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  • 1
    Online Resource
    Online Resource
    Splenic vein rupture in pregnancy: A case report and systematic review of the literature
    Wiley ; 2024
    In:  International Journal of Gynecology & Obstetrics
    Details
    In: International Journal of Gynecology & Obstetrics, Wiley
    Abstract: Splenic vein aneurysm (SVA) rupture is a rare clinical entity, with few case reports detailing its occurrence during pregnancy.
    Type of Medium: Online Resource
    ISSN: 0020-7292 , 1879-3479
    URL: Article
    DOI: 10.1002/ijgo.15842
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1500480-6
    detail.hit.zdb_id: 80149-5
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  • 2
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    Structural design of the dry fibrin sealant dressing and its impact on the hemostatic efficacy of the product
    Wiley ; 2004
    In:  Journal of Biomedical Materials Research Part B: Applied Biomaterials Vol. 70B, No. 1 ( 2004-07-15), p. 114-121
    Details
    In: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Wiley, Vol. 70B, No. 1 ( 2004-07-15), p. 114-121
    Abstract: We compared the hemostatic efficacy of a production version of a dry fibrin sealant dressing (DFSD) to a prototype that was previously successful in large animal studies. The results were used to improve manufacturing processes. Grade‐V liver injuries were induced in swine and treated with gauze sponges (GAU), the prototype dressings (DFSD‐1), or the scaled‐up production version dressings (DFSD‐2 in experiment 1 and DFSD‐3 in experiment 2). Blood loss, hemostasis, resuscitation volume, and 60‐min survival were quantified. In experiment 1, the DFSD‐1 treatment reduced blood loss ( p 〈 0.01), increased hemostasis at 4 min ( p 〈 0.05), and improved survival ( p 〈 0.05) compared with GAU. The DFSHD‐2 decreased blood loss ( p 〈 0.05) but did not increase hemostasis or survival significantly. Based on these results, manufacturing processes were altered, producing DFSD‐3. In experiment 2, the DFSD‐1 and DFSD‐3 were equally effective in reducing blood loss ( p 〈 0.01) and resuscitation volume ( p 〈 0.05) compared with GAU. Hemostasis occurred more frequently in both the DFSD‐1 and DFSD‐3 groups ( p 〈 0.01) compared with GAU. The structural design of DFSD‐2 did not meet the efficacy requirement for release of the product. The subsequent change incorporated in DFSD‐3 improved all hemostatic parameters of the dressings equal to those of the prototype product. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 70B: 114–121, 2004
    Type of Medium: Online Resource
    ISSN: 1552-4973 , 1552-4981
    URL: Issue
    URL: Article
    DOI: 10.1002/jbm.b.v70b:1
    DOI: 10.1002/jbm.b.30031
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2130917-6
    detail.hit.zdb_id: 2099992-6
    SSG: 12
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  • 3
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    Folate‐related gene polymorphisms as risk factors for cleft lip and cleft palate
    Wiley ; 2008
    In:  Birth Defects Research Part A: Clinical and Molecular Teratology Vol. 82, No. 9 ( 2008-09), p. 636-643
    Details
    In: Birth Defects Research Part A: Clinical and Molecular Teratology, Wiley, Vol. 82, No. 9 ( 2008-09), p. 636-643
    Abstract: Cleft lip with or without cleft palate (CLP) and cleft palate only (CPO) have an inherited component and, many studies suggest, a relationship with folate. Attempts to find folate‐related genes associated with clefts have, however, often been inconclusive. This study examined four SNPs related to folate metabolism ( MTHFR 677 C→T, MTHFR 1298 A→C, MTHFD1 1958 G→A, and TC II 776 C→G) in a large Irish population to clarify their relationship with clefts. METHODS: Cases and their parents were recruited from major surgical centers performing cleft repairs in Ireland and a support organization. Data on risk factors, medical history, and DNA were collected. Controls were pregnant women from the greater Dublin area ( n = 1,599). RESULTS: CLP cases numbered 536 and CPO cases 426 after exclusions. CPO mothers were significantly more likely than controls to be MTHFR 677 TT, OR 1.50 (95% CI: 1.05–2.16; p = .03). Log‐linear analysis showed a borderline association ( p = .07). Isolated CPO case mothers were significantly more likely than controls to be homozygous for the MTHFD1 1958 G→A variant, OR 1.50 (95%CI: 1.08–2.09; p = .02). When multiple cases were added, both CPO cases and case mothers were significantly more likely to be AA ( p = .02 and p = .007, respectively). The CLP case‐control and mother‐control analyses also showed significant effects, ORs 1.38 (95% CI: 1.05–1.82; p = .03) and 1.39 (95% CI: 1.04–1.85; p = .03), respectively. CONCLUSIONS: Associations were found for both CPO and CLP and MTHFD1 1958 G→A in cases and case mothers. MTHFR 677 C→T could be a maternal risk factor for clefts but the association was not strong. Because multiple comparisons were made, these findings require additional investigation. Given the known association between MTHFD1 1958 G→A and NTDs, these findings should be explored in more detail. Birth Defects Research (Part A) 2008. © 2008 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1542-0752 , 1542-0760
