In:
Journal of the Chinese Chemical Society, Wiley, Vol. 70, No. 1 ( 2023-01), p. 68-75
Abstract:
A novel fluorescent probe, LCH , based on dicyanisophorone and carbazole, was prepared for the visual detection of Cu 2+ . The probe LCH could recognize Cu 2+ by fluorescence quenching in EtOH/H 2 O (1/4, v/v) solution, which could be easily identified under the 365 nm UV lamp, and the detection limit was as low as 0.785 μM. The recognition mechanism of probe LCH with Cu 2+ was determined by combining 1 H NMR titration, MS, and theoretical calculations. Practical application experiments showed that probe LCH could be used to detect Cu 2+ in the test strip experiments. Cell imaging experiments showed that the probe LCH owned good cell permeability and could be applied to the imaging of Cu 2+ in HepG2 cells. In addition, fluorescence colocalization experiments showed that LCH could target lipid droplets. These results indicate that the probe LCH will have a good application prospect in environmental detection and clinical medicine.
Type of Medium:
Online Resource
ISSN:
0009-4536
,
2192-6549
DOI:
10.1002/jccs.202200401
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2029538-8
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