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  • 1
    Online Resource
    Online Resource
    Deep Drug Penetration of Nanodrug Aggregates at Tumor Tissues by Fast Extracellular Drug Release
    Wiley ; 2021
    In:  Advanced Healthcare Materials Vol. 10, No. 3 ( 2021-02)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 10, No. 3 ( 2021-02)
    Abstract: Herein, a new nanodrug of azobenzene‐functionalized interfacial cross‐linked reverse micelles (AICRM) with 5‐fluorouracil loading (5‐FU@AICRM) is reported. Upon irradiation with 530 nm light in water, the surface azobenzenes of the nanoparticles change from polar cis ‐conformation to nonpolar trans ‐conformation, resulting in the aggregation of 5‐FU@AICRM within minutes. Simultaneously, the conformation change unlocks hydrophilic 5‐FU with a strong water immigration propensity, allowing them to spray out from the AICRM quickly. This fast release ensures a thorough release of the drug, before the aggregates are internalized by adjacent cells, making it possible to achieve deep tissue penetration. A study of in vivo anticancer activity in A549 tumor‐bearing nude mice shows that the tumor inhibition rate (TIR) of 5‐FU@AICRM is up to ≈86.2%, 31.6% higher than that of group without green light irradiation and 20.7% higher than that of carmofur (CF, a hydrophobic analog of 5‐FU)‐loaded AICRM (CF@AICRM), in which CF is released slowly under light irradiation because of its hydrophobicity. Fast drug release upon nanodrug aggregation provides a good solution for balancing the contradiction of “aggregation and penetration” in tumor treatment with nanodrugs.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v10.3
    DOI: 10.1002/adhm.202001430
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2645585-7
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  • 2
    Online Resource
    Online Resource
    Asymmetric Alloy Acceptor Strategy Guided by Similarity Principle Enables Highly Efficient and Stable Organic Solar Cells
    Wiley ; 2024
    In:  Advanced Functional Materials Vol. 34, No. 2 ( 2024-01)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 34, No. 2 ( 2024-01)
    Abstract: Introducing the guest materials into binary active layer to construct ternary organic solar cells (OSCs) is widely used to improve device performance. Nevertheless, designing the guest materials is a challenging task. Herein, asymmetric alloy acceptor strategy guided by similarity principle to design the guest materials is employed. Two small molecular acceptors (ZH1 with symmetric end groups and ZH2 with asymmetric end groups) with the same skeleton to the host acceptor are synthesized and compared. Compared to symmetric ZH1, asymmetric ZH2 delivers a remarkably higher efficiency (3.86% vs 13.03%) when paired with PM6, benefiting from the larger dipole moment to facilitate charge dynamics and more favorable morphology. More importantly, by introducing ZH1 and ZH2 as the guest materials into the PM6:BTP‐eC9 blend, both ZH1 and ZH2 well alloy with acceptor BTP‐eC9 due to the similar skeleton, not only providing a complementary absorption, but also optimizing and stabilizing the blend morphology. Notably, the asymmetric alloy acceptor distinctly outperforms symmetric alloy acceptor, PM6:BTP‐eC9:ZH2‐based device achieves an outstanding efficiency of 18.75% with better stability and reduced non‐radiative energy loss. Therefore, developing asymmetric alloy acceptor is an effective strategy to develop high‐performance and stable OSCs.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v34.2
    DOI: 10.1002/adfm.202308151
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 3
    Online Resource
    Online Resource
    Therapeutic targeting of PLK1 in TERT promoter‐mutant hepatocellular carcinoma
    Wiley ; 2024
    In:  Clinical and Translational Medicine Vol. 14, No. 5 ( 2024-05)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 14, No. 5 ( 2024-05)
