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  • 1
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    Online Resource
    Antioxidant activities of chicken liver hydrolysates by pepsin treatment
    Wiley ; 2014
    In:  International Journal of Food Science & Technology Vol. 49, No. 7 ( 2014-07), p. 1654-1662
    Details
    In: International Journal of Food Science & Technology, Wiley, Vol. 49, No. 7 ( 2014-07), p. 1654-1662
    Abstract: This study was divided into two parts: (i) an optimal hydrolysing procedure of chicken liver hydrolysates ( CLHs ) and (ii) the in vivo antioxidant properties of CLHs via a D‐galactose‐induced mouse model. A pepsin‐to‐raw chicken liver mass ratio (1:400, w:w) and 2‐h hydrolysing period were chosen to manufacture CLHs based on yield, peptide level and antioxidant effect. Molecular masses of CLHs were lower than 10 kDa. CLH was rich in aspartic acid and glutamic acid, and also contained both manganese and selenium, which are essential cofactors of superoxide dismutase and glutathione peroxidase, respectively. The contents of cadmium, mercury, tin, and arsenic in CLHs were very low and even no detectible. Regarding the in vivo antioxidant activity of CLHs , a dosage of 1.2 g D‐galactose kg −1 body weight increased ( P  〈   0.05) 2‐thiobarbituric acid reactive substances values and decreased ( P  〈   0.05) glutathione and Trolox equivalent antioxidant capacity values, as well as superoxide dismutase, catalase, and glutathione peroxidase activities in serum and organs of mice. However, the in vivo antioxidant capacities were improved ( P  〈   0.05) by supplementing CLHs .
    Type of Medium: Online Resource
    ISSN: 0950-5423 , 1365-2621
    URL: Issue
    URL: Article
    DOI: 10.1111/ijfs.2014.49.issue-7
    DOI: 10.1111/ijfs.12471
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2016518-3
    detail.hit.zdb_id: 2401430-8
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  • 2
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    Chicken surimi fortified by omega‐3 fatty acid addition: manufacturing and quality properties
    Wiley ; 2016
    In:  Journal of the Science of Food and Agriculture Vol. 96, No. 5 ( 2016-03), p. 1609-1617
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 96, No. 5 ( 2016-03), p. 1609-1617
    Abstract: The meat of spent hens is hard to use owing to its small amount and poor quality. A washing process to remove sarcoplasmic proteins and other impurities can prolong the shelf life of surimi‐like products. Owing to the benefits of omega‐3 polyunsaturated fatty acids ( ω ‐3 PUFAs ), functional foods fortified with ω ‐3 PUFAs are increasingly being marketed. Hence, in this study, ω ‐3 FA ‐fortified chicken surimi was manufactured, and how to ameliorate its lipid peroxidation during frozen storage was investigated. RESULTS A 0.10% (w/v) solution of sodium chloride ( NaCl ) instead of distilled water in the third washing step decreased ( P 〈 0.05) myofibrillar protein loss and moisture content of spent hen breast protein recoveries. Oil droplets in fish, flaxseed or soybean oil‐added chicken surimi were well distributed. Moreover, flaxseed oil addition increased ( P 〈 0.05) total ω ‐3 FAs and ω ‐3/ ω ‐6 FA ratio, while only fish oil provided long‐chain PUFAs . Oil addition decreased ( P 〈 0.05) hardness and gumminess of chicken surimi, while flaxseed oil resulted in more ( P 〈 0.05) yellow surimi than fish and soybean oil. Fish oil‐added samples showed higher ( P 〈 0.05) lipid oxidation than flaxseed or soybean oil‐added samples under −15 to −10 °C storage, but α ‐tocopherol addition ameliorated it. CONCLUSION A novel semi‐manufactured chicken surimi product with nutritional benefits could be developed by fortification with fish or flaxseed oil. © 2015 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.2016.96.issue-5
    DOI: 10.1002/jsfa.7262
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2001807-1
