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  • 1
    Online Resource
    Online Resource
    Predicting and treating stress‐Induced vulnerability to epilepsy and depression
    Wiley ; 2015
    In:  Annals of Neurology Vol. 78, No. 1 ( 2015-07), p. 128-136
    Details
    In: Annals of Neurology, Wiley, Vol. 78, No. 1 ( 2015-07), p. 128-136
    Abstract: Accumulation of stressful events can render individuals susceptible to develop epilepsy and comorbidities. Whether such vulnerability can be predicted and reversed is not known. Here we show that social defeat, although not producing depression by itself, produced in 50% of rats reduced threshold for status epilepticus (SE), accelerated epileptogenesis, and once epilepsy was induced, depression‐like profile and cognitive deficits. Low serum brain‐derived neurotrophic factor (BDNF) levels measured before SE identified this vulnerable population. Treatment with a BDNF analog before SE prevented the occurrence of comorbidities. Thus, vulnerability to comorbidities after epilepsy onset due to unresolved past stressful events may be predicted and reversed. Ann Neurol 2015;78:128–136
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v78.1
    DOI: 10.1002/ana.24414
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 80362-5
    detail.hit.zdb_id: 2037912-2
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  • 2
    Online Resource
    Online Resource
    Incidence and survival in late liver metastases of colorectal cancer
    Wiley ; 2015
    In:  Journal of Gastroenterology and Hepatology Vol. 30, No. 1 ( 2015-01), p. 82-85
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 30, No. 1 ( 2015-01), p. 82-85
    Abstract: Data concerning the risk of long‐term liver metastasis following surgery of colorectal cancer in the general population are scarce. The 10‐year incidence and prognosis of metachronous liver metastases remain unknown. Methods Among 4584 patients resected for cure for colorectal cancer recorded in two French digestive population‐based cancer registries between 1985 and 2000, 602 presented metastases including liver metastases. Results The cumulated incidence of liver metastasis was 15% at 5 years and 17% at 10 years, and was mainly related to stage at diagnosis. The 10‐year cumulative incidence was 6% for stage I and 30% for stage III . The hazard ratio was 3.2 [2.4–4.3] for stage II and 6.9 [5.1–9.2] for stage III compared with stage I . Among survivors with no recurrence five years after diagnosis, 2.2% developed liver metastasis between 5 and 10 years. Resection for cure of liver metastases was performed in 35% of patients aged under 75 years and in 10% of patients over 75 ( P   〈  0.001). After resection for cure, 10‐year relative survival improved from 21% during the period 1985–1997 to 34% during the period 1998–2011 ( P  = 0.023). Survival in patients with liver metastasis diagnosed between six and 12 months after surgery was less than half that in patients with metastasis diagnosed later ( HR : 0.6 [0.4–1.0]). Conclusion Liver metastases from colorectal cancer remain a substantial problem and continue to occur long after five years. This study furnishes unbiased figures that can be used as a reference. Liver metastases that appear late have a better prognosis.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.2015.30.issue-1
    DOI: 10.1111/jgh.12685
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 632882-9
    detail.hit.zdb_id: 2006782-3
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  • 3
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    Treatment and prognosis of hepatocellular carcinoma: A population based study in France
    Wiley ; 2008
    In:  Journal of Surgical Oncology Vol. 98, No. 7 ( 2008-12), p. 505-509
    Details
    In: Journal of Surgical Oncology, Wiley, Vol. 98, No. 7 ( 2008-12), p. 505-509
    Abstract: Few data are available from population‐based statistics on hepatocellular carcinoma (HCC). The aim of this study was to report on their management and their prognosis in a French population. Methods Between 1997 and 1998, 1,007 cases of HCC were registered in nine French departments: clinical presentation of patients with and without cirrhosis were compared as well as treatment. Prognosis was determined using crude and relative survival rates. A multivariate relative survival analysis was performed. HCC was associated with cirrhosis in 795 patients (79%) and to the absence of cirrhosis in 156 (15%). Results Whereas the presence of symptoms was the principal mode of discovery (63% of cirrhotic cases and 70% of non‐cirrhotic cases), the follow‐up of hepatic affections revealed the cancer in respectively 26% and 3% ( P  = 0.001). The diagnosis was histologically verified in 50% of cirrhotic patients and 80% of non‐cirrhotic patients ( P  = 0.01). The size of tumours was significantly greater in non‐cirrhotic than in cirrhotic cases ( P  = 0.004). Treatment for cure were implemented in respectively 15% and 30% ( P  = 0.001), resulting in 5‐year survival rates of respectively 34% and 28%. Only 24 HCC cases received a liver transplant, with a 5‐year survival rate of 60%. Surgical resection for cure was carried out in respectively 10% and 31% of HCC and HCNC cases ( P  = 0.001), with a 5‐year survival rate of respectively 39% and 29%. The overall 5‐year survival rates of HCC and HCNC were respectively 6% and 9%. Conclusion HCC with and without cirrhosis has a poor prognosis with the majority of patients receiving palliative treatments, the efficiency of which is very limited. Considerable efforts are needed to develop primary and secondary prevention. J. Surg. Oncol. 2008;98:505–509. © 2008 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0022-4790 , 1096-9098
    URL: Issue
    URL: Article
    DOI: 10.1002/jso.v98:7
