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  • 1
    Online Resource
    Online Resource
    Functional Reorganizations Outside the Sensorimotor Regions Following Complete Thoracolumbar Spinal Cord Injury
    Wiley ; 2021
    In:  Journal of Magnetic Resonance Imaging Vol. 54, No. 5 ( 2021-11), p. 1551-1559
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 54, No. 5 ( 2021-11), p. 1551-1559
    Abstract: Studies have shown that loss of sensorimotor function in spinal cord injury (SCI) leads to brain functional reorganization, which may play important roles in motor function recovery. However, the specific functional changes following SCI are still poorly understood. Purpose To investigate whether there are functional reorganizations outside the sensorimotor regions after complete thoracolumbar SCI (CTSCI), and how these reorganizations are associated with clinical manifestations. Study Type Prospective. Subjects Eighteen CTSCI patients (28–67 years of age; 16 men) and 18 age‐, gender‐matched healthy controls (HCs) (27–64 years of age; 16 men). Field Strength/Sequence Resting‐state functional magnetic resonance imaging (RS‐fMRI) using echo‐planar‐imaging (EPI) sequence at 3.0 T. Assessment Data preprocessing was performed using Data Processing Assistant for Resting‐State fMRI (DPARSF). Amplitude of low‐frequency fluctuations (ALFF) was used to characterize regional neural function, and seed‐based functional connectivity (FC) was used to evaluate the functional integration of the brain network. Statistical Tests Two‐sample t ‐tests were used for ALFF and FC measures (the data conform to the normal distribution), partial correlation analysis was used to analyze the correlation between clinical and imaging indicators, and receiver operating characteristic (ROC) analysis was used to search for sensitive imaging indicators. Results Compared with HCs, CTSCI patients showed decreased ALFF in right lingual gyrus (LG), increased ALFF in right middle frontal gyrus (MFG), and decreased FC between the right LG and Vermis_3 (cluster‐level FWE correction with P   〈  0.05). Subsequent correlation analyses revealed that decreased FC between the right LG and Vermis_3 positively correlated with the visual analog scale (VAS) ( P  = 0.043, r  = 0.443). Finally, the ROC analysis showed that the area under the curve (AUC) of FC value between right LG and Vermis3 was 0.881. Data Conclusion These findings suggest a possible theoretical basis of the mechanism of visual‐, emotion‐, and cognition‐related techniques in rehabilitation training for CTSCI.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v54.5
    DOI: 10.1002/jmri.27764
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1497154-9
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  • 2
    Online Resource
    Online Resource
    Altered Brain Function in Pediatric Patients With Complete Spinal Cord Injury: A Resting‐State Functional MRI Study
    Wiley ; 2024
    In:  Journal of Magnetic Resonance Imaging Vol. 60, No. 1 ( 2024-07), p. 304-313
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 60, No. 1 ( 2024-07), p. 304-313
    Abstract: Injury to the spinal cord of children may cause potential brain reorganizations, affecting their rehabilitation. However, the specific functional alterations of children after complete spinal cord injury (CSCI) remain unclear. Purpose To explore the specific functional changes in local brain and the relationship with clinical characteristics in pediatric CSCI patients, clarifying the impact of CSCI on brain function in developing children. Study Type Prospective. Subjects Thirty pediatric CSCI patients (7.83 ± 1.206 years) and 30 age‐, gender‐matched healthy children as controls (HCs) (8.77 ± 2.079 years). Field Strength/Sequence 3.0 T/Resting‐state functional MRI ( rs‐fMRI ) using echo‐planar‐imaging ( EPI ) sequence. Assessment Amplitude of low‐frequency fluctuation (ALFF), fractional ALFF (fALFF), and regional homogeneity (ReHo) were used to characterize regional neural function. Statistical Tests Two‐sample t ‐tests were used to compare the ALFF, fALFF, ReHo values of the brain between pediatric CSCI and HCs (voxel‐level FWE correction, P 〈 0.05). Spearman correlation analyses were performed to analyze the associations between the ALFF, fALFF, ReHo values in altered regions and the injury duration, sensory motor scores of pediatric CSCI patients ( P 〈 0.05). Then receiver operating characteristic (ROC) analysis was conducted to identify possible sensitive imaging indicators for clinical therapy. Results Compared with HCs, pediatric CSCI showed significantly decreased ALFF in the right postcentral gyrus (S1), orbitofrontal cortex, and left superior temporal gyrus (STG), increased ALFF in bilateral caudate nucleus, thalamus, middle cingulate gyrus, and cerebellar lobules IV‐VI, and increased ReHo in left cerebellum Crus II and Brodmann area 21. The ALFF value in the right S1 negatively correlated with the pinprick and light touch sensory scores of pediatric CSCI. When the left STG was used as an imaging biomarker for pediatric CSCI, it achieved the highest area under the curve of 0.989. Conclusions These findings may provide potential neural mechanisms for sensory motor and cognitive‐emotional deficits in children after CSCI. Evidence Level 2 Technical Efficacy Stage 5
