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  • 1
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    Online Resource
    Investors' carbon risk exposure and their potential for shareholder engagement
    Wiley ; 2021
    In:  Business Strategy and the Environment Vol. 30, No. 1 ( 2021-01), p. 282-301
    Details
    In: Business Strategy and the Environment, Wiley, Vol. 30, No. 1 ( 2021-01), p. 282-301
    Abstract: This article examines the exposure to and management of carbon risks of different investor types. Considering the dual role as portfolio manager and partial owner, we analyze carbon risk for investors both in terms of exposure to portfolio values and in terms of responsibility as shareholder of carbon‐intensive firms. We show that among various investor types, the preference for holding carbon‐intensive stocks differs substantially, even when considering traditional investment decision parameters. In particular, it is governments whose portfolio values are most threatened by a carbon risk exposure of 49%, but at the same time, they prefer larger ownership shares in polluting firms. In contrast, individual investors, investment advisors, and mutual funds avoid holding stakes in these firms, while revealing only a moderate exposure of their assets to carbon risk. In view of the Paris Agreement, which includes the consistent steering of financial flows towards a low carbon transformation of the economy, our study provides policymakers with important implications regarding the coverage and effects of respective regulations. By identifying the ownership structures of carbon‐intensive firms and respective owners' portfolio compositions, we also offer implications for further research on portfolio decarbonization and shareholders' influence of corporate carbon management.
    Type of Medium: Online Resource
    ISSN: 0964-4733 , 1099-0836
    URL: Issue
    URL: Article
    DOI: 10.1002/bse.v30.1
    DOI: 10.1002/bse.2621
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2025936-0
    detail.hit.zdb_id: 1127954-0
    SSG: 3,2
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  • 2
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    CASE REPORTS: Trepopnea Associated with Paroxysmal Severe Tricuspid Regurgitation Triggered at Left Lateral Decubitus Position : Trepopnea Associated with Paroxysmal Severe Tricuspid Regurgitation
    Wiley ; 2010
    In:  Echocardiography Vol. 27, No. 8 ( 2010-06-09), p. E77-E79
    Details
    In: Echocardiography, Wiley, Vol. 27, No. 8 ( 2010-06-09), p. E77-E79
    Type of Medium: Online Resource
    ISSN: 0742-2822
    URL: Issue
    URL: Article
    DOI: 10.1111/echo.2010.27.issue-8
    DOI: 10.1111/j.1540-8175.2010.01159.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2041033-5
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  • 3
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    Incidence of Cardiac Perforation With Conventional and With Leadless Pacemaker Systems: A Systematic Review and Meta‐Analysis
    Wiley ; 2017
    In:  Journal of Cardiovascular Electrophysiology Vol. 28, No. 3 ( 2017-03), p. 336-346
    Details
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 28, No. 3 ( 2017-03), p. 336-346
    Abstract: Two leadless pacemaker (PM) systems were recently developed to avoid pocket‐ and lead‐related complications. As leadless PMs are implanted with a large delivery catheter, cardiac perforation remains a major safety concern. We aimed to provide a literature review on incidence of cardiac perforation with conventional and with leadless PM systems. Methods and Results A systematic review over the last 25 years for studies reporting data on PM lead perforation was performed. Findings were synthesized descriptively. Where control groups were available, data were meta‐analyzed to identify important clinical risk factors. A total of 28 studies comprising 60,744 patients undergoing conventional PM implantation were analyzed. The incidence of lead perforation ranged from 0% to 6.37% (mean 0.82%, weighted mean 0.31%, median of 0.40%). There was no significant difference in perforation risk between atrial and ventricular electrodes (POR 0.72, 95% confidence interval [CI], 0.28–1.87, P = 0.50) and between MRI conditional and conventional leads (POR 5.93, 95% CI, 0.72–48.76, P = 0.10). The use of active fixation leads (POR 4.25, 95% CI, 1.00–17.95, P = 0.05) and utilization of DDD versus VVI PM systems (POR 3.50, 95% CI, 1.48–8.28, P 〈 0.01) were associated with higher rates of perforation. In the 2 leadless PM studies, the incidence of cardiac perforation was 1.52% for each. Conclusion PM lead perforation rates vary in individual studies with an overall low incidence. Leadless PMs seem to be associated with a slightly higher perforation risk, most likely reflecting a learning curve effect of this novel technology.
