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  • 1
    Online Resource
    Online Resource
    Adequate asparaginase is important to prevent central nervous system and testicular relapse of pediatric Philadelphia chromosome‐negative B‐cell acute lymphoblastic leukemia
    Wiley ; 2021
    In:  International Journal of Cancer Vol. 149, No. 1 ( 2021-07), p. 158-168
    Details
    In: International Journal of Cancer, Wiley, Vol. 149, No. 1 ( 2021-07), p. 158-168
    Abstract: What's new? Asparaginase is one of the most important drugs for treating acute lymphoblastic leukemia. However, off‐protocol asparaginase administration or hypersensitivity may disturb its pharmacokinetic profile. This is the first retrospective study to demonstrate that off‐protocol reduction of injection times during a chemotherapy course with no change in the total asparaginase dosage could significantly increase the risk of extramedullary relapse, including central nervous system and testicular relapse. A higher cumulative extramedullary relapse incidence was also observed in patients hypersensitive to asparaginase. Asparaginase is important for ameliorating overall survival and preventing extramedullary relapse, and attention should be paid to optimising administration.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v149.1
    DOI: 10.1002/ijc.33529
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 2
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    Online Resource
    Long‐term results of the risk‐stratified treatment of childhood acute lymphoblastic leukemia in China
    Wiley ; 2018
    In:  Hematological Oncology Vol. 36, No. 4 ( 2018-10), p. 679-688
    Details
    In: Hematological Oncology, Wiley, Vol. 36, No. 4 ( 2018-10), p. 679-688
    Abstract: Long‐term follow‐up data for childhood acute lymphoblastic leukemia (ALL) are scarce in China because of lacking population‐based and hospitalized registry system. This retrospective study, conducted at Shanghai's Children's Medical Center in China (SCMC), aimed to investigate the long‐term results of childhood ALL and to identify prognostic factors. The Pediatric Oncology Network Database, designed by St. Jude Children's Research Hospital, USA, were used to collect data for the enrolled patients starting in 2005. From 2005 to 2014, 1085 evaluable patients with ALL aged 1 to 18 years old were enrolled and treated using SCMC‐ALL‐2005 risk‐stratified protocol. Complete remission was achieved in 95.6% of patients. At 5 and 10 years, the event‐free survival rate was 68.3 ± 1.4% and 64.6 ± 1.6%, and the overall survival rate was 80.0 ± 1.2% and 76.3 ± 1.6%, respectively. The 5‐year event‐free survival rates were 81.8 ± 2.0%, 67.0 ± 1.9%, and 14.3 ± 4.0% for patients in low‐risk, intermediate‐risk, and high‐risk groups, respectively. The cumulative risk of relapse was 24.5% at 10 years. Induction failure conferred worse prognosis. Patients younger than 1 year of age at diagnosis, intermediate‐risk/high‐risk group, male gender, and positive minimal residual disease (MRD) results at day 55, both in the univariate and multivariate analysis, were associated with significantly worse prognosis ( P   〈  .05). Patients with positive MRD at both day 35 and day 55 were related to a significantly poor outcome ( P   〈  .0001), but not for patients with negitive MRD at day 35. The overall outcomes for ALL patients treated with protocol SCMC‐ALL‐2005 in SCMC are lower than in developed countries. Factors including age, gender, risk group and MRD results at day 55 were associated with treatment outcomes in childhood ALL.