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  • 3
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    Protective effects of antioxidant egg‐chalaza hydrolysates against chronic alcohol consumption‐induced liver steatosis in mice
    Wiley ; 2019
    In:  Journal of the Science of Food and Agriculture Vol. 99, No. 5 ( 2019-03-30), p. 2300-2310
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 99, No. 5 ( 2019-03-30), p. 2300-2310
    Abstract: Reactive oxygen species (ROS) overproduction is highly related to some human chronic diseases. There are approximately 400 metric tons of chalazae produced yearly after the processing of the liquid‐egg production, which are disposed of as waste. The objectives of this study were to look for the optimal production condition of antioxidant crude chalaza hydrolysates and evaluate the in vivo antioxidant capacity via a chronic alcohol consumption mouse model. RESULTS Antioxidant crude chalaza hydrolysates (CCH‐As) could be produced by protease A at 1:100 ratio (w/w) and 0.5 h hydrolytic period. After our analyses, CCH‐As were rich in leucine, arginine, phenylalanine, valine, lysine and antioxidant dipeptides (anserine and carnosine), and the major molecular masses were lower than 15 kDa. Regarding protective effects of CCH‐As against oxidative damage in alcoholic‐liquid‐diet‐fed mice, alcohol‐fed mice had lower ( P 〈 0.05) liver antioxidant capacities, and higher ( P 〈 0.05) liver lipid contents, serum lipid/liver damage indices and IL‐1β/IL‐6 values. CCH‐A supplementation reversed ( P 〈 0.05) liver antioxidant capacities and reduced ( P 〈 0.05) serum/liver lipids in alcohol‐fed mice, which may result from increased ( P 〈 0.05) fecal lipid output, upregulated ( P 〈 0.05) fatty acid β‐oxidation and downregulated ( P 〈 0.05) lipogenesis in the liver. CONCLUSION Taken together, this CCH‐A should benefit the liquid‐egg industry, while also offering consumers a choice of healthy ingredients from animal sources. © 2018 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.2019.99.issue-5
    DOI: 10.1002/jsfa.9426
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001807-1
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  • 4
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    Preventive effects of Ophiocordyceps sinensis mycelium on the liver fibrosis induced by thioacetamide
    Wiley ; 2017
    In:  Environmental Toxicology Vol. 32, No. 6 ( 2017-06), p. 1792-1800
    Details
    In: Environmental Toxicology, Wiley, Vol. 32, No. 6 ( 2017-06), p. 1792-1800
    Abstract: Thioacetamide (TAA), usually used as a fungicide to control the decay of citrus products, itself is not toxic to the liver, but its intermediates are able to increase oxidative stress in livers and further cause fibrosis. Ophiocordyceps sinensis mycelium (OSM) which contains 10% polysaccharides and 0.25% adenosine decreased ( P 〈 0.05) the lipid accumulation and increased ( P   〈  0.05) antioxidative capacity in livers of thioacetamide (TAA) injected rats. Meanwhile, the increased ( P 〈 0.05) liver sizes, serum alanine transaminase (AST) and aspartate transaminase (ALT) values in thioacetamide (TAA)‐injected rats were ameliorated ( P   〈  0.05) by OSM supplementation. Moreover, the levels of proinflammatory cytokines, such as the tumor necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β), were also reduced ( P   〈  0.05). The fibrosis phenomena in pathological (Masson's trichrome and H & E stainings) and immunohistochemical [α‐smooth actin (αSMA) and CD86/ED1] observations in TAA‐treated rats were reduced ( P 〈 0.05) by OSM cotreatment. The protective effect of OSM against TAA‐induced liver inflammation/fibrosis may be via downregulations ( P   〈  0.05) of TGF‐β pathways and NFκB which further influenced ( P   〈  0.05) the expressions of fibrotic and inflammatory genes (i. e., αSMA, Col1α, COX2). Therefore, OSM shows preventive effects on the development of TAA‐induced hepatic fibrosis.
