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  • 1
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    Online Resource
    TGF‐β/Alk5 signaling prevents osteoarthritis initiation via regulating the senescence of articular cartilage stem cells
    Wiley ; 2021
    In:  Journal of Cellular Physiology Vol. 236, No. 7 ( 2021-07), p. 5278-5292
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 236, No. 7 ( 2021-07), p. 5278-5292
    Abstract: Osteoarthritis (OA) is the most common joint disease. The surface of joint cartilage is a defensive and first affected structure of articular cartilage (AC) during the pathogenesis of OA. Alk5 signaling is critical for maintaining AC homeostasis, however, the role and underlying mechanism for the involvement of Alk5 signaling in the phenotypes of articular cartilage stem cells (ACSCs) at the surface of AC is still unclear. The role of Alk5 in OA development was explored using an ACSCs‐specific Alk5 ‐deficient (cKO) mouse model. Alterations in cartilage structure were evaluated histologically. Senescence was detected by SA‐β‐gal, while reactive oxygen species (ROS), MitoTracker, and LysoTracker staining were used to detect changes related to senescence. In addition, mice were injected intra‐articularly with ganciclovir to limit the detrimental roles of senescent cells (SnCs). Alk5 cKO mice showed a decreased number of the slow‐cell cycle cells and less lubricant secretion at the surface accompanied with drastically accelerated cartilage degeneration under ageing and surgically induced OA conditions. Further studies showed that Alk5 deficient ACSCs exhibited senescence‐like manifestations including decreased proliferation and differentiation, more SA‐β‐gal‐positive cells and ROS production, as well as significantly swollen mitochondria and lysosome breakdown. We further found that local limitation of the detrimental roles of SnCs can attenuate the development of posttraumatic OA. Taken together, our findings suggest that Alk5 signaling acts as an important regulator of the SnCs in the superficial layer during AC maintenance and OA initiation.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v236.7
    DOI: 10.1002/jcp.30231
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1478143-8
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  • 2
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    Clinical recommendations for perioperative immunotherapy‐induced adverse events in patients with non‐small cell lung cancer
    Wiley ; 2021
    In:  Thoracic Cancer Vol. 12, No. 9 ( 2021-05), p. 1469-1488
    Details
    In: Thoracic Cancer, Wiley, Vol. 12, No. 9 ( 2021-05), p. 1469-1488
    Abstract: Perioperative adjuvant treatment has become an increasingly important aspect of the management of patients with non‐small cell lung cancer (NSCLC). In particular, the success of immune checkpoint inhibitors, such as antibodies against PD‐1 and PD‐L1, in patients with lung cancer has increased our expectations for the success of these therapeutics as neoadjuvant immunotherapy. Neoadjuvant therapy is widely used in patients with resectable stage IIIA NSCLC and can reduce primary tumor and lymph node stage, improve the complete resection rate, and eliminate microsatellite foci; however, complete pathological response is rare. Moreover, because the clinical benefit of neoadjuvant therapy is not obvious and may complicate surgery, it has not yet entered the mainstream of clinical treatment. Small‐scale clinical studies performed in recent years have shown improvements in the major pathological remission rate after neoadjuvant therapy, suggesting that it will soon become an important part of NSCLC treatment. Nevertheless, neoadjuvant immunotherapy may be accompanied by serious adverse reactions that lead to delay or cancellation of surgery, additional illness, and even death, and have therefore attracted much attention. In this article, we draw on several sources of information, including (i) guidelines on adverse reactions related to immune checkpoint inhibitors, (ii) published data from large‐scale clinical studies in thoracic surgery, and (iii) practical experience and published cases, to provide clinical recommendations on adverse events in NSCLC patients induced by perioperative immunotherapy.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v12.9
    DOI: 10.1111/1759-7714.13942
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2559245-2
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  • 3
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    Periprocedural myocardial infarction is associated with increased mortality in patients with coronary artery bifurcation lesions after implantation of a drug‐eluting stent
