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  • Wiley  (1,013)
  • 1
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    Standardized uptake value and apparent diffusion coefficient of endometrial cancer evaluated with integrated whole‐body PET/MR: Correlation with pathological prognostic factors
    Wiley ; 2015
    In:  Journal of Magnetic Resonance Imaging Vol. 42, No. 6 ( 2015-12), p. 1723-1732
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 42, No. 6 ( 2015-12), p. 1723-1732
    Abstract: To evaluate the correlation between maximum standardized uptake value (SUV max ) and minimum apparent diffusion coefficient (ADC min ) of endometrial cancer derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors. Materials and Methods This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive patients with endometrial cancer were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty‐six patients with measurable tumors on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUV max and ADC min of the tumors. The Mann–Whitney U ‐test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors. Results The mean SUV max and ADC min were 14.7 ± 7.1 and 0.48 ± 0.13 × 10 −3 mm 2 /s, respectively. A significant inverse correlation was found between SUV max and ADC min ( r  = –0.53; P  = 0.001). SUV max was significantly higher in tumors with advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis ( P   〈  0.05). ADC min was lower in tumors with higher grade, advanced stage, and cervical invasion ( P   〈  0.05). The ratio of SUV max to ADC min was higher in tumors with higher grade, advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis ( P   〈  0.05). Conclusion SUV max and ADC min of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors. J. MAGN. RESON. IMAGING 2015;42:1723–1732.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v42.6
    DOI: 10.1002/jmri.24932
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1497154-9
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  • 2
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    Genomic characteristics and drug screening among organoids derived from non‐small cell lung cancer patients
    Wiley ; 2020
    In:  Thoracic Cancer Vol. 11, No. 8 ( 2020-08), p. 2279-2290
    Details
    In: Thoracic Cancer, Wiley, Vol. 11, No. 8 ( 2020-08), p. 2279-2290
    Abstract: Patient‐derived organoid (PDO) models are highly valuable and have potentially widespread clinical applications. However, limited information is available regarding organoid models of non‐small cell lung cancer (NSCLC). This study aimed to characterize the consistency between primary tumors in NSCLC and PDOs and to explore the applications of PDOs as preclinical models to understand and predict treatment response during lung cancer. Methods Fresh tumor samples were harvested for organoid culture. Primary tumor samples and PDOs were analyzed via whole‐exome sequencing. Paired samples were subjected to immunohistochemical analysis. There were 26 antineoplastic drugs tested in the PDOs. Cell viability was assessed using the Cell Titer Glo assay 7–10 days after drug treatment. A heatmap of log‐transformed values of the half‐maximal inhibitory concentrations was generated on the basis of drug responses of PDOs through nonlinear regression (curve fit). A total of 12 patients (stages I–III) were enrolled, and 7 paired surgical tumors and PDOs were analyzed. Results PDOs retained the histological and genetic characteristics of the primary tumors. The concordance between tumors and PDOs in mutations in the top 20 NSCLC‐related genes was 〉 80% in five patients. Sample purity was significantly and positively associated with variant allele frequency (Pearson r = 0.82, P = 0.0005) and chromosome stability. The in vitro response to drug screening with PDOs revealed high correlation with the mutation profiles in the primary tumors. Conclusions PDOs are highly credible models for detecting NSCLC and for prospective prediction of the treatment response for personalized precision medicine. Key points Lung cancer organoid models could save precious time of drug testing on patients, and accurately select anticancer drugs according to the drug sensitivity results, so as to provide a powerful supplement and verification for the gene sequencing.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v11.8
    DOI: 10.1111/1759-7714.13542
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2559245-2
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  • 3