    Type of Medium: Online Resource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    URL: Article
    DOI: 10.1111/jce.2017.28.issue-3
    DOI: 10.1111/jce.13140
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2037519-0
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  • 4
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    Epineural adipose‐derived stem cell injection in a sciatic rodent model
    Wiley ; 2018
    In:  Brain and Behavior Vol. 8, No. 7 ( 2018-07)
    Details
    In: Brain and Behavior, Wiley, Vol. 8, No. 7 ( 2018-07)
    Abstract: The aim was to evaluate the regenerative effect of epineural injection of rat ASC s ( rASC s) in three different settings of acute and chronic compression in a rat sciatic nerve model. Methods Acute compression (60 s) with a vessel clamp over a distance of 1 mm (group 1) or 10 mm (group 2), as well as chronic compression with a permanent remaining, nonabsorbable polymeric clip over a distance of 1 mm (group 3) was performed. Depending on the group, either 5 × 10 6 rASC s or the same volume (25 μl) of culture medium ( CM ) was injected with a 30G needle in the epineurium at the time of compression. Outcome measures were functional gait evaluations, imaging analysis, histomorphometric analyses, and muscle weight. Results The rats in group 2 had a better function than those with group 1 at one and especially at 2 weeks. After 4 weeks however, almost all rats were close to a normal function. There was a similar Muscle Weight Ratio ( MWR ) after 2 weeks in all groups, whereas after 4 weeks, the MWR in group 3 was lower compared with group 1 and 2. Histomorphometric analysis showed a better myelination in group 1 & 2 compared to group 3 after 4 weeks. ASC s have a beneficial effect on myelin thickness (G‐Ratio). Conclusions We successfully evaluated the regenerative effect of epineural injection of rASC s in three different settings of acute and chronic compression. However, there were no significant differences in outcomes between the ASC ‐treated groups and control groups.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.2018.8.issue-7
    DOI: 10.1002/brb3.1027
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2623587-0
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  • 5
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    Technical assessment in minimally invasive complete mesocolic excision: Is the complete mesocolic excision competency assessment tool valid and reliable?
    Wiley ; 2023
    In:  Colorectal Disease
    Details
    In: Colorectal Disease, Wiley
    Abstract: The complete mesocolic excision competency assessment tool (CMECAT) is a novel tool designed to assess technical skills in minimally invasive complete mesocolic excision (CME) surgery. The aim of this study was to assess construct validity and reliability of CMECAT in a clinical context. Method Colorectal surgeons were asked to submit video recorded laparoscopic CME resections for independent assessment of their technical abilities. The videos were grouped by surgeons' training level, and four established CME experts were recruited as CMECAT assessors. Extended reliability analysis (G‐theory) was applied to describe assessor agreement. Results A total of 19 videos and 72 assessments were included in the analysis. Overall, technical skills assessed by CMECAT improved with increased training level: the experts scored significantly better than the untrained surgeons (3.3 vs. 2.5 points; p   〈  0.01). On right‐sided resections, significantly higher scores were reported with increased training level for all categories and sections, while for left‐sided resections, the variance across groups was smaller and significantly higher scores were only reported for oncological safety describing items. Overall, assessor agreement was high (G‐coefficient: 0.81). Conclusion This study confirms that CMECAT can be applied to video recorded CME cases for technical skill assessment. Further, it can reliably assess technical performance in right sided CME surgery, where construct validity has now been established. More videos are required to evaluate its validity on left colonic CME. In the future, we hope CMECAT can improve feedback during CME training, serve as a tool in certification processes and contribute to distinguishing CME from conventional surgery in future research.