    URL: Issue
    URL: Article
    DOI: 10.1002/bdra.v82:9
    DOI: 10.1002/bdra.20491
    Language: English
    Publisher: Wiley
    Publication Date: 2008
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  • 4
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    Testing reported associations of genetic risk factors for oral clefts in a large Irish study population
    Wiley ; 2010
    In:  Birth Defects Research Part A: Clinical and Molecular Teratology Vol. 88, No. 2 ( 2010-02), p. 84-93
    Details
    In: Birth Defects Research Part A: Clinical and Molecular Teratology, Wiley, Vol. 88, No. 2 ( 2010-02), p. 84-93
    Abstract: Suggestive, but not conclusive, studies implicate many genetic variants in oral cleft etiology. We used a large, ethnically homogenous study population to test whether reported associations between nonsyndromic oral clefts and 12 genes ( CLPTM1 , CRISPLD2 , FGFR2 , GABRB3 , GLI2 , IRF6 , PTCH1 , RARA , RYK , SATB2 , SUMO1 , TGFA ) could be confirmed. METHODS: Thirty‐one single nucleotide polymorphisms (SNPs) in exons, splice sites, and conserved non‐coding regions were studied in 509 patients with cleft lip with or without cleft palate (CLP), 383 with cleft palate only (CP), 838 mothers and 719 fathers of patients with oral clefts, and 902 controls from Ireland. Case‐control and family‐based statistical tests were performed using isolated oral clefts for the main analyses. RESULTS: In case‐control comparisons, the minor allele of PTCH1 A562A (rs2066836) was associated with reduced odds of CLP (odds ratios [OR], 0.29; 95% confidence interval [CI] , 0.13–0.64 for homozygotes), whereas the minor allele of PTCH1 L1315P (rs357564) was associated with increased odds of CLP (OR, 1.36; 95% CI, 1.07–1.74 for heterozygotes; and OR, 1.56; 95% CI, 1.09–2.24 for homozygotes). The minor allele of one SUMO1 SNP, rs3769817 located in intron 2, was associated with increased odds of CP (OR, 1.45; 95% CI, 1.06–1.99 for heterozygotes). Transmission disequilibrium was observed for the minor allele of TGFA V159V (rs2166975) which was over‐transmitted to CP cases ( p = 0.041). CONCLUSIONS: For 10 of the 12 genes, this is the largest candidate gene study of nonsyndromic oral clefts to date. The findings provide further evidence that PTCH1 , SUMO1 , and TGFA contribute to nonsyndromic oral clefts. Birth Defects Research (Part A) 2010. © 2009 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1542-0752 , 1542-0760
    URL: Issue
    URL: Article
    DOI: 10.1002/bdra.v88:2
    DOI: 10.1002/bdra.20639
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2108606-0
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  • 5
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    Microcephaly: Genetic counselling and antenatal diagnosis after the birth of an affected child
    Wiley ; 1987
    In:  American Journal of Medical Genetics Vol. 27, No. 3 ( 1987-07), p. 583-594
    Details
    In: American Journal of Medical Genetics, Wiley, Vol. 27, No. 3 ( 1987-07), p. 583-594
    Abstract: We describe the clinical and genetic details of a series of microcephalic patients who were referred to the Genetic Counselling Service for the West of Scotland. There were 29 isolated cases of microcephaly and 9 families with recurrent microcephaly. The sib recurrence risk was 19%, which reflects the high incidence of autosomal recessive microcephaly in this series. There was evidence for several varieties of recessive microcephaly. The most frequent, affecting 5 sib pairs, was associated with spastic quadriplegia, seizures, and profound mental handicap. In 15 families with one microcephalic child, prenatal diagnosis by serial ultrasound scans was undertaken in 21 subsequent pregnancies. Four recurrences of microcephaly were detected in the third trimester and one recurrence was missed because no scans were performed after 24 wk gestation when the ultrasound measurements indicated satisfactory head growth. The main reason for late diagnosis of affected fetuses was that head growth did not slow appreciably until the last trimester. The high recurrence risk in this prospective series emphasizes the contribution of autosomal recessive inheritance of microcephaly amongst patients of our Genetic Counselling Service.
