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  • 1
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    Online Resource
    Anemia as a useful biomarker in patients with diffuse large B‐cell lymphoma treated with R‐ CHOP immunochemotherapy
    Wiley ; 2014
    In:  Cancer Science Vol. 105, No. 12 ( 2014-12), p. 1569-1575
    Details
    In: Cancer Science, Wiley, Vol. 105, No. 12 ( 2014-12), p. 1569-1575
    Abstract: The aim of the current study is to evaluate the prognostic value of anemia, an easily estimable parameter in patients with diffuse large B‐cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R‐CHOP) immunochemotherapy. A total of 157 patients with newly diagnosed diffuse large B‐cell lymphoma treated with ≥1 cycle of R‐CHOP were included. Hemoglobin level without red cell transfusion within 7 days of initiation of treatment was chosen as a parameter of baseline cancer‐induced anemia. To investigate the clinical significance of chemotherapy‐induced anemia and its recovery after completion of treatment, 87 patients in complete remission for ≥6 months from the time of the last cycle of R‐CHOP were grouped and analyzed separately. Patients with a cancer‐induced anemia of hemoglobin 〈 10 g/dL showed inferior event‐free and disease‐free survival compared to those with hemoglobin ≥10 g/dL. This finding was observed irrespective of the status of pre‐treatment bone marrow involvement. In multivariate analysis, hemoglobin 〈 10 g/dL was found to be an international prognostic index‐independent prognostic factor. Risk of relapse was significantly higher for patients who were still anemic at 6 months after R‐CHOP, compared to those who achieved complete recovery from chemotherapy‐induced anemia within 6 months.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.2014.105.issue-12
    DOI: 10.1111/cas.12544
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 2
    Online Resource
    Online Resource
    Performance evaluation of Mindray CAL 8000(BC-6800 and SC-120) hematology analyzer and slidemaker/stainer
    Wiley ; 2017
    In:  Journal of Clinical Laboratory Analysis Vol. 31, No. 4 ( 2017-07), p. e22065-
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 31, No. 4 ( 2017-07), p. e22065-
    Type of Medium: Online Resource
    ISSN: 0887-8013
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2017.31.issue-4
    DOI: 10.1002/jcla.22065
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001635-9
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  • 3
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    Online Resource
    Detection and genomic analysis of genital group B streptococcus in pregnant Korean women
    Wiley ; 2019
    In:  Journal of Obstetrics and Gynaecology Research Vol. 45, No. 1 ( 2019-01), p. 69-77
    Details
    In: Journal of Obstetrics and Gynaecology Research, Wiley, Vol. 45, No. 1 ( 2019-01), p. 69-77
    Abstract: Group B streptococcus (GBS) is a leading cause of life‐threatening bacterial infections among newborns, and neonates born to heavily colonized women may be subject to vertical transmission. We sought to determine an appropriate detection method for genital GBS in pregnant women by comparing culture‐based methods and real‐time polymerase chain reaction (PCR). In addition, we performed molecular serotyping and multilocus sequence typing (MLST) on isolates. Methods A total of 150 pregnant women were enrolled and underwent vaginal‐rectal swabbing at 16–40 weeks of gestation. GBS was identified by conventional culture and real‐time PCR with or without enrichment. Molecular serotyping and MLST were performed on isolates. Results Overall genital GBS positive rate among the 150 study subjects was 17.3%. Direct culture identified 18 (12.0%) positive specimens, enrichment culture 22 (14.6%), direct PCR 24 (16.0%) and enrichment PCR 25 (16.6%). The sensitivity and specificity by direct and enrichment PCR were as follows: for direct PCR, 90.9% and 96.9%, respectively; and for enrichment PCR, 95.5% and 96.9%, respectively. Resistance rates to clindamycin and erythromycin were 33.3% and 19.1%, respectively. Serotype III‐1 was the most common (26.3%), followed by serotype Ib (21.1%), III‐3 (15.8%), V (15.8%), II (10.5%), IV (5.3%) and VI (5.3%). Most common sequence types (ST) were ST‐1, ST‐19 and ST‐862 (15.8%), followed by ST‐2 and ST‐654 (10.5%). Conclusion Direct real‐time PCR using vaginal‐rectal specimen could be used for detecting GBS in emergent conditions. Molecular serotypes III, Ib and V were most common. MLST analysis frequently presented ST‐1, ST‐19 and ST‐862.
