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  • 1
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    Effect of sodium glucose cotransporter 2 inhibitors on atrial tachy‐arrhythmia burden in patients with cardiac implantable electronic devices
    Wiley ; 2023
    In:  Journal of Cardiovascular Electrophysiology Vol. 34, No. 8 ( 2023-08), p. 1595-1604
    Details
    In: Journal of Cardiovascular Electrophysiology, Wiley, Vol. 34, No. 8 ( 2023-08), p. 1595-1604
    Abstract: Use of sodium glucose cotransporter 2 inhibitors (SGLT2i) was associated with a reduction in atrial fibrillation hospitalizations. Therefore, we aim to evaluate the effects of SGLT2i on atrial tachy‐arrhythmias (ATA) in patients with cardiac implantable electronic devices (CIEDs). Methods All 13 888 consecutive patients implanted with a CIED in two tertiary medical centers were enrolled. Treatment with SGLT2i was assessed as a time dependent variable. The primary endpoint was the total number of ATA. Secondary endpoints included total number of ventricular tachy‐arrhythmias (VTA), ATA and VTA, and death. All events were independently adjudicated blinded to the treatment. Multivariable propensity score modeling was performed. Results During a total follow‐up of 24 442 patient years there were 62 725 ATA and 10 324 VTA events. Use of SGLT2i ( N  = 696) was independently associated with a significant 22% reduction in the risk of ATA (hazard ratio [HR] = 0.78 [95% confidence interval {CI} = 0.70–0.87] ; p   〈  .001); 22% reduction in the risk of ATA/VTA (HR = 0.78 [95% CI = 0.71–0.85]; p   〈  .001); and with a 35% reduction in the risk of all‐cause mortality (HR = 0.65 [95% CI = 0.45–0.92]; p  = .015), but was not significantly associated with VTA risk (HR = 0.92 [95% CI = 0.80–1.06]; p  = .26). SGLT2i were associated with a lower ATA burden in heart failure (HF) patients but not among diabetes patients (HF: HR = 0.68, 95% CI = 0.58–0.80, p   〈  .001 vs. Diabetes: HR = 0.95, 95% CI = 0.86–1.05, p  = .29; p   〈  .001 for interaction between SGLT2i indication and ATA burden). Conclusion Our real world findings suggest that in CIED HF patients, those with SGLT2i had a pronounced reduction in ATA burden and all‐cause mortality when compared with those not on SGLT2i.
    Type of Medium: Online Resource
    ISSN: 1045-3873 , 1540-8167
    URL: Issue
    URL: Article
    DOI: 10.1111/jce.v34.8
    DOI: 10.1111/jce.15996
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2037519-0
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  • 2
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    The impact of moderate aortic stenosis in acute myocardial infarction: A multicenter retrospective study
    Wiley ; 2023
    In:  Catheterization and Cardiovascular Interventions Vol. 102, No. 1 ( 2023-07), p. 159-165
    Details
    In: Catheterization and Cardiovascular Interventions, Wiley, Vol. 102, No. 1 ( 2023-07), p. 159-165
    Abstract: Aortic stenosis (AS) is associated with myocardial ischemia through different mechanisms and may impair coronary arterial flow. However, data on the impact of moderate AS in patients with acute myocardial infarction (MI) is limited. Aims This study aimed to investigate the impact of moderate AS in patients presenting with acute myocardial infarction (MI). Methods We conducted a retrospective analysis of all patients who presented with acute MI to all Mayo Clinic hospitals, using the Enterprise Mayo PCI Database from 2005 to 2016. Patients were stratified into two groups: moderate AS and mild/no AS. The primary outcome was all cause mortality. Results The moderate AS group included 183 (13.3%) patients, and the mild/no AS group included 1190 (86.7%) patients. During hospitalization, there was no difference between both groups in mortality. Patients with moderate AS had higher in‐hospital congestive heart failure (CHF) (8.2% vs. 4.4%, p  = 0.025) compared with mild/no AS patients. At 1‐year follow‐up, patients with moderate AS had higher mortality (23.9% vs. 8.1%, p   〈  0.001) and higher CHF hospitalization (8.3% vs. 3.7%, p  = 0.028). In multivariate analysis, moderate AS was associated with higher mortality at 1‐year (odds ratio 2.4, 95% confidence interval [1.4–4.1], p  = 0.002). In subgroup analyses, moderate AS increased all‐cause mortality in STEMI and NSTEMI patients. Conclusion The presence of moderate AS in acute MI patients was associated with worse clinical outcomes during hospitalization and at 1‐year follow‐up. These unfavorable outcomes highlight the need for a close follow‐up of these patients and for timely therapeutic strategies to best manage these coexisting conditions.