    Type of Medium: Online Resource
    ISSN: 0278-0232 , 1099-1069
    URL: Issue
    URL: Article
    DOI: 10.1002/hon.v36.4
    DOI: 10.1002/hon.2541
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2001443-0
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  • 3
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    Recent Progress in the Transfer of Graphene Films and Nanostructures
    Wiley ; 2021
    In:  Small Methods Vol. 5, No. 12 ( 2021-12)
    Details
    In: Small Methods, Wiley, Vol. 5, No. 12 ( 2021-12)
    Abstract: The one‐atom‐thick graphene has excellent electronic, optical, thermal, and mechanical properties. Currently, chemical vapor deposition (CVD) graphene has received a great deal of attention because it provides access to large‐area and uniform films with high‐quality. This allows the fabrication of graphene based‐electronics, sensors, photonics, and optoelectronics for practical applications. Zero bandgap, however, limits the application of a graphene film as electronic transistor. The most commonly used bottom‐up approaches have achieved efficient tuning of the electronic bandgap by customizing well‐defined graphene nanostructures. The postgrowth transfer of graphene films/nanostructures to a certain substrate is crucial in utilizing graphene in applicable devices. In this review, the basic growth mechanism of CVD graphene is first introduced. Then, recent advances in various transfer methods of as‐grown graphene to target substrates are presented. The fabrication and transfer methods of graphene nanostructures are also provided, and then the transfer‐related applications are summarized. At last, the challenging issues and the potential transfer‐free approaches are discussed.
    Type of Medium: Online Resource
    ISSN: 2366-9608 , 2366-9608
    URL: Issue
    URL: Article
    DOI: 10.1002/smtd.v5.12
    DOI: 10.1002/smtd.202100771
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2884448-8
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  • 4
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    Online Resource
    Action of the fungal compound citrinin, a bioherbicide candidate, on photosystem II
    Wiley ; 2023
    In:  Pest Management Science
    Details
    In: Pest Management Science, Wiley
    Abstract: Bioherbicides are becoming more attractive as safe weed control tools towards sustainable agriculture. Natural products constitute an important source chemicals and chemical leads for discovery and development of novel pesticide target sites. Citrinin is a bioactive compound produced by fungi of the genera Penicillium and Aspergillus . However, its physiological‐biochemical mechanism as a phytotoxin remains unclear. RESULTS Citrinin causes visible leaf lesions on Ageratina adenophora similar to those produced by the commercial herbicide bromoxynil. Phytotoxicity bioassay tests using 24 plant species confirmed that citrinin has a broad activity spectrum and therefore has potential as a bioherbicide. Based on chlorophyll fluorescence studies, citrinin mainly blocks PSII electron flow beyond plastoquinone Q A at the acceptor side, resulting in the inactivation of PSII reaction centers. Furthermore, molecular modeling of citrinin docking to the A. adenophora D1 protein suggests that it binds to the plastoquinone Q B site by a hydrogen bond between the O1 hydroxy oxygen atom of citrinin and the histidine 215 of the D1 protein, the same way as classical phenolic PSII herbicides do. Finally, 32 new citrinin derivatives were designed and sorted according to free energies on the basis of the molecular model of an interaction between the citrinin molecule and the D1 protein. Five of the modeled compounds had much higher ligand binding affinity within the D1 protein compared with lead compound citrinin. CONCLUSION Citrinin is a novel natural PSII inhibitor that has the potential to be developed into a bioherbicide or utilized as a lead compound for discovery of new derivatives with high herbicidal potency. © 2023 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Article
    DOI: 10.1002/ps.7513
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 5
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    Online Resource
    Association between body mass index at diagnosis and outcomes in Chinese children with newly diagnosed acute lymphoblastic leukemia
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 3 ( 2023-02), p. 2850-2860
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 3 ( 2023-02), p. 2850-2860
    Abstract: We found that overweight/obese children were at higher risk of treatment‐related mortality and developing severe toxicities than underweight or health‐weight children. Our findings reinforce the importance of the normalizing weight during the treatment period to improve survival and treatment outcomes.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.3
    DOI: 10.1002/cam4.5188