    Type of Medium: Online Resource
    ISSN: 1341-8076 , 1447-0756
    URL: Issue
    URL: Article
    DOI: 10.1111/jog.2019.45.issue-1
    DOI: 10.1111/jog.13810
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2079101-X
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  • 4
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    Online Resource
    M ycobacterium wolinskyi Infection Confirmed by rpo B Gene Sequencing
    Wiley ; 2012
    In:  Journal of Clinical Laboratory Analysis Vol. 26, No. 5 ( 2012-09), p. 325-327
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 26, No. 5 ( 2012-09), p. 325-327
    Abstract: Identification of rapidly growing mycobacteria ( RGM ) is problematic because there are many taxonomic changes. 16 S r RNA gene is commonly used to identify M ycobacterium species, but alternative gene targets have been introduced for more accurate identification. We report a rare case of a prosthetic knee infection due to M ycobacterium wolinskyi . The isolate was not identified by 16 S r RNA gene sequencing alone and substantially confirmed by rpo B gene sequencing. The identification was delayed because our laboratory did not routinely identify RGM to the species level. Simultaneous sequencing of both 16 S r RNA and rpo B genes will allow rapid and accurate identification of M . wolinskyi isolates. J. Clin. Lab. Anal. 26:325‐327, 2012. © 2012 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2012.26.issue-5
    DOI: 10.1002/jcla.21526
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2001635-9
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  • 5
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    Online Resource
    Laboratory diagnosis of Clostridium difficile infection: Comparison of Techlab C. diff Quik Chek Complete, Xpert C. difficile, and multistep algorithmic approach
    Wiley ; 2017
    In:  Journal of Clinical Laboratory Analysis Vol. 31, No. 6 ( 2017-11)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 31, No. 6 ( 2017-11)
    Abstract: Clostridium difficile is a major pathogen responsible for nosocomial infectious diarrhea. We explored optimal laboratory strategies for diagnosis of C. difficile infection ( CDI ) in our clinical settings, a 1400‐bed tertiary care hospital. Methods Using 191 fresh stool samples from adult patients, we evaluated the performance of Xpert C. difficile (Xpert CD ), C. diff Quik Chek Complete (which simultaneously detects glutamate dehydrogenase [ GDH ] and C. difficile toxins [ CDT ]), toxigenic culture, and a two‐step algorithm composed of GDH / CDT as a screening test and Xpert CD as a confirmatory test. Results Clostridium difficile was detected in 35 samples (18.3%), and all isolates were toxigenic strains. The sensitivity, specificity, positive predictive value ( PPV ), and negative predictive value of each assay for detecting CDI were as follows: Quik Chek Complete CDT (45.7%, 100%, 100%, 89.1%), Quik Chek Complete GDH (97.1%, 99.4%, 97.1%, 99.4%), Xpert CD (94.3%, 100%, 100%, 98.7%), and toxigenic culture (91.4%, 100%, 100%, 98.1%). A two‐step algorithm performed identically with Xpert CD assay. Conclusion Our data showed that most C. difficile isolates from adult patients were toxigenic. We demonstrated that a two‐step algorithm based on GDH / CDT assay followed by Xpert CD assay as a confirmatory test was rapid, reliable, and cost effective for diagnosis of CDI in an adult patient setting with high prevalence of toxigenic C. difficile .