    Type of Medium: Online Resource
    ISSN: 1522-1946 , 1522-726X
    URL: Issue
    URL: Article
    DOI: 10.1002/ccd.v102.1
    DOI: 10.1002/ccd.30676
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2001555-0
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  • 3
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    Development and application of a prioritization and rehabilitation decision support tool for uncontrolled waste disposal sites in developing countries
    Wiley ; 2023
    In:  Integrated Environmental Assessment and Management Vol. 19, No. 2 ( 2023-03), p. 436-445
    Details
    In: Integrated Environmental Assessment and Management, Wiley, Vol. 19, No. 2 ( 2023-03), p. 436-445
    Abstract: This study presents a pragmatic prioritization model to prioritize dumpsites based on a risk sensitivity index (RSI) with two different tools to address municipal solid waste (MSW) and construction and demolition waste (CDW) dumpsites. The prioritization model serves to categorically stratify uncontrolled municipal waste disposal sites into different classifications based on the RSI, which indicates the risk to the environment and the need for intervention. The rehabilitation decision tool (RDT) provides a methodological framework that describes and compares different remediation scenarios depending on the RSI. The easy‐to‐use model can be used to facilitate the decisions that many municipal authorities have to make when it comes to prioritizing dumpsites for remediation and adopting an appropriate remediation plan.
    Type of Medium: Online Resource
    ISSN: 1551-3777 , 1551-3793
    URL: Issue
    URL: Article
    DOI: 10.1002/ieam.v19.2
    DOI: 10.1002/ieam.4665
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2231760-0
    SSG: 21
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  • 4
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    Hydrological and watershed characteristics of the El‐Kabir River, North Lebanon
    Wiley ; 2005
    In:  Lakes & Reservoirs: Science, Policy and Management for Sustainable Use Vol. 10, No. 2 ( 2005-06), p. 93-101
    Details
    In: Lakes & Reservoirs: Science, Policy and Management for Sustainable Use, Wiley, Vol. 10, No. 2 ( 2005-06), p. 93-101
    Abstract: The El‐Kabir River watershed is the largest in western Lebanon and is shared between Lebanon and Syria. The river forms most of the northern boundary of Lebanon with Syria, being characterized by water flow throughout the year. The characteristics of the river and its variable hydrologic properties are the result of abrupt changes in land physiography. Until recently, data on Lebanese rivers was inadequate, especially for rivers shared with other countries. The El‐Kabir River watershed typifies this situation, particularly when the river has undergone many changes, including water pollution and declining discharge because of changing climate and increased pollution. This study was implemented in the context of a large investigation of the watershed which was funded by the International Development Research Council, Canada, for the purpose of improving the baseline data and knowledge required to effectively manage this important resource. Within the water cycle, ≈ 250 × 10 6  m 3 of precipitation falls on the Lebanese side. Of this volume, ≈ 50% is lost as evaporation and transpiration, while 5–50% of the remainder infiltrates to ground water, with the residual becoming land run‐off. An obvious decline of ≈ 40% of the total river discharge of the river has occurred over the last 50 years. It can be explained by climate change and by water extraction associated with dramatic increases in population and associated land uses. The hydraulic configuration and characteristics of the river have two major orientations; namely, NE–SW and E–W. These orientations are the product of geological structure and lithologies. Furthermore, each has different hydrologic properties related to watershed size, elevation, slope, catchment shape and orientation, although both orientations are directly inter‐related.
