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  • 1
    In: Developmental Medicine & Child Neurology, Wiley, Vol. 62, No. 6 ( 2020-06), p. 673-683
    Abstract: The overall incidence of neonatal brachial plexus palsy is 1.74 per 1000 live births. The incidence has declined significantly. Shoulder dystocia, macrosomia, maternal diabetes, instrumental delivery, and breech delivery are the main risk factors. Prevention is difficult owing to unpredictability and often labour‐related risk. This article's abstract has been translated into Spanish and Portuguese. Follow the links from the abstract to view the translations. This article is commented on by Gherman on page 662 of this issue. Editor's Choice Neonatal brachial plexus palsy results in a high, complex, long‐lasting burden. There is a wide variety in epidemiological reports and the predicting value of classically considered risk factors has been questioned. My Editor’s Choice for the June 2020 issue is this comprehensive systematic review and meta‐analysis of risk factors identified in the literature reporting collectively on nearly 30 million births. 1 It clarifies a number of issues and also stresses challenges associated to this type of enterprise, including with regard to appraisal tools. 2,3 To date, no intervention has effectively prevented the majority of cases of neonatal brachial plexus palsy. 4 Hopefully the presented results will provide a firmer base for designing and studying intervention strategies in the future. REFERENCES 1. Van der Looven R, Le Roy L, Tanghe E, et al. Risk factors for neonatal brachial plexus palsy: a systematic review and meta‐analysis. Dev Med Child Neurol 2020; 62 : 673–83. 2. Rehm A, Thahir A. Validity of a meta‐analysis of risk factors for neonatal brachial plexus palsies. Dev Med Child Neurol 2020; 62 : 763. 3. Van der Looven R, Le Roy L, Pauwels N, Vingerhoets G. Critical appraisal tools and rater training in systematic reviews and meta‐analyses. Dev Med Child Neurol 2020 62 : 764. 4. Gherman R. Are there specific interventions that may reduce the incidence of neonatal brachial plexus palsy? Dev Med Child Neurol 2020; 62 : 662. Video Podcast: https://youtu.be/Yd3gy7aMJXE
    Type of Medium: Online Resource
    ISSN: 0012-1622 , 1469-8749
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2001992-0
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  • 2
    In: Microcirculation, Wiley, Vol. 25, No. 4 ( 2018-05)
    Abstract: Absolute nailfold capillary number should be a putative biomarker in selected rheumatic diseases but could be time‐consuming and not highly repeatable. Objective To validate an automated software for absolute nailfold capillary number and density evaluation, on NVC images in SS c. Methods An automated software to count nailfold capillary number ( AUTOCAPI ) had been constructed, through an exploratory image set. Subsequently, application rules have been created to define the ROI in NVC images, through a training images set. The software reliability was assessed through calculation of the ICC between automatic and manual counting, by four independent observers, on the same NVC images. Results The following ICC 's were obtained per observer, for the patients with SS c (40 images), the healthy (20 images), and the PRP subgroups (20 images), respectively: 0.94, 0.81, and 0.62 (observer 1); 0.94, 0.91, and 0.67 (observer 2); 0.88, 0.56, and 0.64 (observer 3); and 0.88, 0.85, and 0.85 (observer 4). Conclusions The validation of an automated software for measuring absolute nailfold capillary number and density in SS c was achieved. The integration into the pre‐existing imaging software should make the assessment of the capillary number in NVC easier, quicker, and standardized.
    Type of Medium: Online Resource
    ISSN: 1073-9688 , 1549-8719
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008083-9
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  • 3
    In: Journal of Clinical Periodontology, Wiley, Vol. 46, No. S21 ( 2019-06), p. 224-241
    Abstract: To compare immediate implant placement ( IIP ) to delayed single implant placement ( DIP , ≥3 months post‐extraction) in terms of implant survival (primary outcome), surgical, clinical, aesthetic, radiographic and patient‐reported outcomes (secondary outcomes). Materials and Methods Two reviewers independently performed an electronic search in PubMed, Web of Science, EMBASE and Cochrane and a hand search to identify eligible studies up to May 2018. Only randomized controlled trials ( RCT s) and non‐randomized controlled studies ( NRS s) comparing IIP to DIP with at least 1 year of follow‐up were selected for a qualitative analysis and meta‐analysis. Results The search identified 3 RCT s and 5 NRS s out of 2,589 titles providing data on 473 single implants ( IIP : 233, DIP : 240) that had been in function between 12 and 96 months. One RCT showed unclear risk of bias, whereas all other studies demonstrated high risk. Meta‐analysis showed significantly lower implant survival for IIP (94.9%) as compared to DIP (98.9%) ( RR 0.96, 95% CI [0.93; 0.99], p  = 0.02). All were early implant failures. A subgroup meta‐analysis demonstrated a trend towards lower implant survival for IIP when postoperative antibiotics had not been administered ( RR : 0.93, 95% CI [0.86; 1.00], p  = 0.07). This was not observed among studies including the administration of postoperative antibiotics ( RR : 0.98, 95% CI [0.94; 1.02], p  = 0.35). Meta‐analyses showed similar probing depth ( WMD 0.43 mm, 95% CI [−0.47; 1.33], p  = 0.35) and aesthetic outcomes as assessed by the pink aesthetic score (standardized WMD −0.03, 95% CI [−0.46; 0.39], p  = 0.88) for IIP and DIP . Data on marginal bone loss were conflicting and highly biased. Soft tissue recession was underreported and available data were highly biased. Patient‐reported outcomes were underreported, yet both IIP and DIP seemed well tolerated. Conclusion Immediate implant placement demonstrated higher risk for early implant loss than DIP . There is a need for RCT s comparing IIP to DIP with CBCT analyses at different time points and data on midfacial recession with the preoperative status as baseline. In these studies, the need for hard and soft tissue grafting should also be evaluated.
