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  • Wiley  (1,157)
  • 1
    Online Resource
    Online Resource
    Impact of a novel prognostic model on allogeneic hematopoietic stem cell transplantation outcomes in patients with CMML
    Wiley ; 2023
    In:  American Journal of Hematology Vol. 98, No. 9 ( 2023-09), p. 1394-1406
    Details
    In: American Journal of Hematology, Wiley, Vol. 98, No. 9 ( 2023-09), p. 1394-1406
    Abstract: Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell malignancy, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is the only curable treatment. The outcomes after transplant are influenced by both disease characteristics and patient comorbidities. To develop a novel prognostic model to predict the post‐transplant survival of CMML patients, we identified risk factors by applying univariable and multivariable Cox proportional hazards regression to a derivation cohort. In multivariable analysis, advanced age (hazard ratio [HR] 3.583), leukocyte count (HR 3.499), anemia (HR 3.439), bone marrow blast cell count (HR 2.095), and no chronic graft versus host disease (cGVHD; HR 4.799) were independently associated with worse survival. A novel prognostic model termed ABLAG (Age, Blast, Leukocyte, Anemia, cGVHD) was developed and the points were assigned according to the regression equation. The patients were categorized into low risk (0–1), intermediate risk (2, 3), and high risk (4–6) three groups and the 3‐year overall survival (OS) were 93.3% (95%CI, 61%–99%), 78.9% (95%CI, 60%–90%), and 51.6% (95%CI, 32%–68%; p   〈  .001), respectively. In internal and external validation cohort, the area under the receiver operating characteristic (ROC) curves of the ABLAG model were 0.829 (95% CI, 0.776–0.902) and 0.749 (95% CI, 0.684–0.854). Compared with existing models designed for the nontransplant setting, calibration plots, and decision curve analysis showed that the ABLAG model revealed a high consistency between predicted and observed outcomes and patients could benefit from this model. In conclusion, combining disease and patient characteristic, the ABLAG model provides better survival stratification for CMML patients receiving allo‐HSCT.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v98.9
    DOI: 10.1002/ajh.26999
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492749-4
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  • 2
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    Potent Anti‐SARS‐CoV‐2 Efficacy of COVID‐19 Hyperimmune Globulin from Vaccine‐Immunized Plasma
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 14 ( 2022-05)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 14 ( 2022-05)
    Abstract: Coronavirus disease 2019 (COVID‐19) remains a global public health threat. Hence, more effective and specific antivirals are urgently needed. Here, COVID‐19 hyperimmune globulin (COVID‐HIG), a passive immunotherapy, is prepared from the plasma of healthy donors vaccinated with BBIBP‐CorV (Sinopharm COVID‐19 vaccine). COVID‐HIG shows high‐affinity binding to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) spike (S) protein, the receptor‐binding domain (RBD), the N ‐terminal domain of the S protein, and the nucleocapsid protein; and blocks RBD binding to human angiotensin‐converting enzyme 2 (hACE2). Pseudotyped and authentic virus‐based assays show that COVID‐HIG displays broad‐spectrum neutralization effects on a wide variety of SARS‐CoV‐2 variants, including D614G, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), Kappa (B.1.617.1), Delta (B.1.617.2), and Omicron (B.1.1.529) in vitro. However, a significant reduction in the neutralization titer is detected against Beta, Delta, and Omicron variants. Additionally, assessments of the prophylactic and treatment efficacy of COVID‐HIG in an Adv5‐hACE2‐transduced IFNAR −/− mouse model of SARS‐CoV‐2 infection show significantly reduced weight loss, lung viral loads, and lung pathological injury. Moreover, COVID‐HIG exhibits neutralization potency similar to that of anti‐SARS‐CoV‐2 hyperimmune globulin from pooled convalescent plasma. Overall, the results demonstrate the potential of COVID‐HIG against SARS‐CoV‐2 infection and provide reference for subsequent clinical trials.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.14
    DOI: 10.1002/advs.202104333
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 3
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    Global warming and artificial shorelines reshape seashore biogeography
    Wiley ; 2020
    In:  Global Ecology and Biogeography Vol. 29, No. 2 ( 2020-02), p. 220-231
    Details
    In: Global Ecology and Biogeography, Wiley, Vol. 29, No. 2 ( 2020-02), p. 220-231
