endoscopic follow‐up intervals can be appropriately adjusted to once every 2 years.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 7
    In: Cell Proliferation, Wiley, Vol. 49, No. 5 ( 2016-10), p. 541-553
    Abstract: Micro RNA s (mi RNA s) (small, non‐coding RNA s ∼22 nucleotides [nt] in length), have been estimated to regulate in the region of 30% of human gene expression at the post‐transcriptional and translational levels. They are also involved in a series of important cellular processes, such as autophagy. Autophagy is well‐known to be an evolutionarily conserved lysosomal degradation process in which a cell degrades long‐lived proteins and damaged organelles. Recent evidence has shown that mi RNA s can function as either oncogenes or tumour‐suppressive genes in human cancers. Also, they are well‐characterized to be crucial in tumourigenesis, as either oncogenes or tumour suppressors, by regulating autophagy. However, discovering the intricate mechanism of mi RNA ‐modulated autophagy remains in its infancy. Thus, in this review, we focus on summarizing the dual function of oncogenic or tumour‐suppressive mi RNA s in regulation of autophagy and their roles in carcinogenesis, thereby revealing the regulatory mechanism of mi RNA ‐modulated autophagy in cancer, to shed light on more novel RNA therapeutic strategies in the future.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 8
    In: Journal of Clinical Nursing, Wiley, Vol. 32, No. 11-12 ( 2023-06), p. 2371-2382
    Abstract: The aim of this study was to assess methodological quality of all currently available guidelines and consensus statements for IAD using the Appraisal of Guidelines, Research and Evaluation (AGREE) II and the AGREE Recommendation Excellence (AGREE‐REX) instruments. Background Globally, incontinence‐associated dermatitis (IAD) is a significant health challenge. IAD is a complex healthcare problem that reduces quality of life of patients, increases healthcare costs and prolongs hospital stays. Several guidelines and consensus statements are available for IAD. However, the quality of these guidelines and consensus statements remains unclear. Design A systematic review of guidelines and consensus statements. Methods Our study was undertaken using PRISMA guidelines. We searched seven electronic databases. Guidelines and consensus statements had to be published in English, Chinese or German languages. Five independent reviewers assessed the methodological quality of guidelines and consensus statements using the AGREE II and AGREE‐REX instruments. Mean with standard deviation (SD) and median with interquartile range (IQR) were calculated for descriptive analyses. We generated bubble plots to describe the assessment results of each domain of each guideline and consensus statement. Results We included ten guidelines and consensus statements. The NICE guidelines, obtained the highest scores, fulfilled 86.11%–98.61% of criteria in AGREE II and 76.67%–91.11% for AGREE‐REX. In the domains ‘Stakeholder Involvement’ (4.39 ± 1.64), ‘Rigor of Development’ (3.38 ± 1.86), ‘Applicability’ (3.62 ± 1.64), ‘Editorial Independence’ (3.91 ± 2.56) and ‘Values and Preferences’ (2.98 ± 1.41), the remaining guidelines and consensus statements showed deficiencies. Conclusions Altogether, this study demonstrated that the currently available guidelines and consensus statements for IAD have room for methodological improvement. NICE guidelines on faecal incontinence and urinary incontinence have better quality. Remaining guidelines and consensus statements showed substantial methodological weaknesses, especially the domains of ‘Stakeholder Involvement’, ‘Rigor of Development’, ‘Applicability’, ‘Editorial independence’ and ‘Values and Preferences’. This study was registered on INPLASY. (Registration number: INPLASY202190078). Relevance to Clinical Practice The currently available guidelines and consensus statements on IAD have room for methodological improvement.
    Type of Medium: Online Resource
    ISSN: 0962-1067 , 1365-2702
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006661-2
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Journal of Nursing Scholarship Vol. 55, No. 4 ( 2023-07), p. 853-863
    In: Journal of Nursing Scholarship, Wiley, Vol. 55, No. 4 ( 2023-07), p. 853-863
    Abstract: To analyze the AI research in the field of nursing, to explore the current situation, hot topics, and prospects of AI research in the field of nursing, and to provide a reference for researchers to carry out related studies. Methods We used the VOSviewer 1.6.17, SciMAT, and CiteSpace 5.8.R3 to generate visual cooperation network maps for the country, organizations, authors, citations, and keywords and perform burst detection, theme evolution, and so forth. Findings A total of 9318 articles were obtained from the Web of Science Core Collection database. Four hundred and thirty‐one AI research related to the field of nursing was published by 855 institutions from 54 countries. CIN‐Computers Informatics Nursing was the top productive journal. The United States was the dominant country. The transnational cooperation between authors from developed countries was closer than that between authors from developing countries. The main hot topics included nurse rostering, nursing diagnosis, nursing decision support, disease risk factor prediction, nursing big data management, expert system, support vector machine, decision tree, deep learning, natural language processing, and nursing education. Machine learning represented one of the cutting‐edge and most applicable branches of artificial intelligence in the field of nursing, and deep learning was the hottest technology among many machine learning methods in recent years. One of the most cited papers was published by Burke in 2004 and cited 500 times, which critically evaluated AI methods to deal with nurse scheduling problems. Conclusions Although AI has been paid more and more attention to the field of nursing, there is still a lack of high‐yielding authors who have been engaged in this field for a long time. Most of the high contribution authors and institutions came from developed countries; therefore, more transnational and multi‐disciplinary cooperation is needed to promote the development of AI in the nursing field. This bibliometric analysis not only provided a comprehensive overview to help researchers to understand the important articles, journals, potential collaborators, and institutions in this field but also analyzed the history, hot spots, and future trends of the research topic to provide inspiration for researchers to choose research directions.
    Type of Medium: Online Resource
    ISSN: 1527-6546 , 1547-5069
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2116095-8
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  • 10
    In: Advanced Materials, Wiley, Vol. 22, No. 36 ( 2010-09-22), p. 4008-4013
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 1474949-X
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