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  • 1
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    Clinical and Microbiologic Effects of Subgingival Controlled‐Release Delivery of Chlorhexidine Chip in the Treatment of Periodontitis: A Multicenter Study
    Wiley ; 2008
    In:  Journal of Periodontology Vol. 79, No. 2 ( 2008-02), p. 271-282
    Details
    In: Journal of Periodontology, Wiley, Vol. 79, No. 2 ( 2008-02), p. 271-282
    Abstract: Background: The main therapeutic approach for periodontal diseases is mechanical treatment of root surfaces via scaling and root planing (SRP). Multicenter clinical trials have demonstrated that the adjunctive use of a chlorhexidine (CHX) chip is effective in improving clinical results compared to SRP alone. However, some recent studies failed to confirm these clinical results, and conflicting results were reported regarding the effects of the CHX chip on subgingival microflora. The aim of this study was to provide further data on the clinical and microbiologic effects of CHX chips when used as an adjunct to SRP. Methods: A total of 116 systemically healthy individuals with moderate to advanced periodontitis, aged 33 to 65 years, were recruited from the Departments of Periodontology of four Italian universities. For each subject, two experimental sites were chosen that had probing depths (PD) ≥5 mm and bleeding on probing (BOP) and were located in two symmetric quadrants. These two sites were randomized at the split‐mouth level, with one receiving SRP treatment alone and the other receiving treatment with SRP plus one CHX chip (SRP + CHX). PD, relative attachment level (RAL), and BOP were evaluated at baseline, prior to any treatment, and after 3 and 6 months. Supragingival plaque and the modified gingival index were evaluated at baseline and after 15 days and 1, 3, and 6 months. Subgingival microbiologic samples were harvested at baseline and after 15 days and 1, 3, and 6 months, cultured for total bacterial counts (TBCs), and investigated by polymerase chain reaction analysis for the identification of eight putative periodontopathogens. Results: When all of the pockets were considered, the PD and RAL were significantly less at 3 and 6 months compared to the baseline scores ( P 〈 0.01) for both treatments. Moreover, the PD was reduced in the SRP + CHX treatment group compared to the SRP treatment group at 3 and 6 months, whereas the RAL was similar for both treatments at 3 months and was reduced in the SRP + CHX treatment group at 6 months. The differences in PD reductions between the treatments were 0.30 and 0.55 mm at 3 and 6 months, respectively ( P 〈 0.01); for the RAL gain, the differences were 0.28 and 0.64 mm, respectively ( P 〈 0.001). The TBCs decreased significantly with both treatments. A similar, although less evident, pattern was noted when only the pockets with an initial PD ≥7 mm were considered. The percentage of sites positive for BOP was similar between the treatments at each time point. At 15 days and 1 month, the TBC for the SRP + CHX treatment group was significantly lower than for the SRP treatment group ( P 〈 0.01 and P 〈 0.05, respectively). Over time, both treatments generally reduced the percentages of sites positive for the eight putative periodontopathic bacteria, although greater reductions were seen often for the SRP + CHX treatment group. Conclusions: The adjunctive use of the CHX chip resulted in a significant PD reduction and a clinical attachment gain compared to SRP alone. These results were concomitant with a significant benefit of SRP + CHX treatment on the subgingival microbiota.