    Type of Medium: Online Resource
    ISSN: 0148-7299 , 1096-8628
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.v27:3
    DOI: 10.1002/ajmg.1320270311
    RVK:
    WA 15000
    RVK:
    XA 18980
    Language: English
    Publisher: Wiley
    Publication Date: 1987
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    detail.hit.zdb_id: 2205916-7
    SSG: 12
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  • 6
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    Why are Cold Molecules so Hot?
    Wiley ; 2009
    In:  ChemPhysChem Vol. 10, No. 4 ( 2009-03-09), p. 604-623
    Details
    In: ChemPhysChem, Wiley, Vol. 10, No. 4 ( 2009-03-09), p. 604-623
    Abstract: Brrrr! Cold molecule and cold atom research are juxtaposed and the challenges in cooling and trapping molecules are recounted. Both indirect and direct techniques of producing cold and slow molecules (such as buffer‐gas cooling and magnetic trapping, see picture) are described. Advanced techniques of manipulating cold or slow molecules are reviewed and ongoing work with cold molecules is outlined. magnified image Herein, we aim to show why the work on translationally (and otherwise) cold molecules has sparked so much inspiration—and anticipation—in both the physics and chemistry communities. We begin by discussing the basic features of cold molecules as implied by their de Broglie wavelengths, large compared with molecular dimensions. We juxtapose cold molecule and cold atom research and recount the challenges that had to be met if molecules were to be cooled and trapped. Subsequently, both the indirect and direct techniques of producing cold and slow molecules are described in some detail, and their applicability to various classes of molecules is discussed. Advanced techniques of manipulating cold or slow molecules are illustrated by the examples of DC and AC trapping and storage. Finally, ongoing and future work with cold and/or trapped molecules is outlined. This includes precision spectroscopy, chemical reaction dynamics, simulations of few‐ and many‐body physics, quantum computing, and tests of fundamental physics.
