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  • 1
    Online Resource
    Online Resource
    LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis
    Wiley ; 2022
    In:  Clinical and Translational Medicine Vol. 12, No. 1 ( 2022-01)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 12, No. 1 ( 2022-01)
    Abstract: Treatments for pulmonary fibrosis (PF) are ineffective because its molecular pathogenesis and therapeutic targets are unclear. Here, we show that the expression of low‐density lipoprotein receptor (LDLR) was significantly decreased in alveolar type II (ATII) and fibroblast cells, whereas it was increased in endothelial cells from systemic sclerosis‐related PF (SSc‐PF) patients and idiopathic PF (IPF) patients compared with healthy controls. However, the plasma levels of low‐density lipoprotein (LDL) increased in SSc‐PF and IPF patients. The disrupted LDL–LDLR metabolism was also observed in four mouse PF models. Upon bleomycin (BLM) treatment, Ldlr ‐deficient ( Ldlr −/−) mice exhibited remarkably higher LDL levels, abundant apoptosis, increased fibroblast‐like endothelial and ATII cells and significantly earlier and more severe fibrotic response compared to wild‐type mice. In vitro experiments revealed that apoptosis and TGF‐β1 production were induced by LDL, while fibroblast‐like cell accumulation and ET‐1 expression were induced by LDLR knockdown. Treatment of fibroblasts with LDL or culture medium derived from LDL‐pretreated endothelial or epithelial cells led to obvious fibrotic responses in vitro. Similar results were observed after LDLR knockdown operation. These results suggest that disturbed LDL–LDLR metabolism contributes in various ways to the malfunction of endothelial and epithelial cells, and fibroblasts during pulmonary fibrogenesis. In addition, pharmacological restoration of LDLR levels by using a combination of atorvastatin and alirocumab inhibited BLM‐induced LDL elevation, apoptosis, fibroblast‐like cell accumulation and mitigated PF in mice. Therefore, LDL–LDLR may serve as an important mediator in PF, and LDLR enhancing strategies may have beneficial effects on PF.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v12.1
    DOI: 10.1002/ctm2.711
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2697013-2
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  • 2
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    Enhanced Performance for Selective Catalytic Reduction of NO x with NH 3 over Nanosized Cu/SAPO‐34 Catalysts
    Wiley ; 2019
    In:  ChemCatChem Vol. 11, No. 16 ( 2019-08-21), p. 3865-3870
    Details
    In: ChemCatChem, Wiley, Vol. 11, No. 16 ( 2019-08-21), p. 3865-3870
    Abstract: A series of nanosized Cu/SAPO‐34 catalysts with different silicon contents were successfully synthesized by in situ hydrothermal method by using tetraethylammonium hydroxide and copper‐tetraethylenepentamine as co‐templates. The in situ prepared nanosized Cu/SAPO‐34 catalysts possess strong Brønsted acidity and well‐dispersed Cu species, showing enhanced performance for selective catalytic reduction of NO x with NH 3 compared with micronsized and nanosized counterparts prepared by post impregnation method. Significantly, Cu/SAPO‐34 nanocatalysts prepared by in situ method maintain the catalytic activity after the hydrothermal aging treatment, suggesting their excellent hydrothermal stability. This work will provide some guidance for the design of highly efficient catalysts for NH 3 −SCR reactions.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Issue
    URL: Article
    DOI: 10.1002/cctc.v11.16
    DOI: 10.1002/cctc.201900412
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2501161-3
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  • 3
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    Readout‐Segmented Echo‐Planar Diffusion‐Weighted MR Imaging Improves the Differentiation of Breast Cancer Receptor Statuses Compared With Conventional Diffusion‐Weighted Imaging
    Wiley ; 2022
    In:  Journal of Magnetic Resonance Imaging Vol. 56, No. 3 ( 2022-09), p. 691-699
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 56, No. 3 ( 2022-09), p. 691-699