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    PET / MRI in Cervical Cancer: Associations Between Imaging Biomarkers and Tumor Stage, Disease Progression, and Overall Survival
    Wiley ; 2021
    In:  Journal of Magnetic Resonance Imaging Vol. 53, No. 1 ( 2021-01), p. 305-318
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 53, No. 1 ( 2021-01), p. 305-318
    Abstract: Positron emission tomography (PET)/MRI biomarkers have been shown to have prognostic significance in patients with cervical cancer. Their associations with progression‐free survival (PFS) and overall survival (OS) merit further investigation. Purpose To evaluate the association between PET/MRI biomarkers and tumor stage, PFS, and OS in patients with cervical cancer. Study Type Prospective cohort study. Population In all, 54 patients with newly diagnosed cervical cancer and measurable tumors ( 〉 1 cm) were included in the image analysis. Field Strength/Sequence 3.0T integrated PET/MRI including diffusion‐weighted echo‐planar imaging (b = 50 and 1000 s/mm 2 ) and [18F]fluorodeoxyglucose PET. Assessment Two radiologists measured the minimum and mean apparent diffusion coefficient (ADC min and ADC mean ), maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumors. Statistical Tests A Mann–Whitney U ‐test was used to evaluate the association between the imaging biomarkers and tumor stage. A Cox proportional hazards model was used to assess the relationships between the imaging biomarkers and survival. Results In advanced tumors (T ≥ 1b2, M1, stage ≥ IB3), ADC min was significantly lower and MTV, TLG, MTV/ADC min , and TLG/ADC min were significantly higher ( P values between 〈 0.001 and 0.036). In N1 tumors, ADC min was significantly lower and MTV and MTV/ADC min were significantly higher ( P values between 0.005 and 0.016). In survival analysis, SUV max was an independent predictor of PFS (hazard ratio [HR] = 4.57, P   〈  0.05), and ADC min was an independent predictor of OS (HR = 0.02, P   〈  0.05). In subgroup analysis of patients with different stages, MTV/ADC min was a predictor of PFS in stage I disease ( P = 0.003), ADC min ( P = 0.038), and MTV ( P = 0.020) in stage II, SUV max ( P = 0.006), and TLG ( P = 0.006) in stage IV; and ADC min was a predictor of OS in stage III disease ( P = 0.008). Data Conclusion PET/MRI biomarkers of cervical cancer are associated with tumor stage and survival. SUV max and ADC min are independent predictors of PFS and OS, respectively. Level of Evidence 1 Technical Efficacy 3
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v53.1
    DOI: 10.1002/jmri.27311
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1497154-9
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  • 4
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    Effects of PTEN inhibition on regulation of tau phosphorylation in an okadaic acid‐induced neurodegeneration model
    Wiley ; 2012
    In:  International Journal of Developmental Neuroscience Vol. 30, No. 6 ( 2012-10), p. 411-419
    Details
    In: International Journal of Developmental Neuroscience, Wiley, Vol. 30, No. 6 ( 2012-10), p. 411-419
    Abstract: One of pathological hallmarks of Alzheimer's disease (AD) is neurofibrillary tangles (NFTs) consisting of abnormally hyperphosphorylated tau. The molecular mechanisms underlying the regulation of tau hyperphosphorylation remain largely unclear. The phosphoinositide 3‐kinase (PI3K)/Akt pathway has been implicated in the pathogenesis of AD, however, potential functions and role of tumor suppressor phosphatase and tensin homologue deleted on chromosome 10 (PTEN) in AD pathogenesis have not been fully explored. Here, we report that okadaic acid (OA)‐induced tau phosphorylation is accompanied by PTEN induction, knockdown of PTEN reduces the tau hyperphosphorylation by OA in SH‐SY5Y cells and increases cell proliferation and survival. The effect of PTEN suppression on tau dephosphorylation appeared to be mediated by inhibition of glycogen synthase kinase 3 while enhancing the Akt activity. Reduction of tau phosphorylation was also observed in the OA‐induced parental SH‐SY5Y cells co‐treated with bisperoxovanadate (bpv), a potent PTEN inhibitor. Our studies provide evidence for an effect of PTEN on the phosphorylation of tau in AD pathogenesis and give some insight into the mechanisms through which suppression of PTEN expression may contribute towards the amelioration of tauopathy, implying that pharmacological intervention of PTEN may be a new therapeutic approach for the treatment of AD.
