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  • 1
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    Stable High‐Nitrogen Energetic Trinuclear Compounds based on 4‐Amino‐3, 5‐dimethyl‐1, 2, 4‐triazole: Synthesis, Structures, Thermal and Explosive Properties
    Wiley ; 2014
    In:  Zeitschrift für anorganische und allgemeine Chemie Vol. 640, No. 7 ( 2014-06), p. 1467-1473
    Details
    In: Zeitschrift für anorganische und allgemeine Chemie, Wiley, Vol. 640, No. 7 ( 2014-06), p. 1467-1473
    Abstract: Six multi‐ligand coordination compounds of the general formula [ M 3 (AMTz) 4 (N 3 ) 6 ] [ M = Cu ( 1 ), Co ( 2 ), Ni ( 3 ), Zn ( 4 ), Mn ( 5 ), and Cd ( 6 ), AMTz = 4‐amino‐3, 5‐dimethyl‐1, 2, 4‐triazole] were synthesized using 4‐amino‐3, 5‐dimethyl‐1, 2, 4‐triazole (AMTz) and azido groups. Compounds 1 – 6 were characterized by elemental analysis and FT‐IR spectroscopy. Furthermore, compound 4 was characterized by X‐ray single crystal diffraction. The crystal structure of 4 belongs to the monoclinic P 2 1 / c space group. Surprisingly, the Zn1 cations are five‐coordinated with two AMTz molecules as the bidentate ligands through N1 and N5 atoms, two azido ligands with μ‐1 coordination modes and one azido ligand with μ‐1, 1 coordination mode. In addition, the Zn2 cation is six‐coordinated with four AMTz molecules as the bidentate ligands through N2 and N6 atoms, and two azido ligands with μ‐1, 1 coordination modes. Thermal decomposition mechanisms were determined based on differential scanning calorimetry (DSC), and kinetic parameters of the first exothermic process were studied using Kissinger's and Ozawa's method, respectively. The critical temperatures of thermal explosion, entropies of activation (Δ S ≠ ), enthalpies of activation (Δ H ≠ ), and free energies of activation (Δ G ≠ ) were calculated. In the end, the sensitivities properties were also determined with standard methods.
    Type of Medium: Online Resource
    ISSN: 0044-2313 , 1521-3749
    URL: Issue
    URL: Article
    DOI: 10.1002/zaac.v640.7
    DOI: 10.1002/zaac.201300446
    RVK:
    VA 8102
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 201094-X
    detail.hit.zdb_id: 1481139-X
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  • 2
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    Expression of CXCR4 and VEGF‐C is correlated with lymph node metastasis in non‐small cell lung cancer
    Wiley ; 2017
    In:  Thoracic Cancer Vol. 8, No. 6 ( 2017-11), p. 634-641
    Details
    In: Thoracic Cancer, Wiley, Vol. 8, No. 6 ( 2017-11), p. 634-641
    Abstract: This study investigated the correlations between CXCR4 and VEGF‐C expression and lymph node metastasis in non‐small cell lung cancer (NSCLC). Methods Tumor specimens, lymph nodes, and normal lung tissues were obtained from 110 NSCLC patients who underwent complete resection. Quantitative reverse transcription‐PCR and immunohistochemistry assays were conducted to evaluate messenger RNA (mRNA) and protein expression of CXCR4 and VEGF‐C. Logistic regression analysis was performed to determine the independent risk factors for lymph node metastasis in NSCLC. Results CXCR4 and VEGF‐C mRNA expression were observed in 78 (70.9%) and 64 (58.2%) lung cancer tissues, while CXCR4 and VEGF‐C protein expression were observed in 76 (69.9%) and 58 (52.7%) lung cancer tissues, respectively. The expression rates of CXCR4 and VEGF‐C mRNA in metastatic lymph nodes were 84.8% and 66.7%, which were higher than that in non‐metastatic lymph nodes (27.3% and 18.2%), respectively. Logistic regression analysis revealed that positive expressions of CXCR4 and VEGF‐C mRNA were independent risk factors for lymph node metastasis in NSCLC. Furthermore, combined expression of CXCR4 and VEGF‐C showed a much higher odds ratio than CXCR4 or VEGF‐C expression alone. Conclusions CXCR4 and VEGF‐C were highly expressed in lung cancer tissues and metastatic lymph nodes. CXCR4 and VEGF‐C expression levels were significantly correlated with lymph node metastasis in NSCLC. CXCR4 and VEGF‐C might synergically promote lymphatic metastasis in lung cancer and might be a clinical predictor of lymph node metastasis in NSCLC patients.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.2017.8.issue-6
    DOI: 10.1111/1759-7714.12500
