GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Evaluating awareness, knowledge and practice of healthcare professionals following implementation of a revised pregnancy prevention programme for isotretinoin in Ireland: A multi‐stakeholder cross‐sectional study
    Wiley ; 2023
    In:  Pharmacoepidemiology and Drug Safety Vol. 32, No. 2 ( 2023-02), p. 137-147
    Details
    In: Pharmacoepidemiology and Drug Safety, Wiley, Vol. 32, No. 2 ( 2023-02), p. 137-147
    Abstract: In 2018, following an EU‐wide safety review, a revised pregnancy prevention programme (PPP) was introduced for isotretinoin (Roaccutane®). This study aimed to examine awareness, knowledge, and experience implementing the revised isotretinoin PPP in clinical practice across three healthcare professional (HCP) groups in Ireland. Methods A cross‐sectional study using anonymous online surveys among general practitioners (GPs), community pharmacists, and specialist consultants was undertaken. Descriptive analyses are presented. Results Across all HCP groups there was high (≥87%) awareness that oral isotretinoin is contraindicated in women of childbearing potential (WCBP) unless the conditions of the PPP are fulfilled, but varying awareness among GPs (54.9%) and community pharmacists (45.9%) that exposure during pregnancy can cause both severe fetal malformations and spontaneous abortions. Implementation of the PPP in clinical practice varied across HCP groups. When initiating isotretinoin in WCBP, 66.7% of specialists and 40.8% of GPs indicated they had considered alternative treatment options, and 71.4% of specialists and 31.6% of GPs reported they first requested a pregnancy test. There was limited provision of the patient reminder card to WCBP, where 26.1% of community pharmacists provide this at each dispensing, while 47.6% of specialists and 11.8% of GPs ensured WCBP had a copy of the card when initiating treatment. Across all HCP groups, there was high (≥81.6%) awareness of the need for urgent consultation and immediate cessation of isotretinoin in the event of an unplanned or suspected pregnancy. Conclusions Reinforcement of the provision and utilisation of the isotretinoin patient reminder card may be required, and further targeted education on specific elements of the PPP should be considered for GPs and community pharmacists.
    Type of Medium: Online Resource
    ISSN: 1053-8569 , 1099-1557
    URL: Issue
    URL: Article
    DOI: 10.1002/pds.v32.2
    DOI: 10.1002/pds.5538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1491218-1
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Drug‐drug interactions and the risk of adverse drug reaction‐related hospital admissions in the older population
    Wiley ; 2023
    In:  British Journal of Clinical Pharmacology
    Details
    In: British Journal of Clinical Pharmacology, Wiley
    Abstract: To estimate potentially clinically important drug‐drug interaction (DDI) prevalence, the average causal effect of DDI exposure on adverse drug reaction (ADR)‐related hospital admission, and examine differences in health‐related quality of life (HRQoL) and length of stay (LOS) per DDI exposure in an older (≥65 years) population acutely hospitalised. Methods A cross‐sectional study conducted among N=798 older individuals acutely admitted to hospital in Ireland between 2016‐17. Medication (current/recently discontinued/over‐the‐counter) and clinical data (e.g., creatinine clearance) were available. DDIs were identified using the BNF and Stockley’s. Causal inference models for DDI exposure on ADR‐related hospital admission were developed using directed acyclic graphs. Multivariable logistic regression was used to estimate the average causal effect. Differences in HRQoL (EQ‐5D) and LOS per DDI exposure were examined non‐parametrically. DDI prevalence, adjusted odds ratios (aOR), and 95% confidence intervals (CIs) are reported. Results N=782 (98.0%) individuals using ≥2 drugs were included, mean age=80.9(SD±7.5)years (range:66‐105); 52.2% female; 45.1% (n=353) had an ADR‐related admission. At admission, n=316 (40.4% [95%CI: 37.0‐43.9]) patients had at least one DDI. The average causal effect of DDI exposure on ADR‐related hospital admission was aOR=1.21[ 95%CI: 0.89‐1.64]. This was significantly increased by exposure to: DDIs which increase bleeding risk (aOR=2.00[1.26‐3.12] ); aspirin‐warfarin (aOR=2.78[1.37‐5.65]); and esomeprazole‐escitalopram (aOR=3.22[1.13‐10.25] . DDI‐exposed patients had lower HRQoL (mean EQ‐5D=0.49[±0.39]) compared to non‐DDI‐exposed (mean EQ‐5D=0.57[±0.41] ),(p=0.03); and greater median LOS in hospital (8 [IQR5‐16]days) compared to non‐DDI‐exposed (7 [IQR 4‐14] days),(p=0.04). Conclusion Potentially clinically important DDIs carry an increased average causal effect on ADR‐related admission, significantly (2‐fold) by exposure to DDIs that increase bleeding risk, which should be targeted for medicines optimisation.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Article
