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  • 1
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    Online Resource
    Trends in survival of children with severe congenital heart defects by gestational age at birth: A population‐based study using administrative hospital data for England
    Wiley ; 2023
    In:  Paediatric and Perinatal Epidemiology Vol. 37, No. 5 ( 2023-07), p. 390-400
    Details
    In: Paediatric and Perinatal Epidemiology, Wiley, Vol. 37, No. 5 ( 2023-07), p. 390-400
    Abstract: Children with congenital heart defects (CHD) are twice as likely as their peers to be born preterm ( 〈 37 weeks' gestation), yet descriptions of recent trends in long‐term survival by gestational age at birth (GA) are lacking. Objectives To quantify changes in survival to age 5 years of children in England with severe CHD by GA. Methods We estimated changes in survival to age five of children with severe CHD and all other children born in England between April 2004 and March 2016, overall and by GA‐group using linked hospital and mortality records. Results Of 5,953,598 livebirths, 5.7% (339,080 of 5,953,598) were born preterm, 0.35% (20,648 of 5,953,598) died before age five and 3.6 per 1000 (21,291 of 5,953,598) had severe CHD. Adjusting for GA, under‐five mortality rates fell at a similar rate between 2004–2008 and 2012–2016 for children with severe CHD (adjusted hazard ratio [HR] 0.79, 95% CI 0.71, 0.88) and all other children (HR 0.78, 95% CI 0.76, 0.81). For children with severe CHD, overall survival to age five increased from 87.5% (95% CI 86.6, 88.4) in 2004–2008 to 89.6% (95% CI 88.9, 90.3) in 2012–2016. There was strong evidence for better survival in the ≥39‐week group (90.2%, 95% CI 89.1, 91.2 to 93%, 95% CI 92.4, 93.9), weaker evidence at 24–31 and 37–38 weeks and no evidence at 32–36 weeks. We estimate that 51 deaths (95% CI 24, 77) per year in children with severe CHD were averted in 2012–2016 compared to what would have been the case had 2004–2008 mortality rates persisted. Conclusions Nine out of 10 children with severe CHD in 2012–2016 survived to age five. The small improvement in survival over the study period was driven by increased survival in term children. Most children with severe CHD are reaching school age and may require additional support by schools and healthcare services.
    Type of Medium: Online Resource
    ISSN: 0269-5022 , 1365-3016
    URL: Issue
    URL: Article
    DOI: 10.1111/ppe.v37.5
    DOI: 10.1111/ppe.12959
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008566-7
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  • 2
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    Effect of a Long‐Term Intensive Lifestyle Intervention on Cognitive Function: Action for Health in Diabetes Study
    Wiley ; 2017
    In:  Journal of the American Geriatrics Society Vol. 65, No. 5 ( 2017-05), p. 966-972
    Details
    In: Journal of the American Geriatrics Society, Wiley, Vol. 65, No. 5 ( 2017-05), p. 966-972
    Abstract: To assess whether randomization to 10 years of lifestyle intervention to induce and maintain weight loss improves cognitive function. Design Randomized controlled clinical trial. Setting Data obtained as part of the Action for Health in Diabetes (Look AHEAD ) trial ( NCT 00017953) and Look AHEAD Continuation study (U01 DK 057136‐15). Participants Overweight and obese individuals with type 2 diabetes mellitus aged 45 to 76 (N = 3,751). Intervention Intensive lifestyle intervention ( ILI ) for weight loss through reduced caloric intake and increased physical activity compared with a control condition of diabetes support and education ( DSE ). Measurements Certified examiners who were masked to intervention assignment administered a standard battery of cognitive function tests (Modified Mini‐Mental State Examination, Rey Auditory Verbal Learning Test, Digit Symbol Coding, Trail‐Making Test, Modified Stroop Color‐Word Test) to participants 10 to 13 years after enrollment. Results Assignment to lifestyle intervention was not associated with significantly different overall ( P = .10) or domain‐specific (all P 〉 .10) cognitive function than assignment to diabetes support and education. Results were fairly consistent across prespecified groups, but there was some evidence of trends for differential intervention effects showing modest harm in ILI in participants with greater body mass index and in individuals with a history of cardiovascular disease. Cognitive function was not associated with changes in weight or fitness (all P 〉 .05). Conclusion A long‐term behavioral weight loss intervention for overweight and obese adults with diabetes mellitus was not associated with cognitive benefit. Trial Registration clinicaltrials.gov Identifier: NCT 00017953.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    URL: Article
    DOI: 10.1111/jgs.2017.65.issue-5
    DOI: 10.1111/jgs.14692
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2040494-3
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  • 3
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    Synthesis, structure, and characterization of the thorium zirconolite CaZr 1‐x Th x Ti 2 O 7 system
    Wiley ; 2021
    In:  Journal of the American Ceramic Society Vol. 104, No. 7 ( 2021-07), p. 2937-2951
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 104, No. 7 ( 2021-07), p. 2937-2951