    Abstract: Readout‐segmented echo‐planar diffusion‐weighted imaging (RS‐EPI) can improve image quality and signal‐to‐noise ratio, the resulting apparent diffusion coefficient (ADC) value acts as a more sensitive biomarker to characterize tumors. However, data regarding the differentiation of breast cancer (BC) receptor statuses using RS‐EPI are limited. Purpose To determine whether RS‐EPI improves the differentiation of receptor statuses compared with conventional single‐shot (SS) EPI in breast MRI. Study Type Retrospective. Population A total of 151 BC women with the mean age of 50.6 years. Field strength/Sequence A 3 T/ RS‐EPI and SS‐EPI . Assessment The ADCs of the lesion and normal background tissue from the two sequences were collected by two radiologists with 15 years of experience working of breast MRI (M.H.Z. and X.F.C.), and a normalized ADC was calculated by dividing the mean ADC value of the lesion by the mean ADC value of the normal background tissue. Statistical Tests Agreement between the ADC measurements from the two sequences was assessed using the Pearson correlation coefficient and Bland–Altman plots. One‐way analysis of variance, Kruskal–Wallis test, and median difference were used to compare the ADC measurements for all lesions and different receptor statuses. A P value less than 0.05 indicated a significant result. Results The ADC measurements of all lesions and normal background tissues were significantly higher on RS‐EPI than on SS‐EPI (1.82 ± 0.33 vs. 1.55 ± 0.30 and 0.83 ± 0.11 vs. 0.79 ± 0.10). The normalized ADC was lower on RS‐EPI than on SS‐EPI (0.47 ± 0.11 vs. 0.53 ± 0.12, a median difference of −0.04 [95% CI: −0.256 to 0.111]). For both diffusion methods, only the ADC measurement of RS‐EPI was higher for human epidermal growth factor receptor‐2 (HER‐2)‐positive tumors than for HER‐2‐negative tumors (0.87 ± 0.10 vs. 0.81 ± 0.11), and this measurement was associated with HER‐2 positive status (adjusted odds ratio [OR]  = 654.4); however, similar results were not observed for the ADC measurement of SS‐EPI (0.80 ± 0.10 vs. 0.78 ± 0.11 with P  = 0.199 and adjusted OR = 0.21 with P  = 0.464, respectively). Data Conclusion RS‐EPI can improve the distinction between HER‐2‐positive and HER‐2‐negative breast cancer, complementing the clinical application of diffusion imaging. Evidence Level 3 Technical Efficacy Stage 1
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v56.3
    DOI: 10.1002/jmri.28065
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1497154-9
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  • 4
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    Cotyledons facilitate the adaptation of early‐maturing soybean varieties to high‐latitude long‐day environments
    Wiley ; 2021
    In:  Plant, Cell & Environment Vol. 44, No. 8 ( 2021-08), p. 2551-2564
    Details
    In: Plant, Cell & Environment, Wiley, Vol. 44, No. 8 ( 2021-08), p. 2551-2564
    Abstract: The cotyledons induce soybean flowering by expressing flowering promoting gene GmFT2a after perceiving light signals at seedling stage. The cotyledon‐dependent floral induction accelerates the flowering of early‐maturing varieties in long‐day and facilitate them adapting to high latitudes.
    Type of Medium: Online Resource
    ISSN: 0140-7791 , 1365-3040
    URL: Issue
    URL: Article
    DOI: 10.1111/pce.v44.8
    DOI: 10.1111/pce.14120
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 391893-2
    detail.hit.zdb_id: 2020843-1
    SSG: 12
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  • 5
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    Inside Cover: Bimetallic Effects of Silver‐Modified Nickel Catalysts and their Synergy in Glycerol Hydrogenolysis (ChemCatChem 11/2016)
    Wiley ; 2016
    In:  ChemCatChem Vol. 8, No. 11 ( 2016-06-07), p. 1859-1859
    Details
    In: ChemCatChem, Wiley, Vol. 8, No. 11 ( 2016-06-07), p. 1859-1859
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Issue
    URL: Article
    DOI: 10.1002/cctc.v8.11
    DOI: 10.1002/cctc.201600625
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2501161-3
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  • 6
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    Association of the manganese superoxide dismutase gene Ala–9Val polymorphism with age of smoking initiation in male schizophrenia smokers
    Wiley ; 2016
    In:  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Vol. 171, No. 2 ( 2016-03), p. 243-249
    Details
    In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 171, No. 2 ( 2016-03), p. 243-249