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 6
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    Relatively favorable prognosis for MLL ‐rearranged childhood acute leukemia with reciprocal translocations
    Wiley ; 2018
    In:  Pediatric Blood & Cancer Vol. 65, No. 10 ( 2018-10)
    Details
    In: Pediatric Blood & Cancer, Wiley, Vol. 65, No. 10 ( 2018-10)
    Abstract: Mixed‐lineage leukemia ( MLL ) with multifarious partner genes leads to aggressive leukemia with dismal outcomes. Methods Using panel‐based targeted sequencing, we examined 90 cases with MLL ‐rearranged ( MLL ‐r) childhood acute leukemia, including 55 with acute lymphoblastic leukemia (ALL) and 35 with acute myeloid leukemia (AML). Results MLL breakpoints and complete rearrangements were identified. A total of 37.8% (34/90) of patients displayed a single direct MLL fusion gene, 15.6% (14/90) carried a single reciprocal fusion, and 27.8% (25/90) had both reciprocal MLL fusion alleles. The remaining 17 MLL ‐r cases exhibited complex translocations with homozygous disruptions on chromosome 11 or two breakpoints on the same MLL allele with a deletion of functional regions. A total of 77 patients (45 ALL and 32 AML) received chemotherapy with a median follow‐up of 2.5 years. Unexpectedly, we identified children with reciprocal MLL fusions who exhibited relatively favorable outcomes compared with those in children with complex translocations or a single direct MLL fusion allele (66.1% vs. 24.6% and 27.6%, P  = 0.001). Reciprocal MLL fusion may be functionally rescued by a partially truncated MLL protein. Conclusion Comprehensive MLL ‐r analysis by targeted next‐generation sequencing can provide detailed molecular information and is helpful for precise stratified treatment and clinical prognosis determination.
    Type of Medium: Online Resource
    ISSN: 1545-5009 , 1545-5017
    URL: Issue
    URL: Article
    DOI: 10.1002/pbc.v65.10
    DOI: 10.1002/pbc.27266
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2130978-4
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  • 7
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    Biological nanopores for sensing applications
    Wiley ; 2022
    In:  Proteins: Structure, Function, and Bioinformatics Vol. 90, No. 10 ( 2022-10), p. 1786-1799
    Details
    In: Proteins: Structure, Function, and Bioinformatics, Wiley, Vol. 90, No. 10 ( 2022-10), p. 1786-1799
    Abstract: Biological nanopores are proteins with transmembrane pore that can be embedded in lipid bilayer. With the development of single‐channel current measurement technologies, biological nanopores have been reconstituted into planar lipid bilayer and used for single‐molecule sensing of various analytes and events such as single‐molecule DNA sensing and sequencing. To improve the sensitivity for specific analytes, various engineered nanopore proteins and strategies are deployed. Here, we introduce the origin and principle of nanopore sensing technology as well as the structure and associated properties of frequently used protein nanopores. Furthermore, sensing strategies for different applications are reviewed, with focus on the alteration of buffer condition, protein engineering, and deployment of accessory proteins and adapter‐assisted sensing. Finally, outlooks for de novo design of nanopore and nanopore beyond sensing are discussed.
    Type of Medium: Online Resource
    ISSN: 0887-3585 , 1097-0134
    URL: Issue
    URL: Article
    DOI: 10.1002/prot.v90.10
    DOI: 10.1002/prot.26308
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1475032-6
    SSG: 12
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  • 8
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    Predictive value of the geriatric nutrition risk index for postoperative delirium in elderly patients undergoing cardiac surgery
    Wiley ; 2023
    In:  CNS Neuroscience & Therapeutics
    Details
    In: CNS Neuroscience & Therapeutics, Wiley
    Abstract: The aims of the study were to determine the relationship between preoperative geriatric nutritional risk index (GNRI) and the occurrence of postoperative delirium (POD) in elderly patients after cardiac surgery and to evaluate the additive value of GNRI for predicting POD. Methods The data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC‐IV) database. Patients who underwent cardiac surgery and were aged 65 or older were included. The relationship between preoperative GNRI and POD was investigated using logistic regression. We determined the added predictive value of preoperative GNRI for POD by measuring the changes in the area under the receiver operating characteristic curve (AUC) and calculating the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Results A total of 4286 patients were included in the study, and 659 (16.1%) developed POD. Patients with POD had significantly lower GNRI scores than patients without POD (median 111.1 vs. 