    Abstract: A series of zirconolite ceramics with composition CaZr 1‐x Th x Ti 2 O 7 (Δx = 0.10) were reactively sintered at 1350°C for 20 h, in air (0 ≤ x ≤ 0.60) and 5% H 2 /N 2 (0 ≤ x ≤ 0.40). A sample with composition corresponding to x = 0.20 was also produced by hot isostatic pressing (HIP) at 1300°C and 100 MPa for 4 hours. Th 4+ immobilization was most readily achieved under oxidizing conditions, with Th 4+ preferentially incorporated within a pyrochlore‐structured phase in the range 0.10 ≤ x ≤ 0.50, yet formation of the zirconolite‐4M polytype was not observed. We report the novel synthesis of single‐phase pyrochlore with nominal composition CaZr 0.40 Th 0.60 Ti 2 O 7 when targeting x = 0.60. Th 4+ incorporation under reducing conditions produced a secondary Th‐bearing perovskite, comprising 24.2 ± 0.6 wt% of the phase assemblage when targeting x = 0.40, alongside 8.8 ± 0.3 wt% undigested ThO 2 . Under reducing conditions, powder XRD data were consistent with zirconolite adopting the 3T polytype structure. The sample produced by HIP presented a nonequilibrium phase assemblage, yielding a major phase of zirconolite‐2M alongside accessory Th 4+ ‐bearing phases ThTi 2 O 6 , ThO 2 , and perovskite. These data highlight the efficacy of Th 4+ as a Pu 4+ surrogate, with implications for the formation of Zr‐stabilized Th‐pyrochlore phases as matrices for waste with elevated Th 4+ content.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.v104.7
    DOI: 10.1111/jace.17627
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 4
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    Expanding the clinical and phenotypic heterogeneity associated with biallelic variants in ACO2
    Wiley ; 2020
    In:  Annals of Clinical and Translational Neurology Vol. 7, No. 6 ( 2020-06), p. 1013-1028
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 7, No. 6 ( 2020-06), p. 1013-1028
    Abstract: We describe the clinical characteristics and genetic etiology of several new cases within the ACO2‐related disease spectrum. Mitochondrial aconitase (ACO2) is a nuclear‐encoded tricarboxylic acid cycle enzyme. Homozygous pathogenic missense variants in the ACO2 gene were initially associated with infantile degeneration of the cerebrum, cerebellum, and retina, resulting in profound intellectual and developmental disability and early death. Subsequent studies have identified a range of homozygous and compound heterozygous pathogenic missense, nonsense, frameshift, and splice‐site ACO2 variants in patients with a spectrum of clinical manifestations and disease severities. Methods We describe a cohort of five novel patients with biallelic pathogenic variants in ACO2 . We review the clinical histories of these patients as well as the molecular and functional characterization of the associated ACO2 variants and compare with those described previously in the literature. Results Two siblings with relatively mild symptoms presented with episodic ataxia, mild developmental delays, severe dysarthria, and behavioral abnormalities including hyperactivity and depressive symptoms with generalized anxiety. One patient presented with the classic form with cerebellar hypoplasia, ataxia, seizures, optic atrophy, and retinitis pigmentosa. Another unrelated patient presented with ataxia but developed severe progressive spastic quadriplegia. Another patient demonstrated a spinal muscular atrophy‐like presentation with severe neonatal hypotonia, diminished reflexes, and poor respiratory drive, leading to ventilator dependence until death at the age of 9 months. Interpretation In this study, we highlight the importance of recognizing milder forms of the disorder, which may escape detection due to atypical disease presentation.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v7.6
    DOI: 10.1002/acn3.51074
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2740696-9
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  • 5
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    Online Resource
    Using delimiting surveys to characterize the spatiotemporal dynamics facilitates the management of an invasive non‐native insect
    Wiley ; 2013
    In:  Population Ecology Vol. 55, No. 4 ( 2013-10), p. 545-555
    Details
    In: Population Ecology, Wiley, Vol. 55, No. 4 ( 2013-10), p. 545-555
    Abstract: The ability to ascertain abundance and spatial extent of a nascent population of a non‐native species can inform management decisions. Following initial detection, delimiting surveys, which involve the use of a finer network of samples around the focal point of a newly detected colony, are often used to quantify colony size, spatial extent, and the location of the population core. Despite the widespread use of pheromone‐baited traps in delimitation surveys to manage invading populations of Lymantria dispar (L.) in North America, there has been no prior comprehensive attempt to analytically determine the adequacy of these surveys. We used data from 2,190 delimiting grids collected from 2000 to 2010 in the United States to quantify the information gained from delimiting surveys. The use of delimiting surveys revealed that ≈53 % of populations of low initial abundance persisted as detectable populations in the following year; however, when trap data from delimiting surveys were excluded, only ≈16 % of these low density populations were detected in the following year. Measurements of abundance and spatial extent of a detected population were affected by the increased use of delimiting traps after accounting for initial abundance, the distance from an infested area, and colony area. The use of delimiting traps had a lesser effect on the estimation of the spatial location of the population core, indicating that initial detection of a population often reflects the population core. The need to prioritize resources in efforts to manage non‐native species is paramount, and early detection is a key in invasive species management.
