In:
Diabetic Medicine, Wiley, Vol. 23, No. 10 ( 2006-10), p. 1151-1154
Abstract:
Aims To evaluate the relationship between HbA 1c and fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) levels, and to estimate the mean plasma glucose (mPG) derived from FPG and PPG that would predict Type 2 diabetic subjects with poor glycaemic control. Methods FPG, PPG and HbA 1c values from 565 Type 2 diabetic patients (247 men and 318 women) were recorded. Linear regression analysis and Pearson's correlation was used to determine the relationship between HbA 1c , FPG and PPG. FPG and PPG were included as explanatory variables of HbA 1c in linear regression analysis. Results The American Diabetes Association's objective of achieving an HbA 1c level 〈 7.0% was obtained in 26.2% of the patients. The coefficients of FPG and PPG which determined HbA 1c were similar. Therefore, mPG was calculated using the equation (FPG + PPG)/2. Pearson's correlation coefficient for HbA 1c and FPG, PPG and mPG were 0.723 ( P 〈 0.0001), 0.734 and 0.761 ( P 〈 0.0001), respectively. A mPG cut‐off value of 10 mmol/l predicted an HbA 1c 〉 7% in the whole population, with a sensitivity of 84.2% and specificity of 80.4%. The area was high (0.90) in receiver‐operating characteristic (ROC) curve analysis performed to examine the performance of mPG to predict HbA 1c 〉 7%. Conclusions The mPG derived from FPG and PPG correlates strongly with HbA 1c . We therefore suggest that using a cut‐off of 10 mmol/l for mPG may be appropriate in diabetes management in the primary‐care setting, where most management of Type 2 diabetes occurs.
Type of Medium:
Online Resource
ISSN:
0742-3071
,
1464-5491
DOI:
10.1111/dme.2006.23.issue-10
DOI:
10.1111/j.1464-5491.2006.01927.x
Language:
English
Publisher:
Wiley
Publication Date:
2006
detail.hit.zdb_id:
2019647-7
Permalink