    Wiley ; 2015
    In:  Catheterization and Cardiovascular Interventions Vol. 85, No. S1 ( 2015-03), p. 696-705
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 85, No. S1 ( 2015-03), p. 696-705
    Abstract: The present study aimed to investigate the association between periprocedural myocardial infarction (PMI), defined by creatine kinase (CK)‐MB or troponin I (TNI) level elevations 〉 5 times the 99th percentile of the upper reference limit (URL) within 48 hr after implantation of a drug‐eluting stent (DES), and one‐year mortality in patients with coronary bifurcation. Background PMI is reported to be associated with increased one‐year mortality after DES implantation. However, the prevalence and association of PMI with mortality after stenting bifurcation lesions remains unclear. Methods We prospectively followed 1,971 patients with true coronary bifurcations who underwent DES implantation as part of the multicenter DEFINITION study. These patients were grouped into categories based on PMI outcome: Non‐PMI, CKMB‐PMI, TNI‐PMI, and CKMB/TNI‐PMI. The primary endpoint was the rate of all‐cause mortality at one year. Results PMI occurred in 11.4% of patients by CKMB criteria and 41.3% of patients by TNI criteria. At one‐year follow‐up, the mortality rate was 2.3% in the entire patient population. However, mortality was significantly higher in the CKMB‐PMI (6.4%) and CKMB/TNI‐PMI (6.1%) groups compared to the Non‐PMI (1.7%) and TNI‐PMI (2.1%) groups (all P   〈  0.05). A 10‐fold increase in TNI levels resulted in similar PMI rate (5.2%) and mortality risk (adjusted HR 2.7, 95% CI 3.0–5.2) as a fivefold increase in CKMB levels. Conclusions PMI, as defined by CKMB elevations following coronary bifurcation lesion stenting, was associated with increased one‐year mortality. Additionally, to attain an equal frequency of PMI, the elevation in TNI levels needed to be twice as high as the elevation in CKMB levels. © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v85.S1
    DOI: 10.1002/ccd.25857
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2001555-0
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  • 4
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    Non‐pharmacological treatment reducing not only behavioral symptoms, but also psychotic symptoms of older adults with dementia: A prospective cohort study in T aiwan
    Wiley ; 2014
    In:  Geriatrics & Gerontology International Vol. 14, No. 2 ( 2014-04), p. 440-446
    Details
    In: Geriatrics & Gerontology International, Wiley, Vol. 14, No. 2 ( 2014-04), p. 440-446
    Abstract: The clinical effectiveness of non‐pharmacological interventions on behavioral and psychological symptoms of dementia ( BPSD ) among older C hinese with dementia remains unclear, and the evidence supporting the benefits of a non‐pharmacological approach on psychotic symptoms is scarce. Methods A prospective cohort study including 104 older men with dementia living in two veterans homes in T aiwan was carried out in 2011. An organized program of music therapy, orientation training, art‐cognitive activities and physical activities was carried out for the intervention group. All participants were evaluated for neuropsychiatric inventory (NPI), defined daily dose of psychotropic drug use, B arthel I ndex, I nstrumental A ctivities of D aily L iving, M ini‐ M ental S tate E xamination, G eriatric D epression S cale, T inetti balance score and T inetti gait score. Results Overall, 104 residents were enrolled and 92 of them completed the study. The intervention group had a more significant reduction than the reference group in the overall NPI score (−2.36, P  = 0.046), and in the subcategories of delusion (−0.9, P  = 0.018), hallucination (−0.82, P  = 0.004) and agitation (−0.91, P  = 0.038). Multivariate analysis showed that the non‐pharmacological intervention was associated with a favorable outcome in overall NPI score ( OR 4.113, P  = 0.013) and in the subcategories of hallucination ( OR 14.309, P  = 0.049) and agitation ( OR 6.604, P  = 0.037). Meanwhile, a higher baseline NPI score was also associated with a favorable outcome in overall NPI score, and in the subcategories of delusion, hallucination and agitation. Conclusion Non‐pharmacological interventions have a positive effect on behavioral and psychological symptoms of dementia, not only in outward symptoms like agitation, but also intrinsic psychotic symptoms like hallucination and delusion, and agitation in older Chinese men with dementia. Geriatr Gerontol Int 2013; 14: 440–446.