    Abstract: Rapid anthropogenic warming coupled with changes in land use is altering the distributions of species, with consequences for ecosystem functioning and services. It is crucial to evaluate species range shifts based on understanding of the interaction of temperature with non‐climatic factors such as habitat availability and dispersal potential. Here, we aim to investigate roles of environmental temperature, habitat availability and population connectivity on the distributions of hard‐shore intertidal animals. We further examine potential roles of extensive artificial seawall construction in enabling poleward expansion of species in China, thus reshaping coastal biogeography. Location Chinese coast. Time period 2013–2017. Major taxa studied Intertidal invertebrates. Methods We took an integrative approach encompassing distributional ecology, thermal physiology, molecular genetics, heat budget modelling and larval dispersal to elucidate how interacting multiple drivers, including temperature, habitat availability and larval dispersal, determine distributions of hard‐shore invertebrates, focusing on what sets their range edges at a boundary between biogeographic provinces. Results Our results untangle the complex interactions of global climate change with the impacts of regional scale coastal development. Temperature, larval transport and habitat availability are the major proximate factors controlling the range limits of coastal marine species. The artificial shorelines provide suitable habitats for hard‐shore species on the Yangtze River Delta, and minimum temperature in winter is an important factor setting the new northern range limit of these hard‐shore species along the Chinese coast. Main conclusions In the face of global warming and global sprawl of marine hard infrastructure, species distributions, community structures and biogeographic patterns are experiencing dramatic changes. The combined influence of multiple human stressors including climate change and artificial shorelines can be evaluated by using a multidisciplinary framework, including ecological distribution, physiological sensitivity of species to these stressors, and the role of dispersal in maintaining population connectivity.
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    URL: Article
    DOI: 10.1111/geb.v29.2
    DOI: 10.1111/geb.13019
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1479787-2
    detail.hit.zdb_id: 2021283-5
    SSG: 12
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  • 4
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    Promoting Effect of Bismuth Oxide on Palladium for Low‐Temperature Carbon Monoxide Oxidation
    Wiley ; 2017
    In:  ChemCatChem Vol. 9, No. 3 ( 2017-02-06), p. 499-504
    Details
    In: ChemCatChem, Wiley, Vol. 9, No. 3 ( 2017-02-06), p. 499-504
    Abstract: By using a modified coimpregnation method, a multicomponent Pd & Bi(1.4)/TiO 2 ‐N catalyst with hierarchical metal–metal oxide interfaces was prepared that showed a better activity and stability for low‐temperature CO oxidation than Pd/TiO 2 ‐N and Pd/P25. The structural characterization and catalytic activity results proved that an appropriate amount of Bi species has a clear promoting effect on the Pd‐based catalyst. Particularly, the catalyst can be mass‐produced conveniently, which may be beneficial for versatile reactions and practical applications.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Issue
    URL: Article
    DOI: 10.1002/cctc.v9.3
    DOI: 10.1002/cctc.201601181
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2501161-3
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  • 5
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    Comparison of Interobserver Agreement of Four Classification Systems for Lateral Clavicle Fractures between Two Groups of Surgeons: A Multicenter Study
    Wiley ; 2023
    In:  Orthopaedic Surgery Vol. 15, No. 8 ( 2023-08), p. 2138-2143
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 15, No. 8 ( 2023-08), p. 2138-2143
    Abstract: Distal clavicle fracture classification directly affects the treatment decisions. It is unclear whether the classification systems implemented differ depending on surgeons' backgrounds. This study aimed to compare the interobserver agreement of four classification systems used for lateral clavicle fractures by shoulder specialists and general trauma surgeons. Methods Radiographs of 20 lateral clavicle fractures representing a full spectrum of adult fracture patterns were analyzed by eight experienced shoulder specialists and eight general trauma surgeons from 10 different hospitals. All cases were graded according to the Orthopedic Trauma Association (OTA), Neer, Jäger/Breitner, and Gongji classification systems. To measure observer agreement, Fleiss' kappa coefficient (κ) was applied and assessed. Results When only X‐ray films were presented, both groups achieved fair agreement. However, when the 3D‐CT scan images were provided, improved interobserver agreement was found in the specialist group when the OTA, Jäger/Breitner, and Gongji classification systems were used. In the generalist groups, improved agreement was found when using the Gongji classification system. In terms of interobserver reliability, the OTA, Neer, and Jäger/Breitner classification systems showed better agreement among shoulder specialists, while a slightly lower level of agreement was found using the Gongji classification system. For the OTA classification system, interobserver agreement had a mean kappa value of 