In:
Endocrinology, Diabetes & Metabolism, Wiley, Vol. 4, No. 3 ( 2021-07)
Abstract:
Longitudinal data on progression, complications, and management of type 2 diabetes mellitus (T2DM) across India are scarce. LANDMARC (CTRI/2017/05/008452), the first pan ‐India, longitudinal, prospective, observational study, aims to understand the management and real‐world outcomes of T2DM over 3 years. Methods Adults (≥25 to ≤60 years old at T2DM diagnosis; diabetes duration ≥2 years at enrollment; controlled/uncontrolled on ≥2 anti‐diabetic agents) were enrolled. Baseline characteristics were analyzed using descriptive statistics. Results Of the 6279 recruited participants, 6236 were eligible for baseline assessment (56.6% [ n / N = 3528/6236] men; mean ± SD age: 52.1 ± 9.2 years, diabetes duration: 8.6 ± 5.6 years). mean ± SD HbA1c, fasting plasma glucose, and postprandial glucose values were 64 ± 17 mmol/mol (8.1 ± 1.6%), 142.8 ± 50.4 mg/dl, and 205.7 ± 72.3 mg/dl, respectively. Only 25.1% ( n / N = 1122/6236) participants had controlled glycemia (HbA1c 〈 53 mmol/mol, 〈 7%). Macrovascular and microvascular complications were prevalent in 2.3% ( n / N = 145/6236) and 14.5% ( n / N = 902/6236) participants, respectively. Among those with complications, non‐fatal myocardial infarction ( n / N = 74/145, 51.0%) and neuropathy ( n / N = 737/902, 81.7%) were the most reported macrovascular and microvascular complication, respectively. Hypertension ( n / N = 2566/3281, 78.2%) and dyslipidemia ( n / N = 1635/3281, 49.8%) were the most reported cardiovascular risks. Majority (74.5%; n / N = 4643/6236) were taking oral anti‐diabetic drugs (OADs) only, while 24.4% ( n / N = 1522/6236) participants were taking OADs+insulin. Biguanides ( n / N = 5796/6236, 92.9%) and sulfonylureas ( n / N = 4757/6236, 76.3%) were the most reported OADs. Basal ( n / N = 837/6236, 13.4%) and premix ( n / N = 684/6236, 11.0%) insulins were the most reported insulins. Conclusions Baseline data from LANDMARC help understand the clinical/medical profile of study participants and underscore the extent of suboptimal glycemic control and prevalence of associated complications in a vast majority of Indians with T2DM.
Type of Medium:
Online Resource
ISSN:
2398-9238
,
2398-9238
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
2934368-9
Permalink