In:
International Journal of Developmental Neuroscience, Wiley, Vol. 5, No. 5-6 ( 1987-01), p. 429-433
Abstract:
Neural control of creatine kinase (CK, adenosine 5′‐triphosphate creatine phosphotransferase: EC 2.7.3.2) was investigated by measuring enzymatic activity and isoenzymatic representation of CK in extensor digitorum longus (EDL) muscles of adult rats during and after regeneration. Experimental models were ischemized EDLs, reversibly or permanently denervated. Results showed that, during regeneration, CK in muscle fibers was likewise modified in both reversibly and permanently denervated EDLs. After regeneration a clear dichotomy was observed between the regenerated EDLs which were innervated and recovering CK activity, and those in which innervation was prevented and were rapidly losing activity. Further to investigate the neural influence on CK turnover, merely denervated agematched EDLs were analysed and found to lose CK activity rapidly. The major conclusions are that during regeneration muscle CK is autonomously expressed, but following regeneration neural influence becomes an absolute requirement for stabilization and amplification of CK.
Type of Medium:
Online Resource
ISSN:
0736-5748
,
1873-474X
DOI:
10.1016/0736-5748(87)90020-7
Language:
English
Publisher:
Wiley
Publication Date:
1987
detail.hit.zdb_id:
2012538-0
detail.hit.zdb_id:
2013748-5
SSG:
12
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