    Type of Medium: Online Resource
    ISSN: 1439-4235 , 1439-7641
    URL: Issue
    URL: Article
    DOI: 10.1002/cphc.v10:4
    DOI: 10.1002/cphc.200800577
    Language: English
    Publisher: Wiley
    Publication Date: 2009
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    detail.hit.zdb_id: 2021755-9
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  • 7
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    Direct Time‐Domain Observation of Conformational Relaxation in Gas‐Phase Cold Collisions
    Wiley ; 2016
    In:  Angewandte Chemie Vol. 128, No. 16 ( 2016-04-11), p. 5041-5045
    Details
    In: Angewandte Chemie, Wiley, Vol. 128, No. 16 ( 2016-04-11), p. 5041-5045
    Abstract: Cooling molecules in the gas phase is important for precision spectroscopy, cold molecule physics, and physical chemistry. Measurements of conformational relaxation cross sections shed important light on potential energy surfaces and energy flow within a molecule. However, gas‐phase conformational cooling has not been previously observed directly. In this work, we directly observe conformational dynamics of 1,2‐propanediol in cold (6 K) collisions with atomic helium using microwave spectroscopy and buffer‐gas cooling. Precise knowledge and control of the collisional environment in the buffer‐gas allows us to measure the absolute collision cross‐section for conformational relaxation. Several conformers of 1,2‐propanediol are investigated and found to have relaxation cross‐sections with He ranging from σ=4.7(3.0)×10 −18  cm 2 to σ 〉 5×10 −16  cm 2 . Our method is applicable to a broad class of molecules and could be used to provide information about the potential energy surfaces of previously uninvestigated molecules.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v128.16
    DOI: 10.1002/ange.201600030
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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    detail.hit.zdb_id: 1479266-7
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  • 8
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    Case‐control study of lung cancer in los angeles county welders
    Wiley ; 1989
    In:  American Journal of Industrial Medicine Vol. 16, No. 1 ( 1989-01), p. 103-112
    Details
    In: American Journal of Industrial Medicine, Wiley, Vol. 16, No. 1 ( 1989-01), p. 103-112
    Abstract: A case‐control study of lung cancer in white male welders was undertaken to investigate possible environmental and occupational causes of a 50% excess of lung cancer observed in this occupational group. The subjects were identified from a populationbased cancer registry in Los Angeles County. A standardized questionnaire was administered to either subjects or proxy informants of 90 lung cancer cases and 116 non‐lung‐cancer controls. Significantly increased risks of lung cancer were associated with tobacco smoking (odds ratio 7.6, p 〈 .005) and shipyard welding with at least a 10‐year latency since first exposure (odds ratio 1.7, p 〈 .05). Although there were elevated risks associated with some specific welding processes, none were statistically significant. Control subjects were more likely to have had exposure to confined‐space welding (odds ratio 0.6, 95% CI = 0.3–1.2), and this association was greatest where there had been at least a 20‐year latency since first exposure (0.5, 95% CI = 0.3–1.0). We conclude that the excess of lung cancer in this welding population is contributed to by a higher frequency of smoking and probable exposure to asbestos in shipyards. Other factors may be important, but probably because of limited power and reliance on proxy information, this study failed to detect other statistically significant risks.
    Type of Medium: Online Resource
    ISSN: 0271-3586 , 1097-0274
    URL: Issue
    URL: Article
    DOI: 10.1002/ajim.v16:1
    DOI: 10.1002/ajim.4700160111
    Language: English
    Publisher: Wiley
    Publication Date: 1989
    detail.hit.zdb_id: 604538-8
    detail.hit.zdb_id: 1491156-5
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  • 9
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    The Neu–Laxova syndrome in female sibs: Clinical and pathological features with prenatal diagnosis in the second sib
    Wiley ; 1987
    In:  American Journal of Medical Genetics Vol. 27, No. 1 ( 1987-05), p. 175-182
    Details
    In: American Journal of Medical Genetics, Wiley, Vol. 27, No. 1 ( 1987-05), p. 175-182
    Abstract: We report on affected sisters with the Neu–Laxova syndrome. Prenatal diagnosis of the condition was achieved by serial ultrasound examinations which demonstrated abnormal fetal growth in the second affected fetus before 24 weeks gestation.
    Type of Medium: Online Resource
    ISSN: 0148-7299 , 1096-8628
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.v27:1
    DOI: 10.1002/ajmg.1320270118
    RVK:
    WA 15000
    RVK:
    XA 18980
    Language: English
    Publisher: Wiley
    Publication Date: 1987
    detail.hit.zdb_id: 133387-2
    detail.hit.zdb_id: 2205916-7
    SSG: 12
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  • 10
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    Physics and Chemistry with Cold Molecules
    Wiley ; 2016
    In:  ChemPhysChem Vol. 17, No. 22 ( 2016-11-18), p. 3581-3582
    Details
    In: ChemPhysChem, Wiley, Vol. 17, No. 22 ( 2016-11-18), p. 3581-3582
    Type of Medium: Online Resource
    ISSN: 1439-4235 , 1439-7641
    URL: Issue
    URL: Article
    DOI: 10.1002/cphc.v17.22
    DOI: 10.1002/cphc.201601131
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2025223-7
    detail.hit.zdb_id: 2021755-9
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