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2559245-2
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  • 3
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    Association between Weitbrecht's Retinaculum Injury and Femoral Head Necrosis in Femoral Neck Fractures
    Wiley ; 2022
    In:  Orthopaedic Surgery Vol. 14, No. 8 ( 2022-08), p. 1759-1767
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 14, No. 8 ( 2022-08), p. 1759-1767
    Abstract: To investigate associations between femoral head necrosis (FHN) and injury to the retinaculum of Weitbrecht in patients with femoral neck fractures who had undergone initial trials of either closed reduction or direct open reduction. Methods This prospective observational study included 110 patients with displaced femoral neck fractures admitted to the Sixth People's Hospital Affiliated to Shanghai Jiaotong University and Shanghai Tongji Hospital between January 2008 and May 2017. Among these, 25 patients underwent initial closed reductions, and 85 patients underwent an open reduction directly. Watson‐Jones anterolateral approach was used during the surgery for injury to the retinaculum of Weitbrecht, and FHN was assessed as a surgical outcome. The severity of injury to the retinaculum of Weitbrecht was evaluated using a scoring system developed by our surgical team. Follow‐up was at least 24 months. Results The initial closed reduction treatment group had significantly higher total scores of injury to the retinaculum of Weitbrecht (6.24 ± 2.20 vs 4.62 ± 2.12, p  = 0.009) compared to the open reduction group. High total scores were significantly associated with initial trials of closed reduction treatment, especially for the broken and released injury to the superior and anterior retinacula (both p  = 0.01). Twenty‐six patients experienced FHN postoperatively, with mean onset time of 19.42 ± 3.87 months. FHN was significantly associated with the severity of injury to the retinaculum of Weitbrecht ( p   〈  0.001) at the superior, anterior, and inferior retinacula. FHN was significantly associated with injury to the retinaculum of Weitbrecht in females. Conclusions Femoral neck displacement in patients treated initially with closed reduction is associated with subsequent injury to the retinaculum of Weibrecht, which may lead to FHN. Severity of injury to the retinaculum of Weibrecht may be used as a biomarker to evaluate bone necrosis in patients with femoral neck fractures.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.v14.8
    DOI: 10.1111/os.13378
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2483883-4
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  • 4
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    Allogeneic hand transplantation and rehabilitation of hand function: a 10‐year follow‐up study
    Wiley ; 2016
    In:  International Wound Journal Vol. 13, No. 6 ( 2016-12), p. 1303-1308
    Details
    In: International Wound Journal, Wiley, Vol. 13, No. 6 ( 2016-12), p. 1303-1308
    Abstract: The purpose of this study is to present the long‐term outcomes of allogenic hand transplantations performed at our centre. Between January 2001 and October 2002, five allogeneic limb transplantations were performed in three patients (two bilateral forearm and one left hand transplantation). Donors and recipients were matched for blood types ( ABO/Rh ) and had at least two human leukocyte antigen (HLA) matches. A comprehensive rehabilitation plan integrating preoperative, intraoperative and postoperative management was developed for each patient. After 10 years, all transplantations were performed successfully without complications. As of 2014, all grafts were viable. The transplanted hands showed palmate morphology, perceived superficial pain and tactile sensations, and the static two‐point discrimination ranged from 2·5 to 4·0 mm. Chronic rejection at 4 years after surgery reduced hand function in case 2. Grip strength ranged from 3 kg (case 2) to 16–18 kg (case 1) to 41–43 kg for case 3. Lifting strength ranged from 3 kg (case 2) to 21–23 kg (case 1) to 47–51 kg for case 3. They lead a completely independent life. In summary, hand function following allogeneic limb transplantation allows the ability to perform tasks of daily living.
