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  • 1
    Online Resource
    Online Resource
    Reactogenicity of the Messenger RNA SARS – CoV ‐2 Vaccines Associated With Immunogenicity in Patients With Autoimmune and Inflammatory Disease
    Wiley ; 2022
    In:  Arthritis Care & Research Vol. 74, No. 12 ( 2022-12), p. 1953-1960
    Details
    In: Arthritis Care & Research, Wiley, Vol. 74, No. 12 ( 2022-12), p. 1953-1960
    Abstract: Little is known regarding the reactogenicity and related SARS–CoV‐2 vaccine response in patients with chronic inflammatory disease (CID). Our objective was to characterize the adverse event profile of CID patients following SARS–CoV‐2 vaccination and understand the relationship between reactogenicity and immunogenicity of SARS–CoV‐2 vaccines. Methods CID patients and healthy controls eligible to receive messenger RNA (mRNA) SARS–CoV‐2 vaccines participated in 3 study visits (pre‐vaccine, after dose 1, and after dose 2) in which blood and clinical data were collected. Assessment of adverse events were solicited within 7 days of receiving each dose. Serum anti–SARS–CoV‐2 spike IgG ± antibody titers were quantified following vaccination. Statistical analysis was performed utilizing mixed models and tobit regressions, with adjustment for covariates. Results The present study included 441 participants (322 CID patients and 119 control subjects). Compared to controls, CID patients reported greater symptom severity after dose 1 ( P  = 0.0001), including more myalgia and fatigue ( P   〈  0.05). For immunogenicity, a higher symptom severity after dose 1 and a higher number of symptoms after dose 2 was associated with higher antibody titers ( P  ≤ 0.05). Each increase of 1 symptom was associated with a 15.1% increase in antibody titer. Symptom association was strongest with site pain after dose 1 (105%; P  = 0.03) and fatigue after dose 2 (113%; P  = 0.004). Conclusion Patients with CID have a distinct reactogenicity profile following SARS–CoV‐2 vaccination compared to controls. Furthermore, there is an association between increased reactogenicity and increased vaccine response. This finding may speak to the more variable immunogenicity in CID patients and may be an important indicator of vaccine response to the novel SARS–CoV‐2 vaccines.
    Type of Medium: Online Resource
    ISSN: 2151-464X , 2151-4658
    URL: Issue
    URL: Article
    DOI: 10.1002/acr.v74.12
    DOI: 10.1002/acr.24894
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2016713-1
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  • 2
    Online Resource
    Online Resource
    Sleep Disturbance and SARS–CoV‐2 Vaccinations in Patients With Chronic Inflammatory Disease
    Wiley ; 2023
    In:  Arthritis Care & Research Vol. 75, No. 8 ( 2023-08), p. 1849-1856
    Details
    In: Arthritis Care & Research, Wiley, Vol. 75, No. 8 ( 2023-08), p. 1849-1856
    Abstract: Immunocompromised patients with chronic inflammatory disease (CID) may have experienced additional psychosocial burden during the COVID‐19 pandemic due to their immunocompromised status. This study was undertaken to determine if vaccination would result in improved patient‐reported outcomes longitudinally among individuals with CID undergoing SARS–CoV‐2 vaccination regardless of baseline anxiety. Methods Data are from a cohort of individuals with CID from 2 sites who underwent SARS–CoV‐2 vaccination. Participants completed 3 study visits before and after 2 messenger RNA vaccine doses in the initial vaccination series when clinical data were collected. Patient‐reported outcomes were measured using the Patient‐Reported Outcomes Measurement Information System 29‐item Health Profile and expressed as T scores, with 2 groups stratified by high and low baseline anxiety. Mixed‐effects models were used to examine longitudinal changes, adjusting for age, sex, and study site. Results A total of 72% of the cohort was female with a mean ± SD age of 48.1 ± 15.5 years. Overall, sleep disturbance improved following both doses of SARS–CoV‐2 vaccinations, and anxiety decreased after the second dose. Physical function scores worsened but did not meet the minimally important difference threshold. When stratifying by baseline anxiety, improvement in anxiety, fatigue, and social participation were greater in the high anxiety group. Physical function worsened slightly in both groups, and sleep disturbance improved significantly in the high anxiety group. Conclusion Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased, and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS–CoV‐2 vaccination may improve mental health and well‐being, particularly among those with greater anxiety.
