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  • 1
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 34, No. 2 ( 2020-02)
    Kurzfassung: Vitamin D (mainly 25‐hydroxyvitamin D, 25[OH]D) has stimulated increasing interest in Saudi Arabia over the current years due to its association with several different chronic diseases such as diabetes. This study aims to ascertain whether the vitamin D level has any influence on glycemic control in Saudi patients with type 2 diabetes (T2DM). Method This retrospective study included 200 patients with T2DM who visited Prince Sattam Bin Abdulaziz University Hospital between January 2015 and December 2015. Venous blood was collected and examined for “serum/plasma levels of 25(OH)D” and related variables using kit methods. HbA1C levels 〈 7% and ≥7% were taken as indicators of good and poor glycemic control, respectively. An association between vitamin D deficiency and poor glycemic control was determined using multinomial logistic regression analysis. Results Among the total of 200 patients with type 2 diabetes, 118 (59%) were female and 82 (41%) were males with the mean age 42.4 ± 14.8 years. Good glycemic control (HbA1c  〈  7) was observed in 127 (63.5%), and poor glycemic control (HbA1c   〉   7) was found in 73(36.5%). The mean serum 25(OH)vit D was 20.27 ± 8.66 ng/mL, with (52% vs 82%; P  ≤ .001) of subjects identified to have vitamin D deficiency in good and poor glycemic control groups, respectively. Conclusion Taken together, our results demonstrated an association of vitamin D level with poor glycemic control in patients with type 2 diabetes. However, additional studies with larger sample size from local population are warranted in future to confirm and extend the findings of the present study.
    Materialart: Online-Ressource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2020
    ZDB Id: 2001635-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Molecular Genetics & Genomic Medicine, Wiley
    Kurzfassung: Transcobalamin II ( TCN 2) defect is a rare metabolic disorder associated with a range of neurological manifestations, including mild developmental delay, severe intellectual disability, ataxia, and, in some cases, seizures. Cobalamin, an essential nutrient, plays a crucial role in central nervous system myelination. Clinical Presentation We present a family with an index patient who exhibited progressive neurodevelopmental regression starting at 9 months of age, accompanied by myoclonic seizures, ataxia, and tremor. No significant hematological abnormalities were observed. Exome sequencing analysis identified a novel homozygous mutation, c.3G 〉 A – P(Met1I), affecting the acceptor site of intron 4 of the TCN 2 gene (chromosome 22: 31003321, NM_000355.4), leading to likely pathogenic variant potentially affecting translation. Following treatment with hydroxocobalamin, the patient demonstrated partial clinical improvement. He has a sibling with overt hematological abnormalities and subtle neurological abnormalities who is homozygous to the same mutation. Both parents are heterozygous for the same mutation. Conclusions In infants presenting with unexplained non‐specific neurological symptoms, irrespective of classical signs of vitamin B12 deficiency, evaluation for TCN 2 defect should be considered. Early diagnosis and appropriate management can lead to favorable outcomes.
    Materialart: Online-Ressource
    ISSN: 2324-9269 , 2324-9269
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 2734884-2
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    In: Pediatric Transplantation, Wiley, Vol. 28, No. 3 ( 2024-05)
    Kurzfassung: Most kidneys from small pediatric donors are transplanted to adult recipients because of the perceived risk of surgical complications and graft thrombosis. In this study, we aim to demonstrate our favorable outcomes in transplanting pediatric kidneys from donors 〈 15 k into pediatric recipients. Methods This study retrospectively analyzes the outcomes of seven pediatric recipients of en block kidney transplants from pediatric donors weighing 〈 15 kg performed at King Fahad Specialist Hospital‐Dammam from December 2014 to January 2018. Baseline characteristics of donors and recipients were collected. The incidences of surgical complication, immediate, and intermediate graft function were the primary outcomes. Results The study included seven recipients monitored for a mean duration of 6.86 ± 1.35. Donors’ and recipients’ mean weights were 7.4 ± 3.2 kg and 20.7 ± 9.2 kg, respectively. Ureteric stricture occurred in one patient. There was a substantial improvement of 1‐year estimated glomerular filtration rate (eGFR) compared to the 1‐week mark (106.7 ± 26.38 mL/min. 1.73 m 2 vs. 63.7 ± 22.92 mL/min/1.73 m 2 , p = .0069). The observed improvement in renal function persisted at the 5‐year mark and during the last follow‐up, with eGFR of 70.3 ± 40.7 mL/min/1.73 m 2 , and 79.8 ± 30.8 mL/min/1.73 m 2 , respectively. There was also increase of 27.9% in the size of the en bloc kidney observed at the 6 months. Conclusion In a specialized transplant center with highly skilled surgeons, the utilization of en bloc kidney transplant from donors weighing less than 15 kg is an effective strategy for expanding the donor pool and ensuring favorable graft outcomes.
