In:
Pacing and Clinical Electrophysiology, Wiley, Vol. 28, No. 4 ( 2005-04), p. 304-310
Abstract:
Aim: The aim of this article is to examine whether cardiac resynchronization therapy (CRT) induces improvements in the neurohumoral system. Methods and Results: Thirteen patients with HF (left ventricular (LV) ejection fraction 〈 35%) were included. Before and after 6 months of CRT, myocardial 123 I‐metaiodobenzylguanidine ( 123 I‐MIBG) uptake indices, used as an index of neural norepinephrine reuptake and retention, and brain natriuretic peptide (BNP) levels, used as an index of LV end‐diastolic pressure, NYHA classification and echocardiographic indices were assessed. Six months of CRT resulted in significant improvement in (1) NYHA classification and reduction in QRS width (P 〈 0.001), (2) decrease of LV end‐diastolic diameter (P = 0.005), LV end‐systolic diameter (P = 0.005), septal to lateral delay (P = 0.01) and mitral regurgitation (MR, P = 0.04), (3) delayed 123 I‐MIBG heart/mediastinum ratios improved (P = 0.03) and 123 I‐MIBG washout decreased (P = 0.001), and (4) BNP levels decreased (P = 0.001). Conclusions: Parallel to significant functional improvement and echocardiographic reverse remodeling and resynchronization, our data indicate that CRT induces favorable changes in the neurohumoral system.
Type of Medium:
Online Resource
ISSN:
0147-8389
,
1540-8159
DOI:
10.1111/pace.2005.28.issue-4
DOI:
10.1111/j.1540-8159.2005.09508.x
Language:
English
Publisher:
Wiley
Publication Date:
2005
detail.hit.zdb_id:
2037547-5
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