    Abstract: Hotspot mutations in the promoter of telomerase reverse transcriptase ( TERT ) gene are the most common genetic variants in hepatocellular carcinoma (HCC) and associated with poor prognosis of the disease. However, no drug was currently approved for treating TERT promoter mutation positive HCC patients. Here, we aim to explore the potential therapeutic strategy for targeting TERT promoter mutation in HCC. Methods The Liver Cancer Model Repository database was used for screening potential drugs to selectively suppress the growth of TERT promoter mutant HCC cells. RNA‐seq, CRISPR‐Cas9 technology and siRNA transfection were performed for mechanistic studies. Cell counting kit‐8 (CCK8) assay and the xenograft tumour models were used for cell growth detection in vitro and in vivo, respectively. Cell apoptosis and cell cycle arrest were analysed by Annexin V‐FITC staining and/or propidium iodide staining. Results PLK1 inhibitors were remarkably more sensitive to HCC cells harbouring TERT promoter mutation than wild‐type cells in vitro and in vivo, which were diminished after TERT promoter mutation was edited to the wild‐type nucleotide. Comparing the HCC cells with wild‐type promoter of TERT , PLK1 inhibitors specifically downregulated Smad3 to regulate TERT for inducing apoptosis and G2/M arrest in TERT mutant HCC cells. Moreover, knockout of Smad3 counteracted the effects of PLK1 inhibitors in TERT mutant HCC cells. Finally, a cooperative effect of PLK1 and Smad3 inhibition was observed in TERT mutant cells. Conclusions PLK1 inhibition selectively suppressed the growth of TERT mutant HCC cells through Smad3, thus contributed to discover a novel therapeutic strategy to treat HCC patients harbouring TERT promoter mutations. Key points TERT promoter mutation confers sensitivity to PLK1 inhibitors in HCC. The selective growth inhibition of TERT mutant HCC cells induced by PLK1 inhibitor was mediated by Smad3. Combined inhibition of PLK1 and Smad3 showed a cooperative anti‐tumor effect in TERT mutant HCC cells.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v14.5
    DOI: 10.1002/ctm2.1703
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2697013-2
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  • 4
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    Online Resource
    Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells
    Wiley ; 2020
    In:  Journal of Biochemical and Molecular Toxicology Vol. 34, No. 5 ( 2020-05)
    Details
    In: Journal of Biochemical and Molecular Toxicology, Wiley, Vol. 34, No. 5 ( 2020-05)
    Abstract: With the rapid development of nanotechnology, nanomaterials are now being used for cancer treatment. Although studies on the application of silver nanoparticles in cancer treatment are burgeoning, few studies have investigated the toxicology mechanisms of autophagy in cancer cells under exposure to sublethal silver nanoparticles. Here, we clarified the distinct mechanisms of silver nanoparticles for the regulation of autophagy in prostate cancer PC‐3 cells under sublethal exposure. Silver nanoparticle treatment caused lysosome injury, including the decline of lysosomal membrane integrity, decrease of lysosomal quantity, and attenuation of lysosomal protease activity, which resulted in blockage of autophagic flux. In addition, sublethal silver nanoparticle exposure activated AMP‐activated protein kinase/mammalian target of rapamycin‐dependent signaling pathway to modulate autophagy, which resulted from silver nanoparticles‐induced cell hypoxia and energy deficiency. Taken together, the results show that silver nanoparticles could regulate autophagy via lysosome injury and cell hypoxia in PC‐3 cells under sublethal dose exposure. This study will provide an experimental basis for the cancer therapy of nanomaterials.
    Type of Medium: Online Resource
    ISSN: 1095-6670 , 1099-0461
    URL: Issue
    URL: Article
    DOI: 10.1002/jbt.v34.5
    DOI: 10.1002/jbt.22474
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1481995-8
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Enhancing the Reversibility of Lattice Oxygen Redox Through Modulated Transition Metal–Oxygen Covalency for Layered Battery Electrodes
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 20 ( 2022-05)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 20 ( 2022-05)