113.4, p   〈  0.001). Malnourished patients (GNRI ≤ 98) had a significantly higher risk of POD (odds ratio, 1.83, 90% CI, 1.42–2.34, p   〈  0.001) than those without malnutrition (GNRI  〉  98). This correlation remains after adjusting for confounding variables. The addition of GNRI to the multivariable models slightly but not significantly increases the AUCs (all p   〉  0.05). Incorporating GNRI increases NRIs in some models and IDIs in all models (all p   〈  0.05). Conclusions Our results showed a negative association between preoperative GNRI and POD in elderly patients undergoing cardiac surgery. The addition of GNRI to POD prediction models may improve their predictive accuracy. However, these findings were based on a single‐center cohort and will need to be validated in future studies involving multiple centers.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.14343
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2423467-9
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  • 9
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    Predictive factors for lymph node metastasis in early gastric cancer with signet ring cell histology: a meta‐analysis
    Wiley ; 2017
    In:  ANZ Journal of Surgery Vol. 87, No. 12 ( 2017-12), p. 981-986
    Details
    In: ANZ Journal of Surgery, Wiley, Vol. 87, No. 12 ( 2017-12), p. 981-986
    Abstract: Less invasive surgery is widely used in the treatment of early gastric cancer; however, no definite guidelines exist regarding indications for less invasive surgery to treat early gastric cancer with signet ring cell histology. The aim of this study was to identify risk factors for lymph node metastasis ( LNM ) in early signet ring cell carcinoma ( SRC ). An extensive search of PubMed , Embase and the Cochrane library was performed for pertinent articles involving early SRC and LNM . Methods Eligible data (gender, depth of invasion, lymphovascular invasion, size, ulceration, macroscopic type and location) were extracted from the included studies and systematically reviewed via a meta‐analysis. Review Manager version 5.3 was used to perform the data processing. The Newcastle–Ottawa Scale was utilized to evaluate the quality of the included articles. Results Fourteen studies were included in the final analysis. After meta‐analysis, female gender, submucosal invasion, lymphovascular invasion and size  〉 20 mm were associated with LNM in early SRC . Conclusion Four variables were identified as risk factors for LNM in early SRC . The significance of the results of the present study should be further confirmed in more early SRC patients for future clinical use.
    Type of Medium: Online Resource
    ISSN: 1445-1433 , 1445-2197
    URL: Issue
    URL: Article
    DOI: 10.1111/ans.2017.87.issue-12
    DOI: 10.1111/ans.14089
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2095927-8
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  • 10
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    Nanomaterials in Neural‐Stem‐Cell‐Mediated Regenerative Medicine: Imaging and Treatment of Neurological Diseases
    Wiley ; 2018
    In:  Advanced Materials Vol. 30, No. 17 ( 2018-04)
    Details
    In: Advanced Materials, Wiley, Vol. 30, No. 17 ( 2018-04)
    Abstract: Patients are increasingly being diagnosed with neuropathic diseases, but are rarely cured because of the loss of neurons in damaged tissues. This situation creates an urgent clinical need to develop alternative treatment strategies for effective repair and regeneration of injured or diseased tissues. Neural stem cells (NSCs), highly pluripotent cells with the ability of self‐renewal and potential for multidirectional differentiation, provide a promising solution to meet this demand. However, some serious challenges remaining to be addressed are the regulation of implanted NSCs, tracking their fate, monitoring their interaction with and responsiveness to the tissue environment, and evaluating their treatment efficacy. Nanomaterials have been envisioned as innovative components to further empower the field of NSC‐based regenerative medicine, because their unique physicochemical characteristics provide unparalleled solutions to the imaging and treatment of diseases. By building on the advantages of nanomaterials, tremendous efforts have been devoted to facilitate research into the clinical translation of NSC‐based therapy. Here, recent work on emerging nanomaterials is highlighted and their performance in the imaging and treatment of neurological diseases is evaluated, comparing the strengths and weaknesses of various imaging modalities currently used. The underlying mechanisms of therapeutic efficacy are discussed, and future research directions are suggested.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v30.17
    DOI: 10.1002/adma.201705694
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1474949-X
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