    Type of Medium: Online Resource
    ISSN: 0303-6979 , 1600-051X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2026349-1
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2015
    In:  Clinical Implant Dentistry and Related Research Vol. 17, No. S1 ( 2015-01)
    In: Clinical Implant Dentistry and Related Research, Wiley, Vol. 17, No. S1 ( 2015-01)
    Abstract: To identify risk factors for failure and bone loss of implants in a large study sample on the basis of multivariate analyses. Materials and Methods Patient files of all patients referred for implant treatment from N ovember 2004 to December 2007 were scrutinized, and information on implant‐ and patient‐related factors was collected. The study sample in this retrospective cohort study consisted of both partially dentate and fully edentulous patients referred for various indications. The only inclusion criterion was a follow‐up of at least 2 years. Implant survival and bone loss were assessed by an external investigator ( SV ) comparing digital periapical radiographs taken during recall visits with the postoperative ones. Univariate and multivariate tests were adopted to identify possible risk indicators for implant failure and peri‐implant bone loss. Results Twenty‐one of 1,320 (1.6%) implants were lost in 19 of 376 (5.1%) patients (210 female, 166 male; mean age 56, range 17–82) after a mean follow‐up of 32 months (range 24–62). Based on multivariate analysis, only smoking ( p  = .001) and recall compliance ( p  = .010) had a significant influence on implant failure, with smokers more prone to failure. The overall mean bone loss was 0.36 mm ( SD 0.68, range 0.00–7.10). Smoking ( p  = .001) and jaw of treatment ( p  = .001) affected peri‐implant bone loss. More peri‐implant bone loss was observed in smokers and in the maxilla. A clear discrepancy was found between univariate and multivariate analysis with regard to identification of risk factors. Conclusion Multivariate analysis demonstrated that implant‐related factors did not affect the clinical outcome, but smoking was identified as a predictor for implant failure. Predictors for peri‐implant bone loss were smoking and jaw of treatment.
    Type of Medium: Online Resource
    ISSN: 1523-0899 , 1708-8208
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2094120-1
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  • 5
    In: Journal of Child Psychology and Psychiatry, Wiley, Vol. 53, No. 7 ( 2012-07), p. 782-789
    Type of Medium: Online Resource
    ISSN: 0021-9630
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 1470297-6
    SSG: 5,2
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  • 6
    In: Neurourology and Urodynamics, Wiley, Vol. 38, No. 1 ( 2019-01), p. 231-238
    Abstract: To investigate if the standard protocol for uroflowmetry, recommended by the International Children's Continence Society, remains accurate when integrating EMG measurement by means of superficial electrodes. Methods A cross‐sectional study was conducted including healthy children. Group A performed two direct repetitions of uroflowmetry in combination with electromyography (uroflow/EMG). Group B performed a preceding measurement of isolated uroflowmetry, followed by two randomized measurements of uroflowmetry with and without EMG. Interpretation of uroflow curve was assessor blinded by a pediatric urologist and secondly performed using the flow index methodology. Statistical analysis compared different voids within each group and between group A and B. Results Eighty‐three children were included and 206 uroflow measurements were obtained. In both groups statistical findings confirmed the hypothesis that it is preferable to perform an additional measurement before the use of uroflow/EMG. Although both groups showed improvement between voids, the group with initial uroflow measurement followed by uroflow/EMG measurement showed more improvement in concern of curve pattern. An initially better first void in group A, but no statistical difference between the second void in group A and uroflow/EMG testing in group B further demonstrates a higher improvement in group B. This suggests the use of a precedent uroflowmetry without EMG is preferable to immediate testing with EMG. Conclusions It should be mandatory to perform one measurement in advance to ensure the reliability of the results. It is suggested to initiate the procedure with a single uroflowmetry measurement followed by one measurement of uroflow with EMG testing.
