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  • Wiley  (511)
  • 1
    Online Resource
    Online Resource
    ChemInform Abstract: Unusual Nor-Sesquiterpene Lactone from the Fruits of Illicium henryi.
    Wiley ; 2014
    In:  ChemInform Vol. 45, No. 1 ( 2014-01-07), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 45, No. 1 ( 2014-01-07), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Issue
    URL: Article
    DOI: 10.1002/chin.v45.1
    DOI: 10.1002/chin.201401220
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2110203-X
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  • 2
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    Efficacy, immunogenicity and safety of the AS04‐HPV‐16/18 vaccine in Chinese women aged 18‐25 years: End‐of‐study results from a phase II/III, randomised, controlled trial
    Wiley ; 2019
    In:  Cancer Medicine Vol. 8, No. 14 ( 2019-10), p. 6195-6211
    Details
    In: Cancer Medicine, Wiley, Vol. 8, No. 14 ( 2019-10), p. 6195-6211
    Abstract: Cervical cancer is a major public health concern in China. We report the end‐of‐study results of a phase II/III trial to assess the efficacy, immunogenicity, and safety of the AS04‐human papillomavirus (HPV)‐16/18 vaccine in Chinese women aged 18‐25 years followed for up to 72 months after first vaccination. Results of approximately 57 months following first vaccination have been previously reported. Methods Healthy 18‐25‐year‐old women (N = 6051) were randomized (1:1) to receive three doses of AS04‐HPV‐16/18 vaccine or Al(OH) 3 (control) at Months 0‐1‐6. Vaccine efficacy against HPV‐16/18 infection and cervical intraepithelial neoplasia (CIN), cross‐protective vaccine efficacy against infections and lesions associated with nonvaccine oncogenic HPV types, immunogenicity, and safety were assessed. Efficacy was assessed in the according‐to‐protocol efficacy (ATP‐E) cohort (vaccine N = 2888; control N = 2892), total vaccinated cohort for efficacy (TVC‐E; vaccine N = 2987; control N = 2985) and TVC‐naïve (vaccine N = 1660; control N = 1587). Results In initially HPV‐16/18 seronegative/DNA‐negative women, vaccine efficacy against HPV‐16/18‐associated CIN grade 2 or worse was 87.3% (95% CI: 5.5, 99.7) in the ATP‐E, 88.7% (95% CI: 18.5, 99.7) in the TVC‐E, and 100% (95% CI: 17.9, 100) in the TVC‐naïve. Cross‐protective efficacy against incident infection with HPV‐31, HPV‐33 and HPV‐45 was 59.6% (95% CI: 39.4, 73.5), 42.7% (95% CI: 15.6, 61.6), and 54.8% (95% CI: 19.3, 75.6), respectively (ATP‐E). At Month 72, 〉 95% of initially seronegative women who received HPV vaccine in the ATP cohort for immunogenicity (N = 664) remained seropositive for anti‐HPV‐16/18 antibodies; anti‐HPV‐16 and anti‐HPV‐18 geometric mean titers were 678.1 EU/mL (95% CI: 552.9, 831.5) and 343.7 EU/mL (95% CI: 291.9, 404.8), respectively. Serious adverse events were infrequent (1.9% vaccine group [N = 3026]; 2.7% control group [N = 3025] ). Three and zero women died in the control group and the vaccine group respectively. New onset autoimmune disease was reported in two women in the vaccine group and two in the control group. Conclusions This is the first large‐scale randomized clinical trial of HPV vaccination in China. High and sustained vaccine efficacy against HPV‐16/18‐associated infection and cervical lesions was demonstrated up to Month 72. The vaccine had an acceptable safety profile. Combined with screening, prophylactic HPV vaccination could potentially reduce the high burden of HPV infection and cervical cancer in China. Trial registration NCT00779766.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v8.14
    DOI: 10.1002/cam4.2399
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2659751-2
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  • 3