    Type of Medium: Online Resource
    ISSN: 1320-5331 , 1440-1770
    URL: Issue
    URL: Article
    DOI: 10.1111/lre.2005.10.issue-2
    DOI: 10.1111/j.1440-1770.2005.00262.x
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2020624-0
    SSG: 12
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  • 5
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    Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups
    Wiley ; 2022
    In:  Brain and Behavior Vol. 12, No. 1 ( 2022-01)
    Details
    In: Brain and Behavior, Wiley, Vol. 12, No. 1 ( 2022-01)
    Abstract: Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects ( N  = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n  = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects ( n  = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset ( n  = 386) of controls (brainageR: ICC = 0.71, R  = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R  = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R  = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v12.1
    DOI: 10.1002/brb3.2413
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2623587-0
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  • 6
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    Evidence on the Relationship between Housing and Consumption in the United States: A State-Level Analysis : MONEY, CREDIT AND BANKING
    Wiley ; 2013
    In:  Journal of Money, Credit and Banking Vol. 45, No. 4 ( 2013-06), p. 559-590
    Details
    In: Journal of Money, Credit and Banking, Wiley, Vol. 45, No. 4 ( 2013-06), p. 559-590
    Type of Medium: Online Resource
    ISSN: 0022-2879
    URL: Article
    DOI: 10.1111/jmcb.12016
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2010422-4
    detail.hit.zdb_id: 218362-6
    SSG: 3,2
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  • 7
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    Reorganization of brain connectivity in obesity
    Wiley ; 2017
    In:  Human Brain Mapping Vol. 38, No. 3 ( 2017-03), p. 1403-1420
    Details
    In: Human Brain Mapping, Wiley, Vol. 38, No. 3 ( 2017-03), p. 1403-1420
    Abstract: Global brain connectivity (GBC) identifies regions of the brain, termed “hubs,” which are densely connected and metabolically costly, and have a wide influence on brain function. Since obesity is associated with central and peripheral metabolic dysfunction we sought to determine if GBC is altered in obesity. Two independent fMRI data sets were subjected to GBC analyses. The first data set was acquired while participants ( n  = 15 healthy weight and 15 obese) tasted milkshake and the second with participants at rest ( n  = 33 healthy weight and 28 obese). In the resting state and during milkshake consumption GBC is consistently decreased in the ventromedial and ventrolateral prefrontal cortex, insula and caudate nucleus, and increased in brain regions belonging to the dorsal attention network including premotor areas, superior parietal lobule, and visual cortex. During milkshake consumption, but not at rest, additional decreases in GBC are observed in feeding‐related circuitry including the insula, amygdala, anterior hippocampus, hypothalamus, midbrain, brainstem and somatomotor cortex. Additionally, GBC differences were not accounted for by age. These results demonstrate that obesity is associated with decreased GBC in prefrontal and feeding circuits and increased GBC in the dorsal attention network. We therefore conclude that global brain organization is altered in obesity to favor networks important for external orientation over those monitoring homeostatic state and guiding feeding decisions. Furthermore, since prefrontal decreases are also observed at rest in obese individuals future work should evaluate whether these changes are associated with neurocognitive impairments frequently observed in obesity and diabetes. Hum Brain Mapp 38:1403–1420, 2017 . © 2016 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v38.3
    DOI: 10.1002/hbm.23462
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1492703-2
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  • 8
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    Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder
    Wiley ; 2016
    In:  Human Brain Mapping Vol. 37, No. 9 ( 2016-09), p. 3214-3223
    Details
    In: Human Brain Mapping, Wiley, Vol. 37, No. 9 ( 2016-09), p. 3214-3223
