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  • Wiley  (7)
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  • Wiley  (7)
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  • 1
    Online Resource
    Online Resource
    EuroSurg: a new European student‐driven research network in surgery
    Wiley ; 2016
    In:  Colorectal Disease Vol. 18, No. 2 ( 2016-02), p. 214-215
    Details
    In: Colorectal Disease, Wiley, Vol. 18, No. 2 ( 2016-02), p. 214-215
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.2016.18.issue-2
    DOI: 10.1111/codi.13260
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2004820-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Timing of nasogastric tube insertion and the risk of postoperative pneumonia: an international, prospective cohort study
    Wiley ; 2020
    In:  Colorectal Disease Vol. 22, No. 12 ( 2020-12), p. 2288-2297
    Details
    In: Colorectal Disease, Wiley, Vol. 22, No. 12 ( 2020-12), p. 2288-2297
    Abstract: Aspiration is a common cause of pneumonia in patients with postoperative ileus. Insertion of a nasogastric tube (NGT) is often performed, but this can be distressing. The aim of this study was to determine whether the timing of NGT insertion after surgery (before versus after vomiting) was associated with reduced rates of pneumonia in patients undergoing elective colorectal surgery. Method This was a preplanned secondary analysis of a multicentre, prospective cohort study. Patients undergoing elective colorectal surgery between January 2018 and April 2018 were eligible. Those receiving a NGT were divided into three groups, based on the timing of the insertion: routine NGT (inserted at the time of surgery), prophylactic NGT (inserted after surgery but before vomiting) and reactive NGT (inserted after surgery and after vomiting). The primary outcome was the development of pneumonia within 30 days of surgery, which was compared between the prophylactic and reactive NGT groups using multivariable regression analysis. Results A total of 4715 patients were included in the analysis and 1536 (32.6%) received a NGT. These were classified as routine in 926 (60.3%), reactive in 461 (30.0%) and prophylactic in 149 (9.7%). Two hundred patients (4.2%) developed pneumonia (no NGT 2.7%; routine NGT 5.2%; reactive NGT 10.6%; prophylactic NGT 11.4%). After adjustment for confounding factors, no significant difference in pneumonia rates was detected between the prophylactic and reactive NGT groups (odds ratio 1.03, 95% CI 0.56–1.87, P  = 0.932). Conclusion In patients who required the insertion of a NGT after surgery, prophylactic insertion was not associated with fewer cases of pneumonia within 30 days of surgery compared with reactive insertion.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.v22.12
    DOI: 10.1111/codi.15311
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2004820-8
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Ileus Management International (IMAGINE): protocol for a multicentre, observational study of ileus after colorectal surgery
    Wiley ; 2018
    In:  Colorectal Disease Vol. 20, No. 1 ( 2018-01)
    Details
    In: Colorectal Disease, Wiley, Vol. 20, No. 1 ( 2018-01)
    Abstract: The management of postoperative ileus following colorectal surgery remains controversial. It is the commonest complication after elective colorectal resection and is associated with an increased incidence of postoperative adverse events. The prevention and management of postoperative ileus remains unstandardized. This study aims to describe an international profile of gastrointestinal recovery after colorectal surgery and will assess the role of non‐steroidal anti‐inflammatory drugs, when used as postoperative analgesia, in expediting the return of gastrointestinal function. Methods A multicentre, student‐ and trainee‐led, prospective cohort study will be conducted across both Europe and Australasia. Adult patients undergoing elective colorectal resection during 2‐week data collection periods between January and April 2018 will be included. A site‐specific questionnaire will capture compliance to Enhanced Recovery after Surgery components at participating centres. The primary outcome is time to gastrointestinal recovery, measured using a composite outcome of bowel function and oral tolerance. The impact of non‐steroidal anti‐inflammatory drugs on gastrointestinal recovery will be evaluated along with safety data with respect to anastomotic leak, acute kidney injury and complications within 30 days of surgery. Discussion This protocol describes the methodology of an international, observational assessment of gastrointestinal recovery after colorectal surgery. It discusses key challenges and describes how the results will impact on future investigation. The study will be conducted across a large student‐ and trainee‐led collaborative network, with prospective quality assurance and data validation strategies.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.2018.20.issue-1
    DOI: 10.1111/codi.13976
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2004820-8
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    Online Resource
  • 4
    Online Resource
    Online Resource
    Acute PresentatiOn of coLorectaL cancer ‐ an internatiOnal snapshot (APOLLO): Protocol for a prospective, multicentre cohort study
    Wiley ; 2023
    In:  Colorectal Disease Vol. 25, No. 1 ( 2023-01), p. 144-149
    Details
    In: Colorectal Disease, Wiley, Vol. 25, No. 1 ( 2023-01), p. 144-149
    Abstract: The primary aim of the study is to describe the variation in the operative and nonoperative management of emergency presentations of colon and rectal cancer in an international cohort. Secondary aims will be to develop a risk prediction model for mortality and primary anastomosis and validate risk criteria of large bowel obstruction (LBO) in patients with previously known colorectal cancer undergoing neoadjuvant chemotherapy or awaiting elective surgery. Method This prospective, multicentre audit will be conducted via the student‐ and trainee‐led EuroSurg Collaborative network internationally over 2023 with 90‐day follow‐up. Data will be collected on consecutive adult patients presenting to the hospital in an unplanned and urgent manner with colorectal cancer (CRC) due to malignant LBO, perforation, CRC‐related haemorrhage, or other related reasons. Primary outcome is 90‐day mortality. Secondary outcomes include rates of stomas, primary anastomosis, stenting, preoperative imaging, and complications or readmissions. Conclusion This protocol describes the methodology for the first international audit on the management of acutely presenting CRC. This study will utilise a large collaborative network with robust data validation and assurance strategies. APOLLO will provide a comprehensive understanding of current practice, develop risk prediction tools in this setting, and validate existing trial results.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.v25.1