    Type of Medium: Online Resource
    ISSN: 1520-4081 , 1522-7278
    URL: Issue
    URL: Article
    DOI: 10.1002/tox.v32.6
    DOI: 10.1002/tox.22402
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2027534-1
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  • 5
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    Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis : Hepatoprotective mechanism of silymarin against TAA
    Wiley ; 2012
    In:  Journal of the Science of Food and Agriculture Vol. 92, No. 7 ( 2012-05), p. 1441-1447
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 92, No. 7 ( 2012-05), p. 1441-1447
    Type of Medium: Online Resource
    ISSN: 0022-5142
    URL: Article
    DOI: 10.1002/jsfa.4723
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2001807-1
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  • 6
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    Modulation effects of black‐vinegar‐based supplement against a high‐fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy‐metabolism effects
    Wiley ; 2020
    In:  Journal of the Science of Food and Agriculture Vol. 100, No. 6 ( 2020-04), p. 2380-2388
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 100, No. 6 ( 2020-04), p. 2380-2388
    Abstract: An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents, we investigated the antiobesity effects of BV‐based supplements in rats fed a high‐fat diet (HFD). RESULTS HFD (30% fat, w/w) feeding increased ( P 〈  0.05) body weight, weight gains, weights of livers and mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of rats fed a normal diet (4% fat, w/w; CON). These increased values were ameliorated ( P 〈  0.05) by supplementing with BV‐based supplements but were still higher ( P 〈  0.05) than those of CON rats. The increased areas of perirenal adipocytes in rats fed with an HFD were also decreased ( P   〈  0.05) by supplementing with BV‐based supplements, which might result from an upregulation ( P   〈  0.05) of 5′‐adenosine monophosphate‐activated protein kinase (AMPK), carnitine palmitoyltransferase‐1 (CPT1), and uncoupling protein‐2 (UCP2) in the perirenal adipose tissues. A similar effect was observed for AMPK, peroxisome proliferator‐activated receptor alpha, retinoid X receptor alpha, CPT1, and UCP2 gene and protein levels in livers ( P   〈  0.05). Generally, BV‐based supplements increased the fecal triglyceride, cholesterol, and bile acid levels of rats fed with an HFD, which partially contribute to the lipid‐lowering effects. Furthermore, BV‐based supplements increased ( P   〈  0.05) hepatic Trolox equivalent antioxidant capacity and lowered ( P   〈  0.05) serum/liver thiobarbituric acid reactive substances values in HFD‐fed rats. CONCLUSION In a chronic high‐fat dietary habit, the food‐grade BV‐based supplement is a good daily choice to ameliorate obesity and its associated comorbidities. © 2020 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.v100.6
    DOI: 10.1002/jsfa.10246
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 7
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    Analysis of steroid hormones in shell eggs from layer breeds common to Taiwan by liquid chromatography–tandem mass spectrometry
    Wiley ; 2019
    In:  Food Science & Nutrition Vol. 7, No. 7 ( 2019-07), p. 2319-2326
    Details
    In: Food Science & Nutrition, Wiley, Vol. 7, No. 7 ( 2019-07), p. 2319-2326
    Abstract: Steroid hormones are often used in animal agriculture but are currently banned for use in domesticated fowl because residual hormones could be present in eggs for human consumption. Egg samples from eight common commercial poultry layer breeds (Hy‐Line W‐36, Hy‐Line Brown, ISA‐White, ISA‐Brown, Lohnmann Ultra‐Lite, Lohnmann‐Brown, Hisex White, Hisex Brown) in Taiwan were screened for a combination of 15 natural and synthetic steroid hormones by liquid chromatography–tandem mass spectrometry (LC‐MS/MS) for consumer assurance. Only natural hormones such as progesterone, 4‐androstene‐3,17‐dione, and testosterone were detected. Regarding each breed, the interaction effect (age × shell color), main effect (age or shell color), and blocking effect (lighting system) were further analyzed by using 2 × 2 factorial arrangement of treatment in a randomized block design. We also discovered associations between yolk steroid hormone levels and laying hen age, as well as lighting conditions. Additionally, we found a correlation between hormone levels and eggshell color, suggesting a potential role in brown pigmentation. Ultimately, we concluded that detectable steroid hormone levels in eggs were not a consumer health risk. Furthermore, these data provide empirical hormone concentrations in various types of commercial layer breeds for future research.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.2019.7.issue-7
    DOI: 10.1002/fsn3.1074
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2703010-6
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  • 8
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    The association between clinically diagnosed insomnia and age‐related macular degeneration: a population‐based cohort study
    Wiley ; 2020
    In:  Acta Ophthalmologica Vol. 98, No. 2 ( 2020-03)
    Details
    In: Acta Ophthalmologica, Wiley, Vol. 98, No. 2 ( 2020-03)
    Abstract: The decreased level of melatonin, the substance involved in the control of the sleep–wake cycle, has been reported among the patients with age‐related macular degeneration ( AMD ). However, knowledge about the relationship between sleep disturbance and AMD is still limited. This longitudinal case–control study aims to investigate the risk of incident AMD among the patients with clinically diagnosed insomnia using the Taiwan National Health Insurance Research Database. Methods The insomnia cohort ( n  = 15 465) consisted of newly diagnosed insomnia cases aged ≥55 years between 2000 and 2009. Subjects without insomnia, matched for age, gender and enrolment time, were randomly sampled as the control cohort ( n  = 92 790). Cox proportional hazard regressions were performed to calculate the hazard ratios ( HR ) of incident AMD for the two cohorts after adjusting for potential confounders. Results Of the 108 255 sampled subjects, 2094 (1.9%) were diagnosed with AMD , including 214 (0.2%) with neovascular AMD , during a mean follow‐up period of 5.1 ± 2.8 years. Insomnia patients were more likely to have subsequent AMD than those without insomnia (2.5% versus 1.8%, p  〈  0.001). Further, the incidence of exudative AMD was also higher in the insomnia cohort than the control cohort (0.3% versus 0.2%, p = 0.002). The adjusted HR was 1.33 (95% confidence interval [ CI ], 1.18–1.48, p  〈  0.001) for AMD and 1.67 (95% CI , 1.20–2.33, p = 0.002) for exudative AMD . Conclusions Clinically diagnosed insomnia is an independent indicator for the increased risk of subsequent AMD development.
