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  • 1
    Online-Ressource
    Online-Ressource
    Wiley ; 1998
    In:  Journal of Cardiovascular Electrophysiology Vol. 9, No. 8 ( 1998-08), p. 791-797
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 9, No. 8 ( 1998-08), p. 791-797
    Materialart: Online-Ressource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 1998
    ZDB Id: 2037519-0
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Wiley ; 2021
    In:  The Laryngoscope Vol. 131, No. 3 ( 2021-03)
    In: The Laryngoscope, Wiley, Vol. 131, No. 3 ( 2021-03)
    Kurzfassung: Arytenoid adduction (AA) has been indicated for unilateral vocal fold paralysis (UVFP) patients with vertical vocal fold height mismatch and/or large posterior glottic gaps that are unable to be adequately addressed by anterior medialization techniques. Although AA offers several advantages over other methods, it is technically challenging and involves significant laryngeal manipulation of the cricoarytenoid joint. A novel, minimally invasive endoscopic arytenoid medialization technique is presented for the closure of the posterior commissure. Study Design Prospective case series. Methods Seventeen consecutive patients were diagnosed and treated with unilateral endoscopic arytenoid medialization (EAM) combined with injection laryngoplasty because of unilateral vocal fold paralysis. Jitter, shimmer, harmonics‐to‐noise ratio (HNR), maximum phonation time (MPT), fundamental frequency (F 0 ), Voice Handicap Index (VHI), peak inspiratory flow (PIF), and quality of life (QoL) were evaluated preoperatively, 1 month, and 1 year after EAM. Results Jitter, shimmer, HNR, and MPT significantly improved and remained stable 1 year after the intervention. F 0 and PIF remained unchanged. Significant improvements in VHI and QoL demonstrated patient satisfaction with voicing and respiratory functions. Conclusions Endoscopic arytenoid medialization is a quick, minimally invasive solution for unilateral vocal fold paralysis. With simultaneous augmentation of the vocal fold, it provides a complete glottic closure along the entire vocal fold in UVFP patients. Level of Evidence 4 Laryngoscope , 131:E903–E910, 2021
    Materialart: Online-Ressource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2026089-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: The Laryngoscope, Wiley, Vol. 130, No. 4 ( 2020-04)
    Kurzfassung: Subglottic stenosis is the most common laryngeal anomaly necessitating tracheostomy in early childhood. Crico‐ and laryngotracheal resection and laryngotracheal reconstruction—usually with autologous cartilage graft implantation—are the most effective treatments. These surgical techniques are obviously challenging in neonatal age and infancy. However, a reconstructive surgery performed at early age may prevent the sequel of complications. Methods The authors present their novel surgical method for congenital subglottic stenosis. Seven infants had inspiratory stridor; two of them had to be intubated and one required tracheostomy. Laryngotracheoscopy, CT or MRI revealed subglottic stenosis: Cotton‐Myer grade II in one, and grade III in six cases. Slide laryngotracheoplasty was performed before 5 months of age (10–130 days), with a follow‐up period of average 36 months (4–80 months). Phoniatry and quality of life questionnaire were used for evaluation of postoperative results. Results Slide laryngotracheoplasty in the neonatal age made the temporary tracheostomy unnecessary. All babies remained intubated for 3 to 10 days with an uncuffed tracheal tube. After extubation, no dyspnea or swallowing disorder occurred. A subjective quality of life questionnaire, laryngotracheoscopy, clinical growth charts showed satisfactory functional results. Conclusions Single‐stage slide laryngotracheoplasty might be a favorable solution for subglottic stenosis, even in early childhood. In one step, the airway can be maintained without stenting and tracheostomy. Level of Evidence 4 Laryngoscope , 130:E199–E205, 2020
    Materialart: Online-Ressource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2020
    ZDB Id: 2026089-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: The Laryngoscope, Wiley, Vol. 125, No. 11 ( 2015-11), p. 2522-2529
    Kurzfassung: Comparison of different endoscopic glottis‐widening procedures designed for bilateral vocal cord immobility (BVCI) is a challenge. This is because a statistically efficient analysis and comparable clinical series is hard to obtain considering the variable aspects of the results and the evaluation methods. This study of a large number of cadaver larynges provides comparable, objective data for the evaluation of the possible postoperative breathing and voicing function. Study Design A morphometric study was performed on 50 male and 50 female larynges to compare the different suture lateralization and resection procedures. Methods The postoperative characteristic of glottic configuration was evaluated following vocal cord laterofixation, endolaryngeal arytenoid abduction lateropexy (EAAL), Schobel's external lateralization procedure (SELP), transverse cordotomy (TC), and medial and total arytenoidectomies (AE). The glottic area and the parameters determining the phoniatric outcomes were assessed by a digital image analyzer program. Results Improvement of glottic area was observed after all procedures, but arytenoid abduction procedures were significantly the most effective. However, the smallest vocal cord angles were found in TC and AE; the injury of the voicing structures results in a deterioration of vocal mechanics and can be reasonably assumed to negatively influence the voice. Endolaryngeal arytenoid abduction lateropexy and SELP may provide the best phonation closure when residual adduction regeneration can occur. Conclusion This study demonstrates the complexity of the correct surgical decision making in BVCI. Procedures that utilize physiological abduction of the arytenoid cartilage seem to be more advantageous, especially if recovery of adductor function occurs. Level of Evidence N/A. Laryngoscope , 125:2522–2529, 2015