    Materialart: Online-Ressource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2024
    ZDB Id: 2008614-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    In: Photodermatology, Photoimmunology & Photomedicine, Wiley, Vol. 38, No. 4 ( 2022-07), p. 328-333
    Kurzfassung: The aim was to assess the effectiveness of antimicrobial photodynamic therapy (aPDT) as an adjunct to mechanical instrumentation (MI) in reducing Enterococcus faecalis ( E faecalis ) and Candida albicans ( C albicans ) counts from C‐shaped root‐canals. Methods Teeth with C‐shaped canals as identified on cone beam computed tomographic images were included. Following incubation with E faecalis and C albicans , samples were divided into 4 groups a four follows: Group‐1: MI with adjunct aPDT; Group‐2: aPDT alone; Group‐3: MI alone; and Group‐4: no treatment. The pulp chambers of these teeth were exposed and coronal pulp was mechanically derided using sterile endodontic excavators. Using flexible files, all canals were debrided up to size #30 K‐files with intermittent irrigation with 2.5% sodium hypochlorite irrigation. In Groups 1 and 3, methylene‐blue was injected in all canals and aPDT was performed using a 600 nm diode laser. Sample‐size estimation was done on data from a pilot investigation and group‐comparisons were done using one way analysis of variance and Bonferroni post‐hoc adjustment tests. P 〈 .05 was considered statistically significant. Results Sixty periodontally hopeless mandibular second molars with C‐shaped canals were included. There was a statistically significant reduction CFU/mL of E faecalis ( P 〈 .001) and C albicans ( P 〈 .001). At post‐operative microbial assessments in Group‐1. There was no difference CFU/mL of E faecalis and C albicans at post‐operative microbial assessments in Groups 2‐4. Conclusion MI with adjunct aPDT is more effective in reducing count of E faecalis and C albicans from C‐shaped root canals.
    Materialart: Online-Ressource
    ISSN: 0905-4383 , 1600-0781
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2026222-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    In: Clinical Case Reports, Wiley, Vol. 10, No. 4 ( 2022-04)
    Kurzfassung: The neurobehavioral syndrome known as spatial neglect, which could be a result of a brain tumor, is common but difficult to diagnose and manage. This case study describes the evaluation of spatial neglect syndrome psychologically in detail and also builds an initial discussion of the role of the Arabic language, which requires a right‐to‐left‐oriented spatial frame, to understand the severity of the symptoms. We report a case of spatial neglect syndrome after a brain tumor. A 7‐year‐old boy presented to the CDC clinics with a significant limitation of attention and very poor school achievement. The patient underwent several neuropsychological assessments, including an intellectual IQ test, social and adaptive behavior testing, attention deficit hyperactivity disorder testing, and a battery of neuropsychological tests to detect the presence of spatial neglect, as well as a psychological interview and observation. We present a 7‐year‐old boy with spatial neglect syndrome who visited the primary children's mental health department. The additional role of the Arabic language could have more of an impact on the symptoms and the proper rehabilitation intervention. After the proper diagnosis and rehabilitation intervention, the child showed a good outcome with regard to his attention and focusing skills as well as his school performance.