    Type of Medium: Online Resource
    ISSN: 1755-375X , 1755-3768
    URL: Issue
    URL: Article
    DOI: 10.1111/aos.v98.2
    DOI: 10.1111/aos.14238
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2466981-7
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  • 9
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    Targeting of miR‐31/96/182 to the Numb gene during head and neck oncogenesis
    Wiley ; 2018
    In:  Head & Neck Vol. 40, No. 4 ( 2018-04), p. 808-817
    Details
    In: Head & Neck, Wiley, Vol. 40, No. 4 ( 2018-04), p. 808-817
    Abstract: MicroRNAs (miRNAs) play crucial roles in head and neck squamous cell carcinoma (HNSCC). This study investigates whether miR‐31, miR‐96 , and miR‐182 are involved in targeting Numb during HNSCC. Methods The expression of miR‐31/96/182 in tumor tissues was analyzed. Reporter assay, knockdown, expression, and oncogenic analysis were carried out in cell lines. Results Upregulation of miR‐31/96/182 was detected in tumor tissues. In addition, advanced tumors showed higher expression levels of these miRNAs. The expression of these miRNAs was upregulated after treatment with areca ingredients ( P   〈  .01 or P   〈  .001). These miRNAs directly targeted the 3′ untranslated region (UTR) sequence of the Numb gene. An increased migration and invasion of HNSCC cells was associated with the exogenous expression of miR‐31/96/182 ( P   〈  .01 or P   〈  .001), and this was reverted by expression of Numb . Conclusion This study provides new evidence demonstrating that there is frequent and concordant upregulation of miR‐31, miR‐96 , and miR‐182 during HNSCC and these miRNAs co‐target Numb .
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    URL: Article
    DOI: 10.1002/hed.v40.4
    DOI: 10.1002/hed.25063
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001440-5
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  • 10
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    Factors associated with prolonged progression‐free survival of patients treated with first‐line afatinib for advanced epidermal growth factor receptor‐mutated non‐small cell lung cancer
    Wiley ; 2024
    In:  Thoracic Cancer Vol. 15, No. 7 ( 2024-03), p. 529-537
    Details
    In: Thoracic Cancer, Wiley, Vol. 15, No. 7 ( 2024-03), p. 529-537
    Abstract: This study aimed to investigate the factors associated with prolonged progression‐free survival (PFS) ( 〉 36 months) of advanced non‐small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations treated with first‐line afatinib. Methods We performed a retrospective analysis of data of patients with advanced EGFR ‐mutated NSCLC receiving first‐line afatinib at two tertiary care referral centers, Linkou and Kaohsiung Chang Gung Memorial Hospital, in Taiwan between June 2014 and April 2022. Results The data of 546 treatment‐naïve EGFR ‐mutated advanced NSCLC patients were analyzed. Median PFS and overall survival were 14.5 months and 27.2 months, respectively. The PFS of 462 patients (84.6%) was less than 36 months and of 84 patients (15.4%) was more than 36 months. The PFS 〉 36 months group had a significantly higher percentage of patients with uncommon mutations ( p = 0.002). The PFS ≤36 months group had significantly higher incidences of bone, liver, and adrenal metastases (all p 〈 0.05) and a higher rate of multiple distant metastases. Multivariate logistic regression analysis showed that liver metastasis was negatively and independently associated with prolonged PFS (adjusted odds ratio = 0.246 [95% CI: 0.067–0.908], p = 0.035). The median overall survival of the PFS 〉 36 months group was 46.0 months and that of the PFS ≤36 months group was 22.9 months (log‐rank test, p 〈 0.001). Conclusions We found that EGFR ‐mutated NSCLC patients receiving first‐line afatinib were prone to shorter PFS if they had distant organ metastasis, especially liver metastasis.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v15.7
    DOI: 10.1111/1759-7714.15212
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2559245-2
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