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v60.1
    DOI: 10.1002/jmri.29045
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1497154-9
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  • 3
    Online Resource
    Online Resource
    Identification of acquired PIGA mutations and additional variants by next‐generation sequencing in paroxysmal nocturnal hemoglobinuria
    Wiley ; 2020
    In:  International Journal of Laboratory Hematology Vol. 42, No. 4 ( 2020-08), p. 473-481
    Details
    In: International Journal of Laboratory Hematology, Wiley, Vol. 42, No. 4 ( 2020-08), p. 473-481
    Abstract: Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal disease of hematopoietic stem cells. It is caused by somatic mutation of the X‐linked PIGA gene, resulting in a deficient expression of glycosylphosphatidylinositol‐anchored proteins (GPI‐APs). In this study, we aimed to explore the diagnostic value of next‐generation sequencing (NGS) and potential molecular basis in PNH patients. Methods Genomic DNA of 85 PNH patients was analyzed by a 114‐gene NGS panel. Results Mutational analysis of PIGA identified 124 mutations in 92% PNH patients, including 101 distinct mutations and 23 recurrent mutations. Among them, 102 mutations were newly reported. Most mutations were located in exon 2 of PIGA gene, and truncated mutation was the most common one. Other mutations were detected in 26 out of 85 cases, including five cases of DNMT3A variants, four cases of ASXL1 variants, and four cases of U2AF1 variants. Clonal analysis was performed in one case and outlined a linear evolution pattern in classic PNH. There was a positive correlation between number of PIGA mutations and fraction of GPI‐APs deficient granulocytes. Conclusion The detection of PIGA mutations and additional variants by targeted NGS not only shed light on the genetic characteristics of PNH, but also provided an important reference value in the diagnosis of PNH at molecular level.
    Type of Medium: Online Resource
    ISSN: 1751-5521 , 1751-553X
    URL: Issue
    URL: Article
    DOI: 10.1111/ijlh.v42.4
    DOI: 10.1111/ijlh.13228
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2268600-9
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  • 4
    Online Resource
    Online Resource
    Inside Back Cover: Deciphering and Suppressing Over‐Oxidized Nitrogen in Nickel‐Catalyzed Urea Electrolysis (Angew. Chem. Int. Ed. 51/2021)
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 51 ( 2021-12-13), p. 26867-26867
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 51 ( 2021-12-13), p. 26867-26867
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.51
    DOI: 10.1002/anie.202114404
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
    Online Resource
    Online Resource
    The influence of guide stabilizers and their application sequences on trueness and precision of surgical guides in free end situations: An in vitro analysis
    Wiley ; 2024
    In:  Clinical Oral Implants Research Vol. 35, No. 3 ( 2024-03), p. 294-304
    Details
    In: Clinical Oral Implants Research, Wiley, Vol. 35, No. 3 ( 2024-03), p. 294-304
    Abstract: To evaluate the impact of guide stabilizers and their application sequences on implant placement accuracy of guided implant surgery in multiple teeth loss at free end. Materials and Methods In this study, 96 implants were placed in the regions of #34, #36, and #37 of 32 identical mandibular models. The influence of using guide stabilizers or not (group A and group B) and various guide stabilizers application sequences (group B: #34 → #36 → #37; group C: #36 → #34 → #37; group D: #37 → #34 → #36) on implant placement trueness and precision was investigated. Data were analyzed using T ‐tests and one‐way ANOVA. Results Group B showed significant benefits in enhancing implant placement precision. Compared to group A, it resulted in reducing 3D‐deviation at crest and 2D deviation in vestibular‐oral direction at both crest and apex. Furthermore, group D demonstrated greater improvement in global implant placement precision by reducing 2D deviation in mesial‐distal direction at both crest and apex. Among the three different stabilizer application sequences, group D exhibited the highest level of implant placement precision. Conclusions In cases of missing teeth at distal free end, the use of guide stabilizers and their application sequences does not have a significant impact on implant placement trueness. However, they do improve implant placement precision compared to methods that do not utilize guide stabilizers. Specifically, applying a guide stabilizer first at the furthest implant site to change teeth loss classification from free end to edentulous space with posterior support is the most reliable sequence.