    Materialart: Online-Ressource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2026089-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Online-Ressource
    Online-Ressource
    Wiley ; 2017
    In:  The Laryngoscope Vol. 127, No. 5 ( 2017-05), p. 1109-1115
    In: The Laryngoscope, Wiley, Vol. 127, No. 5 ( 2017-05), p. 1109-1115
    Kurzfassung: The complex laryngeal functions are fundamentally defined by the cricoid cartilage. Thus, lesions requiring subtotal or total resection of the cricoid cartilage commonly warrant total laryngectomy. However, from an oncological perspective, the resection of the cricoid cartilage would be an optimal solution in these cases. The poor functional results of the few reported cases of total and subtotal cricoidectomy with different reconstruction techniques confirm the need for new approaches to reconstruct the infrastructure of the larynx post cricoidectomy. Study Design Retrospective case series review. Methods Four consecutive patients with low‐grade chondrosarcoma were treated by cricoidectomy with rotational thyrotracheopexy reconstruction to enable the functional creation of a complete cartilaginous ring that can substitute the functions of the cricoid cartilage. The glottic structures were stabilized with endoscopic arytenoid abduction lateropexy. Patients were evaluated with objective and subjective function tests. Results Tumor‐free margins were proven; patients were successfully decannulated within 3 weeks. Voice outcomes were adequate for social conversation in all cases. Oral feeding was possible in three patients. Conclusion Total and subtotal cricoidectomy can be a surgical option to avoid total laryngectomy in cases of large chondrosarcomas destroying the cricoid cartilage. The thyrotracheopexy rotational advancement technique enables the effective reconstruction of the structural deficit of the resected cricoid cartilage in cases of total and subtotal cricoidectomy. An adequate airway for breathing, swallowing, and voice production can be reconstructed with good oncological control. In cases where the pharynx is not involved, good swallowing function can also be achieved. Level of Evidence 4. Laryngoscope , 127:1109–1115, 2017
    Materialart: Online-Ressource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2026089-1
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    In: Pediatric Dermatology, Wiley, Vol. 34, No. 5 ( 2017-09), p. 540-546
    Kurzfassung: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are medical emergencies. Mainstays of treatment include removal of the offending agent, supportive care, and wound care. The use of immunosuppressive agents such as corticosteroids and intravenous immunoglobulin (IVIg) is controversial. Some case reports and small studies report the successful use of cyclosporin A (CsA) for SJS/TEN in halting disease progression, fostering reepithelialization, and reducing mortality. Objective To report on the efficacy of cyclosporine A in the treatment of SJS/TEN in three pediatric patients. Methods We describe three pediatric patients seen at a tertiary care hospital in Boston, Massachusetts, diagnosed with SJS/TEN confirmed by skin biopsy who were successfully treated with CsA with improvements seen in time to cessation of disease progression or new lesion formation, reepithelialization, and duration of hospital stay. Results The average time cessation of disease progression or new lesion formation after CsA administration was 2.2 days (range 1.5–3 days) and average time to remission or reepithelialization was 13 days (range 10–15 days). The average length of hospital stay was 11.7 days (range 4–19 days). Conclusions We describe three pediatric patients treated successfully with CsA and provide evidence for the use of cyclosporine in children with SJS/TEN. These results further support previous observations that CsA use for SJS/TEN produces consistently favorable outcomes. The results in this case series are limited by their observational nature. Additional trials are needed to evaluate the safety and efficacy of CsA use in children.
    Materialart: Online-Ressource
    ISSN: 0736-8046 , 1525-1470
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2020833-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Solar RRL, Wiley, Vol. 5, No. 8 ( 2021-08)
    Kurzfassung: Nickel oxide (NiO) is used as a hole‐transporting layer (HTL) in perovskite solar cells (PSCs) because of its high optical transmittance, intrinsic p‐type doping, and suitable valence band energy level. However, fabricating high‐quality NiO films typically requires high‐temperature annealing, which limits their applicability for low‐temperature, printable PSCs. Herein, the need for such postprocessing steps is circumvented by coupling 4‐hydroxybenzoic acid (HBA) or trimethyloxonium tetrafluoroborate (Me 3 OBF 4 ) ligand‐modified NiO nanoparticles (NPs) with a Tesla‐valve microfluidic mixer to deposit high‐quality NiO films at a temperature 〈 150 °C. The NP dispersions and the resulting thin films are thoroughly characterized using a combination of optical, structural, thermal, chemical, and electrical methods. While the optical and structural properties of the ligand‐exchanged NiO NPs remain comparable with those possessing the native long‐chained aliphatic ligands, the ligand‐modified NiO thin films exhibit dramatic reductions in surface energy and an increase in hole mobilities. These are correlated with concomitant and significant enhancements in performance and stability factors of PSCs when the ligand‐modified NiO NPs are used as HTL layers within p−i−n device architectures.