    Abstract: Major depressive disorder is a disabling neuropsychiatric condition that is associated with disrupted functional connectivity across brain networks. The precise nature of altered connectivity, however, remains incompletely understood. The current study was designed to examine the coherence of large‐scale connectivity in depression using a recently developed technique termed global brain connectivity. Methods: A total of 82 subjects, including medication‐free patients with major depression ( n  = 57) and healthy volunteers ( n  = 25) underwent functional magnetic resonance imaging with resting data acquisition for functional connectivity analysis. Global brain connectivity was computed as the mean of each voxel's time series correlation with every other voxel and compared between study groups. Relationships between global connectivity and depressive symptom severity measured using the Montgomery‐Åsberg Depression Rating Scale were examined by means of linear correlation. Results: Relative to the healthy group, patients with depression evidenced reduced global connectivity bilaterally within multiple regions of medial and lateral prefrontal cortex. The largest between‐group difference was observed within the right subgenual anterior cingulate cortex, extending into ventromedial prefrontal cortex bilaterally (Hedges' g  = −1.48, P   〈  0.000001). Within the depressed group, patients with the lowest connectivity evidenced the highest symptom severity within ventromedial prefrontal cortex ( r  = −0.47, P  = 0.0005). Conclusions: Patients with major depressive evidenced abnormal large‐scale functional coherence in the brain that was centered within the subgenual cingulate cortex, and medial prefrontal cortex more broadly. These data extend prior studies of connectivity in depression and demonstrate that functional disconnection of the medial prefrontal cortex is a key pathological feature of the disorder. Hum Brain Mapp 37:3214–3223, 2016 . © 2016 Wiley Periodicals, Inc .
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v37.9
    DOI: 10.1002/hbm.23235
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1492703-2
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  • 9
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    Voluntary exercise induces anxiety-like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis
    Wiley ; 2009
    In:  Hippocampus ( 2009), p. NA-NA
    Details
    In: Hippocampus, Wiley, ( 2009), p. NA-NA
    Type of Medium: Online Resource
    ISSN: 1050-9631 , 1098-1063
    URL: Article
    DOI: 10.1002/hipo.20634
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 1498049-6
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  • 10
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    Watershed characteristics, land use and fabric: The application of remote sensing and geographical information systems
    Wiley ; 2005
    In:  Lakes & Reservoirs: Science, Policy and Management for Sustainable Use Vol. 10, No. 2 ( 2005-06), p. 85-92
    Details
    In: Lakes & Reservoirs: Science, Policy and Management for Sustainable Use, Wiley, Vol. 10, No. 2 ( 2005-06), p. 85-92
    Abstract: Integrated watershed assessment, especially relying on remote sensing (RS), is a newly established procedure in developing countries. It is proving to be a major component in river‐basin environmental management. The recurrence of environmental problems in the Akkar El Kabir River watershed, as well as the lack of proper data on sources and sinks of pollutants, and the extent of human interference, led to the current study. Advanced geoinformation tools, such as RS and geographical information systems (GIS), prove to be a valuable asset in securing data on the fabric of the Akkar watershed in relation to its natural setting and anthropic interference. This is particularly true in the current study as the river constitutes the boundary between Lebanon and Syria. Remote sensing captures the watershed characteristics and land use on both sides without constraints. The natural fabric includes geology, drainage, hydrogeology, forest and soil. The anthropic fabric includes settlements, utilities, roads, agriculture and land use. If it were not for geoinformation techniques, the task of securing such data would be difficult. Also, these techniques show the impact of malpractices from excessive human interference that result in degradation of land and water quality. Changes in the watershed, such as environmental deterioration, are observed as water pollution, soil erosion, forest decline and socioeconomic imbalance. Obviously, this is the outcome of malpractices in a multisectorial system. A major challenge for RS and GIS is to quantify, model and predict, if possible, the extent of these changes. Remote sensing inherently captures the impact of interaction between nature and human beings. Detection of change is a major indicator that RS can contribute to the evaluation of the state of the environment. The application of it on this watershed reveals that significant changes have occurred over the last 10–15 years, most of which are anthropic.
    Type of Medium: Online Resource
    ISSN: 1320-5331 , 1440-1770
    URL: Issue
    URL: Article
    DOI: 10.1111/lre.2005.10.issue-2
    DOI: 10.1111/j.1440-1770.2005.00264.x
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2020624-0
    SSG: 12
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