    Type of Medium: Online Resource
    ISSN: 1444-1586 , 1447-0594
    URL: Issue
    URL: Article
    DOI: 10.1111/ggi.2014.14.issue-2
    DOI: 10.1111/ggi.12126
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2078308-5
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  • 5
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    Pediatric acute lymphoblastic leukemia with t(1;19)/ TCF3‐PBX1 in Taiwan
    Wiley ; 2017
    In:  Pediatric Blood & Cancer Vol. 64, No. 10 ( 2017-10)
    Details
    In: Pediatric Blood & Cancer, Wiley, Vol. 64, No. 10 ( 2017-10)
    Abstract: In childhood acute lymphoblastic leukemia (ALL), t(1;19)(q23;p13.3) with TCF3‐PBX1 fusion is one of the most frequent translocations. Historically, it has been associated with poor prognosis. Intensive treatment, however, has improved its outcome. We determined the outcome of children with this genotype treated with contemporary intensive chemotherapy in Taiwan. Procedure In Taiwan Pediatric Oncology Group 2002 ALL studies, genotypes were determined by cytogenetic analysis and/or reverse transcriptase polymerase chain reaction assay. Based on presenting features, immunophenotype and genotype, patients were assigned to one of the three risk groups: standard risk (SR), high risk (HR), or very high risk (VHR). The patients with t(1;19)/ TCF3‐PBX1 were treated in the HR arm receiving more intensive chemotherapy. The outcomes of patients with t(1;19)/ TCF3‐PBX1 were compared to that of patients with other subtypes of B‐precursor ALL (B‐ALL). Results Of the 1,129 patients with B‐ALL, 64 (5.7%) had t(1;19)/ TCF3‐PBX1 ; 51 of whom were treated in the HR arm, but 11 were treated in the VHR and 2 in the SR arm because of physician's preference. As a group, 64 patients with t(1;19)/ TCF3‐PBX1 had similar 5‐year event‐free survival (83.3 ± 4.8%) as those with TEL‐AML1 (85.2 ± 3.4%, P = 0.984) or those with hyperdiploidy 〉 50 (84.0 ± 3.1%, P = 0.748). The cumulative risk of any (isolated plus combined) central nervous system relapse among patients with t(1;19)/ TCF3‐PBX1 (8.7 ± 3.8%) tended to be higher than that of patients with TEL‐AML1 (5.8 ± 2.3%, P = 0.749) or those with hyperdiploidy (4.1 ± 1.8%, P = 0.135), albeit the differences did not reach statistical significance. Conclusions With contemporary intensive chemotherapy, children with t(1;19)/ TCF3‐PBX1 fared as well as those with favorable genotypes ( TEL‐AML1 or hyperdiploidy).
    Type of Medium: Online Resource
    ISSN: 1545-5009 , 1545-5017
    URL: Issue
    URL: Article
    DOI: 10.1002/pbc.v64.10
    DOI: 10.1002/pbc.26557
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2130978-4
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  • 6
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    Development and validation of a prognostic model incorporating tumor thrombus grading for nonmetastatic clear cell renal cell carcinoma with tumor thrombus: A multicohort study
    Wiley ; 2023
    In:  MedComm Vol. 4, No. 4 ( 2023-08)
    Details
    In: MedComm, Wiley, Vol. 4, No. 4 ( 2023-08)
    Abstract: There is significant variability with respect to the prognosis of nonmetastatic clear cell renal cell carcinoma (ccRCC) patients with venous tumor thrombus (VTT). By applying multiregion whole‐exome sequencing on normal‐tumor‐thrombus‐metastasis quadruples from 33 ccRCC patients, we showed that metastases were mainly seeded by VTT (81.8%) rather than primary tumors (PTs). A total of 706 nonmetastatic ccRCC patients with VTT from three independent cohorts were included in this study. C‐index analysis revealed that pathological grading of VTT outperformed other indicators in risk assessment (OS: 0.663 versus 0.501–0.610, 0.667 versus 0.544–0.651, and 0.719 versus 0.511–0.700 for Training, China‐Validation, and Poland‐Validation cohorts, respectively). We constructed a risk predicting model, TT‐GPS score, based on four independent variables: V TT height, VTT g rading, p erinephric fat invasion, and s arcomatoid differentiation in PT. The TT‐GPS score displayed better discriminatory ability (OS, c‐index: 0.706–0.840, AUC: 0.788–0.874; DFS, c‐index: 0.691–0.717, AUC: 0.771–0.789) than previously reported models in risk assessment. In conclusion, we identified for the first‐time pathological grading of VTT as an unheeded prognostic factor. By incorporating VTT grading, the TT‐GPS score is a promising prognostic tool in predicting the survival of nonmetastatic ccRCC patients with VTT.