    Type of Medium: Online Resource
    ISSN: 0736-5748 , 1873-474X
    URL: Article
    DOI: 10.1016/j.ijdevneu.2012.08.003
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2012538-0
    detail.hit.zdb_id: 2013748-5
    SSG: 12
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  • 5
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    Characterization of genes and enzymes in Dunaliella salina involved in glycerol metabolism in response to salt changes : Glycerol metabolism in Dunaliella salina
    Wiley ; 2013
    In:  Phycological Research Vol. 61, No. 1 ( 2013-01), p. 37-45
    Details
    In: Phycological Research, Wiley, Vol. 61, No. 1 ( 2013-01), p. 37-45
    Type of Medium: Online Resource
    ISSN: 1322-0829
    URL: Issue
    URL: Article
    DOI: 10.1111/pre.2013.61.issue-1
    DOI: 10.1111/j.1440-1835.2012.00669.x
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2020835-2
    SSG: 12
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  • 6
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    Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma
    Wiley ; 1999
    In:  Cancer Vol. 85, No. 3 ( 1999-02-01), p. 651-657
    Details
    In: Cancer, Wiley, Vol. 85, No. 3 ( 1999-02-01), p. 651-657
    Type of Medium: Online Resource
    ISSN: 0008-543X , 1097-0142
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/(SICI)1097-0142(19990201)85:3〈〉1.0.CO;2-Q
    DOI: 10.1002/(ISSN)1097-0142
    DOI: 10.1002/(SICI)1097-0142(19990201)85:3〈651::AID-CNCR15〉3.0.CO;2-9
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 1479932-7
    detail.hit.zdb_id: 2599218-1
    detail.hit.zdb_id: 2594979-2
    detail.hit.zdb_id: 1429-1
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  • 7
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    Orexin‐A increases the activity of globus pallidus neurons in both normal and parkinsonian rats
    Wiley ; 2016
    In:  European Journal of Neuroscience Vol. 44, No. 5 ( 2016-09), p. 2247-2257
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 44, No. 5 ( 2016-09), p. 2247-2257
    Abstract: Orexin is a member of neuropeptides which was first identified in the hypothalamus. The globus pallidus is a key structure in the basal ganglia, which is involved in both normal motor function and movement disorders. Morphological studies have shown the expression of both OX 1 and OX 2 receptors in the globus pallidus. Employing single unit extracellular recordings and behavioural tests, the direct in vivo electrophysiological and behavioural effects of orexin‐A in the globus pallidus were studied. Micro‐pressure administration of orexin‐A significantly increased the spontaneous firing rate of pallidal neurons. Correlation analysis revealed a negative correlation between orexin‐A induced excitation and the basal firing rate. Furthermore, application of the specific OX 1 receptor antagonist, SB ‐334867, decreased the firing rate of pallidal neurons, suggesting that endogenous orexinergic systems modulate the firing activity of pallidal neurons. Orexin‐A increased the excitability of pallidal neurons through both OX 1 and OX 2 receptors. In 6‐hydroxydopamine parkinsonian rats, orexin‐A‐induced increase in firing rate of pallidal neurons was stronger than that in normal rats. Immunostaining revealed positive OX 1 receptor expression in the globus pallidus of both normal and parkinsonian rats. Finally, postural test showed that unilateral microinjection of orexin‐A led to contralateral deflection in the presence of systemic haloperidol administration. Further elevated body swing test revealed that pallidal orexin‐A and SB ‐334867 induced contralateral‐biased swing and ipsilateral‐biased swing respectively. Based on the electrophysiological and behavioural findings of orexin‐A in the globus pallidus, the present findings may provide a rationale for the pathogenesis and treatment of Parkinson's disease.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.2016.44.issue-5
    DOI: 10.1111/ejn.13323
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 8
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    Increased risk of second primary malignancies among endometrial cancer survivors receiving surgery alone: A population‐based analysis
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 19 ( 2021-10), p. 6845-6854
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 19 ( 2021-10), p. 6845-6854
    Abstract: Women with endometrial cancer (EC) have favorable prognoses, leaving them vulnerable to the development of second primary cancers (SPCs). We investigated the SPC risk and survival outcomes among EC patients treated with surgery alone in order to exclude the impact of adjuvant treatment on the results. Methods Data from the Taiwan Cancer Registry from 1995 to 2013 were analyzed. Standardized incidence ratios (SIRs) of SPCs among EC survivors were calculated. Results Among 7725 women enrolled, 478 developed an SPC. The overall SIR for SPCs in EC survivors was 2.84 (95% confidence interval [CI] 2.59–3.10) compared with the general female population. Women diagnosed with EC at age 〈 50 years had a higher SIR for an SPC than those diagnosed at age ≥50 years (SIR = 4.38 vs. 1.28). The most frequent site of an SPC was the small intestine (SIR = 8.39, 95% CI 2.72–19.58), followed by the kidney (SIR = 4.84, 95% CI 1.78–10.54), and oral cavity (SIR = 4.52, 95% CI 2.17–8.31). Women, regardless of age at EC diagnosis, had significantly higher SIRs for subsequent breast, colorectal, lung, and thyroid cancer, and lymphoma. Women with an SPC had shorter overall survival than those without (5‐year: 88.9 vs. 94.2%, 10‐year: 71.3 vs. 89.8%, 15‐year: 62.3 vs. 86.1%, and 20‐year: 47.6 vs. 81.1%, all ps 〈 0.001). Conclusions Even women treated for EC with surgery alone, especially young EC survivors, had an increased risk of SPCs. Genetic counseling/testing is recommended for young EC patients, and all are recommended to receive regular surveillance and screening for breast, colorectal, and lung cancers.