    DOI: 10.1111/bcp.15970
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Anatomical texture patterns identify cerebellar distinctions between essential tremor and Parkinson's disease
    Wiley ; 2021
    In:  Human Brain Mapping Vol. 42, No. 8 ( 2021-06), p. 2322-2331
    Details
    In: Human Brain Mapping, Wiley, Vol. 42, No. 8 ( 2021-06), p. 2322-2331
    Abstract: Voxel‐based morphometry is an established technique to study focal structural brain differences in neurologic disease. More recently, texture‐based analysis methods have enabled a pattern‐based assessment of group differences, at the patch level rather than at the voxel level, allowing a more sensitive localization of structural differences between patient populations. In this study, we propose a texture‐based approach to identify structural differences between the cerebellum of patients with Parkinson's disease ( n = 280) and essential tremor ( n = 109). We analyzed anatomical differences of the cerebellum among patients using two features: T1‐weighted MRI intensity, and a texture‐based similarity feature. Our results show anatomical differences between groups that are localized to the inferior part of the cerebellar cortex. Both the T1‐weighted intensity and texture showed differences in lobules VIII and IX, vermis VIII and IX, and middle peduncle, but the texture analysis revealed additional differences in the dentate nucleus, lobules VI and VII, vermis VI and VII. This comparison emphasizes how T1‐weighted intensity and texture‐based methods can provide a complementary anatomical structure analysis. While texture‐based similarity shows high sensitivity for gray matter differences, T1‐weighted intensity shows sensitivity for the detection of white matter differences.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v42.8
    DOI: 10.1002/hbm.25331
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492703-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    The association between medication non‐adherence and adverse health outcomes in ageing populations: A systematic review and meta‐analysis
    Wiley ; 2019
    In:  British Journal of Clinical Pharmacology Vol. 85, No. 11 ( 2019-11), p. 2464-2478
    Details
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 85, No. 11 ( 2019-11), p. 2464-2478
    Abstract: The aim of this systematic review and meta‐analysis was to synthesise the evidence relating to medication non‐adherence and its association with health outcomes in people aged ≥50 years. Methods Seven databases were searched up to February 2019 for observational studies that measured medication (non‐)adherence as a predictor of the following health outcomes in adults aged ≥50 years: healthcare utilisation (hospitalisation, emergency department visits, outpatient visits and general practitioner visits), mortality, adverse clinical events and quality of life. Screening and quality assessment using validated criteria were completed by 2 reviewers independently. Random effects models were used to generate pooled estimates of association using adjusted study results. The full methodological approach was published on PROSPERO (ID: CRD42017077264). Results Sixty‐six studies were identified for qualitative synthesis, with 11 of these studies eligible for meta‐analyses. A meta‐analysis including 3 studies measuring medication non‐adherence in adults aged ≥55 years showed a significant association with all‐cause hospitalisation (adjusted odds ratio 1.17, 95% confidence interval [CI] 1.12, 1.21). A meta‐analysis including 2 studies showed that medication non‐adherence was not significantly associated with an emergency department visit (adjusted odds ratio 1.05, 95% CI 0.90, 1.22). Good adherence was associated with a 21% reduction in long‐term mortality risk in comparison to medication non‐adherence (adjusted hazard ratio 0.79, 95% CI 0.63, 0.98). Conclusion Medication non‐adherence may be significantly associated with all‐cause hospitalisation and mortality in older people. Medication adherence should be monitored and addressed in this cohort to minimise hospitalisation, improve clinical outcomes and reduce healthcare costs.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    URL: Article
    DOI: 10.1111/bcp.v85.11
    DOI: 10.1111/bcp.14075
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Systematic Comparison of Biomaterials‐Based Strategies for Osteochondral and Chondral Repair in Large Animal Models
    Wiley ; 2021
    In:  Advanced Healthcare Materials Vol. 10, No. 20 ( 2021-10)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 10, No. 20 ( 2021-10)