    Type of Medium: Online Resource
    ISSN: 2688-2663 , 2688-2663
    URL: Issue
    URL: Article
    DOI: 10.1002/mco2.v4.4
    DOI: 10.1002/mco2.300
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3021470-1
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  • 7
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    Unveiling unique alternative splicing responses to low temperature in Zoysia japonica through ZjRTD1 .0, a high‐quality reference transcript dataset
    Wiley ; 2024
    In:  Physiologia Plantarum Vol. 176, No. 2 ( 2024-03)
    Details
    In: Physiologia Plantarum, Wiley, Vol. 176, No. 2 ( 2024-03)
    Abstract: Inadequate reference databases in RNA‐seq analysis can hinder data utilization and interpretation. In this study, we have successfully constructed a high‐quality reference transcript dataset, ZjRTD1.0, for Zoysia japonica , a widely‐used turfgrass with exceptional tolerance to various abiotic stress, including low temperatures and salinity. This dataset comprises 113,089 transcripts from 57,143 genes. BUSCO analysis demonstrates exceptional completeness (92.4%) in ZjRTD1.0, with reduced proportions of fragmented (3.3%) and missing (4.3%) orthologs compared to prior datasets. ZjRTD1.0 enables more precise analyses, including transcript quantification and alternative splicing assessments using public datasets, which identified a substantial number of differentially expressed transcripts (DETs) and differential alternative splicing (DAS) events, leading to several novel findings on Z. japonica 's responses to abiotic stresses. First, spliceosome gene expression influenced alternative splicing significantly under abiotic stress, with a greater impact observed during low‐temperature stress. Then, a significant positive correlation was found between the number of differentially expressed genes (DEGs) encoding protein kinases and the frequency of DAS events, suggesting the role of protein phosphorylation in regulating alternative splicing. Additionally, our results suggest possible involvement of serine/arginine‐rich (SR) proteins and heterogeneous nuclear ribonucleoproteins (hnRNPs) in generating inclusion/exclusion isoforms under low‐temperature stress. Furthermore, our investigation revealed a significantly enhanced overlap between DEGs and differentially alternatively spliced genes (DASGs) in response to low‐temperature stress, suggesting a unique co‐regulatory mechanism governing transcription and splicing in the context of low‐temperature response. In conclusion, we have proven that ZjRTD1.0 will serve as a reliable and useful resource for future transcriptomic analyses in Z. japonica .