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    Efficacy, immunogenicity, and safety of the HPV‐16/18 AS04‐adjuvanted vaccine in Chinese women aged 18–25 years: event‐triggered analysis of a randomized controlled trial
    Wiley ; 2017
    In:  Cancer Medicine Vol. 6, No. 1 ( 2017-01), p. 12-25
    Details
    In: Cancer Medicine, Wiley, Vol. 6, No. 1 ( 2017-01), p. 12-25
    Abstract: We previously reported the results of a phase II/III, double‐blind, randomized controlled study in Chinese women (NCT00779766) showing a 94.2% (95% confidence interval: 62.7–99.9) HPV‐16/18 AS04‐adjuvanted vaccine efficacy (VE) against cervical intraepithelial neoplasia grade 1 or higher (CIN1+) and/or 6‐month (M) persistent infection (PI) with a mean follow‐up of 〈 2 years, and immunogenicity until 7 months post‐dose 1. Here, we report efficacy and safety results from an event‐triggered analysis with ~3 years longer follow‐up, and immunogenicity until M24. Healthy 18–25‐year‐old women ( N  = 6051) were randomized (1:1) to receive three doses of HPV‐16/18 vaccine or Al(OH) 3 (control) at M0, 1, 6. VE against HPV‐16/18‐associated CIN2+, and cross‐protective VE against infections with nonvaccine oncogenic HPV types, immunogenicity, and safety were assessed. In the according‐to‐protocol efficacy cohort, in initially seronegative/DNA‐negative women (vaccine group: N  = 2524; control group: N  = 2535), VE against HPV‐16/18‐associated CIN2+ was 87.3% (5.3–99.7); VE against incident infection or against 6‐month persistent infection associated with HPV‐31/33/45 was 50.1% (34.3–62.3) or 52.6% (24.5–70.9), respectively. At least, 99.6% of HPV‐16/18‐vaccines remained seropositive for anti‐HPV‐16/18 antibodies; anti‐HPV‐16 and ‐18 geometric mean titers were 1271.1 EU/mL (1135.8–1422.6) and 710.0 EU/ml (628.6–801.9), respectively. Serious adverse events were infrequent (1.7% vaccine group [ N  = 3026]; 2.5% control group [ N  = 3026]). Of the 1595 reported pregnancies, nine had congenital anomalies (five live infants, three elective terminations, one stillbirth) that were unlikely vaccination‐related (blinded data). VE against HPV‐16/18‐associated CIN2+ was demonstrated and evidence of cross‐protective VE against oncogenic HPV types was shown. The vaccine was immunogenic and had an acceptable safety profile.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2017.6.issue-1
    DOI: 10.1002/cam4.869
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2659751-2
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  • 4
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    Prevalence of Internet addiction and its association with social support and other related factors among adolescents in China
    Wiley ; 2016
    In:  Journal of Adolescence Vol. 52, No. 1 ( 2016-10), p. 103-111
    Details
    In: Journal of Adolescence, Wiley, Vol. 52, No. 1 ( 2016-10), p. 103-111
    Abstract: A cross‐sectional study design was applied amongst a random sample (n = 10158) of Chinese adolescents. Self‐completed questionnaires, including demographic characteristics, Internet use situation, Youth Internet Addiction Test, Youth Social Support Rating Scale and Zung Self‐rating Depression Scale were utilized to examine the study objectives. Among the study population, the prevalence rate of Internet addiction was 10.4%, with 1038 (10.2%) moderately and 21 (0.2%) severely addicted to the Internet. Results from the multivariate logistic regression analyses suggested that a variety of related factors have significant effects on Internet addiction (parental control, per capita annual household income, academic performance, the access to Internet, online activities). The correlation coefficients showed that Internet addiction was negatively correlated with social support and positively associated with depression. Social support had a significant negative predictive effect on Internet addiction. The mediating effect of depression between social support and Internet addiction was remarkable.
