In:
ChemistrySelect, Wiley, Vol. 7, No. 45 ( 2022-12-06)
Abstract:
This article studies the binding of the antitumor drug doxorubicin (DOX) with the nanocluster polyoxometalate (POM) {Mo 72 Fe 30 }, the latter serving as the drug carrier. The formation of a stoichiometric complex POM@(DOX) 12 was observed in aqueous media. Using the Stern‐Volmer technique, we found the binding constant and free Gibbs energy for this interaction. The produced complex POM@(DOX) 12 was examined with ultraviolet‐visible (UV‐Vis), fluorescence (steady state and life‐time), infrared (IR) and X‐ray photoelectron spectroscopy (XPS), which revealed the stoichiometry of complex and a key role of {Mo 3 Fe 3 } host pores on the POM surface to DOX binding. DOX's ability to intercalate into DNA after binding with the {Mo 72 Fe 30 } was investigated using a pH typical for blood (7.4). A pH‐dependent release of DOX from POM@(DOX) 12 was demonstrated (rate constant is 3.3×10 −4 s −1 ). Finally, we showed that the immobilization of doxorubicin on the POM's surface can reduce undesired side effects.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.202203684
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
2844262-3
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