    Type of Medium: Online Resource
    ISSN: 2151-464X , 2151-4658
    URL: Issue
    URL: Article
    DOI: 10.1002/acr.v75.8
    DOI: 10.1002/acr.25065
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2016713-1
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  • 3
    Online Resource
    Online Resource
    Regulation of voltage‐dependent K + channels by methionine oxidation: effect of nitric oxide and vitamin C
    Wiley ; 1999
    In:  FEBS Letters Vol. 442, No. 1 ( 1999-01-08), p. 48-52
    Details
    In: FEBS Letters, Wiley, Vol. 442, No. 1 ( 1999-01-08), p. 48-52
    Abstract: Methionine oxidation is known to alter functional properties of a transient A‐type potassium channel expressed in Xenopus oocytes. We show here that nitric oxide (NO) slows down the K + channel inactivation time course by oxidizing a critical methionine residue in the inactivation ball domain of the channel protein. We also demonstrate that the channel protein is protected from methionine oxidation by the enzyme methionine sulfoxide reductase and the antioxidant vitamin C.
    Type of Medium: Online Resource
    ISSN: 0014-5793 , 1873-3468
    URL: Article
    DOI: 10.1016/S0014-5793(98)01616-0
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 1460391-3
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    The LRRC family of BK channel regulatory subunits: potential roles in health and disease
    Wiley ; 2022
    In:  The Journal of Physiology Vol. 600, No. 6 ( 2022-03), p. 1357-1371
    Details
    In: The Journal of Physiology, Wiley, Vol. 600, No. 6 ( 2022-03), p. 1357-1371
    Abstract: Large conductance K + channels, termed BK channels, regulate a variety of cellular and physiological functions. Although universally activated by changes in voltage or [Ca 2+ ] i , the threshold for BK channel activation varies among loci of expression, often arising from cell‐specific regulatory subunits including a family of leucine rich repeat‐containing (LRRC) γ subunits (LRRC26, LRRC52, LRRC55 and LRRC38). The ‘founding’ member of this family, LRRC26, was originally identified as a tumour suppressor in various cancers. An LRRC26 knockout (KO) mouse model recently revealed that LRRC26 is also highly expressed in secretory epithelial cells and partners with BK channels in the salivary gland and colonic goblet cells to promote sustained K + fluxes likely essential for normal secretory function. To accomplish this, LRRC26 negatively shifts the range of BK channel activation such that channels contribute to K + flux near typical epithelial cell resting conditions. In colon, the absence of LRRC26 increases vulnerability to colitis. LRRC26‐containing BK channels are also likely important regulators of epithelial function in other loci, including airways, female reproductive tract and mammary gland. Based on an LRRC52 KO mouse model, LRRC52 regulation of large conductance K + channels plays a role both in sperm function and in cochlear inner hair cells. Although our understanding of LRRC‐containing BK channels remains rudimentary, KO mouse models may help define other organs in which LRRC‐containing channels support normal function. A key topic for future work concerns identification of endogenous mechanisms, whether post‐translational or via gene regulation, that may impact LRRC‐dependent pathologies. image
    Type of Medium: Online Resource
    ISSN: 0022-3751 , 1469-7793
    URL: Issue
    URL: Article
    DOI: 10.1113/tjp.v600.6
    DOI: 10.1113/JP281952
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1475290-6
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Probiotic Therapy in Radiation-Induced Intestinal Injury and Repair
    Wiley ; 2009
    In:  Annals of the New York Academy of Sciences Vol. 1165, No. 1 ( 2009-05), p. 190-194
    Details
    In: Annals of the New York Academy of Sciences, Wiley, Vol. 1165, No. 1 ( 2009-05), p. 190-194
    Type of Medium: Online Resource
    ISSN: 0077-8923
    URL: Article
    DOI: 10.1111/j.1749-6632.2009.04029.x
    RVK:
    TD 7650
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2834079-6
    detail.hit.zdb_id: 211003-9
    detail.hit.zdb_id: 2071584-5
    SSG: 11
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