    DOI: 10.1002/jso.21159
    Language: English
    Publisher: Wiley
    Publication Date: 2008
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    detail.hit.zdb_id: 1475314-5
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  • 4
    Online Resource
    Online Resource
    Resistance to thienopyridines: Clinical detection of coronary stent thrombosis by monitoring of vasodilator‐stimulated phosphoprotein phosphorylation
    Wiley ; 2003
    In:  Catheterization and Cardiovascular Interventions Vol. 59, No. 3 ( 2003-07), p. 295-302
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 59, No. 3 ( 2003-07), p. 295-302
    Abstract: We carried out a prospective evaluation of a new vasodilator‐stimulated phosphoprotein (VASP) phosphorylation assay in order to detect patients with high‐risk coronary subacute stent thrombosis (SAT) despite thienopyridine regimen. Twenty healthy donors (group 1) without any medication were compared to 16 stented patients (group 2) treated by ticlopidin or clopidogrel initiated 2 days before stenting and aspirin (250 mg/day). No difference in platelet reactivity was noted between group 1 and group 2 treated only with aspirin (72.00% ± 4.17% vs. 69.73% ± 5.62%, respectively; P = NS). Significant differences were found between patients of group 2 treated with aspirin alone (69.73% ± 5.62%), after 2.0 days (60.14% ± 9.60%; P 〈 0.05), and after 4.8 ± 1.3 days (48.37% ± 11.19%; P 〈 0.05) with thienopyridine‐aspirin. Among 1,684 consecutive stented patients, 16 patients who presented an SAT (group 3) were compared with 30 other stented patients free of SAT (group 4). We found a significant difference between group 3 (63.28% ± 9.56%) and group 4 (39.80% ± 10.9%; P 〈 0.0001). VASP phosphorylation analysis may be useful for the detection of coronary SAT. Cathet Cardiovasc Intervent 2003;59:295–302. © 2003 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v59:3
    DOI: 10.1002/ccd.10497
    Language: English
    Publisher: Wiley
    Publication Date: 2003
    detail.hit.zdb_id: 1459995-8
    detail.hit.zdb_id: 2001555-0
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  • 5
    Online Resource
    Online Resource
    Partial nephrectomy after selective embolization of tumor vessels in a hybrid operating room: A new approach of zero ischemia in renal surgery
    Wiley ; 2016
    In:  Journal of Surgical Oncology Vol. 113, No. 2 ( 2016-02), p. 135-137
    Details
    In: Journal of Surgical Oncology, Wiley, Vol. 113, No. 2 ( 2016-02), p. 135-137
    Abstract: It is established that partial nephrectomy is the standard of care for tumors confined to the kidney. Achieving a partial nephrectomy without renal ischemia and limiting operative bleeding is the subject of numerous researches. Since 2010, hybrid operating rooms have been used to perform both interventional radiology and surgical procedures at the same place and time. We used this latest technology to treat 3 patients with localized kidney tumors. The tumors were of moderate complexity and all were treated after immediate hyperselective embolization by laparoscopic surgery without dissection and clamping of the renal pedicle. The embolization of tumor vessels could be performed using image‐stitching software. After embolization, operative time was 50, 70 and 80 minutes and blood loss was less than 100 ml for each case. Postoperative control 3D arteriography confirmed the respect of the vascularization of the healthy renal parenchyma. No postoperative complications occurred. Combined approach including hyperselective embolization and partial nephrectomy in the same time in a dedicated operating room is a new approach of zero ischemia during partial nephrectomy which reduces the difficulty of the surgery, limits injury to the kidney and increases patient safety. J. Surg. Oncol. 2016;113:135–137 . © 2015 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0022-4790 , 1096-9098
    URL: Issue
    URL: Article
    DOI: 10.1002/jso.v113.2
    DOI: 10.1002/jso.24120
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 82063-5
    detail.hit.zdb_id: 1475314-5
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  • 6
    Online Resource
    Online Resource
    C 4 anatomy can evolve via a single developmental change
    Wiley ; 2019
    In:  Ecology Letters Vol. 22, No. 2 ( 2019-02), p. 302-312
    Details
    In: Ecology Letters, Wiley, Vol. 22, No. 2 ( 2019-02), p. 302-312
    Abstract: C 4 photosynthesis is a complex trait that boosts productivity in warm environments. Paradoxically, it evolved independently in numerous plant lineages, despite requiring specialised leaf anatomy. The anatomical modifications underlying C 4 evolution have previously been evaluated through interspecific comparisons, which capture numerous changes besides those needed for C 4 functionality. Here, we quantify the anatomical changes accompanying the transition between non‐C 4 and C 4 phenotypes by sampling widely across the continuum of leaf anatomical traits in the grass Alloteropsis semialata . Within this species, the only trait that is shared among and specific to C 4 individuals is an increase in vein density, driven specifically by minor vein development that yields multiple secondary effects facilitating C 4 function. For species with the necessary anatomical preconditions, developmental proliferation of veins can therefore be sufficient to produce a functional C 4 leaf anatomy, creating an evolutionary entry point to complex C 4 syndromes that can become more specialised.
    Type of Medium: Online Resource
    ISSN: 1461-023X , 1461-0248
    URL: Issue
    URL: Article
    DOI: 10.1111/ele.2019.22.issue-2
    DOI: 10.1111/ele.13191
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1441608-6
    detail.hit.zdb_id: 2020195-3
    SSG: 12
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