    Type of Medium: Online Resource
    ISSN: 0022-3492 , 1943-3670
    URL: Article
    DOI: 10.1902/jop.2008.070308
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2040047-0
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  • 2
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    Endoscopic approach to complex or recurrent pilonidal sinus: A retrospective analysis
    Wiley ; 2023
    In:  International Wound Journal Vol. 20, No. 4 ( 2023-04), p. 1212-1218
    Details
    In: International Wound Journal, Wiley, Vol. 20, No. 4 ( 2023-04), p. 1212-1218
    Abstract: Pilonidal Sinus is a benign, chronic disease that affects the hair follicles of the natal cleft of the sacrococcygeal area. Its ideal treatment is controversial, especially in complex or recurrent cases. The aim of this study is to evaluate the use of minimally invasive endoscopic approach in this setting. We enrolled patients affected by complex or recurrent sacrococcygeal pilonidal sinus from January 2015 through December 2020 who underwent Video‐Assisted Ablation of Pilonidal Sinus. All patients enrolled were re‐evaluated once a year with a standard physical examination. The patients included were 38. Recurrence rate at 1‐, 3‐ and 5‐years follow‐ups were 28.9%, 22.2% and 38.1% respectively. Of interest, the mean (SD) distance from the most lateral orifice to the midline was higher in group of patients with recurrence and the multivariate analysis demonstrated that it was the limiting factor, which influences the recurrence rate. In complex or recurrent pilonidal sinus disease with pits off the midline the endoscopic approach should not be the first choice. This makes us think that these cases should have their own classification to be identified and guide surgeons in choosing the appropriate approach.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.v20.4
    DOI: 10.1111/iwj.13980
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2152163-3
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  • 3
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    Outcome of left atrial appendage closure using cerebral protection system for thrombosis: no patient left behind
    Wiley ; 2022
    In:  Pacing and Clinical Electrophysiology Vol. 45, No. 1 ( 2022-01), p. 23-34
    Details
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 45, No. 1 ( 2022-01), p. 23-34
    Abstract: Left atrial appendage (LAA) thrombosis increases the risk of stroke and its management has to be assessed. The aim of the present study is to evaluate short and long‐term safety and efficacy of a standardized approach of percutaneous LAA closure (LAAC) routinely using a cerebral protection device (CPD) in patients with LAA thrombosis or sludge (LAAT). Methods We prospectively enrolled 14 consecutive patients with atrial fibrillation complicated by LAAT presenting in a high‐volume tertiary center. In seven patients (50%) LAAT was found after anticoagulant withdrawal for severe bleedings and in the remaining half LAAT was found despite appropriate anticoagulant therapy. All patients were treated with a standardized interventional approach of LAAC routinely using a CPD and guided by transoesophageal echocardiography. Results Mean age was 68 ± 14 years and nine patients (64%) were male. Mean CHA 2 DS 2 ‐VASc and HAS‐BLED scores were 3.3 ± 1.6 and 2.3 ± 1.1, respectively. Six patients (42.8%) presented organized thrombi while eight LAA sludge (57.1%). In 13 patients (92.8%) CPD was positioned through a right radial arterial access. Procedural success was achieved in all patients. In one patient we assisted to embolization of the thrombus during deployment of the device in the absence of neurological consequences. During a mean follow up of 426 ± 307 days, one patient died for non‐cardiac cause while no embolic event or major bleeding were reported. Conclusion In an unselected cohort, LAAC with the systematic use of CPD was a feasible, safe and effective therapeutic option for LAAT both acutely and after long‐term follow‐up.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    URL: Article
    DOI: 10.1111/pace.v45.1
    DOI: 10.1111/pace.14398
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2037547-5
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  • 4
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    Etiology is a predictor of recurrence after catheter ablation of ventricular arrhythmias in pediatric patients
    Wiley ; 2021
    In:  Journal of Cardiovascular Electrophysiology Vol. 32, No. 5 ( 2021-05), p. 1337-1345
    Details
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 32, No. 5 ( 2021-05), p. 1337-1345