    Type of Medium: Online Resource
    ISSN: 0733-2467 , 1520-6777
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1500793-5
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  • 7
    Online Resource
    Online Resource
    Wiley ; 2009
    In:  Clinical Oral Implants Research Vol. 20, No. 10 ( 2009-10), p. 1070-1077
    In: Clinical Oral Implants Research, Wiley, Vol. 20, No. 10 ( 2009-10), p. 1070-1077
    Type of Medium: Online Resource
    ISSN: 0905-7161 , 1600-0501
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2027104-9
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  • 8
    In: International Journal of Paediatric Dentistry, Wiley, Vol. 29, No. 4 ( 2019-07), p. 439-447
    Abstract: Oral diseases and socio‐economic inequalities in children are a persisting problem. Aim To investigate the 4‐year longitudinal impact of an oral health promotion programme on oral health, knowledge, and socio‐economic inequalities in primary schoolchildren. Design The intervention was carried out between 2010 and 2014 within a random sample of Flemish primary schoolchildren (born in 2002). It consisted of an annual oral health education session. ICDAS / DMFT , care level, knowledge scores, and plaque index were used as outcome variables. Being entitled to a corrective policy measure was used as social indicator. Mixed model analyses were conducted to evaluate changes over time between intervention and control group and between higher and lower social subgroups. Results A total of 1058 participants (23.8%) attended all four sessions. The intervention had a stabilizing effect on the number of decayed teeth and increased knowledge scores. No statistically different effect on the two social groups could be demonstrated. Socio‐economic inequalities were present both at T 0 and T 4 . Conclusion The oral health promotion programme had a positive impact on oral health knowledge and stabilized the number of decayed teeth. No impact on inequalities could be demonstrated, although a higher dropout rate in children with a lower social status was seen.
    Type of Medium: Online Resource
    ISSN: 0960-7439 , 1365-263X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2009034-1
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  • 9
    In: Phytotherapy Research, Wiley, Vol. 28, No. 2 ( 2014-02), p. 312-316
    Abstract: Few therapeutic options are available to patients with oxidative phosphorylation disorders. Administering pharmacological agents that are able to stimulate mitochondrial biogenesis have been put forward as a possible treatment, yet the approach remains in need of thorough testing. We investigated the effect of resveratrol in an in vitro setting. Mitochondrial enzymatic activities were tested in cultured skin fibroblasts from patients harboring a nuclear defect in either complex II or complex IV (n = 11), and in fibroblasts from healthy controls (n = 11). In the latter, preincubation with resveratrol resulted in a significant increase of citrate synthase, complex II and complex IV enzyme activity. In patients with complex II or complex IV deficiency, however, activity of the deficient complex could not be substantially augmented, and response was dependent upon the residual activity. We conclude that resveratrol is not capable of normalizing oxidative phosphorylation activities in deficient cell lines. Copyright © 2013 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 10
    In: Clinical Oral Implants Research, Wiley, Vol. 23, No. 6 ( 2012-06), p. 758-766
    Abstract: Aim: To compare the survival and peri‐implant bone loss of implants with a fluoride‐modified surface in smokers and nonsmokers. Materials and methods: Patient files of all patients referred for implant treatment from November 2004 to 2007 were scrutinized. All implants were placed by the same experienced surgeon (B. C.). The only inclusion criterion was a follow‐up time of at least 2 years. Implant survival and bone loss were assessed by an external calibrated examiner (S. V.) comparing digital peri‐apical radiographs taken during recall visits with the post‐operative ones. Implant success was determined according to the international success criteria ( Albrektsson et al. 1986 ). Survival of implants installed in smokers and nonsmokers was compared using the log‐rank test. Both nonparametric tests and fixed model analysis were adopted to evaluate bone loss in smokers and nonsmokers. Results: One‐thousand one‐hundred and six implants in 300 patients (186 females; 114 males) with a mean follow‐up of 31 months (SD 7.15; range 24–58) were included. Nineteen implants in 17 patients failed, resulting in an overall survival rate of 98.3% at the implant level and 94.6% at the patient level. After a follow‐up period of 2 years, the cumulative survival rates was 96.7% and 99.1% with the patient and implant as the statistical unit, respectively. Implant survival was significantly higher for nonsmokers compared with smokers (implant level P =0.025; patient level P =0.017). The overall mean bone loss was 0.34 mm ( n =1076; SD 0.65; range 0–7.1). Smokers lost significantly more bone compared with nonsmokers in the maxilla (0.74 mm; SD 1.07 vs. 0.33 mm; SD 0.65; P 〈 0.001), but not in the mandible (0.25 mm; SD 0.65 vs. 0.22 mm; SD 0.5; P =0.298). Conclusion: The present study is the first to compare peri‐implant bone loss in smokers and nonsmokers from the time of implant insertion (baseline) to at least 2 years of follow‐up. Implants with a fluoride‐modified surface demonstrated a high survival rate and limited bone loss. However, smokers are at a higher risk of experiencing implant failure and more prone to show peri‐implant bone loss in the maxilla. Whether this bone loss is predicting future biological complications remains to be evaluated.
    Type of Medium: Online Resource
    ISSN: 0905-7161 , 1600-0501
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2027104-9
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