    Abstract: Schizophrenia patients exhibit higher smoking rates than the general population. A growing body of evidence suggests that cigarette smoke impairs the antioxidant defense mechanisms, leading to oxidative damage. Manganese superoxide dismutase (MnSOD) is the major antioxidant in the mitochondria, catalyzing the metabolism of superoxide radicals to form hydrogen peroxide. Since the identification of a well‐characterized functional polymorphism, Ala–9Val of MnSOD , a number of studies have evaluated the association between Val–9Ala and schizophrenia or cancer. In this study, we hypothesized that the functional polymorphism of MnSOD Ala–9Val was associated with smoking in patients with schizophrenia. This polymorphism was genotyped in 666 chronic male schizophrenia patients (smoker/never‐smoker = 507/159) and 660 male controls (smoker/never‐smoker = 360/300) using a case–control design. The cigarettes smoked per day (CPD) and smoking behaviors were evaluated by clinician‐administered questionnaires and the Fagerstrom Test for Nicotine Dependence (FTND). The results showed no significant differences in MnSOD Ala–9Val genotype and allele distributions between the patients and healthy controls or between smokers and never‐smokers in either patients or healthy controls alone. The smokers with the Ala allele started smoking significantly earlier (19.9 ± 5.8 vs. 21.7 ± 6.5 years, P  = 0.005) only in patients. These results suggest that the MnSOD Ala–9Val polymorphism may not influence smoking status in a Chinese male schizophrenia population, but may influence the age at which smoking is started among schizophrenia smokers. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1552-4841 , 1552-485X
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.b.v171.2
    DOI: 10.1002/ajmg.b.32398
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2143866-3
    SSG: 12
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  • 7
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    Pharmacokinetic/pharmacodynamic integration of cefquinome against Pasteurella Multocida in a piglet tissue cage model
    Wiley ; 2019
    In:  Journal of Veterinary Pharmacology and Therapeutics Vol. 42, No. 1 ( 2019-01), p. 60-66
    Details
    In: Journal of Veterinary Pharmacology and Therapeutics, Wiley, Vol. 42, No. 1 ( 2019-01), p. 60-66
    Abstract: To explore the in vivo antimicrobial activity of cefquinome against Pasteurella multocida in piglets, a piglet tissue cage infection model was used in this study. After the population of P. multocida reached 10 7  CFU/mL in a tissue cage, piglets received an intramuscular administration of cefquinome at 0.2, 0.4, 0.8, 1, 2, and 4 mg/kg once daily for 3 days. To assess the tissue cage pharmacokinetics ( PKTCF ) of cefquinome, tissue cage fluid was collected for cefquinome analysis at 1, 3, 6, 9, 12, and 24 hr after each of the 3 daily drug administrations. Bacteria were counted every 24 hr after drug administration and at 48 and 72 hr after the last administration. Evaluation of the relationship between pharmacokinetic/pharmacodynamic ( PK / PD ) parameters and the antibacterial effect showed that the surrogate of % T  〉  minimum inhibitory concentration ( MIC ) ( R 2  = 0.981) was the best PK / PD index that correlated with effectiveness of cefquinome against P. multocida . The respective values of % T  〉   MIC required for continuous 1/3‐log, 1/2‐log, and 1‐log reductions were 14.23, 34.45, and 73.44%, respectively, during each 24‐hr treatment period. In conclusion, cefquinome exhibited a potent antibacterial effect against P. multocida . When % T  〉   MIC reached 73.44%, cefquinome exhibited a bactericidal effect against P. multocida after three successive daily administrations.
    Type of Medium: Online Resource
    ISSN: 0140-7783 , 1365-2885
    URL: Issue
    URL: Article
    DOI: 10.1111/jvp.2019.42.issue-1
    DOI: 10.1111/jvp.12705
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2023924-5
    SSG: 22
    SSG: 15,3
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  • 8
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    Online Resource
    Bimetallic Effects of Silver‐Modified Nickel Catalysts and their Synergy in Glycerol Hydrogenolysis
    Wiley ; 2016
    In:  ChemCatChem Vol. 8, No. 11 ( 2016-06-07), p. 1929-1936
    Details
    In: ChemCatChem, Wiley, Vol. 8, No. 11 ( 2016-06-07), p. 1929-1936
    Abstract: A series of Ag‐modified Ni catalysts was prepared, and the role of bimetallic effects on the selective cleavage of C−O and C−C bonds was investigated in glycerol hydrogenolysis, a model reaction for the utilization of biomass‐derived polyols. Compared to Raney Ni, the optimal Raney Ni 6 Ag catalyst was more active in glycerol conversion and efficient for C−O bond cleavage to afford a higher selectivity toward C 3 products (1,2‐propanediol and lactic acid; 88 %) at the same ∼70 % conversion of glycerol, especially 1,2‐propanediol (73 %). On Ni catalysts, the hydrogenation of adsorbed species was the most likely rate‐limiting step in glycerol hydrogenolysis under alkaline conditions. The Ag additive enhanced the hydrogenation ability of Ni catalysts, which should be related to the higher strength of the adsorption of hydrogen and the lower strength of the adsorption of substrates on Ni sites because of the formation of Ni‐Ag alloys. A mechanistic interpretation was presented for the excellent catalytic behavior.