    Type of Medium: Online Resource
    ISSN: 0905-7161 , 1600-0501
    URL: Issue
    URL: Article
    DOI: 10.1111/clr.v35.3
    DOI: 10.1111/clr.14226
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2027104-9
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  • 6
    Online Resource
    Online Resource
    Innenrücktitelbild: Deciphering and Suppressing Over‐Oxidized Nitrogen in Nickel‐Catalyzed Urea Electrolysis (Angew. Chem. 51/2021)
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 51 ( 2021-12-13), p. 27071-27071
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 51 ( 2021-12-13), p. 27071-27071
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.51
    DOI: 10.1002/ange.202114404
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 7
    Online Resource
    Online Resource
    Deciphering and Suppressing Over‐Oxidized Nitrogen in Nickel‐Catalyzed Urea Electrolysis
    Wiley ; 2021
    In:  Angewandte Chemie International Edition Vol. 60, No. 51 ( 2021-12-13), p. 26656-26662
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 60, No. 51 ( 2021-12-13), p. 26656-26662
    Abstract: Urea electrolysis is a prospective technology for simultaneous H 2 production and nitrogen suppression in the process of water being used for energy production. Its sustainability is currently founded on innocuous N 2 products; however, we discovered that prevalent nickel‐based catalysts could generally over‐oxidize urea into NO 2 − products with ≈80 % Faradaic efficiencies, posing potential secondary hazards to the environment. Trace amounts of over‐oxidized NO 3 − and N 2 O were also detected. Using 15 N isotopes and urea analogues, we derived a nitrogen‐fate network involving a NO 2 − ‐formation pathway via OH − ‐assisted C−N cleavage and two N 2 ‐formation pathways via intra‐ and intermolecular coupling. DFT calculations confirmed that C−N cleavage is energetically more favorable. Inspired by the mechanism, a polyaniline‐coating strategy was developed to locally enrich urea for increasing N 2 production by a factor of two. These findings provide complementary insights into the nitrogen fate in water–energy nexus systems.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v60.51
    DOI: 10.1002/anie.202107886
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 8
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    Online Resource
    The Chinese Parkinson's Disease Registry ( CPDR ): Study Design and Baseline Patient Characteristics
    Wiley ; 2022
    In:  Movement Disorders Vol. 37, No. 7 ( 2022-07), p. 1335-1345
    Details
    In: Movement Disorders, Wiley, Vol. 37, No. 7 ( 2022-07), p. 1335-1345
    Abstract: There is a lack of large multicenter Parkinson's disease (PD) cohort studies and limited data on the natural history of PD in China. Objectives The objective of this study was to launch the Chinese Parkinson's Disease Registry (CPDR) and to report its protocol, cross‐sectional baseline data, and prospects for a comprehensive observational, longitudinal, multicenter study. Methods The CPDR recruited PD patients from 19 clinical sites across China between January 2018 and December 2020. Clinical data were collected prospectively using at least 17 core assessment scales. Patients were followed up for clinical outcomes through face‐to‐face interviews biennially. Results We launched the CPDR in China based on the Parkinson's Disease & Movement Disorders Multicenter Database and Collaborative Network (PD‐MDCNC). A total of 3148 PD patients were enrolled comprising 1623 men (51.6%) and 1525 women (48.4%). The proportions of early‐onset PD (EOPD, age at onset ≤50 years) and late‐onset PD (LOPD) were 897 (28.5%) and 2251 (71.5%), respectively. Stratification by age at onset showed that EOPD manifested milder motor and nonmotor phenotypes and was related to increased probability of dyskinesia. Comparison across genders suggested a slightly older average age at PD onset, milder motor symptoms, and a higher rate of developing levodopa‐induced dyskinesias in women. Conclusions The CPDR is one of the largest multicenter, observational, longitudinal, and natural history studies of PD in China. It offers an opportunity to expand the understanding of clinical features, genetic, imaging, and biological markers of PD progression. © 2022 International Parkinson and Movement Disorder Society.