    Abstract: Ventricular arrhythmias (VAs) are rare in pediatric patients, especially in absence of structural heart disease (SHD). Few data are available regarding the invasive VAs treatment with catheter ablation (CA) in pediatric patients and predictors of outcomes have not been fully investigated. Objective To describe the clinical presentation, procedural characteristics, and outcomes in pediatric patients undergoing CA for VAs. Methods Eighty‐one consecutive pediatric patients (58 male [72%], 15.5 ± 2.2 years) treated by CA for ventricular tachycardia (VT) or premature ventricular beats (PVBs) were retrospectively evaluated. Study endpoints were VAs recurrence and mortality for any cause. Results Ninety‐five procedures were performed in 81 patients, 52 (55%) PVBs and 43 (45%) VT ablations. During a follow‐up of 35.0 months (interquartile range = 13.0–71.0), 14 patients (14.7%) had a VA recurrence: 11 (33.3%) patients treated with CA for VT and 3 (6.2%) patients treated for PVBs ( p   〈  .001). One patient (1%) died 26 months after the procedure during an electrical storm. Patients with SHD had higher VAs recurrence rate, as compared with idiopathic VAs (pairwise log‐rank p   〈  .001). Patients treated with CA for VT had higher VA recurrence rate, as compared with PVB patients (pairwise log‐rank p  = .002). At Cox multivariate analysis only SHD was an independent predictor of VAs recurrence (hazard ratio = 5.56, 95% confidence interval = 2.68–11.54, p   〈  .001). Conclusion CA of VAs is effective and safe in a pediatric population. CA of idiopathic and fascicular VAs are associated with lower recurrence rate, than VAs in the setting of SHD.
    Type of Medium: Online Resource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    URL: Article
    DOI: 10.1111/jce.v32.5
    DOI: 10.1111/jce.14984
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2037519-0
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  • 5
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    Morphological and functional study of dwarf neurons in the rat striatum
    Wiley ; 1998
    In:  European Journal of Neuroscience Vol. 10, No. 12 ( 1998-12), p. 3575-3583
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 10, No. 12 ( 1998-12), p. 3575-3583
    Abstract: Combination of morphological and electrophysiological techniques provided data, suggesting existence in the young rat striatum of a peculiar class of neurons, the neurogliaform or dwarf neurons. Striatal neurons ( n  = 92), intracellularly recorded from rat brain slices, were filled (one in each slice) with the intracellular marker biocytin, to compare physiological and morphological properties in the same cell. Moreover, some neurons ( n  = 7) were filled with biocytin plus the fluorescent calcium indicator fura‐2, identifying cells during electrophysiological recording. Electrophysiological recordings showed that striatal neurons had different firing patterns, suggestive in most cases ( n  = 80) of spiny neuron class and in others ( n  = 12) of interneuron class. Fura‐2 injection clearly identified the body of six medium‐sized cells and of one distinctive tiny cell. This small cell, however, showed a resting membrane potential and spontaneous and evoked firing pattern characteristic of striatal interneurons. Moreover, the fura‐2 injected in such small neuron also completely filled the cell body of a near large neuron; the fura‐2 fluorescence changed synchronously in the two paired neurons after electrical stimulation of the impaled small one. Accordingly, the biocytin staining identified the morphology of the small recorded neuron as a neurogliaform‐like cell apposed to a dendrite of an aspiny neuron, suggesting that the dye injected in one neuron had diffused to the other of a different type. Furthermore, such heterologous dye coupling unexpectedly involved seven pairs of cells detected with biocytin staining (7.6% of the recorded neurons), invariably represented by a medium or large neuron on one side, and on the other side by a small (5.44 ± 0.15 × 9.14 ± 0.7 μm, mean ± SD; n  = 7) neurogliaform cell, roundish in shape with few slender and short processes, usually apposed to a dendrite of the companion neurons (six out of seven). In the other cases, the biocytin staining revealed in each slice either the morphology of single spiny or aspiny neurons (80.4% of recorded neurons), or of two–three medium‐sized spiny neurons detected near to each other, suggesting that dye coupling had occurred typically between similar neurons (11.9% of the recorded neurons). These data suggest that some neurogliaform cells in the striatum of young rat can be identified as dwarf interneurons, that may be dye‐coupled with neurons of different classes.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Article
    DOI: 10.1046/j.1460-9568.1998.00374.x
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 6
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    Resolution of atrial thrombosis with heparin in a newborn with atrial flutter
    Wiley ; 2009
    In:  Acta Paediatrica Vol. 98, No. 7 ( 2009-07), p. 1211-1214
    Details
    In: Acta Paediatrica, Wiley, Vol. 98, No. 7 ( 2009-07), p. 1211-1214
    Type of Medium: Online Resource
    ISSN: 0803-5253 , 1651-2227