0.418, ranging from 0.446 (specialist group) to 0.402 (generalist group). For the Neer classification system, interobserver agreement had a mean kappa value of 0.368, ranging from 0.402 (specialist group) to 0.390 (generalist group). For the Jäger/Breitner classification system, the inter‐observer agreement had a mean kappa value of 0.380, ranging from 0.413 (specialist group) to 0.404 (generalist group). For the Gongji classification system, interobserver agreement had a mean kappa value of 0.455, ranging from 0.480 (specialist group) to 0.485 (generalist group). Conclusion Generally speaking, 3D‐CT scans provide a richer experience that can lead to better results in most classification systems of lateral clavicle fractures, highlighting the value of digitization and specialization in diagnosis and treatment. Competitive interobserver agreement was exhibited in the generalist group using the Gongji classification system, suggesting that the Gongji classification is suitable for general trauma surgeons who are not highly experienced in the shoulder field.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v15.8
    DOI: 10.1111/os.13659
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2483883-4
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  • 6
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    Prevalence of active and passive tobacco smoking among Beijing residents in 2011
    Wiley ; 2016
    In:  Chronic Diseases and Translational Medicine Vol. 2, No. 2 ( 2016-06), p. 120-128
    Details
    In: Chronic Diseases and Translational Medicine, Wiley, Vol. 2, No. 2 ( 2016-06), p. 120-128
    Abstract: This study was aimed to investigate the prevalence of active and passive tobacco smoking among Beijing residents in 2011. Methods A cross‐sectional survey was conducted, using a stratified multistage cluster random sampling method to select a representative sample of 20,242, among Beijing residents aged 18–79 years. Active and passive tobacco smoking information was collected by a standardized and validated questionnaire in a face‐to‐face interview. All estimates of prevalence and numbers were weighted by the 2010 Beijing Population Census data and the sampling scheme. Results Among Beijing residents aged 18–79 years, the overall prevalence of ever smokers and current smokers were 33.13% and 30.18%, respectively. The prevalence in males was much higher than that in females (60.75% vs . 3.75% for ever smokers, and 55.53% vs . 3.21% for current smokers, respectively). For overall current smokers, 14.12 cigarettes were consumed per day. However, only 8.91% of ever smokers quitted smoking at the time of the survey, and 2.44% of ever smokers quitted smoking in recent two years. Furthermore, 44.74% of overall nonsmokers and former smokers, with 47.03% of males and 43.63% of females, reported exposure to secondhand smoke for at least 15 minutes per day and at least one day per week. Conclusions Tobacco smoking prevalence is still extremely high in Beijing. Nonsmokers do still suffer from secondhand smoke critically. Further urgent efforts for tobacco control are warranted in Beijing.
    Type of Medium: Online Resource
    ISSN: 2589-0514 , 2589-0514
    URL: Article
    DOI: 10.1016/j.cdtm.2016.09.005
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2831148-6
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  • 7
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    Right ventricular volume and function by three‐dimensional echocardiography: results of the echocardiographic measurements in normal Chinese adults (EMINCA) II
    Wiley ; 2024
    In:  MedComm Vol. 5, No. 5 ( 2024-05)
    Details
    In: MedComm, Wiley, Vol. 5, No. 5 ( 2024-05)
    Abstract: Three‐dimensional (3D) echocardiography is an emerging technique for assessing right ventricular (RV) volume and function, but 3D‐RV normal values from a large Chinese population are still lacking. The aim of the present study was to establish normal values of 3D‐RV volume and function in healthy Chinese volunteers. A total of 1117 Han Chinese volunteers from 28 laboratories in 20 provinces of China were enrolled, and 3D‐RV images of 747 volunteers with optimal image quality were ultimately analyzed by a core laboratory. Both vendor‐dependent and vendor‐independent software platforms were used to analyze the 3D‐RV images. We found that men had larger RV volumes than women did in the whole population, even after indexing to body surface area, and older individuals had smaller RV volumes. The normal RV volume was significantly smaller than that recommended by the American Society of Echocardiography/European Association of Cardiovascular Imaging guidelines in both sexes. There were significant differences in 3D‐RV measurements between the two vendor ultrasound systems and the different software platforms. The echocardiographic measurements in normal Chinese adults II study revealed normal 3D‐RV volume and function in a large Chinese population, and there were significant differences between the sexes, ages, races, and vendor groups. Thus, normal 3D‐RV values should be stratified by sex, age, race, and vendor.