    Materialart: Online-Ressource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2882014-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Journal of Neurochemistry, Wiley, Vol. 151, No. 2 ( 2019-10), p. 255-272
    Kurzfassung: Volume‐regulated anion channel (VRAC) is a glutamate‐permeable channel that is activated by physiological and pathological cell swelling and promotes ischemic brain damage. However, because VRAC opening requires cytosolic ATP, it is not clear if and how its activity is sustained in the metabolically compromised CNS. In the present study, we used cultured astrocytes – the cell type which shows prominent swelling in stroke – to model how metabolic stress and changes in gene expression may impact VRAC function in the ischemic and post‐ischemic brain. The metabolic state of primary rat astrocytes was modified with chemical inhibitors and examined using luciferin–luciferase ATP assays and a Seahorse analyzer. Swelling‐activated glutamate release was quantified with the radiotracer D‐[ 3 H]aspartate. The specific contribution of VRAC to swelling‐activated glutamate efflux was validated by RNAi knockdown of the essential subunit, leucine‐rich repeat‐containing 8A (LRRC8A); expression levels of VRAC components were measured with qRT‐PCR. Using this methodology, we found that complete metabolic inhibition with the glycolysis blocker 2‐deoxy‐D‐glucose and the mitochondrial poison sodium cyanide reduced astrocytic ATP levels by 〉  90% and abolished glutamate release from swollen cells (via VRAC). When only mitochondrial respiration was inhibited by cyanide or rotenone, the intracellular ATP levels and VRAC activity were largely preserved. Bypassing glycolysis by providing the mitochondrial substrates pyruvate and/or glutamine led to partial recovery of ATP levels and VRAC activity. Unexpectedly, the metabolic block of VRAC was overridden when ATP‐depleted cells were exposed to extreme cell swelling (≥ 50% reduction in medium osmolarity). Twenty‐four hour anoxic adaptation caused a moderate reduction in the expression levels of the VRAC component LRRC8A, but no significant changes in VRAC activity. Overall, our findings suggest that (i) astrocytic VRAC activity and metabolism can be sustained by low levels of glucose and (ii) the inhibitory influence of diminishing ATP levels and the stimulatory effect of cellular swelling are the two major factors that govern VRAC activity in the ischemic brain. image
    Materialart: Online-Ressource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 2020528-4
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    In: American Journal of Medical Genetics, Wiley, Vol. 76, No. 5 ( 1998-04-13), p. 438-445
    Materialart: Online-Ressource
    ISSN: 0148-7299 , 1096-8628
    URL: Issue
    RVK:
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 1998
    ZDB Id: 2143866-3
    ZDB Id: 2143867-5
    ZDB Id: 1493479-6
    ZDB Id: 2205916-7
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    In: The Laryngoscope, Wiley, Vol. 127, No. 7 ( 2017-07), p. 1608-1614
    Kurzfassung: Bilateral vocal cord paralysis in early childhood is a life‐threatening condition, which often requires immediate intervention. One of the treatment options is a quick, reversible simple suture vocal cord lateralizing technique, whereby the arytenoid cartilage is directly lateralized to the normal abducted position. Considering pediatric laryngeal anatomy, a small endolaryngeal thread guide instrument was designed for precise suture insertion. Study Design New instrument validation. Methods Four newborns had inspiratory stridor immediately after birth; two had to be intubated. Laryngotracheoscopy revealed bilateral vocal cord paralysis. Unilateral, left‐sided endoscopic arytenoid abduction lateropexy was performed with supraglottic jet ventilation on the 4th, 5th, 5th, and 27th day of life for the four patients, respectively. Results All babies remained intubated for 3 to 7 days with an uncuffed tracheal tube. After extubation, no dyspnea or swallowing disorder occurred. A subjective quality of life questionnaire, laryngotracheoscopy, clinical growth charts, and voice analysis showed satisfactory functional results. Conclusions Minimally invasive, quick, reversible endoscopic arytenoid abduction lateropexy might be a more favorable solution for neonatal bilateral vocal cord paralysis than earlier treatment strategies. In one step, the airway can be maintained without the risk of any permanent damage to voice production. Good swallowing function is also preserved. The specially modified endolaryngeal thread guide instrument gives a fast and effective option for creating the lateralized arytenoid position even in the technically challenging surgical context of a neonate larynx. Level of Evidence 4. Laryngoscope , 127:1608–1614, 2017
    Materialart: Online-Ressource
    ISSN: 0023-852X , 1531-4995
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2026089-1
    Standort Signatur Einschränkungen Verfügbarkeit
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