    Materialart: Online-Ressource
    ISSN: 2050-0904 , 2050-0904
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2740234-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Wiley ; 2019
    In:  Phytotherapy Research Vol. 33, No. 11 ( 2019-11), p. 2960-2970
    In: Phytotherapy Research, Wiley, Vol. 33, No. 11 ( 2019-11), p. 2960-2970
    Kurzfassung: Although the approved hepatitis B virus (HBV)‐polymerase inhibitors (e.g., lamivudine) often lead to drug‐resistance, several natural products have shown promising efficacies. Though Aloe vera (AV) gel and its constituents are shown inhibitors of many viruses, their anti‐HBV activity still remains elusive. We therefore, tested the anti‐HBV potential of AV extract and its anthraquinones in hepatoma cells, including molecular docking, high‐performance thin layer chromatography (HPTLC), and cytochrome P450 ( CYP3A4 ) activation analyses. Our anti‐HBV assays (HBsAg/HBeAg Elisa) showed maximal inhibition of viral antigens production by aloe‐emodin (~83%) 〉 chrysophanol (~62%) 〉 aloin B (~61%) 〉 AV extract (~37%) in HepG2.2.15 cells. Interestingly, the effect of aloe‐emodin was comparable with lamivudine (~86%). Moreover, sequential treatment with lamivudine (pulse) followed by aloe‐emodin (chase) enhanced the efficacy of monotherapy by ~12%. Docking (AutoDock Vina) of the anthraquinones indicated strong interactions with HBV‐polymerase residues that formed stable complexes with high Gibbs's free energy. Further, identification of aloe‐emodin and aloin B by validated HPTLC in AV extract strongly endorsed its anti‐HBV potential. In addition, our luciferase‐reporter gene assay of transfected HepG2 cells showed moderate induction of CYP3A4 by aloe‐emodin. In conclusion, this is the first report on anti‐HBV potential of AV–derived anthraquinones, possibly via HBV‐polymerase inhibition. Of these, although aloin B exhibits novel antiviral effect, aloe‐emodin appears as the most promising anti‐HBV natural drug with CYP3A4 activating property towards its enhanced therapeutic efficacy.
    Materialart: Online-Ressource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2019
    ZDB Id: 1493490-5
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Nursing Open, Wiley, Vol. 8, No. 2 ( 2021-03), p. 766-775
    Kurzfassung: The primary aim of this qualitative inquiry is to explore the experiences of Registered Nurses working in Saudi Arabia, which was a guide to answer the question, “what are the lived experiences of Registered Nurses working in a selected government hospital in Eastern Region of Saudi Arabia towards workplace violence?” Background Workplace violence is a social phenomenon that needs a widespread campaign to eradicate. Incidence from all over the world continues to grow in number, especially among Registered Nurses in Saudi Arabia. Methods Descriptive phenomenology. Purposive‐convenience sampling was used in selecting 21 Registered Nurses as participants for individual in‐depth interviews. Data were gathered over an 11 month's period from September 2017 to August 2018. We used Colaizzi's method for analysing the data. COREQ criteria were adapted in reporting the results of the study. Results Three themes had emerged from the experiences of the participants: “co‐workers become unjust and violent”; “socio‐cultural divergence towards healthcare workers”; and “violence from outside influences affecting the workplace.”
    Materialart: Online-Ressource
    ISSN: 2054-1058 , 2054-1058
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2809556-X
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    In: Pediatric Transplantation, Wiley, Vol. 26, No. 3 ( 2022-05)
    Kurzfassung: Graft‐versus‐host disease (GVHD) is a rare but serious complication after pediatric liver transplantation (LTx). Early diagnosis is difficult due to nonspecific presenting symptoms and non‐pathognomonic skin histopathological features. The aim of this article was to describe a case of pediatric GVHD after LTx and to review available data on pediatric GVHD highlighting the diagnostic difficulty. We also propose a diagnostic algorithm to improve the diagnostic capability and increase clinical awareness about this potentially fatal condition. Methods We did a comprehensive literatures review on studies on GvHD following pediatric LTx between 1990 and February 2021, chimerism study by short tandem repeat (STR), HLA typing by sequence‐specific oligonucleotide (SSO) method, and flowcytometry crossmatch. Results Our search yielded 23 case reports. The most common clinical manifestations were fever and rash (91%) followed by diarrhea. Mortality rate was 36.8% mainly due to sepsis and organ failure. Diagnosis was challenging and chimerism study to confirm donor engraftment was performed on only half of the cases. Prevalence of “donor dominant HLA one‐way matching” typically occurs in homozygous parents‐to‐child transplantation was 75% in cases with HLA testing. Conclusion So far, there are no available standard diagnostic criteria for GVHD following pediatric LTx. Recognition of multiple risk factors through proper laboratory assessment can predict the occurrence, and early chimerism study can confirm suggestive clinical manifestation. The strong likelihood of developing GVHD in “donor one‐way HLA match” and the severe problems imposed by this complication may justify avoidance of HLA homozygous parent's donation.