    Type of Medium: Online Resource
    ISSN: 1462-8910 , 1463-1318
    URL: Article
    DOI: 10.1111/codi.16756
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2004820-8
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  • 6
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    A gene signature for late distant metastasis in breast cancer identifies a potential mechanism of late recurrences
    Wiley ; 2013
    In:  Molecular Oncology Vol. 7, No. 5 ( 2013-10), p. 987-999
    Details
    In: Molecular Oncology, Wiley, Vol. 7, No. 5 ( 2013-10), p. 987-999
    Abstract: Breast cancer prognostic classifications are based on clinical and molecular profiles. But they do not allow to select patients for adjuvant treatment after 5 years. 44 K Genomic profiling allowed Identification of a 241‐late metastasis signature. Specific molecular pathways related to late metastases are expressed. CH25H regulates the metabolism of lipids and steroids and is correlated to late events.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Article
    DOI: 10.1016/j.molonc.2013.07.006
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2322586-5
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  • 7
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    Characterization of subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal stenosis
    Wiley ; 2016
    In:  Journal of Orthopaedic Research Vol. 34, No. 8 ( 2016-08), p. 1475-1480
    Details
    In: Journal of Orthopaedic Research, Wiley, Vol. 34, No. 8 ( 2016-08), p. 1475-1480
    Abstract: Facet joint osteoarthritis may be a cause of low back pain in degenerative spine diseases including lumbar spinal stenosis. Subchondral bone is regarded as a potential therapeutic target for osteoarthritis treatment. The goal of this study was to characterize subchondral bone histopathology in osteoarthritic facet joints from lumbar spinal stenosis patients. Fifteen patients with degenerative spinal stenosis scheduled for transforaminal lumbar interbody fusion surgery were recruited for this study. Osteoarthritis severity was graded on T1‐ and T2‐weighted MRI images using Weishaupt scoring system. Dissected osteoarthritic facet joints were subjected to histological and immunohistochemistry analyses to study relative abundance of osteoblast, osteoclasts, and macrophages using van Gieson‘s, tartrate‐resistant acid phosphatase and CD68‐antibody staining, respectively. Presence of nerve fibers was evaluated by PGP9.5‐antibody staining. Differential bone histopathology, independent from radiological osteoarthritis grade, was observed in facet joints. Extensive de novo bone formation was found in subchondral bone tissues of eight of fifteen specimens. Regions of bone formation showed high abundance of blood vessels and CD68‐positive macrophages, but were devoid of multinucleated osteoclasts. Additional pathological changes in subchondral marrow spaces, including inflammatory infiltration and enhanced osteoclast activity, were characterized by macrophage‐rich tissues. PGP9.5‐positive nerve fibers were detected near arterioles, but not in regions displaying bone pathology. Individual histopathological parameters did not associate with clinical features or radiological osteoarthritis severity. Subchondral bone histopathology of facet joint osteoarthritis in lumbar spinal stenosis is characterized by marrow infiltration by macrophage‐rich tissues and enhanced de novo bone formation. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1475–1480, 2016.
    Type of Medium: Online Resource
    ISSN: 0736-0266 , 1554-527X
    URL: Issue
    URL: Article
    DOI: 10.1002/jor.v34.8
    DOI: 10.1002/jor.23281
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2050452-4
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  • 8
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    β‐synuclein aggregates and induces neurodegeneration in dopaminergic neurons
    Wiley ; 2013
    In:  Annals of Neurology Vol. 74, No. 1 ( 2013-07), p. 109-118
    Details
    In: Annals of Neurology, Wiley, Vol. 74, No. 1 ( 2013-07), p. 109-118