    Abstract: Utilizing reversible lattice oxygen redox (OR) in battery electrodes is an essential strategy to overcome the capacity limitation set by conventional transition metal redox. However, lattice OR reactions are often accompanied with irreversible oxygen oxidation, leading to local structural transformations and voltage/capacity fading. Herein, it is proposed that the reversibility of lattice OR can be remarkably improved through modulating transition metal–oxygen covalency for layered electrode of Na‐ion batteries. By developing a novel layered P2‐Na 0.6 Mg 0.15 Mn 0.7 Cu 0.15 O 2 electrode, it is demonstrated that the highly electronegative Cu dopants can improve the lattice OR reversibility to 95% compared to 73% for Cu‐free counterpart, as directly quantified through high‐efficiency mapping of resonant inelastic X‐ray scattering. Crucially, the large energetic overlap between Cu 3d and O 2p states dictates the rigidity of oxygen framework, which effectively mitigates the structural distortion of local oxygen environment upon (de)sodiation and leads to the enhanced lattice OR reversibility. The electrode also exhibits a completely solid‐solution reaction with an ultralow volume change of only 0.45% and a reversible metal migration upon cycling, which together ensure the improved electrochemical performance. These results emphasize the critical role of transition metal–oxygen covalency for enhancing the reversibility of lattice OR toward high‐capacity electrodes employing OR chemistry.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.20
    DOI: 10.1002/adma.202201152
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 6
    Online Resource
    Online Resource
    Periodate‐Based Perovskite Energetic Materials: A Strategy for High‐Energy Primary Explosives
    Wiley ; 2023
    In:  Small
    Details
    In: Small, Wiley
    Abstract: The requirements for high energy and green primary explosives are more and more stringent because of the rising demand in the application of micro initiation explosive devices. Four new energetic compounds with powerful initiation ability are reported and their performances are experimentally proven as designed, including non‐perovskites ([H 2 DABCO](H 4 IO 6 ) 2 ·2H 2 O, named TDPI‐0) and perovskitoid energetic materials (PEMs) ([H 2 DABCO][M(IO 4 ) 3 ]; DABCO=1,4‐Diazabicyclo[2.2.2] octane, M=Na + , K + , and NH 4 + for TDPI‐1, ‐2, and ‐4, respectively). The tolerance factor is first introduced to guide the design of perovskitoid energetic materials (PEMs). In conjunction with [H 2 DABCO](ClO 4 ) 2 ·H 2 O (DAP‐0) and [H 2 DABCO][M(ClO 4 ) 3 ] (M=Na + , K + , and NH 4 + for DAP‐1, ‐2, and ‐4), the physiochemical properties of the two series are investigated between PEMs and non‐perovskites (TDPI‐0 and DAP‐0). The experimental results show that PEMs have great advantages in improving the thermal stability, detonation performance, initiation capability, and regulating sensitivity. The influence of X‐site replacement is illustrated by hard–soft‐acid–base (HSAB) theory. Especially, TDPIs possess much stronger initiation capability than DAPs, which indicates that periodate salts are in favor of deflagration‐to‐detonation transition. Therefore, PEMs provide a simple and feasible method for designing advanced high energy materials with adjustable properties.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Article
    DOI: 10.1002/smll.202302631
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2168935-0
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  • 7
    Online Resource
    Online Resource
    Facile 3D Nitrogen‐Doped Hierarchical Porous Carbon for High‐Performance Supercapacitors
    Wiley ; 2022
    In:  Energy Technology Vol. 10, No. 10 ( 2022-10)
    Details
    In: Energy Technology, Wiley, Vol. 10, No. 10 ( 2022-10)
    Abstract: A novel activated nitrogen‐doped hierarchically porous carbon (ANPC) material has been synthesized using polyurethane foam as the supporting template, phenolic resin with a high carbonization ratio, and low‐cost ammonium polyphosphate as the carbon and nitrogen sources, respectively. The preparation process comprises curing and carbonization combined with KOH activation. Despite the simplicity of the process, the obtained ANPC‐4 exhibits a high specific surface area (1452 m 2  g −1 ), a well‐developed specific pore volume (0.799 cm 3  g −1 ), moderate mesoporous content (32.7%), good electrolyte ions transport property, and appropriate nitrogen dopant content. When used as a material for fabricating supercapacitor electrodes, the ANPC‐4 exhibits a significantly high capacitance value of 356 F g −1 at 0.2 A g −1 in a 6 M KOH electrolyte with outstanding rate performance. In addition, the symmetrical capacitors assembled by ANPC‐4 have good specific capacitance (175 F g −1 at 0.2 A g −1 ), high energy density up to 24.3 Wh kg −1 , and good cycling stability (94.5% capacitance retention after 10 000 cycles of testing).
