In:
FEBS Letters, Wiley, Vol. 452, No. 3 ( 1999-06-11), p. 301-304
Kurzfassung:
The chemokine RANTES is a potent chemoattractant for eosinophils. RANTES is produced by lung epithelial cells during eosinophil‐rich inflammatory diseases such as asthma. In this study, we examined the effects of thiazolidinediones (TZD) on RANTES expression in a human lung epithelial cell line, A549. In A549 cells, interleukin‐1β and tumor necrosis factor‐α induced endogenous RANTES protein secretion, mRNA expression, and promoter activity. The TZD inhibited these effects. Our data indicate that the suppression of the expression of RANTES can be accomplished by TZD treatment, raising the possibility that TZD might be of therapeutic value in diseases such as asthma.
Materialart:
Online-Ressource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(99)00678-X
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
1999
ZDB Id:
1460391-3
SSG:
12
Permalink