    URL: Issue
    URL: Article
    DOI: 10.1111/apa.2009.98.issue-7
    DOI: 10.1111/j.1651-2227.2009.01235.x
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 1492629-5
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  • 7
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    GAUSS satellite solution for location‐based services
    Wiley ; 2004
    In:  International Journal of Satellite Communications and Networking Vol. 22, No. 1 ( 2004-01), p. 55-85
    Details
    In: International Journal of Satellite Communications and Networking, Wiley, Vol. 22, No. 1 ( 2004-01), p. 55-85
    Abstract: The project was carried by an industrial Consortium, involving nine European companies, with proven experience and complementary skill in the fields of telecommunication, equipment manufacturing, communication and navigation system engineering, service provisioning. The GAUSS Team involves ARNI (Azienda Regionale per la Navigazione Interna, I), ASCOM (CH), ERICSSON Telecomunicazioni (I), GMV (E), TELEFONICA (E), THALES Navigation (F), TTI Norte (E), Space Engineering (I) and TELESPAZIO (I) as project co‐ordinator. The work allocation was in line with the companies market and technological prospects, in view of future developments taking benefits from the experience and know‐how acquired in the GAUSS project. GAUSS objective was to design and demonstrate the feasibility of a system providing high quality Location‐based services, from the integration of Satellite Navigation and Communications, within the contexts of GALILEO and the UMTS technology. The GAUSS solution addresses two classes of users profiles, belonging to info‐mobility and inter‐modality (road‐river) markets. It supports highly reliable, near real‐time two‐way communication between mobile users and service centre/provider. GAUSS developed a system, which integrates advanced communication and precise navigation, for providing reliable and effective location‐based services oriented to transport and mobility applications (freight and fleet management, road safety and info‐mobility, emergency assistance, dangerous goods transportation control, inter‐modal transport). The GAUSS system combines off‐the‐shelf and new developed technologies, using S‐UMTS 3GPP compliant point‐to‐point and broadcasting packet‐based communication and GNSS1‐EGNOS accurate positioning. It has an open architecture ready to operate with the future GALILEO and UMTS, and further exploitation scenarios. This paper provides an overview of the project and the main achieved results, along with their assessment and evaluation in terms of possible enhancements and future exploitations. Copyright © 2004 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1542-0973 , 1542-0981
    URL: Issue
    URL: Article
    DOI: 10.1002/sat.v22:1
    DOI: 10.1002/sat.775
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2029384-7
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  • 8
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    Salvage rates and prognostic factors after relapse in children and adolescents with malignant peripheral nerve sheath tumors
    Wiley ; 2018
    In:  Pediatric Blood & Cancer Vol. 65, No. 2 ( 2018-02)
    Details
    In: Pediatric Blood & Cancer, Wiley, Vol. 65, No. 2 ( 2018-02)
    Abstract: Malignant peripheral nerve sheath tumor (MPNST) is one of the most common nonrhabdomyosarcoma soft tissue sarcomas encountered in pediatric age, and it is generally characterized by poor outcome, particularly for relapsing patients. Materials and methods This study considered 73 patients  〈 21 years of age with relapsing MPNST observed among 120 patients enrolled in Italian pediatric protocols from 1979 to 2004. With the aim of possibly establishing a risk‐adapted stratification, patients’ outcome was examined using univariate and multivariate analysis based on clinical features at onset, first‐line treatments, clinical findings at the time of first relapse, and second‐line treatments. Results The time to relapse ranged from 1 to 204 months after first diagnosis (median 7 months). The first relapse event was mainly local. At the time of our analysis, nine patients were alive in remission. The median overall survival after first relapse was 11 months, and the survival rates were 39.2% at 1 year and 15.8% at 5 years. The factors revealing the greatest impact on prognosis were as follows: initial tumor invasiveness, time of relapse, and achievement of a secondary complete remission (which was related to the feasibility of radical surgery). Conclusions Our study confirmed the unsatisfactory prognosis for pediatric patients with relapsing MPNST and pointed to a risk‐adapted stratification model for the purposes of deciding second‐line treatments. For the time being, an aggressive surgical approach seems to be the only effective salvage treatment and should be recommended. New therapeutic approaches are under evaluation with a view to improving current outcomes.