    Abstract: Whereas the contribution of α‐synuclein to neurodegeneration in Parkinson disease is well accepted, the putative impact of its close homologue, β‐synuclein, is enigmatic. β‐Synuclein is widely expressed throughout the central nervous system, as is α‐synuclein, but the physiological functions of both proteins remain unknown. Recent findings have supported the view that β‐synuclein can act as an ameliorating regulator of α‐synuclein–induced neurotoxicity, having neuroprotective rather than neurodegenerative capabilities, and being nonaggregating due to the absence of most of the aggregation‐promoting NAC domain. However, a mutation of β‐synuclein linked to dementia with Lewy bodies rendered the protein neurotoxic in transgenic mice, and fibrillation of β‐synuclein has been demonstrated in vitro. Methods Neurotoxicity and aggregation properties of α‐, β‐, and γ‐synuclein were comparatively elucidated in the rat nigro‐striatal projection and in cultured neurons. Results Supporting the hypothesis that β‐synuclein can act as a neurodegeneration‐inducing factor, we demonstrated that wild‐type β‐synuclein is neurotoxic for cultured primary neurons. Furthermore, β‐synuclein formed proteinase K–resistant aggregates in dopaminergic neurons in vivo, leading to pronounced and progressive neurodegeneration in rats. Expression of β‐synuclein caused mitochondrial fragmentation, but this fragmentation did not render mitochondria nonfunctional in terms of ion handling and respiration even at late stages of neurodegeneration. A comparison of the neurodegenerative effects induced by α‐, β‐, and γ‐synuclein revealed that β‐synuclein was eventually as neurotoxic as α‐synuclein for nigral dopaminergic neurons, whereas γ‐synuclein proved to be nontoxic and had very low aggregation propensity. Interpretation Our results suggest that the role of β‐synuclein as a putative modulator of neuropathology in aggregopathies like Parkinson disease and dementia with Lewy bodies needs to be revisited. Ann Neurol 2013;74:109–118
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v74.1
    DOI: 10.1002/ana.23905
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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  • 9
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    Chalcogen‐Bonding Catalysis: From Neutral to Cationic Benzodiselenazole Scaffolds
    Wiley ; 2018
    In:  Helvetica Chimica Acta Vol. 101, No. 7 ( 2018-07)
    Details
    In: Helvetica Chimica Acta, Wiley, Vol. 101, No. 7 ( 2018-07)
    Abstract: Benzodiselenazoles ( BDS ) are emerging as privileged structures for chalcogen‐bonding catalysis in the focal point of conformationally immobilized σ holes on strong selenium donors in a neutral scaffold. Whereas much attention has been devoted to work out the advantages of selenium compared to the less polarizable sulfur donors, high expectations concerning bidentate, rigid, and neutral scaffolds have been generated with little experimental support. Here we report design, synthesis and evaluation of the necessary catalysts to confirm that i) bidentate BDS are more effective than their monodentate analogs, ii) conformationally immobilized scaffolds are more effective than more flexible ones, iii) cationic BDS scaffolds are more effective than neutral ones, and iv) in dicationic‐bidentate BDS , contributions from chalcogen‐bonding dominate possible contributions from ion‐pairing catalysis. These conclusions result from rate enhancements found for a Ritter ‐type anion‐binding reaction and an X‐ray crystal structure of dicationic BDS with a triflate anion bound with highest precision in the focal point of the σ holes.
    Type of Medium: Online Resource
    ISSN: 0018-019X , 1522-2675
    URL: Issue
    URL: Article
    DOI: 10.1002/hlca.v101.7
    DOI: 10.1002/hlca.201800075
    RVK:
    VA 4500
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 74-7
    detail.hit.zdb_id: 1475013-2
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  • 10
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    Catalysis with Pnictogen, Chalcogen, and Halogen Bonds
    Wiley ; 2018
    In:  Angewandte Chemie International Edition Vol. 57, No. 19 ( 2018-05-04), p. 5408-5412
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 57, No. 19 ( 2018-05-04), p. 5408-5412
    Abstract: Halogen‐ and chalcogen‐based σ‐hole interactions have recently received increased interest in non‐covalent organocatalysis. However, the closely related pnictogen bonds have been neglected. In this study, we introduce conceptually simple, neutral, and monodentate pnictogen‐bonding catalysts. Solution and in silico binding studies, together with high catalytic activity in chloride abstraction reactions, yield compelling evidence for operational pnictogen bonds. The depth of the σ holes is easily varied with different substituents. Comparison with homologous halogen‐ and chalcogen‐bonding catalysts shows an increase in activity from main group VII to V and from row 3 to 5 in the periodic table. Pnictogen bonds from antimony thus emerged as by far the best among the elements covered, a finding that provides most intriguing perspectives for future applications in catalysis and beyond.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v57.19
    DOI: 10.1002/anie.201801452
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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