    Type of Medium: Online Resource
    ISSN: 1742-4801 , 1742-481X
    URL: Issue
    URL: Article
    DOI: 10.1111/iwj.2016.13.issue-6
    DOI: 10.1111/iwj.12520
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2152163-3
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  • 5
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    Transient flow in wellbores and phase transition of CO 2 during formation supercritical CO 2 invasion
    Wiley ; 2019
    In:  Energy Science & Engineering Vol. 7, No. 2 ( 2019-04), p. 323-337
    Details
    In: Energy Science & Engineering, Wiley, Vol. 7, No. 2 ( 2019-04), p. 323-337
    Abstract: CO 2 reservoirs and high CO 2 content gas reservoirs in marine sediments generally have complex pressure system, which usually encounters supercritical CO 2 ( SC ‐ CO 2 ) invasion into the wellbore during drilling process. The wellbore transient flow and phase transition along the wellbore during the drilling process has not been thoroughly investigated, because the CO 2 physical properties and the reservoirs petrophysical properties could affect the transient flow of mixed fluid and phase transition of CO 2 along the well. A numerical model is presented in this research to analyze the transient flow in wellbores and to predict phase transition of CO 2 during formation SC ‐ CO 2 invasion in the drilling process. The main considerations were the following: multiphase transient flow in wellbores was coupled with the non‐Darcy flow through the formation; wellbore temperature, pressure and the mixture of drilling fluid and SC ‐ CO 2 were calculated in the method of coupling; the invaded SC ‐ CO 2 could affect the mixed fluid physical properties in the annulus; the change of physical properties of CO 2 (eg, solubility, phase transition) was considered and integrated. The research results indicate that as the mixture of drilling fluid and SC ‐ CO 2 flows from the bottom to the surface, the invaded CO 2 is difficult to be detected at the early invasion stage because of high CO 2 density and solubility; the CO 2 would change from supercritical to gas phase and the dissolved quantity and density of CO 2 rapidly decrease near the wellhead, and further cause well‐control issues. Furthermore, the bottom‐hole pressure ( BHP ) would decrease and could not provide sufficient balance to the formation pressure, which could significantly increase the risk of well blowout. Sensitivity analysis was utilized to evaluate the effects of the choke pressure, drilling fluid pumping rate, initial pressure difference, reservoir permeability, and drilled reservoir thickness on the BHP and the depth of phase transition of CO 2 .
    Type of Medium: Online Resource
    ISSN: 2050-0505 , 2050-0505
    URL: Issue
    URL: Article
    DOI: 10.1002/ese3.2019.7.issue-2
    DOI: 10.1002/ese3.256
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2720339-6
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  • 6
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    Improving Efficiency and Stability of p– i –n Perovskite Solar Cells by Capsaicin‐Based Antisolvent Additive Engineering
    Wiley ; 2023
    In:  Solar RRL
    Details
    In: Solar RRL, Wiley
    Abstract: Improving the morphology and crystallinity of polycrystalline perovskite films is essential for perovskite solar cells (PSCs) with high efficiency and stability. Herein, capsaicin‐based antisolvent additive engineering (AAE) is proposed to fabricate MAPbI 3 ‐based p– i –n PSCs by simply adding capsaicin into antisolvent to simultaneously regulate crystallization and passivate defects of perovskite films. Meanwhile, a more n‐type surface is formed by the spatially confined distribution of capsaicin at grain boundaries and top interfaces of perovskite induced by the proposed AAE process, which facilitates the transport of charge carriers. As a result, the MAPbI 3 ‐based PSCs with p– i –n architecture achieve a high power conversion efficiency (PCE) of 20.85% with negligible hysteresis (active area of 0.07 cm 2 ), as well as an improved stability by maintaining 70.7% of the initial PCE after monitoring for over 400 h under ambient environment (25%–35% relative humidity) without encapsulation. In this work, a facile and effective strategy is proposed to prepare high‐quality perovskite films, which improves the efficiency and stability of PSCs and paves the way for further commercialization of PSCs.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Article
    DOI: 10.1002/solr.202300511
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2882014-9
