In:
FEBS Letters, Wiley, Vol. 474, No. 2-3 ( 2000-06-02), p. 242-245
Abstract:
A novel organic anion transporting polypeptide (Oatp)4 1 was isolated from rat liver that is 35 amino acids longer than the reported rat liver specific organic anion transporter (rlst)‐1 and exhibits a 64% amino acid sequence identity with the human OATP‐C (LST‐1/OATP2; gene symbol SLC21A6 ). When expressed in Xenopus laevis oocytes, Oatp4 (Slc21a10) mediated polyspecific uptake of a variety of organic anions including taurocholate ( K m ∼27 μM), bromosulfophthalein ( K m ∼1.1 μM) and steroid conjugates. Based on nuclease protection analysis Oatp4 appears to be the predominant transcript in rat liver indicating that rlst‐1 plays a minor role in overall hepatic organic anion uptake.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/S0014-5793(00)01596-9
Language:
English
Publisher:
Wiley
Publication Date:
2000
detail.hit.zdb_id:
1460391-3
SSG:
12
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