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.19
    DOI: 10.1002/cam4.3861
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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  • 9
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    Atypical posterior reversible encephalopathy syndrome in a noncompliant hemodialysis patient: Case report and literature review
    Wiley ; 2019
    In:  Hemodialysis International Vol. 23, No. 4 ( 2019-10)
    Details
    In: Hemodialysis International, Wiley, Vol. 23, No. 4 ( 2019-10)
    Abstract: Posterior reversible encephalopathy syndrome (PRES) is a reversible vasogenic brain edema in patients who present with seizure, headache, visual disturbance, and altered mental status, and a characteristic neuroimaging profile. Although PRES predominantly affects the bilateral parieto‐occipital areas, involvement of the frontal and temporal lobes, basal ganglia, brainstem, and cerebellum is not uncommon. Isolated involvement of the brainstem and cerebellum sparing the parieto‐occipital lobe is rarely reported. Here, we describe a 47‐year‐old man with end‐stage renal disease on chronic hemodialysis who presented with prominent hypertension and coma after missing three dialysis sessions. On examination, there was paucity of focal neurologic signs. Diagnosis of PRES was based on brain magnetic resonance imaging findings that were consistent with vasogenic edema of the pons and cerebellum without involvement of other areas. With antihypertensive therapy and intense ultrafiltration during hemodialysis, the patient's blood pressure and consciousness returned to normal, along with complete resolution of the abnormal imaging findings. This case stresses that noncompliance with dialysis should be considered a risk factor for PRES. This case is considered relative to the available literature on three patients with brainstem variant of PRES.
    Type of Medium: Online Resource
    ISSN: 1492-7535 , 1542-4758
    URL: Issue
    URL: Article
    DOI: 10.1111/hdi.v23.4
    DOI: 10.1111/hdi.12735
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2103570-2
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  • 10
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    Protection of primary cilia is an effective countermeasure against the impairment of osteoblast function induced by simulated microgravity
    Wiley ; 2023
    In:  Journal of Cellular and Molecular Medicine Vol. 27, No. 1 ( 2023-01), p. 36-51
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 27, No. 1 ( 2023-01), p. 36-51
    Abstract: The molecular mechanism for the microgravity‐induced decrease in bone formation remains unclear and there is a lack of effective specific preventative therapies. We recently reported that primary cilia of osteoblasts became shorter and even disappeared when the cells were exposed to random positioning machine (RPM)‐simulated microgravity and that the microgravity‐induced loss of osteogenic potential of osteoblasts could be attenuated when the resorption of primary cilia was prevented by treatment with 0.1 μM cytochalasin D. In the current study, it was further found that the loss of the osteogenic capacity of rat calvarial osteoblasts (ROBs) was associated with the inhibition of the BMP‐2/Smad1/5/8 signalling pathway, of which most of the signalling proteins including BMP‐2, BMPRII, Smad1/5/8 and p‐Smad1/5/8 were found localized to primary cilia. Accompanying the resorption of primary cilia following the cells being exposed to simulated microgravity, the expression levels of these signalling proteins were reduced significantly. Furthermore, the expression of miRNA‐129‐3p, a microRNA previously reported to control cilium biogenesis, was found to be reduced quickly and changed in a similar tendency with the length of primary cilia. Moreover, overexpression of miRNA‐129‐3p in ROBs significantly attenuated microgravity‐induced inhibition of BMP‐2 signalling and loss of osteogenic differentiation and mineralization. These results indicated the important role of miRNA‐129‐3p in microgravity‐induced resorption of primary cilia of osteoblasts and the potential of replenishing the miRNA‐129‐3p as an effective countermeasure against microgravity‐induced loss of primary cilia and impairment of osteoblast function.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v27.1
    DOI: 10.1111/jcmm.17628
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2076114-4
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