    Type of Medium: Online Resource
    ISSN: 1438-3896 , 1438-390X
    URL: Article
    DOI: 10.1007/s10144-013-0382-5
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1474902-6
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  • 6
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    Predicting costs of alien species surveillance across varying transportation networks
    Wiley ; 2017
    In:  Journal of Applied Ecology Vol. 54, No. 1 ( 2017-02), p. 225-233
    Details
    In: Journal of Applied Ecology, Wiley, Vol. 54, No. 1 ( 2017-02), p. 225-233
    Abstract: This work predicts costs associated with surveillance of invasive species populations. We find that the cost per survey point diminishes with increasing survey point density and also depends on road network characteristics. When combined with maps for the relative risk of alien species establishment across landscapes and measures of surveillance efficacy dependent on effort, these cost predictions can increase efficiency of surveillance and eradication efforts for the gypsy moth and other invasive species.
    Type of Medium: Online Resource
    ISSN: 0021-8901 , 1365-2664
    URL: Issue
    URL: Article
    DOI: 10.1111/jpe.2017.54.issue-1
    DOI: 10.1111/1365-2664.12754
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020408-5
    detail.hit.zdb_id: 410405-5
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  • 7
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    Effects of genetic deletion of adenosine deaminase and A1 receptors in normoxic and ischemic hearts
    Wiley ; 2006
    In:  The FASEB Journal Vol. 20, No. 4 ( 2006-03)
    Details
    In: The FASEB Journal, Wiley, Vol. 20, No. 4 ( 2006-03)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v20.4
    DOI: 10.1096/fasebj.20.4.A743
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 1468876-1
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  • 8
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    The Effect of Self Efficacy and Meaning in Life on Posttraumatic Stress Disorder and Depression Severity Among Veterans
    Wiley ; 2015
    In:  Journal of Clinical Psychology Vol. 71, No. 3 ( 2015-03), p. 219-228
    Details
    In: Journal of Clinical Psychology, Wiley, Vol. 71, No. 3 ( 2015-03), p. 219-228
    Abstract: The current study examined the relationships among combat exposure, presence of and search for meaning in life, general and social self‐efficacy, and both posttraumatic stress disorder (PTSD) and depression symptom severity for a Veteran sample ( N = 93). Method Participants completed an online survey comprising the Combat Exposure Scale, Meaning in Life Questionnaire, Self‐Efficacy Scale, Depression subscale of the Depression, Anxiety, Stress Scales‐21, and PTSD Checklist‐Specific Stressor version. The majority of participants were male and Caucasian. Participants served in various service eras Results To determine factors that predicted PTSD and depression severity, separate hierarchical linear regressions were performed. In the final PTSD model, rank, combat exposure, and general self‐efficacy were significant predictors, with officer rank, lower combat exposure, and higher general self‐efficacy associated with lower PTSD severity. The interaction between combat exposure and general self‐efficacy was also significant, with self‐efficacy moderating the relationship between combat exposure and PTSD severity. For depression, rank, presence of meaning in life, and general self‐efficacy were significant predictors in the model, with officer rank, higher presence of meaning in life, and general self‐efficacy associated with lower depression severity. Conclusion A focus on strengthening self‐efficacy may assist with lower levels of PTSD and depression symptomatology after combat trauma.