    Type of Medium: Online Resource
    ISSN: 1867-3880 , 1867-3899
    URL: Issue
    URL: Article
    DOI: 10.1002/cctc.v8.11
    DOI: 10.1002/cctc.201600239
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2501161-3
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  • 9
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    Withdrawal time of danofloxacin and difloxacin and in vitro binding phenomenon to melanin in black‐boned silky fowl
    Wiley ; 2023
    In:  Journal of Food Science
    Details
    In: Journal of Food Science, Wiley
    Abstract: Fluoroquinolones are commonly used in poultry breeding. Few studies have evaluated the causes of serious drug residues in black‐boned silky fowl until enrofloxacin has been banned in black‐boned silky fowl breeding in the Chinese Veterinary Commission of Chinese Veterinary Pharmacopoeia (2020). However, similarly structured fluoroquinolones have not been studied in black‐boned silky fowl. In this study, the elimination of tissue residues of danofloxacin (DAN) and difloxacin (DIF) was studied in four tissues of black‐boned silky fowl. The specific administration methods were 100 mg/L of DIF aqueous solution for free drinking for 5 days and 50 mg/L of DAN aqueous solution for free drinking for 3 days. Based on the experiment, the withdrawal times of 44 days for muscle, 95 days for skin + fat, 3 days for liver, and 44 days for kidney of DAN were acquired, of 43 days for muscle, 61 days for skin + fat, 0 days for liver, and 38 days for kidney of DIF were acquired, which showed that DIF and DAN should be used with caution for application in black‐boned silky fowl. In vitro experiments showed that black‐boned silky fowl tissues had stronger adsorption capacity to DAN and DIF than yellow chicken tissues (especially in skin + fat), and melanin has a strong adsorption effect on DAN and DIF, which is an important reason for the high residual concentrations of fluoroquinolone in black‐boned silky fowl.
    Type of Medium: Online Resource
    ISSN: 0022-1147 , 1750-3841
    URL: Article
    DOI: 10.1111/1750-3841.16753
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006705-7
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  • 10
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    Disrupted citric acid metabolism inhibits hair growth
    Wiley ; 2022
    In:  The Journal of Dermatology Vol. 49, No. 10 ( 2022-10), p. 1037-1048
    Details
    In: The Journal of Dermatology, Wiley, Vol. 49, No. 10 ( 2022-10), p. 1037-1048
    Abstract: Hair follicles (HFs) play an essential role in sustaining a persistent hair growth cycle. The activities of dermal papilla cells (DPCs) and other cells inside the HFs dominate the process of hair growth. However, the detailed molecular mechanisms remain largely unknown. To investigate the role of citric acid (CA) metabolism in hair growth, we evaluated the effect of citrate synthase (CS)–CA axis on hair growth in vivo and in vitro. Mice hair growth was evaluated by morphology and histopathology analysis. The inflammation and apoptosis levels in mice, HFs, and DPCs were detected by immunohistofluorescence, qPCR, ELISA, western blot, and TUNEL assay. Cell proliferation, cell cycle, and cell apoptosis in DPCs were analyzed by real‐time cell analysis and flow cytometer. We found that subcutaneous injection of CA in mice caused significant hair growth suppression, skin lesion, inflammatory response, cell apoptosis, and promotion of catagen entry, compared with the saline control, by activating p‐p65 and apoptosis signaling in an NLRP3‐dependent manner. In cultured human HFs , CA attenuated the hair shaft production and accelerated HF catagen entry by regulating the above‐mentioned pathways. Additionally, CA hampered the proliferation rate of DPCs via inducing cell apoptosis and cell cycle arrest. Considering that citrate synthase (CS) is responsible for CA production and is a rate‐limiting enzyme of the tricarboxylic acid cycle, we also investigated the role of CS in CA metabolism and hair growth. As expected, knockdown of CS reduced CA production and reversed CA‐induced hair growth inhibition, anagen shrink, inflammation, and apoptosis both in HFs and DPCs. Our experiments demonstrated that CS–CA axis serves as an important mediator and might be a potential therapeutic target in hair growth.
    Type of Medium: Online Resource
    ISSN: 0385-2407 , 1346-8138
    URL: Issue
    URL: Article
    DOI: 10.1111/jde.v49.10
    DOI: 10.1111/1346-8138.16509
    RVK:
    XA 53120
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2222121-9
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