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  • 1
    Online Resource
    Online Resource
    Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis
    Wiley ; 2019
    In:  Alcoholism: Clinical and Experimental Research Vol. 43, No. 2 ( 2019-02), p. 270-276
    Details
    In: Alcoholism: Clinical and Experimental Research, Wiley, Vol. 43, No. 2 ( 2019-02), p. 270-276
    Abstract: Alcoholic gastritis, a superficial erosive disease of the stomach, is a common manifestation of risky alcohol use. In contrast, cannabis which is frequently co‐used with alcohol suppresses gastric acidity and might counteract the deleterious effect of alcohol on the gastric mucosa. However, no clinical study has examined the impact of cannabis use on the development of alcoholic gastritis among risky alcohol users. Methods We analyzed hospital discharge records of adults (age ≥ 18 years), from 2014 of the Nationwide Inpatient Sample, with a diagnosis of risky alcohol use ( n  = 316,916). We used a propensity‐based matching algorithm to match cannabis users to nonusers on 1:1 ratio (30,713: 30,713). We then measured the adjusted relative risk ( aRR ) for having alcoholic gastritis using conditional Poisson regression models with generalized estimating equations. Results Our study revealed that among risky alcohol users, cannabis co‐users have a lower prevalence of alcoholic gastritis compared to noncannabis users (1,289 [1,169 to 1,421] vs. 1,723 [1,583 to 1,875] per 100,000 hospitalizations for risky alcohol use), resulting in a 25% decreased probability of alcoholic gastritis ( aRR : 0.75 [0.66 to 0.85]; p ‐value 〈 0.0001). Furthermore, dependent cannabis usage resulted in a lower prevalence of alcoholic gastritis when compared to both nondependent cannabis users (0.72 [0.52 to 0.99]) and to nonc annabis users (0.56 [0.41 to 0.76]). Conclusions We reveal that risky alcohol drinking combined with cannabis use is associated with reduced prevalence of alcohol‐associated gastritis in patients. Given increased cannabis legislation globally, understanding whether and how the specific ingredients in cannabis plant extract can be used in the treatment of alcoholic gastritis is paramount. In this regard, further molecular mechanistic studies are needed to delineate the mechanisms of our novel findings not only for alcoholic gastritis but also for gastritis from other causes.
    Type of Medium: Online Resource
    ISSN: 0145-6008 , 1530-0277
    URL: Issue
    URL: Article
    DOI: 10.1111/acer.2019.43.issue-2
    DOI: 10.1111/acer.13930
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2046886-6
    detail.hit.zdb_id: 3167872-5
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Inferior Outcomes of Patients With Acute Myocardial Infarction and Comorbid Protein‐Energy Malnutrition
    Wiley ; 2020
    In:  Journal of Parenteral and Enteral Nutrition Vol. 44, No. 3 ( 2020-03), p. 454-462
    Details
    In: Journal of Parenteral and Enteral Nutrition, Wiley, Vol. 44, No. 3 ( 2020-03), p. 454-462
    Abstract: Protein‐energy malnutrition (PEM) diminishes amino acid and energy availability, impairing the body's healing capability after injury, such as in myocardial damage following acute myocardial infarction (AMI). Aims We sought to investigate the influence of PEM on clinical outcomes of AMI. Methods We identified records with a primary discharge diagnosis of AMI from the Nationwide Inpatient Sample (2012–2014), stratified by concomitant PEM. We matched PEM to no‐PEM (1:1) using a greedy algorithm–based propensity methodology and estimated the impact of PEM on health outcomes (SAS 9.4). Results Of the 332,644 hospitalizations for AMI, 11,675 had concomitant PEM accounting for roughly $US 1.5 billion and over 119,792 hospital days. PEM was associated with older age (74.43‐ vs. 66.90‐years; P   〈  0.0001), female sex (49.19% vs. 38.44%; P   〈  0.0001), black race (12.78% vs. 10.46%; P   〈  0.0001), and higher comorbidity burden (Deyo 〉 3: 32.77% vs. 16.69%; P   〈  0.0001). After propensity matching, PEM was associated with higher mortality (Adjusted odds ratio [AOR]: 1.59 [1.46–1.73] ), cardiogenic shock (AOR: 2.26 [2.08–2.44]), discharge to secondary facilities (AOR: 2.21 [2.10–2.33] ), charges ($135,500 [$131,956–139,139] vs. $81,084 [$79,241–82,970] ), cardiac artery bypass surgery (AOR:1.81 [1.66–1.97]), intra‐aortic balloon pump placement (AOR: 1.83 [1.65–2.04] ) and longer length of stay (10.15‐ vs. 5.52‐days). Conclusions PEM is a predisposing factor for devastating clinical outcomes among AMI hospitalizations. Higher prevention, identification and management of PEM among high‐risk individuals (older age, female sex, and black race) residing in the community are needed.
    Type of Medium: Online Resource
    ISSN: 0148-6071 , 1941-2444
    URL: Issue
    URL: Article
    DOI: 10.1002/jpen.v44.3
    DOI: 10.1002/jpen.1680
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2170060-6
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  • 3
    Online Resource
    Online Resource
    Reduced Risk of Alcohol‐Induced Pancreatitis With Cannabis Use
    Wiley ; 2019
    In:  Alcoholism: Clinical and Experimental Research Vol. 43, No. 2 ( 2019-02), p. 277-286
    Details
    In: Alcoholism: Clinical and Experimental Research, Wiley, Vol. 43, No. 2 ( 2019-02), p. 277-286
    Abstract: Pancreatitis is an increasingly common clinical condition that causes significant morbidity and mortality. Cannabis use causes conflicting effects on pancreatitis development. We conducted a larger and more detailed assessment of the impact of cannabis use on pancreatitis. Methods We analyzed data from 2012 to 2014 of the Healthcare Cost and Utilization Project—Nationwide Inpatient Sample discharge records of patients 18 years and older. We used the International Classification of Disease, Ninth Edition codes, to identify 3 populations: those with gallstones (379,125); abusive alcohol drinkers (762,356); and non‐alcohol‐non‐gallstones users (15,255,464). Each study population was matched for cannabis use record by age, race, and gender, to records without cannabis use. The estimation of the adjusted odds ratio ( aOR ) of having acute and chronic pancreatitis ( AP and CP ) made use of conditional logistic models. Results Concomitant cannabis and abusive alcohol use were associated with reduced incidence of AP and CP ( aOR : 0.50 [0.48 to 0.53] and 0.77 [0.71 to 0.84] ). Strikingly, for individuals with gallstones, additional cannabis use did not impact the incidence of AP or CP . Among non‐alcohol‐non‐gallstones users, cannabis use was associated with increased incidence of CP , but not AP (1.28 [1.14 to 1.44] and 0.93 [0.86 to 1.01] ). Conclusions Our findings suggest a reduced incidence of only alcohol‐associated pancreatitis with cannabis use.
    Type of Medium: Online Resource
    ISSN: 0145-6008 , 1530-0277
    URL: Issue
    URL: Article
    DOI: 10.1111/acer.2019.43.issue-2
    DOI: 10.1111/acer.13929
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2046886-6
    detail.hit.zdb_id: 3167872-5
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
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