    Type of Medium: Online Resource
    ISSN: 0031-9317 , 1399-3054
    URL: Issue
    URL: Article
    DOI: 10.1111/ppl.v176.2
    DOI: 10.1111/ppl.14280
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 208872-1
    detail.hit.zdb_id: 2020837-6
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  • 8
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    Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation : FGFR2 PROMOTES BONE FORMATION AFTER BMX
    Wiley ; 2017
    In:  Journal of Bone and Mineral Research Vol. 32, No. 11 ( 2017-11), p. 2194-2206
    Details
    In: Journal of Bone and Mineral Research, Wiley, Vol. 32, No. 11 ( 2017-11), p. 2194-2206
    Type of Medium: Online Resource
    ISSN: 0884-0431
    URL: Article
    DOI: 10.1002/jbmr.3204
    RVK:
    XA 52230
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008867-X
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  • 9
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    Depletion of m 6 A reader protein YTHDC1 induces dilated cardiomyopathy by abnormal splicing of Titin
    Wiley ; 2021
    In:  Journal of Cellular and Molecular Medicine Vol. 25, No. 23 ( 2021-12), p. 10879-10891
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 25, No. 23 ( 2021-12), p. 10879-10891
    Abstract: N 6 ‐methyladenosine (m 6 A) is the most prevalent modification in mRNA and engages in multiple biological processes. Previous studies indicated that m 6 A methyltransferase METTL3 (‘writer’) and demethylase FTO (‘eraser’) play critical roles in heart‐related disease. However, in the heart, the function of m 6 A ‘reader’, such as YTH (YT521‐B homology) domain‐containing proteins remains unclear. Here, we report that the defect in YTHDC1 but not other YTH family members contributes to dilated cardiomyopathy (DCM) in mice. Cardiac‐specific conditional Ythdc1  knockout led to obvious left ventricular chamber enlargement and severe systolic dysfunction. YTHDC1 deficiency also resulted in the decrease of cardiomyocyte contractility and disordered sarcomere arrangement. By means of integrating multiple high‐throughput sequence technologies, including m 6 A‐MeRIP, RIP‐seq and mRNA‐seq, we identified 42 transcripts as potential downstream targets of YTHDC1. Amongst them, we found that Titin mRNA was decorated with m 6 A modification and depletion of YTHDC1 resulted in aberrant splicing of Titin . Our study suggests that Ythdc1 plays crucial role in regulating the normal contractile function and the development of DCM. These findings clarify the essential role of m 6 A reader in cardiac biofunction and provide a novel potential target for the treatment of DCM.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v25.23
    DOI: 10.1111/jcmm.16955
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2076114-4
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  • 10
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    Effect of artificial liver blood purification treatment on the survival of critical ill COVID‐19 patients
    Wiley ; 2021
    In:  Artificial Organs Vol. 45, No. 7 ( 2021-07), p. 762-769
    Details
    In: Artificial Organs, Wiley, Vol. 45, No. 7 ( 2021-07), p. 762-769
    Abstract: Our aim was to investigate the effect of artificial liver blood purification treatment on the survival of severe/critical patients with coronavirus disease 2019 (COVID‐19). A total of 101 severe and critical patients with coronavirus SARS‐CoV‐2 infection were enrolled in this open, case‐control, multicenter, prospective study. According to the patients’ and their families’ willingness, they were divided into two groups. One was named the treatment group, in which the patients received artificial liver therapy plus comprehensive treatment ( n = 50), while the other was named the control group, in which the patients received only comprehensive treatment ( n = 51). Clinical data and laboratory examinations, as well as the 28‐day mortality rate, were collected and analyzed. Baseline data comparisons on average age, sex, pre‐treatment morbidity, initial symptoms, vital signs, pneumonia severity index score, blood routine examination and biochemistry indices etc. showed no difference between the two groups. Cytokine storm was detected, with a significant increase of serum interleukin‐6 (IL‐6) level. The serum IL‐6 level decreased from 119.94 to 20.49 pg/mL in the treatment group and increased from 40.42 to 50.81 pg/mL in the control group ( P   〈  .05), indicating that artificial liver therapy significantly decreased serum IL‐6. The median duration of viral nucleic acid persistence was 19 days in the treatment group (ranging from 6 to 67 days) and 17 days in the control group (ranging from 3 to 68 days), no significant difference was observed ( P  = .36). As of 28‐day follow‐up,17 patients in the treatment group experienced a median weaning time of 24 days, while 11 patients in the control group experienced a median weaning time of 35 days, with no significant difference between the two groups ( P  = .33). The 28‐day mortality rates were 16% (8/50) in the treatment group and 50.98% (26/51) in the control group, with a significant difference ( z  = 3.70, P   〈  .001). Cytokine storm is a key factor in the intensification of COVID‐19 pneumonia. The artificial liver therapy blocks the cytokine storm by clearing inflammatory mediators, thus preventing severe cases from progressing to critically ill stages and markedly reducing short‐term mortality.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.v45.7
    DOI: 10.1111/aor.13884
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2003825-2
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