    Type of Medium: Online Resource
    ISSN: 0140-1971 , 1095-9254
    URL: Article
    DOI: 10.1016/j.adolescence.2016.07.012
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1469149-8
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  • 5
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    Long‐Term Effects of Novel Combination Coating Anti‐CD34 Antibody Applied on Sirolimus‐Eluting Stents
    Wiley ; 2015
    In:  Journal of Interventional Cardiology Vol. 28, No. 3 ( 2015-06), p. 257-263
    Details
    In: Journal of Interventional Cardiology, Wiley, Vol. 28, No. 3 ( 2015-06), p. 257-263
    Abstract: We investigated whether the combination coating of a novel “prohealing coating” hyaluronan‐chitosan (HC) and anti‐CD34 antibody applied on an SES (HCASES) can reduce neointimal formation while promoting endothelialization compared to either agent alone. Background Drug‐eluting stents have considerably reduced the incidence of in‐stent restenosis compared with bare metal stents. However, the beneficial effect of drug elution is overshadowed by delayed re‐endothelialization as well as later “catch‐up” proliferation related to the drug. Methods Three different stents: Sirolimus‐eluting stents (SES), Genous anti‐CD34 antibody stents (GS), and the combination of HC‐anti‐CD34 antibody with sirolimus‐eluting stents (HCASES) were deployed in 54 normal porcine coronary arteries and harvested for scanning electron microscopy (SEM) and histological analysis at 60, 90, and 120 days. Results At 60 and 90 days, SEM analysis showed stent surface endothelial coverage was nearly completed in the HCASES (87 ± 3%, 95 ± 3%) compared with that in the SES (68 ± 6%, 77 ± 8%, P = 0.03). Histological examination at 90 days showed that the HCASES group had less percentage of stenosis than the GS group (P  〈  0.05). At 120 days, SEM showed a significantly higher extent of endothelial coverage above struts in the HCASES (96 ± 2%) and the GS (95 ± 3%) as compared with the SES group (66 ± 3%; P = 0.02). The HCASES group showed less stenosis than that in the GS group (P  〈  0.05), but it was not significantly different from the SES group (P = 0.063). Conclusions Histological and SEM analyses demonstrate that the HCASES can reduce neointimal formation and inflammation while promoting endothelialization in the long term. (J Interven Cardiol 2015;28:257–263)
    Type of Medium: Online Resource
    ISSN: 0896-4327 , 1540-8183
    URL: Issue
    URL: Article
    DOI: 10.1111/joic.v28.3
    DOI: 10.1111/joic.12208
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2103585-4
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  • 6
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    Enhanced Efficiency and Mechanical Robustness of Flexible Perovskite Solar Cells by Using HPbI 3 Additive
    Wiley ; 2021
    In:  Solar RRL Vol. 5, No. 4 ( 2021-04)
    Details
    In: Solar RRL, Wiley, Vol. 5, No. 4 ( 2021-04)
    Abstract: High efficiency and mechanical stability are in great demand for commercial applications of the flexible perovskite solar cells (PSCs) in portable and wearable electronics. Herein, power conversion efficiency (PCE) and mechanical robustness of the methylammonium (MA)‐free flexible PSCs are simultaneously enhanced by incorporating a HPbI 3 additive with optimal content in the perovskite precursor solution. The HPbI 3 additive facilitates an improved morphology and crystallinity, as well as a decreased work function of the perovskite films, leading to improved device performance. As a result, PCEs of 20.1% and 18.74% are obtained for the rigid and flexible PSCs, respectively, which are among the best results for inverted MA‐free PSCs. The flexible PSCs maintain 95% and 70% of the initial PCE value after 1000 and 5000 bending cycles, respectively, at a bending radius of 4 mm. The current result reveals that using the HPbI 3 additive is a universal strategy to enhance performance of the flexible PSCs effectively and promote the development of the perovskite‐based photovoltaics.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v5.4
    DOI: 10.1002/solr.202000821
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2882014-9
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  • 7
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    Preoperative Assessment for High‐Risk Endometrial Cancer by Developing an MRI ‐ and Clinical‐Based Radiomics Nomogram: A Multicenter Study
    Wiley ; 2020
    In:  Journal of Magnetic Resonance Imaging Vol. 52, No. 6 ( 2020-12), p. 1872-1882
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 52, No. 6 ( 2020-12), p. 1872-1882