    Abstract: Joint repair remains a major challenge in orthopaedics. Recent progress in biomaterial design has led to the fabrication of a plethora of promising devices. Pre‐clinical testing of any joint repair strategy typically requires the use of large animal models (e.g., sheep, goat, pig or horse). Despite the key role of such models in clinical translation, there is still a lack of consensus regarding optimal experimental design, making it difficult to draw conclusions on their efficacy. In this context, the authors performed a systematic literature review and a risk of bias assessment on large animal models published between 2010 and 2020, to identify key experimental parameters that significantly affect the biomaterial therapeutic outcome and clinical translation potential (including defect localization, animal age/maturity, selection of controls, cell‐free versus cell‐laden). They determined that mechanically strong biomaterials perform better at the femoral condyles; while highlighted the importance of including native tissue controls to better evaluate the quality of the newly formed tissue. Finally, in cell‐laded biomaterials, the pre‐culture conditions played a more important role in defect repair than the cell type. In summary, here they present a systematic evaluation on how the experimental design of preclinical models influences biomaterial‐based therapeutic outcomes in joint repair.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v10.20
    DOI: 10.1002/adhm.202100878
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2645585-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Gabapentinoids in Ireland 2010 to 2020: An observational study of trends in gabapentinoid prescribing, law enforcement drug seizures and postmortem toxicology
    Wiley ; 2024
    In:  British Journal of Clinical Pharmacology
    Details
    In: British Journal of Clinical Pharmacology, Wiley
    Abstract: We explored trends in gabapentinoid prescribing, drug seizures and postmortem toxicology using a national pharmacy claims database, law enforcement drug seizures data and a population‐based postmortem toxicology database. Methods Gabapentinoid prescribing rates per 100 000 eligible population (2010–2020), annual number of drug seizures involving gabapentinoids (2012–2020) and gabapentinoid detection (positive) rates per 100 postmortem toxicology case (2013–2020) were calculated. Negative binomial regression models were used to evaluate longitudinal trends for gabapentin and pregabalin separately. Results Gabapentin (adjusted rate ratio [RR] 1.06, 95% confidence interval [CI] 1.05–1.06, P 〈 .001) and pregabalin (adjusted RR 1.08, 95% CI 1.08–1.09, P 〈 .001) prescribing increased annually, with higher rates of pregabalin (vs. gabapentin) observed every year. Drug seizures involving pregabalin also increased over time (RR 1.54 95% CI 1.25–1.90, P 〈 .0001). Of the 26 317 postmortem toxicology cases, 0.92% tested positive for gabapentin, and 6.37% for pregabalin. Detection rates increased for both gabapentin (RR 1.28, 95% CI 1.11–1.48, P 〈 .001) and pregabalin (RR 1.13, 95% CI 1.11–1.48, P 〈 .001) between 2013 and 2020. A total of 1901 cases (7.2%) tested positive for heroin/methadone; this sub‐group had a higher detection rate for pregabalin ( n = 528, 27.8%) and gabapentin ( n = 41, 2.2%) over the study period, with a high burden of codetections for pregabalin with benzodiazepines (peaking at 37.3% in 2018), and pregabalin with prescription opioids (peaking at 28.9% in 2020). Conclusion This study raises concerns regarding the wide availability of pregabalin in Ireland, including a growing illicit supply, and the potential for serious harm arising from poly drug use involving pregabalin among people who use heroin or methadone.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Article
    DOI: 10.1111/bcp.15984
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Transethnic genome‐wide scan identifies novel Alzheimer's disease loci
    Wiley ; 2017
    In:  Alzheimer's & Dementia Vol. 13, No. 7 ( 2017-07), p. 727-738
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 13, No. 7 ( 2017-07), p. 727-738
    Abstract: Genetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood. Methods We conducted a transethnic genome‐wide association study (GWAS) for late‐onset AD in Stage 1 sample including whites of European Ancestry, African‐Americans, Japanese, and Israeli‐Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset. Results Genome‐wide significant (GWS) associations in single‐nucleotide polymorphism (SNP)–based tests ( P   〈  5 × 10 −8 ) were identified for SNPs in PFDN1/HBEGF , USP6NL/ECHDC3 , and BZRAP1‐AS1 and for the interaction of the (apolipoprotein E) APOE ε4 allele with NFIC SNP. We also obtained GWS evidence ( P   〈  2.7 × 10 −6 ) for gene‐based association in the total sample with a novel locus, TPBG ( P  = 1.8 × 10 −6 ). Discussion Our findings highlight the value of transethnic studies for identifying novel AD susceptibility loci.
