In:
Acta Psychiatrica Scandinavica, Wiley, Vol. 141, No. 6 ( 2020-06), p. 492-509
Abstract:
To compare the peripheral blood levels of methionine (Met), S‐adenosylmethionine (SAM), S‐adenosylhomocysteine (SAH), and the SAM/SAH ratio (the most core and predictive indices of cellular methylation ability) between patients with autism spectrum disorder (ASD) and control subjects. Methods PubMed, Embase, PsycINFO, Web of Science, and Cochrane Library were searched from inception to August 2, 2019, without language restriction. The random‐effects model was used to summarize effect sizes. Results We retrieved 1,493 records, of which 22 studies met inclusion criteria. Our overall analyses revealed that individuals with ASD had significantly decreased levels of Met (22 studies; Hedges’ g = −0.62; 95% confidence interval [CI]: −0.89, −0.35), SAM (8 studies; Hedges’ g = −0.60; 95% CI: −0.86, −0.34), and the SAM/SAH ratio (8 studies; Hedges’ g = −0.98; 95% CI: −1.30, −0.66) and significantly increased levels of SAH (8 studies; Hedges’ g = 0.69; 95% CI: 0.43, 0.94). The findings of the overall analyses were quite stable after being verified by sensitivity analyses and in agreement with the corresponding outcomes of subgroup analyses. Additionally, our results from meta‐analytic techniques confirmed that the effect estimates of this meta‐analysis did not originate from publication bias. Conclusion Individuals with ASD have substantially aberrant peripheral blood levels of Met, SAM, SAH, and the SAM/SAH ratio, which supports the association between impaired methylation capacity and ASD. Therefore, further investigations into these indices as potential biomarkers for diagnosis and therapeutic targets of ASD are warranted.
Type of Medium:
Online Resource
ISSN:
0001-690X
,
1600-0447
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2378389-8
detail.hit.zdb_id:
2005703-9
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