    Abstract: High‐ and low‐risk endometrial cancer (EC) differ in whether lymphadenectomy is performed. Assessment of high‐risk EC is essential for planning surgery appropriately. Purpose To develop a radiomics nomogram for high‐risk EC prediction preoperatively. Study Type Retrospective. Population In all, 717 histopathologically confirmed EC patients (mean age, 56 years ± 9) divided into a primary group (394 patients from Center A), validation groups 1 and 2 (146 patients from Center B and 177 patients from Centers C–E). Field Strength/Sequence 1.5/ 3T scanners; T 2 ‐weighted imaging, diffusion‐weighted imaging, apparent diffusion coefficient, and contrast enhancement sequences. Assessment A radiomics nomogram was generated by combining the selected radiomics features and clinical parameters (metabolic syndrome, cancer antigen 125, age, tumor grade following curettage, and tumor size). The area under the curve (AUC) of the receiver operator characteristic was used to evaluate the predictive performance of the radiomics nomogram for high‐risk EC. The surgical procedure suggested by the nomogram was compared with the actual procedure performed for the patients. Net benefit of the radiomics nomogram was evaluated by a clinical decision curve (CDC), net reclassification index (NRI), and integrated discrimination improvement (IDI). Statistical Tests Binary least absolute shrinkage and selection operator (LASSO) logistic regression, linear regression, and multivariate binary logistic regression were used to select radiomics features and clinical parameters. Results The AUC for prediction of high‐risk EC for the radiomics nomogram in the primary group, validation groups 1 and 2 were 0.896 (95% confidence interval [CI]: 0.866–0.926), 0.877 (95% CI: 0.825–0.930), and 0.919 (95% CI: 0.879–0.960), respectively. The nomogram achieved good net benefit by CDC analysis for high‐risk EC. NRIs were 1.17, 1.28, and 1.51, and IDIs were 0.41, 0.60, and 0.61 in the primary group, validation groups 1 and 2, respectively. Data Conclusion The radiomics nomogram exhibited good performance in the individual prediction of high‐risk EC, and might be used for surgical management of EC. Level of Evidence 4 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2020;52:1872–1882.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v52.6
    DOI: 10.1002/jmri.27289
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1497154-9
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  • 8
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    The Microbiome Protocols eBook initiative: Building a bridge to microbiome research
    Wiley ; 2024
    In:  iMeta
    Details
    In: iMeta, Wiley
    Type of Medium: Online Resource
    ISSN: 2770-5986 , 2770-596X
    URL: Article
    DOI: 10.1002/imt2.182
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 3114873-6
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  • 9
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    A high baseline HBV load and antiviral therapy affect the survival of patients with advanced HBV‐related HCC treated with sorafenib
    Wiley ; 2015
    In:  Liver International Vol. 35, No. 9 ( 2015-09), p. 2147-2154
    Details
    In: Liver International, Wiley, Vol. 35, No. 9 ( 2015-09), p. 2147-2154
    Abstract: Although a high viral load is an independent risk factor for recurrence of hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) after surgery, the prognostic impact of viral load on advanced HCC is unclear. This study investigated the impact of baseline HBV load and antiviral therapy on survival of patients with advanced HCC treated with sorafenib. Methods Of 130 patients with advanced HBV‐related HCC received first‐line sorafenib therapy were evaluated in a multicenter, retrospective study. Results No patients experienced severe hepatic impairment because of HBV reactivation during sorafenib therapy. The median progression‐free survival (PFS) and overall survival (OS) of all patients were 5.7 and 9.6 months respectively. Patients with a baseline HBV DNA ≤10 4  copies/ml had significantly better OS than those with 〉 10 4  copies/ml (10.4 vs 6.6 months; P  =   0.002), but PFS showed an increasing trend (5.8 vs 4.8 months; P  =   0.068). Patients who received antiviral therapy had a better trend in OS than those who did not (12.0 vs 8.3 months; P  =   0.058), but there was no difference in PFS (6.4 vs 4.1 months; P  =   0.280). In a multivariate analysis, the baseline HBV DNA level 〉 10 4  copies/ml ( P  =   0.001; hazard ration [HR] = 2.294; 95% CI 1.429–3.676) and antiviral therapy ( P  =   0.038; HR 0.617; 95% CI 0.390–0.975) were independent predictors of OS. Conclusion In patients with advanced HBV‐related HCC treated with sorafenib, a high baseline HBV load was an adverse prognostic factor for survival. However, survival was significantly improved with the use of antiviral therapy.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.2015.35.issue-9
    DOI: 10.1111/liv.12805
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2124684-1
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  • 10
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    TRY plant trait database – enhanced coverage and open access
    Wiley ; 2020
    In:  Global Change Biology Vol. 26, No. 1 ( 2020-01), p. 119-188
    Details
    In: Global Change Biology, Wiley, Vol. 26, No. 1 ( 2020-01), p. 119-188
    Abstract: Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v26.1
    DOI: 10.1111/gcb.14904
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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