    Type of Medium: Online Resource
    ISSN: 0021-9762 , 1097-4679
    URL: Issue
    URL: Article
    DOI: 10.1002/jclp.2015.71.issue-3
    DOI: 10.1002/jclp.22133
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 1475037-5
    SSG: 5,2
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  • 9
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    Rbbp4 loss disrupts neural progenitor cell cycle regulation independent of Rb and leads to Tp53 acetylation and apoptosis
    Wiley ; 2022
    In:  Developmental Dynamics Vol. 251, No. 8 ( 2022-08), p. 1267-1290
    Details
    In: Developmental Dynamics, Wiley, Vol. 251, No. 8 ( 2022-08), p. 1267-1290
    Abstract: Rbbp4 regulates neural progenitor cell cycle independent of Rb Rbbp4 loss leads to Tp53 acetylation, gamma‐H2AX labeling and apoptosis in neural progenitors Suppression of gamma‐H2AX labeling and apoptosis by Tp53 knockdown in Rbbp4 mutants indicates Rbpp4 may induce apoptosis by transcriptional activation of Tp53 independent of the DNA damage response pathway
    Type of Medium: Online Resource
    ISSN: 1058-8388 , 1097-0177
    URL: Issue
    URL: Article
    DOI: 10.1002/dvdy.v251.8
    DOI: 10.1002/dvdy.467
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1473797-8
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  • 10
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    Do deficits in mitochondrial spare respiratory capacity contribute to neuropsychological changes seen in Alzheimer’s disease? : Neuropsychology/Neuropsychological correlates of physiologic markers of cognitive decline/Dementia
    Wiley ; 2020
    In:  Alzheimer's & Dementia Vol. 16, No. S6 ( 2020-12)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 16, No. S6 ( 2020-12)
    Abstract: In clinical settings, AD is defined by characteristic deficits in neuropsychological testing supported by amyloid and tau biomarkers and neuroimaging abnormalities. The biological cause of neuropsychological changes is not established. Tau deposition correlates with, but does not fully account for all observed neuropsychological impairments. We have shown mitochondrial spare respiratory capacity (MRSC) is lowered in AD patient fibroblasts. This study investigates if fibroblast mitochondrial functional abnormalities correlate with neuropsychological/neuroimaging changes in AD. Method 10 AD patient and 10 control fibroblast samples were taken via skin biopsy. Adenosine Triphosphate (ATP) and extracellular lactate were measured using luminescent and fluorescent protocols respectively. Mitochondrial membrane potential (MMP) was measured using tetramethylrhodamine dye. Mitochondrial respiration and glycolytic function were measured using a Seahorse XF Analyzer. In‐depth Neuropsychological profiling, and brain structural MRIs were undertaken on all participants. Correlations were performed between MMP, MRSC and neuropsychological/MRI AD markers. Result Reductions in delayed (p 〈 0.0001) and immediate recall (p 〈 0.0001), semantic fluency (p 〈 0.0001), phonemic fluency (p=0.0033) and MMSE (p=0.0009) scores were seen in AD patients. After controlling for age, education and brain reserve; left hippocampal (p=0.001), left parietal (p=0.002), right parietal (p=0.001) and anterior medial prefrontal cortical (p=0.017) gray matter volumes were reduced in AD patients. Fibroblast metabolic markers showed a reduction in MMP (p=0.001), MRSC (p 〈 0.0001), glycolytic reserve(p=0.05), and extracellular lactate (p 〈 0.05) in AD patients. MRSC and MMP correlated significantly with immediate recall ([MRSC, p=0.0041],[MMP, p=0.0115] ), delayed recall ([MRSC, p=0.0013],[MMP, p=0.0138] ) and semantic memory ([MRSC, p=0.0039],[MMP, p=0.009] ) tests. The correlations between MRSC and neuropsychological measures remained after controlling for age, education and brain reserve. No correlations were seen between grey matter volumes and fibroblast metabolism. Conclusion This study highlights how in‐depth metabolic analysis of sporadic AD fibroblasts identifies functional abnormalities that correlate with neuropsychological features distinctive to AD. This work may also explain how some of the fundamental biological processes that are affected in Alzheimer’s disease may contribute to the neuropsychological profiles that define the condition.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Issue
    URL: Article
    DOI: 10.1002/alz.v16.S6
    DOI: 10.1002/alz.037527
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2201940-6
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