GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Wiley ; 2018
    In:  Psychiatry and Clinical Neurosciences Vol. 72, No. 7 ( 2018-07), p. 541-542
    In: Psychiatry and Clinical Neurosciences, Wiley, Vol. 72, No. 7 ( 2018-07), p. 541-542
    Type of Medium: Online Resource
    ISSN: 1323-1316 , 1440-1819
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2010264-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    Wiley ; 2014
    In:  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Vol. 165, No. 1 ( 2014-01), p. 19-27
    In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 165, No. 1 ( 2014-01), p. 19-27
    Abstract: Associations between human leukocyte antigen (HLA) polymorphisms on chromosome 6p and schizophrenia (SZ) risk have been evaluated for over five decades. Numerous case–control studies from the candidate gene era analyzed moderately sized samples and reported nominally significant associations with several loci in the HLA region (sample sizes, n = 100–400). The risk conferred by individual alleles was modest (odds ratios  〈  2.0). The basis for the associations could not be determined, though connections with known immune and auto‐immune abnormalities in SZ were postulated. Interest in the HLA associations has re‐emerged following several recent genome‐wide association studies (GWAS); which utilized 10‐ to 100‐fold larger samples and also identified associations on the short arm of chromosome 6. Unlike the earlier candidate gene studies, the associations are statistically significant following correction for multiple comparisons. Like the earlier studies; they have modest effect sizes, raising questions about their utility in risk prediction or pathogenesis research. In this review, we summarize the GWAS and reflect on possible bases for the associations. Suggestions for future research are discussed. We favor, in particular; efforts to evaluate local population sub‐structure as well as further evaluation of immune‐related variables in future studies. © 2013 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1552-4841 , 1552-485X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2143866-3
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    In: Veterinary Medicine and Science, Wiley, Vol. 10, No. 1 ( 2024-01)
    Abstract: Bee venom is used for medicinal purposes, including the treatment of neurological and liver diseases, but its use as a primary health care approach for preventive purposes requires further exploration. The aim of this study was to provide the first investigation into the possible protective effects of bee venom against hepatic encephalopathy, a serious neurodegenerative disease. Materials and Methods An experimental animal study was conducted in which healthy albino Sprague–Dawley rats were randomized into three groups: healthy, control and bee venom groups. All rats were tested for locomotor activity at the beginning and end of the study. No intervention was made in the healthy group, whereas hepatic encephalopathy was induced in the control and bee venom groups by the administration of thioacetamide (TAA) (200 mg/kg/day). The bee venom group also received bee venom (5 mg/kg/day) subcutaneously every day for 14 days prior to the TAA administration. Results The results for the final locomotor activity tests were statistically better in the bee venom group than in the control group, supporting a beneficial effect of prophylactic bee venom application. Blood ammonia levels and liver weights, determined as indicators of inflammation, were lower in the bee venom group than in the control group and were close to levels in the healthy group, but not statistically significant. Conclusions Bee venom administration has protective effects against the development of hepatic encephalopathy and offers a promising therapeutic opportunity in preventive medicine.
    Type of Medium: Online Resource
    ISSN: 2053-1095 , 2053-1095
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2819409-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    In: Asia-Pacific Psychiatry, Wiley, Vol. 12, No. 4 ( 2020-12)
    Abstract: Brain‐derived neurotrophic factor (BDNF) is involved in the regulation of many neuronal processes, including neurogenesis. Therefore, it is thought to be closely associated with many psychopathologies with a neurodevelopmental basis, for example, schizophrenia. Methods The patients admitted to the Psychiatry Department of the Faculty of Medicine with a diagnosis of non‐affective drug‐naïve first‐episode psychosis (FEP) were included in the study. The relationship between laboratory and clinical findings and psychometric data (Positive and Negative Syndrome Scale) was examined. Results The study population consisted of 34 FEP and 34 healthy control (HC) volunteers. Mean BNDF levels of FEP and HC groups were 14.95 ± 6.13 and 17.89 ± 4.84 pg/ml, respectively. The difference between the groups was statistically significant (t = 2.197; p = .032). There was a negative correlation between mean BDNF levels and PANSS general psychopathology subscale scores ( r = .358; p = .038), and total PANSS scores ( r = .356; p = .039). Discussion There is a consensus on low serum BDNF levels both in FEP and in schizophrenia. However, it is still not clear which clinical findings are associated with lower serum BDNF levels. The relationship between BDNF levels and psychopathologies in schizophrenia has to be investigated.