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2016.12.012
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2201940-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Dominant‐negative variant in SLC1A4 causes an autosomal dominant epilepsy syndrome
    Wiley ; 2023
    In:  Annals of Clinical and Translational Neurology Vol. 10, No. 6 ( 2023-06), p. 1046-1053
    Details
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 10, No. 6 ( 2023-06), p. 1046-1053
    Abstract: SLC1A4 is a trimeric neutral amino acid transporter essential for shuttling L‐serine from astrocytes into neurons. Individuals with biallelic variants in SLC1A4 are known to have spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) syndrome, but individuals with heterozygous variants are not thought to have disease. We identify an 8‐year‐old patient with global developmental delay, spasticity, epilepsy, and microcephaly who has a de novo heterozygous three amino acid duplication in SLC1A4 (L86_M88dup). We demonstrate that L86_M88dup causes a dominant‐negative N‐glycosylation defect of SLC1A4, which in turn reduces the plasma membrane localization of SLC1A4 and the transport rate of SLC1A4 for L‐serine.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    URL: Article
    DOI: 10.1002/acn3.v10.6
    DOI: 10.1002/acn3.51786
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2740696-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Genome‐wide association studies of alcohol dependence, DSM‐IV criterion count and individual criteria
    Wiley ; 2019
    In:  Genes, Brain and Behavior Vol. 18, No. 6 ( 2019-07)
    Details
    In: Genes, Brain and Behavior, Wiley, Vol. 18, No. 6 ( 2019-07)
    Abstract: Genome‐wide association studies (GWAS) of alcohol dependence (AD) have reliably identified variation within alcohol metabolizing genes (eg, ADH1B ) but have inconsistently located other signals, which may be partially attributable to symptom heterogeneity underlying the disorder. We conducted GWAS of DSM‐IV AD (primary analysis), DSM‐IV AD criterion count (secondary analysis), and individual dependence criteria (tertiary analysis) among 7418 (1121 families) European American (EA) individuals from the Collaborative Study on the Genetics of Alcoholism (COGA). Trans‐ancestral meta‐analyses combined these results with data from 3175 (585 families) African‐American (AA) individuals from COGA. In the EA GWAS, three loci were genome‐wide significant: rs1229984 in ADH1B for AD criterion count ( P = 4.16E−11) and Desire to cut drinking ( P = 1.21E−11); rs188227250 (chromosome 8, Drinking more than intended , P = 6.72E−09); rs1912461 (chromosome 15, Time spent drinking , P = 1.77E−08). In the trans‐ancestral meta‐analysis, rs1229984 was associated with multiple phenotypes and two additional loci were genome‐wide significant: rs61826952 (chromosome 1, DSM‐IV AD, P = 8.42E−11); rs7597960 (chromosome 2, Time spent drinking , P = 1.22E−08). Associations with rs1229984 and rs18822750 were replicated in independent datasets. Polygenic risk scores derived from the EA GWAS of AD predicted AD in two EA datasets ( P   〈  .01; 0.61%‐1.82% of variance). Identified novel variants (ie, rs1912461, rs61826952) were associated with differential central evoked theta power (loss − gain; P = .0037) and reward‐related ventral striatum reactivity ( P = .008), respectively. This study suggests that studying individual criteria may unveil new insights into the genetic etiology of AD liability.
    Type of Medium: Online Resource
    ISSN: 1601-1848 , 1601-183X
    URL: Issue
    URL: Article
    DOI: 10.1111/gbb.2019.18.issue-6
    DOI: 10.1111/gbb.12579
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2061212-6
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care Approach: Preliminary Data from the Implementation of a Centers for Medicare and Medicaid Services Nursing Facility Demonstration Project
    Wiley ; 2015
    In:  Journal of the American Geriatrics Society Vol. 63, No. 1 ( 2015-01), p. 165-169
    Details
    In: Journal of the American Geriatrics Society, Wiley, Vol. 63, No. 1 ( 2015-01), p. 165-169
    Abstract: The Optimizing Patient Transfers, Impacting Medical Quality, and Improving Symptoms: Transforming Institutional Care ( OPTIMISTIC ) project aims to reduce avoidable hospitalizations of long‐stay residents enrolled in 19 central Indiana nursing facilities. This clinical demonstration project, funded by the Centers for Medicare and Medicaid Services Innovations Center, places a registered nurse in each nursing facility to implement an evidence‐based quality improvement program with clinical support from nurse practitioners. A description of the model is presented, and early implementation experiences during the first year of the project are reported. Important elements include better medical care through implementation of Interventions to Reduce Acute Care Transfers tools and chronic care management, enhanced transitional care, and better palliative care with a focus on systematic advance care planning. There were 4,035 long‐stay residents in 19 facilities enrolled in OPTIMISTIC between February 2013 and January 2014. Root‐cause analyses were performed for all 910 acute transfers of these long stay residents. Of these transfers, the project RN evaluated 29% as avoidable (57% were not avoidable and 15% were missing), and opportunities for quality improvement were identified in 54% of transfers. Lessons learned in early implementation included defining new clinical roles, integrating into nursing facility culture, managing competing facility priorities, communicating with multiple stakeholders, and developing a system for collecting and managing data. The success of the overall initiative will be measured primarily according to reduction in avoidable hospitalizations of long‐stay nursing facility residents.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Issue
    URL: Article
    DOI: 10.1111/jgs.2015.63.issue-1
    DOI: 10.1111/jgs.13141
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2040494-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...