    Type of Medium: Online Resource
    ISSN: 2688-2663 , 2688-2663
    URL: Issue
    URL: Article
    DOI: 10.1002/mco2.v5.5
    DOI: 10.1002/mco2.550
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 3021470-1
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  • 8
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    Front Cover
    Wiley ; 2020
    In:  Global Ecology and Biogeography Vol. 29, No. 2 ( 2020-02)
    Details
    In: Global Ecology and Biogeography, Wiley, Vol. 29, No. 2 ( 2020-02)
    Type of Medium: Online Resource
    ISSN: 1466-822X , 1466-8238
    URL: Issue
    URL: Article
    DOI: 10.1111/geb.v29.2
    DOI: 10.1111/geb.13067
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1479787-2
    detail.hit.zdb_id: 2021283-5
    SSG: 12
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  • 9
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    An Unbalanced Battle in Excellence: Revealing Effect of Ni/Co Occupancy on Water Splitting and Oxygen Reduction Reactions in Triple‐Conducting Oxides for Protonic Ceramic Electrochemical Cells
    Wiley ; 2022
    In:  Small Vol. 18, No. 30 ( 2022-07)
    Details
    In: Small, Wiley, Vol. 18, No. 30 ( 2022-07)
    Abstract: Porous electrodes that conduct electrons, protons, and oxygen ions with dramatically expanded catalytic active sites can replace conventional electrodes with sluggish kinetics in protonic ceramic electrochemical cells. In this work, a strategy is utilized to promote triple conduction by facilitating proton conduction in praseodymium cobaltite perovskite through engineering non‐equivalent B‐site Ni/Co occupancy. Surface infrared spectroscopy is used to study the dehydration behavior, which proves the existence of protons in the perovskite lattice. The proton mobility and proton stability are investigated by hydrogen/deuterium (H/D) isotope exchange and temperature‐programmed desorption. It is observed that the increased nickel replacement on the B‐site has a positive impact on proton defect stability, catalytic activity, and electrochemical performance. This doping strategy is demonstrated to be a promising pathway to increase catalytic activity toward the oxygen reduction and water splitting reactions. The chosen PrNi 0.7 Co 0.3 O 3− δ oxygen electrode demonstrates excellent full‐cell performance with high electrolysis current density of −1.48 A cm −2 at 1.3 V and a peak fuel‐cell power density of 0.95 W cm −2 at 600 °C and also enables lower‐temperature operations down to 350 °C, and superior long‐term durability.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v18.30
    DOI: 10.1002/smll.202201953
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2168935-0
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  • 10
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    3D Self‐Architectured Steam Electrode Enabled Efficient and Durable Hydrogen Production in a Proton‐Conducting Solid Oxide Electrolysis Cell at Temperatures Lower Than 600 °C
    Wiley ; 2018
    In:  Advanced Science Vol. 5, No. 11 ( 2018-11)
    Details
    In: Advanced Science, Wiley, Vol. 5, No. 11 ( 2018-11)
    Abstract: Hydrogen production via water electrolysis using solid oxide electrolysis cells (SOECs) has attracted considerable attention because of its favorable thermodynamics and kinetics. It is considered as the most efficient and low‐cost option for hydrogen production from renewable energies. By using proton‐conducting electrolyte (H‐SOECs), the operating temperature can be reduced from beyond 800 to 600 °C or even lower due to its higher conductivity and lower activation energy. Technical barriers associated with the conventional oxygen‐ion conducting SOECs (O‐SOECs), that is, hydrogen separation and electrode instability that is primarily due to the Ni oxidation at high steam concentration and delamination associated with oxygen evolution, can be remarkably mitigated. Here, a self‐architectured ultraporous (SAUP) 3D steam electrode is developed for efficient H‐SOECs below 600 °C. At 600 °C, the electrolysis current density reaches 2.02 A cm −2 at 1.6 V. Instead of fast degradation in most O‐SOECs, performance enhancement is observed during electrolysis at an applied voltage of 1.6 V at 500 °C for over 75 h, attributed to the “bridging” effect originating from reorganization of the steam electrode. The H‐SOEC with SAUP steam electrode demonstrates excellent performance, promising a new prospective for next‐generation steam electrolysis at reduced temperatures.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v5.11
    DOI: 10.1002/advs.201800360
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2808093-2
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