    Type of Medium: Online Resource
    ISSN: 2194-4288 , 2194-4296
    URL: Issue
    URL: Article
    DOI: 10.1002/ente.v10.10
    DOI: 10.1002/ente.202200508
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2700412-0
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  • 8
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    Online Resource
    Effective Removal of Congo Red from Water using Chitosan@UiO‐67 Hydrogel Spheres: Synthesis, Characterization and Adsorption Mechanisms
    Wiley ; 2023
    In:  ChemistrySelect Vol. 8, No. 20 ( 2023-05-25)
    Details
    In: ChemistrySelect, Wiley, Vol. 8, No. 20 ( 2023-05-25)
    Abstract: A hydrogel (Chitosan@UiO‐67) adsorbent was prepared by a green and simple method for the adsorption of Congo red. SEM, FT‐IR, TGA, BET, and XRD were used to characterize CS@UiO‐67 hydrogel. The effects of temperature, initial CR concentration, contact time, pH, and adsorbent dose on the adsorption properties of CS@UiO‐67 hydrogel were studied in batch adsorption experiments. FT‐IR analysis showed that the hydroxyl group of chitosan had covalent coordination with Zr, which enhanced the stability of chitosan after complexation with UiO‐67. As for the adsorption experiment, the maximum adsorption capacity of the adsorbent calculated by the Langmuir model was 1001.2 mg ⋅ g −1 at room temperature (301 K). Kinetic analysis showed that the adsorption of congo red on CS@UiO‐67 hydrogel conformed to the pseudo‐second‐order model. The adsorption process accorded with the Langmuir model by isotherm analysis. Thermodynamic analysis showed that the adsorption process was spontaneous and exothermic. The adsorption of CR on CS@UiO‐67 hydrogel spheres was mainly attributed to electrostatic attraction, hydrogen bonds, and π‐π bonds. After four cycles of regeneration, the material removal rate can still reach about 65 %. The new adsorbent has good application prospects.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v8.20
    DOI: 10.1002/slct.202204367
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2844262-3
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  • 9
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    Online Resource
    SC1 sustains the self‐renewal capacity and pluripotency of chicken blastodermal cells by inhibiting the phosphorylation of ERK1 and promoting the phosphorylation of Akt
    Wiley ; 2018
    In:  Reproduction in Domestic Animals Vol. 53, No. 5 ( 2018-10), p. 1052-1059
    Details
    In: Reproduction in Domestic Animals, Wiley, Vol. 53, No. 5 ( 2018-10), p. 1052-1059
    Abstract: Small molecules discovered during the recent years can be used to regulate the growth of embryonic stem cells (ES cells). Chicken blastodermal cells (cBCs) play an important role in both basic and transgenic researches as an important ES cell. However, the regulatory mechanism of small molecules involved in the self‐renewal and pluripotency of cBCs remains unknown. This study revealed that the small molecule, SC1, can maintain cBCs in an undifferentiated, pluripotent state in serum‐ and feeder‐free E8 media without leukaemia inhibitory factor. Furthermore, SC1 inhibits downregulation of pluripotency‐related genes caused by retinoic acid and promotes the proliferation of cBCs. Furthermore, the results of this study indicated that SC1 functions by inhibiting ERK1 phosphorylation and promoting Akt phosphorylation, thus promoting the expression of pluripotency‐related genes and maintaining the pluripotency of cBCs. The results also demonstrated that SC1 sustains the self‐renewal capacity and pluripotency of cBCs cells by inhibiting ERK1 phosphorylation and promoting Akt phosphorylation. This kind of regulatory mechanism might be conserved in avian ES cells. Other molecules, similar to SC1, might provide insights into the molecular mechanisms that control the fate of stem cells and ultimately help in‐vivo stem cell biology and therapy.
    Type of Medium: Online Resource
    ISSN: 0936-6768 , 1439-0531
    URL: Issue
    URL: Article
    DOI: 10.1111/rda.2018.53.issue-5
    DOI: 10.1111/rda.13202
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020494-2
    SSG: 12
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  • 10
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    Gliadin analysis of Elymus nutans Griseb. from the Qinghai-Tibetan Plateau and Xinjiang, China : Gliadin analysis of Elymus nutans
    Wiley ; 2011
    In:  Grassland Science Vol. 57, No. 3 ( 2011-09), p. 127-134
    Details
    In: Grassland Science, Wiley, Vol. 57, No. 3 ( 2011-09), p. 127-134
    Type of Medium: Online Resource
    ISSN: 1744-6961
    URL: Article
    DOI: 10.1111/j.1744-697X.2011.00219.x
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2186539-5
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