    Type of Medium: Online Resource
    ISSN: 1545-5009 , 1545-5017
    URL: Issue
    URL: Article
    DOI: 10.1002/pbc.v65.2
    DOI: 10.1002/pbc.26816
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 9
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    Pheochromocytomas and paragangliomas in children: Data from the Italian Cooperative Study (TREP)
    Wiley ; 2020
    In:  Pediatric Blood & Cancer Vol. 67, No. 8 ( 2020-08)
    Details
    In: Pediatric Blood & Cancer, Wiley, Vol. 67, No. 8 ( 2020-08)
    Abstract: Pheochromocytomas (PCs) are neuroendocrine tumors arising from the chromaffin cells of the adrenal gland, and paragangliomas (PGLs) are their extra‐adrenal counterparts arising from ganglia along the sympathetic/parasympathetic chain. Surgery is the cornerstone of treatment. A sporatic or inherited germline mutation is commonly associated. Materials and methods Among over 1000 patients registered into the Tumori Rari in Età Pediatrica—rare tumors in pediatric age project—from 2000 to 2019, 50 were affected by PC/PGL. All clinical and therapeutic data were evaluated. Results Twenty‐eight patients had PC and 22 had PGL. Age at diagnosis ranged between 5 and 17 years. Thirty‐five patients had symptoms related to catecholamine hypersecretion; in 7 of 50 patients, diagnosis was incidental or done during assessment of a familial syndrome. In all cases, conventional imaging was effective to assess the presence of a tumor. In addition, 18 of 38 functional imaging studies were positive (61%). Forty‐eight patients were eligible for surgery: a complete resection was more frequently achieved in PC than in PGL (26/28 vs 11/22). All relapses were treated with surgery alone, surgery plus medical treatment, or chemotherapy alone; one PC with metastasis at diagnosis received radiotherapy only. Forty‐four patients were in the first, second, or third complete remission (10/50 recurred; 8/10 carried a germline mutation). Five of 50 patients were alive with disease. One patient died of disease. Conclusions Surgery can be curative in most tumors but it may not be always effective in removing PGLs. Severe postsurgical sequelae may affect these patients. Genetic tests should always be considered in individuals affected, and genetic counseling should be offered to their families.
    Type of Medium: Online Resource
    ISSN: 1545-5009 , 1545-5017
    URL: Issue
    URL: Article
    DOI: 10.1002/pbc.v67.8
    DOI: 10.1002/pbc.28332
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2130978-4
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  • 10
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    Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients : Orlistat and l-carnitine on inflammation parameters
    Wiley ; 2011
    In:  Fundamental & Clinical Pharmacology Vol. 25, No. 5 ( 2011-10), p. 642-651
    Details
    In: Fundamental & Clinical Pharmacology, Wiley, Vol. 25, No. 5 ( 2011-10), p. 642-651
    Type of Medium: Online Resource
    ISSN: 0767-3981
    URL: Issue
    URL: Article
    DOI: 10.1111/fcp.2011.25.issue-5
    DOI: 10.1111/j.1472-8206.2010.00888.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2006242-4
    SSG: 15,3
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