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  • Wiley  (4)
  • 1
    Online Resource
    Online Resource
    Rodent‐borne viruses in the region of Middle East
    Wiley ; 2023
    In:  Reviews in Medical Virology Vol. 33, No. 4 ( 2023-07)
    Details
    In: Reviews in Medical Virology, Wiley, Vol. 33, No. 4 ( 2023-07)
    Abstract: Rodents are one of the most abundant mammal species in the world. They form more than two‐fifth of all mammal species and there are approximately 4600 existing rodent species. Rodents are capable of transmitting deadly diseases, especially those that are caused by viruses. Viruses and their consequences have plagued the world for the last two centuries, three pandemics occurred during the last century only. The Middle East is situated at the crossroads of Africa and Asia, along with the Mediterranean Sea and the Indian Ocean, its geographic importance is gained through the diversity of topographies, biosphere, as well as climate aspects that make the region vulnerable to host emerging diseases. Refugee crises also play a major role in expected epidemic outbreaks in the region. Public health has always been the most important priority, and our aim in this review is to raise awareness among public health organisations across the Middle East about the dangers of rodent borne diseases that have been reported or are suspected to be found in the region.
    Type of Medium: Online Resource
    ISSN: 1052-9276 , 1099-1654
    URL: Issue
    URL: Article
    DOI: 10.1002/rmv.v33.4
    DOI: 10.1002/rmv.2440
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2002162-8
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    Online Resource
  • 2
    Online Resource
    Online Resource
    The controversy of SARS‐CoV‐2 integration into the human genome
    Wiley ; 2024
    In:  Reviews in Medical Virology Vol. 34, No. 1 ( 2024-01)
    Details
    In: Reviews in Medical Virology, Wiley, Vol. 34, No. 1 ( 2024-01)
    Abstract: Bat borne disease have attracted many researchers for years. The ability of the bat to host several exogenous viruses has been a focal point in research lately. The latest pandemic shifted the focus of scholars towards understanding the difference in response to viral infection between humans and bats. In a way to understand the basis of the interaction and behaviour between SARS‐CoV‐2 and the environment, a conflict between different researchers across the globe arose. This conflict asked many questions about the truth of virus‐host integration, whether an interaction between RNA viruses and human genomes has ever been reported, the possible route and mechanism that could lead to genomic integration of viral sequences and the methods used to detect integration. This article highlights those questions and will discuss the diverse opinions of the controversy and provide examples on reported integration mechanisms and possible detection techniques.
    Type of Medium: Online Resource
    ISSN: 1052-9276 , 1099-1654
    URL: Issue
    URL: Article
    DOI: 10.1002/rmv.v34.1
    DOI: 10.1002/rmv.2511
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2002162-8
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  • 3
    Online Resource
    Online Resource
    Pharmacogenomics of genetic polymorphism within the genes responsible for SARS‐CoV‐2 susceptibility and the drug‐metabolising genes used in treatment
    Wiley ; 2021
    In:  Reviews in Medical Virology Vol. 31, No. 4 ( 2021-07)
    Details
    In: Reviews in Medical Virology, Wiley, Vol. 31, No. 4 ( 2021-07)
    Abstract: The ongoing outbreak of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) represents a significant challenge to international health. Pharmacogenomics aims to identify the different genetic variations that exist between individuals and populations in order to determine appropriate treatment protocols to enhance the efficacy of drugs and reduce their side‐effects. This literature review provides an overview of recent studies of genetic polymorphisms in genes that mediate the SARS‐CoV‐2 infection mechanism (ACE1, ACE2, TMPRSS2 and CD26). In addition, genetic variations in the drug‐metabolising enzyme genes of several selected drugs used in the treatment of COVID‐19 are summarised. This may help construct an effective health protocol based on genetic biomarkers to optimise response to treatment. Potentially, pharmacogenomics could contribute to the development of effective high‐throughput assays to improve patient evaluation, but their use will also create ethical, medical, regulatory, and legal issues, which should now be considered in the era of personalised medicine.
    Type of Medium: Online Resource
    ISSN: 1052-9276 , 1099-1654
    URL: Issue
    URL: Article
    DOI: 10.1002/rmv.v31.4
    DOI: 10.1002/rmv.2194
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2002162-8
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  • 4
    Online Resource
    Online Resource
    Genomic and biological variation in bat IFNs: An antiviral treatment approach
    Wiley ; 2024
    In:  Reviews in Medical Virology Vol. 34, No. 1 ( 2024-01)
    Details
    In: Reviews in Medical Virology, Wiley, Vol. 34, No. 1 ( 2024-01)
    Abstract: Bat‐borne viruses have attracted considerable research, especially in relation to the Covid‐19 pandemic. Although bats can carry multiple zoonotic viruses that are lethal to many mammalian species, they appear to be asymptomatic to viral infection despite the high viral loads contained in their bodies. There are several differences between bats and other mammals. One of the major differences between bats and other mammals is the bats' ability to fly, which is believed to have induced evolutionary changes. It may have also favoured them as suitable hosts for viruses. This is related to their tolerance to viral infection. Innate immunity is the first line of defence against viral infection, but bats have metamorphosed the type of responses induced by innate immunity factors such as interferons. The expression patterns of interferons differ, as do those of interferon‐related genes such as interferon regulatory factors and interferon‐stimulated genes that contribute to the antiviral response of infected cells. In addition, the signalling pathways related to viral infection and immune responses have been subject to evolutionary changes, including mutations compared to their homologues in other mammals and gene selection. This article discusses the differences in the interferon‐mediated antiviral response in bats compared to that of other mammals and how these differences are correlated to viral tolerance in bats. The effect of bat interferons related genes on human antiviral response against bat‐borne viruses is also discussed.
    Type of Medium: Online Resource
    ISSN: 1052-9276 , 1099-1654
    URL: Issue
    URL: Article
    DOI: 10.1002/rmv.v34.1
    DOI: 10.1002/rmv.2488
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2002162-8
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