    DOI: 10.1111/codi.16464
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004820-8
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    Online Resource
  • 5
    Online Resource
    Online Resource
    Body mass index and complications following major gastrointestinal surgery: a prospective, international cohort study and meta‐analysis
    Wiley ; 2018
    In:  Colorectal Disease Vol. 20, No. 8 ( 2018-08)
    Details
    In: Colorectal Disease, Wiley, Vol. 20, No. 8 ( 2018-08)
    Abstract: Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a meta‐analysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end‐point was 30‐day major complications (Clavien–Dindo Grades III –V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta‐analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance ( P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta‐analysis demonstrated that obese patients undergoing surgery for malignancy were at increased risk of major complications ( OR 2.10, 95% CI 1.49–2.96, P 〈 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk ( OR 0.59, 95% CI 0.46–0.75, P 〈 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta‐analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.2018.20.issue-8
    DOI: 10.1111/codi.14292
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2004820-8
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    Online Resource
  • 6
    Online Resource
    Online Resource
    Management of COMPlicAted intra‐abdominal collectionS after colorectal Surgery (COMPASS): protocol for a multicentre, observational, prospective international study of drain placement practices in colorectal surgery
    Wiley ; 2020
    In:  Colorectal Disease Vol. 22, No. 12 ( 2020-12), p. 2315-2321
    Details
    In: Colorectal Disease, Wiley, Vol. 22, No. 12 ( 2020-12), p. 2315-2321
    Abstract: Postoperative drains have historically been used for the prevention and early detection of intra‐abdominal collections. However, current evidence suggests that prophylactic drain placement following colorectal surgery has no significant clinical benefit. This is reflected in the enhanced recovery after surgery (ERAS) guidelines, which recommend against their routine use. The Ileus Management International study found more than one‐third of participating centres across the world routinely used drains in the majority of colorectal resections. The aim of the present study is to audit international compliance with ERAS guidelines regarding the use of postoperative drains in colorectal surgery. Method This prospective, multicentre audit will be conducted via the student‐ and trainee‐led EuroSurg Collaborative network across Europe, South Africa and Australasia. Data will be collected on consecutive patients undergoing elective and emergency colorectal surgery with 30‐day follow‐up. This will include any colorectal resection, formation of colostomy/ileostomy and reversal of stoma. The primary end‐point will be adherence to ERAS guidelines for intra‐abdominal drain placement. Secondary outcomes will include the following: time to diagnosis of intra‐abdominal postoperative collections; output and time to removal of drains; and 30‐day postoperative complications defined by the Clavien–Dindo classification. Conclusion This protocol describes the methodology for the first international audit of intra‐abdominal drain placement after colorectal surgery. The study will be conducted across a large collaborative network with quality assurance and data validation strategies. This will provide a clear understanding of current practice and novel evidence regarding the efficacy and safety of intra‐abdominal drain placement in colorectal surgical patients.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Issue
    URL: Article
    DOI: 10.1111/codi.v22.12
    DOI: 10.1111/codi.15275
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2004820-8
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  • 7
    Online Resource
    Online Resource
    Safety and efficacy of intraperitoneal drain placement after emergency colorectal surgery: An international, prospective cohort study
    Wiley ; 2023
    In:  Colorectal Disease
    Details
    In: Colorectal Disease, Wiley
    Abstract: Intraperitoneal drains are often placed during emergency colorectal surgery. However, there is a lack of evidence supporting their use. This study aimed to describe the efficacy and safety of intraperitoneal drain placement after emergency colorectal surgery. Method COMPlicAted intra‐abdominal collectionS after colorectal Surgery (COMPASS) is a prospective, international, cohort study into which consecutive adult patients undergoing emergency colorectal surgery were enrolled (from 3 February 2020 to 8 March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included rate and time‐to‐diagnosis of postoperative intraperitoneal collections, rate of surgical site infections (SSIs), time to discharge and 30‐day major postoperative complications (Clavien–Dindo III–V). Multivariable logistic and Cox proportional hazards regressions were used to estimate the independent association of the outcomes with drain placement. Results Some 725 patients (median age 68.0 years; 349 [48.1%] women) from 22 countries were included. The drain insertion rate was 53.7% (389 patients). Following multivariable adjustment, drains were not significantly associated with reduced rates (odds ratio [OR] = 1.56, 95% CI: 0.48–5.02, p  = 0.457) or earlier detection (hazard ratio [HR] = 1.07, 95% CI: 0.61–1.90, p  = 0.805) of collections. Drains were not significantly associated with worse major postoperative complications (OR = 1.26, 95% CI: 0.67–2.36, p  = 0.478), delayed hospital discharge (HR = 1.11, 95% CI: 0.91–1.36, p  = 0.303) or increased risk of SSIs (OR = 1.61, 95% CI: 0.87–2.99, p  = 0.128). Conclusion This is the first study investigating placement of intraperitoneal drains following emergency colorectal surgery. The safety and clinical benefit of drains remain uncertain. Equipoise exists for randomized trials to define the safety and efficacy of drains in emergency colorectal surgery.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Article
    DOI: 10.1111/codi.16737
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004820-8
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