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  • 7
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    Indications, strategies, and development on prostate targeted biopsy: Report of the Panjiayuan Consensus Conference 2022
    Wiley ; 2023
    In:  UroPrecision Vol. 1, No. 1 ( 2023-03), p. 3-19
    Details
    In: UroPrecision, Wiley, Vol. 1, No. 1 ( 2023-03), p. 3-19
    Abstract: Prostate biopsy is the gold standard for diagnosing prostate cancer (PCa). Prostate targeted biopsy (TB) having a higher rate of detecting clinically significant PCa (csPCa) than traditional systematic biopsy (SB) is supported by high‐quality evidence. However, the TB indications and strategies are controversial. The National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences, invited a panel of recognized urology experts in PCa to address these topics at the Panjiayuan Consensus Conference 2022. The conference results on prostate TB are presented herein. The National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences identified 10 key areas of prostate biopsy: (1) selection of imaging examination; (2) indications of TB; (3) transperineal and transrectal prostate biopsy; (4) TB pathways; (5) TB and SB; (6) three techniques of TB; (7) the number of TB cores needed for one lesion; (8) core number for SB; (9) free‐hand TB; (10) future development of TB/prostate diagnosis. Thus, a panel of 25 recognized urologists and 2 radiologists from China were invited to attend this conference. The panel voted anonymously on 14 predetermined questions. Voting was based on the panelists' clinical practice and opinion, rather than high‐level evidence. The voting outcomes were supported by the panel unequally, and details of the voting results were reported. The voting results can help clinicians to decide on biopsy timing and proper strategies, for which guidelines are sparse. We also focused on the future development of TB and SB, such as the combined pathway of TB and SB, techniques of TB, biopsy cores, free‐hand TB, and prostate‐specific membrane antigen positron emission tomography/computed tomography.
    Type of Medium: Online Resource
    ISSN: 2835-1053 , 2835-1053
    URL: Issue
    URL: Article
    DOI: 10.1002/uro2.v1.1
    DOI: 10.1002/uro2.18
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 8
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    Cytokine activin C ameliorates chronic neuropathic pain in peripheral nerve injury rodents by modulating the TRPV1 channel
    Wiley ; 2020
    In:  British Journal of Pharmacology Vol. 177, No. 24 ( 2020-12), p. 5642-5657
    Details
    In: British Journal of Pharmacology, Wiley, Vol. 177, No. 24 ( 2020-12), p. 5642-5657
    Abstract: The cytokine activin C is mainly expressed in small‐diameter dorsal root ganglion (DRG) neurons and suppresses inflammatory pain. However, the effects of activin C in neuropathic pain remain elusive. Experimental Approach Male rats and wild‐type and TRPV1 knockout mice with peripheral nerve injury ‐ sciatic nerve axotomy and spinal nerve ligation in rats; chronic constriction injury (CCI) in mice – provided models of chronic neuropathic pain. Ipsilateral lumbar (L)4–5 DRGs were assayed for activin C expression. Chronic neuropathic pain animals were treated with intrathecal or locally pre‐administered activin C or the vehicle. Nociceptive behaviours and pain‐related markers in L4–5 DRGs and spinal cord were evaluated. TRPV1 channel modulation by activin C was measured. Key Results Following peripheral nerve injury, expression of activin βC subunit mRNA and activin C protein was markedly up‐regulated in L4–5 DRGs of animals with axotomy, SNL or CCI . [Correction added on 26 November 2020, after first online publication: The preceding sentence has been corrected in this current version.] Intrathecal activin C dose‐dependently inhibited neuropathic pain in spinal nerve ligated rats. Local pre‐administration of activin C decreased neuropathic pain, macrophage infiltration into ipsilateral L4–5 DRGs and microglial reaction in L4–5 spinal cords of mice with CCI. In rat DRG neurons, activin C enhanced capsaicin‐induced TRPV1 currents. Pre‐treatment with activin C reduced capsaicin‐evoked acute hyperalgesia and normalized capsaicin‐evoked persistent hypothermia in mice. Finally, the analgesic effect of activin C was abolished in TRPV1 knockout mice with CCI. Conclusion and Implications Activin C inhibits neuropathic pain by modulating TRPV1 channels, revealing potential analgesic applications in chronic neuropathic pain therapy.
