In:
Influenza and Other Respiratory Viruses, Wiley, Vol. 7, No. 5 ( 2013-09), p. 838-846
Abstract:
Influenza virus A ( H 1 N 1)pdm09 first appeared in I srael in late A pril 2009, disappeared in mid‐ M arch 2010, and reappeared in late O ctober 2010. Symptoms were mostly mild without need for medical care. Objectives To provide targets for future pandemic preparedness and response by evaluating the dynamics and cumulative incidence of A ( H 1 N 1)pdm09 infection, the virus‐specific seroprevalence ( HI antibody titer 〉 1:40) at the height of the pandemic, during its decline and thereafter. Methods A cross‐sectional seroepidemiological study was conducted on 6911 serum samples collected before, during, and after the pandemic. Results Cumulative incidence of infection derived from the differences between post‐ and pre‐pandemic seroprevalence was 54·1%, 32·9%, 22·9%, 14·8%, and 6·3% in age‐groups 0–9, 10–19, 20–49, 50–79, and ≥80 years, respectively, and 28·5% for all age‐groups combined. Vaccination could have contributed at the most 4·6% to the post‐pandemic population seroprevalence. High pre‐pandemic immune response (47·4%) found in a cohort aged 15–18 year was strongly associated with birth years 1990–1993. Morbidity began to decline in mid‐November 2009 at 32·8% population seroprevalence (45% in ages 0–19 year) and stopped in March 2010 at 43·4% population seroprevalence in February 2010 (70% in ages 0–19 year). Between F ebruary and S eptember 2010, seroprevalence declined by 12·2% allowing virus recirculation from O ctober 2010. Conclusions Our study provides targets for controlling future influenza pandemics in Israel. Vaccination should focus on the younger age‐groups (0–19 year) which played a key role in transmission of the A ( H 1 N 1)pdm09 due to lack of background immunity (ages 0–9 year) and high exposure rates (ages 10–19 year).
Type of Medium:
Online Resource
ISSN:
1750-2640
,
1750-2659
DOI:
10.1111/irv.2013.7.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2272349-3
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