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2017.31.issue-6
    DOI: 10.1002/jcla.22135
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2001635-9
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  • 6
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    Online Resource
    How useful is bone marrow study as an initial investigative tool without lymph node biopsy in malignant lymphoma?: Eleven years of experience at a single institution
    Wiley ; 2019
    In:  Journal of Clinical Laboratory Analysis Vol. 33, No. 4 ( 2019-05)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 33, No. 4 ( 2019-05)
    Abstract: Bone marrow (BM) study plays an important role as initial investigation specimen of lymphoma as well as staging lymphoma. This study aimed to investigate the utility of BM studies for classification of lymphoma and evaluate features of BM involvement by lymphoma over a period of 11 years. Methods A total of 1162 cases of BM studies for lymphoma evaluation were reviewed for the incidence of lymphoma subtypes, the percentage of marrow involvement, the pattern of involvement and discordance with histopathologic diagnoses of lymph nodes and other tissues. Results A total of 255 of 1162 cases underwent BM study without pathologic information, and 108 cases show lymphoma involvement. Lymph node biopsy underwent in 66 cases, and 10 cases show discordant result between BM and lymph node biopsy. Seven discordant cases were due to insufficient further studies. Lymphoma was diagnosed only by BM study in 38 cases. Abnormal lymphocytes were found in BM aspiration in 34 cases. Also, abnormal clonal lymphocytes were detected by flow cytometry in 26 cases. Four cases showed disease‐related chromosomal abnormalities. FISH analysis detected abnormal findings in two cases, however, discordant with other additional studies. Conclusions Discrepancies between the BM study and lymph node biopsy were due to insufficient further study and discordance of immunohistochemical stain result. BM study can be utilized as initial diagnosis of lymphoma by the combination of morphological feature, involvement pattern, and additional tests such as flow cytometry, chromosomal analysis, and FISH analysis. Thus, BM study with further analysis is an essential choice when lymph node biopsies are unavailable.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2019.33.issue-4
    DOI: 10.1002/jcla.22841
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001635-9
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  • 7
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    Online Resource
    Evaluation of global laboratory methods and establishing on‐therapy ranges for monitoring apixaban and rivaroxaban: Experience at a single institution
    Wiley ; 2019
    In:  Journal of Clinical Laboratory Analysis Vol. 33, No. 5 ( 2019-06)
    Details
    In: Journal of Clinical Laboratory Analysis, Wiley, Vol. 33, No. 5 ( 2019-06)
    Abstract: Apixaban and rivaroxaban are approved for the prevention and treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and embolic stroke in atrial fibrillation (AF) patients. The aim of this study was to find appropriate methods of monitoring the anticoagulant effects of are direct oral anticoagulants (DOACs) and establish on‐therapy ranges using conventional tests. Methods A total of 184 samples were collected from 91 patients receiving DOACs. Concentrations of apixaban and rivaroxaban in plasma were accessed by an anti‐factor Xa chromogenic assay. PT, APTT, antithrombin, D‐dimer, dRVVT screen/confirm, FDP, and fibrinogen levels were measured. On‐therapy ranges were calculated by substituting previously reported trough plasma concentrations of DOACs. Results Anti‐factor Xa chromogenic assay‐based DOACs levels were 26.0‐279.5 (115.9 ± 56.5) ng/mL for apixaban at 2.5 mg BID, 19.9‐565.1 (205.3 ± 162.4) ng/mL for apixaban at 5 mg BID, 2.3‐395.3 (205.3 ± 162.4) ng/mL for rivaroxaban at 15 mg OD, 3.6‐494.8 (119.6 ± 95.1) ng/mL for rivaroxaban at 20 mg OD, and 9.6‐431.4 (140.8 ± 113.6) ng/mL for rivaroxaban at 15 mg BID. PT (%), antithrombin, and dRVVT confirm tests showed good correlation with plasma apixaban levels. Plasma rivaroxaban concentrations were correlated well with PT (sec), PT (%),and dRVVT confirm results. On‐therapy ranges established for dRVVT confirm test by linear regression were as follows: 1.32‐1.52 for apixaban 2.5 mg BID, 1.12‐1.75 for apixaban 5 mg BID, 1.11‐1.78 for rivaroxaban 15 mg OD, 1.09‐1.64 for rivaroxaban 20 mg OD, and 1.22‐1.81 for rivaroxaban 20 mg BID. Conclusions Apixaban concentrations were well correlated with PT (%), antithrombin, and dRVVT confirm test. Rivaroxaban concentrations showed good correlation with PT (sec), PT (%), and dRVVT confirm test.
    Type of Medium: Online Resource
    ISSN: 0887-8013 , 1098-2825
    URL: Issue
    URL: Article
    DOI: 10.1002/jcla.2019.33.issue-5
    DOI: 10.1002/jcla.22869
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2001635-9
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