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v37.7
    DOI: 10.1002/mds.29037
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2041249-6
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  • 9
    Online Resource
    Online Resource
    Deciphering and Suppressing Over‐Oxidized Nitrogen in Nickel‐Catalyzed Urea Electrolysis
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 51 ( 2021-12-13), p. 26860-26866
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 51 ( 2021-12-13), p. 26860-26866
    Abstract: Urea electrolysis is a prospective technology for simultaneous H 2 production and nitrogen suppression in the process of water being used for energy production. Its sustainability is currently founded on innocuous N 2 products; however, we discovered that prevalent nickel‐based catalysts could generally over‐oxidize urea into NO 2 − products with ≈80 % Faradaic efficiencies, posing potential secondary hazards to the environment. Trace amounts of over‐oxidized NO 3 − and N 2 O were also detected. Using 15 N isotopes and urea analogues, we derived a nitrogen‐fate network involving a NO 2 − ‐formation pathway via OH − ‐assisted C−N cleavage and two N 2 ‐formation pathways via intra‐ and intermolecular coupling. DFT calculations confirmed that C−N cleavage is energetically more favorable. Inspired by the mechanism, a polyaniline‐coating strategy was developed to locally enrich urea for increasing N 2 production by a factor of two. These findings provide complementary insights into the nitrogen fate in water–energy nexus systems.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.51
    DOI: 10.1002/ange.202107886
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 10
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    Online Resource
    Overview of antiviral drug candidates targeting coronaviral 3C‐like main proteases
    Wiley ; 2021
    In:  The FEBS Journal Vol. 288, No. 17 ( 2021-09), p. 5089-5121
    Details
    In: The FEBS Journal, Wiley, Vol. 288, No. 17 ( 2021-09), p. 5089-5121
    Abstract: Coronaviruses (CoVs) are positive single‐stranded RNA viruses that cause severe respiratory syndromes in humans, including severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS). Coronavirus disease 2019 (COVID‐19) caused by a novel severe acute respiratory syndrome CoV (SARS‐CoV‐2) at the end of 2019 became a global pandemic. The 3C‐like cysteine protease (3CLpro) processes viral polyproteins to yield mature non‐structural proteins, thus playing an important role in the CoV life cycle, and therefore is considered as a prominent target for antiviral drugs. To date, many 3CLpro inhibitors have been reported, and their molecular mechanisms have been illustrated. Here, we briefly introduce the structural features of 3CLpro of the human‐related SARS‐CoV, MERS‐CoV and SARS‐CoV‐2, and explore the potency and mechanism of their cognate inhibitors. This information will shed light on the development and optimization of CoV 3CLpro inhibitors, which may benefit the further designation of therapeutic strategies for treating CoV diseases.
    Type of Medium: Online Resource
    ISSN: 1742-464X , 1742-4658
    URL: Issue
    URL: Article
    DOI: 10.1111/febs.v288.17
    DOI: 10.1111/febs.15696
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2172518-4
    SSG: 12
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