    Type of Medium: Online Resource
    ISSN: 1758-5864 , 1758-5872
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2506343-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    In: Journal of Applied Toxicology, Wiley, Vol. 28, No. 5 ( 2008-07), p. 591-598
    Type of Medium: Online Resource
    ISSN: 0260-437X , 1099-1263
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 1475015-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    Wiley ; 2007
    In:  Environmental and Molecular Mutagenesis Vol. 48, No. 6 ( 2007-07), p. 421-429
    In: Environmental and Molecular Mutagenesis, Wiley, Vol. 48, No. 6 ( 2007-07), p. 421-429
    Abstract: The Berdan River, which empties into the Mediterranean Sea on the east coast of Turkey, receives discharges of industrial and municipal waste. In the present study, the in vivo piscine micronucleus (MN) test was used to evaluate the genotoxicity of water samples collected from different locations along the Berdan River. Nile tilapia ( Oreochromis niloticus ) were exposed in the laboratory for 2, 4, and 6 days, and micronuclei were evaluated in peripheral blood erythrocytes, gill cells, and caudal fin epithelial cells. A single dose of 5 mg/L cyclophosphamide was used as a positive control. In addition to micronuclei, nuclear abnormalities (NAs), such as binucleated cells and blebbed, notched, and lobed nuclei, were assessed in the erythrocytes, and chemical analyses were carried out to determine the amount of heavy metals in the water samples. MN and NA frequencies were significantly elevated (up to 2‐ to 3‐fold) in fish exposed to river water samples taken downstream of potential discharges, and the elevated responses in gill and fin cells were related to the concentration of heavy metals in the water. MN frequencies (expressed as micronucleated cells/1,000 cells), in both treated and untreated fish, were greatest in gill cells (range: 0.80–3.70), and generally lower in erythrocytes (range: 0.50–2.80), and fin cells (range: 0.45–1.70). The results of this study indicate that the Berdan River is contaminated with genotoxic pollutants and that the genotoxicity is related to the discharge of wastes into the river water. Environ. Mol. Mutagen., 2007. © 2007 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0893-6692 , 1098-2280
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 1497682-1
    SSG: 12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    In: Annals of Noninvasive Electrocardiology, Wiley, Vol. 20, No. 4 ( 2015-07), p. 338-344
    Abstract: Coronary slow flow (CSF) is characterized by normal or near‐normal coronary arteries with delayed opacification of the distal vasculature that it may cause angina pectoris, acute myocardial infarction, life‐threatening arrhythmias, and sudden cardiac death. The Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio are also known as predictors of ventricular arrhythmogenesis. The aim of this study was to assess ventricular repolarization in patients with CSF by using Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio. Methods This study included 50 patients with CSF and 51 control subjects. Coronary flow rates of all subjects were documented by thrombolysis in myocardial infarction (TIMI) frame count (TFC). Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio were measured from the 12‐lead electrocardiogram. These parameters were compared between groups. Results In electrocardiographic parameters analysis, QT, QTc, QTd, and QTcd were significantly increased in CSF patients compared with the control subjects (P 〈 0.001, P = 0.019, P 〈 0.001, P 〈 0.001, respectively). The Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc ratio in the CSF patients were significantly higher than those in the control subjects (Tp‐e: 117 ± 21 milliseconds [ms] vs 96 ± 16 ms, P 〈 0.001; Tp‐e/QT: 0.30 ± 0.06 vs 0.27 ± 0.06, P = 0.005; Tp‐e/QTc: 0.27 ± 0.06 vs 0.24 ± 0.05, P 〈 0.001). In the multivariate analysis, increased Tp‐e and Tp‐e/QT ratio were associated with CSF. Conclusions Our study revealed that when compared to the control subjects, Tp‐e interval, Tp‐e/QT ratio, and Tp‐e/QTc were significantly increased in the CSF patients.
    Type of Medium: Online Resource
    ISSN: 1082-720X , 1542-474X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2111515-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...