    Materialart: Online-Ressource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2022
    ZDB Id: 2008614-3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Wiley ; 2023
    In:  Journal of Biochemical and Molecular Toxicology Vol. 37, No. 2 ( 2023-02)
    In: Journal of Biochemical and Molecular Toxicology, Wiley, Vol. 37, No. 2 ( 2023-02)
    Kurzfassung: The cytochrome P450 1 A (CYP1A) subfamily enzymes are involved in the metabolic activation of several xenobiotics to toxic metabolites and reactive intermediates, resulting ultimately in carcinogenesis. Mercury and halogenated aromatic hydrocarbons (HAHs), typified by 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), are persistent environmental pollutants involved in the modulation of aryl hydrocarbon receptor (AHR) gene battery, including cytochrome P450 ( CYP ) genes. We previously investigated the effect of coexposure to either inorganic or organic mercury (Hg +2 and MeHg) with TCDD on CYP1A1 in vitro. Thus, we examined the impact of coexposure to Hg +2 or MeHg and TCDD on AHR‐regulated genes ( Cyp1a1/1a2 ) in vivo and in vitro. Therefore, male C57BL/6 mice were injected intraperitoneally with MeHg or Hg +2 (2.5 mg/kg) in the absence and presence of TCDD (15 μg/kg) for 6 or 24 h. The concentration‐dependent effect of MeHg was examined in murine hepatoma Hepa1c1c7 cells. In vivo, both MeHg and Hg 2+ inhibited the TCDD‐mediated induction of Cyp1a1/1a2 mRNA levels. However, Only Hg 2+ was able to inhibit the TCDD‐mediated induction at posttranscriptional levels of CYP1A1/1A2 protein and catalytic activity, suggesting differential modulation effects by Hg +2 and MeHg. In addition, the inhibitory role of HO‐1 (Heme oxygenase‐1) on CYP1A activity induced by TCDD was investigated using a HO‐1 competitive inhibitor, tin‐mesoporphyrin, that partially restored the MeHg‐mediated decrease in CYP1A1 activity. This study demonstrates that MeHg, alongside Hg 2+ , can differentially modulate the TCDD‐induced AHR‐regulated genes ( Cyp1a1/1a2 ) at different expression levels in C57BL/6 mice liver and Hepa1c1c7 cells.
    Materialart: Online-Ressource
    ISSN: 1095-6670 , 1099-0461
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2023
    ZDB Id: 1481995-8
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Online-Ressource
    Online-Ressource
    Wiley ; 2021
    In:  Catheterization and Cardiovascular Interventions Vol. 97, No. 3 ( 2021-02-15), p. 470-474
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 97, No. 3 ( 2021-02-15), p. 470-474
    Kurzfassung: We sought to evaluate the nationwide trends in the characteristics and outcomes of for endovascular stroke therapy in contemporary practice. Methods We selected patients with acute ischemic stroke who underwent endovascular stroke therapy between 01 October 2015 and 30 September 2019 in a large academic consortium database. The end points of this study were (a) in‐hospital mortality and functional outcomes and, (b) predictors of poor functional outcome, defined as death or discharge to hospice, or to a long‐term nursing facility. Results Among the 22,193 included patients; 50.3% were females, and 66.5% were white. Mean age was 68±15 years. Poor functional outcomes occurred in 8,274 patients (37.4%), of whom 2,741 (12.4%) died in the hospital, 1,345 (6.1%) were discharged to hospice, and 4,188 (18.9%) were discharged to other long‐term facilities. Most common in‐hospital complications were mechanical ventilation (32.3%), intracranial hemorrhage (18.9%), and acute kidney injury (15.6%). Median total and intensive‐care length‐of‐stay were 7 days (IQR = 4–9), and 2 days (IQR = 1–4), respectively. Median cost was $36,609 (IQR = $26,034–$54,313). In a multi‐logistic regression analysis; age, hypertension, diabetes, anemia, heart failure, vascular disease, chronic pulmonary disease, renal insufficiency, Medicare/medicaid insurance, transfer from nonendovascular capable hospital, and low procedural volume independently predicted poor functional outcomes. Tissue plasminogen activator use was associated with better functional outcomes. Conclusion There is a substantial growth in the performance of endovascular stroke interventions in the United States in recent years, and those were associated with favorable short‐term outcomes.
    Materialart: Online-Ressource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2021
    ZDB Id: 2001555-0
    Standort Signatur Einschränkungen Verfügbarkeit
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