    Type of Medium: Online Resource
    ISSN: 0007-1188 , 1476-5381
    URL: Issue
    URL: Article
    DOI: 10.1111/bph.v177.24
    DOI: 10.1111/bph.15284
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029728-2
    SSG: 15,3
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  • 9
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    Identification and Characterization of a Periplasmic α‐Carbonic Anhydrase (CA) in the Gametophytes of Saccharina japonica (Phaeophyceae)
    Wiley ; 2021
    In:  Journal of Phycology Vol. 57, No. 1 ( 2021-02), p. 295-310
    Details
    In: Journal of Phycology, Wiley, Vol. 57, No. 1 ( 2021-02), p. 295-310
    Abstract: Periplasmic or external carbonic anhydrases (CAs) have been well accepted as playing a crucial role in the acquisition of dissolved inorganic carbon; however, no cytological evidence or molecular information on these enzymes has been reported in seaweeds to date. In this study, the full‐length cDNA sequence coding for a putative periplasmic Sjα‐CA2 was cloned from the gametophytes of Saccharina japonica , an industrial brown seaweed. It was 1,728 bp in length and included a 263‐bp 5′‐untranslated region (UTR), a 577‐bp 3′‐UTR, and an 888‐bp open reading frame encoding a protein precursor consisting of 295 amino acids. The mature protein, after removal of a predicted 28‐residue signal peptide, was composed of 267 amino acids with a relative molecular weight of 29.27 kDa. Multisequence alignment and phylogenetic analysis indicated that it was a member of the α‐CA family. Enzyme activity assays showed that the recombinant Sjα‐CA2 in Escherichia coli possessed CO 2 hydration and esterase activities, thus identifying this gene Sjα ‐ CA2 in function. Immunogold electron microscopic observations with the prepared anti‐Sjα‐CA2 polyclonal antibody illustrated that Sjα‐CA2 was located in periplasmic space of the kelp gametophyte cells. Quantitative real‐time PCR results revealed that the transcription of Sjα‐CA2 was induced by elevated levels, but it was little changed while the kelp gametophytes were subjected to elevated CO 2 concentrations. This study suggests that the periplasmic Sjα‐CA2 might play a role in adapting to elevated environmental levels of by dehydration of to generate CO 2 , which could be readily taken up by S . japonica gametophytes.
    Type of Medium: Online Resource
    ISSN: 0022-3646 , 1529-8817
    URL: Issue
    URL: Article
    DOI: 10.1111/jpy.v57.1
    DOI: 10.1111/jpy.13091
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 281226-5
    detail.hit.zdb_id: 1478748-9
    SSG: 12
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  • 10
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    Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 4 ( 2022-04), p. 1807-1821
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 4 ( 2022-04), p. 1807-1821
    Abstract: Most antiangiogenic inhibitors targeting endothelium‐dependent vessels cannot inhibit tumor growth but promote tumor invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct endothelium‐dependent vessels. Inhibiting VM may be a novel antiangiogenic strategy against alternative tumor vascularization. In this paper, myricetin was selected from among several flavonoid compounds as an effective PAR1 antagonist. In two different hepatocellular carcinoma (HCC) cell lines high‐expressed PAR1, myricetin inhibited cell migration, invasion and VM formation and reversed the expression of epithelial–endothelial transition (EET) markers by inhibiting PAR1 activation. Knockout of PAR1 inhibited HCC cell invasion and metastasis and weakened the inhibitory effect of myricetin on HCC cells. The migration, invasion and tube formation ability of PLC‐PRF‐5 cells were enhanced after PAR1 overexpression, and the inhibitory effect of myricetin was enhanced. A docking assay revealed that myricetin binds to Leu258 and Thr261 in the PAR1 activity pocket. Mutation of Leu258 and Thr261 inhibited the antitumor effect of myricetin in vitro and in vivo. In summary, myricetin reverses PAR1‐mediated EET and inhibits HCC cell invasion, metastasis, VM formation and angiogenesis by targeting PAR1, and Leu258 and Thr261 of PAR1 participate in VM and angiogenesis in HCC tissues.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.4
    DOI: 10.1002/ptr.7427
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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