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  • 1
    Online Resource
    Online Resource
    Iloprost and exercise haemodynamics in heart failure with preserved ejection fraction—the ILO‐HOPE randomised controlled trial
    Wiley ; 2021
    In:  British Journal of Clinical Pharmacology Vol. 87, No. 3 ( 2021-03), p. 1165-1174
    Details
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 87, No. 3 ( 2021-03), p. 1165-1174
    Abstract: A dramatic increase in pulmonary capillary wedge pressure (PCWP) during exercise is observed in patients with heart failure with preserved ejection fraction (HFpEF). This study was designed to determine whether iloprost inhalation could improve exercise haemodynamics and cardiac reserve in patients with HFpEF. Methods Thirty‐four HFpEF patients were enrolled in this double‐blind, randomized, placebo‐controlled, parallel‐group trial. Patients received both cardiac catheterization and underwent expired gas analysis at rest, during exercise, and before and 10 minutes after treatment with either inhaled iloprost or placebo. The primary endpoint was decrease in exercise PCWP. Results At baseline, enrolled patients showed an increase in PCWP during exercise (from 16 [range, 14–23] mmHg to 27 [21–36] mmHg; P 〈 .0001). After iloprost inhalation, exercise PCWP was significantly reduced compared to placebo (adjusted mean: 20 [16–29] mmHg vs 23 [17–32] mmHg; P = .002). There was no difference for cardiac output reserve with exercise in the 2 groups (0.2 [−1.3–1.2] L/min vs –0.7 [−1.9–0.1] L/min; P = .099). Iloprost improved the pulmonary artery pressure flow relationships in HFpEF with exercise compared to placebo. Conclusion Iloprost inhalation improved haemodynamic deficits during exercise in patients with HFpEF. Prospective trials testing long‐term iloprost therapy in this population are warranted.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    URL: Article
    DOI: 10.1111/bcp.v87.3
    DOI: 10.1111/bcp.14484
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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    SSG: 15,3
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  • 2
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    A Spin‐Orbit Torque Switch at Ferromagnet/Antiferromagnet Interface Toward Stochastic or Memristive Applications via Tailoring Antiferromagnetic Ordering
    Wiley ; 2023
    In:  Advanced Electronic Materials Vol. 9, No. 12 ( 2023-12)
    Details
    In: Advanced Electronic Materials, Wiley, Vol. 9, No. 12 ( 2023-12)
    Abstract: Antiferromagnet (AFM) has currently participated in the spin‐orbit torque (SOT) technology due to its great potential to be applied to the field‐free SOT switching and to promote the thermal stability of MRAM. However, the effect of varying AFM ordering on the SOT switching and the associated properties is still not comprehensively understood. This work reports how an AFM ordering modifies the strength of Dzyaloshinskii–Moriya‐interaction (DMI) in a heavy metal (Pt)/FM (Co)/AFM (IrMn) trilayer and its effects on SOT switching. Increasing the AFM ordering reflects the enhanced exchange bias through increasing IrMn thickness appears to significantly reduce the DMI strength of the trilayer. Controlling the IrMn thickness appears to serve as a unique switch to activate memristivity/stochasticity in the devices via tailoring AFM ordering on exchange bias: The strong AFM ordering via increasing IrMn thickness enables to increase the stability of multi‐levels for SOT switching, which promotes the memristivity for neuromorphic application. On the contrary, the weak AFM ordering via reducing IrMn thickness will lead to significant stochasticity for the physically unclonable functionality. This work demonstrates an intrinsic tuning over the AFM ordering will serve as a switch to turn the SOT device into a stochastic/memristive cell to bridge probabilistic and neuromorphic computing.
    Type of Medium: Online Resource
    ISSN: 2199-160X , 2199-160X
    URL: Issue
    URL: Article
    DOI: 10.1002/aelm.v9.12
    DOI: 10.1002/aelm.202300472
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2810904-1
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  • 3
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    Pulsed Wave Doppler Ultrasound Is Useful to Assess Vasomotor Response in Patients with Multiple System Atrophy and Well Correlated with Tilt Table Study
    Wiley ; 2012
    In:  The Scientific World Journal Vol. 2012 ( 2012), p. 1-8
    Details
    In: The Scientific World Journal, Wiley, Vol. 2012 ( 2012), p. 1-8
    Abstract: The study aim was to assess sympathetic vasomotor response (SVR) by using pulsed wave Doppler (PWD) ultrasound in patients with multiple system atrophy (MSA) and correlate with the tilt table study. We recruited 18 male patients and 10 healthy men as controls. The SVR of the radial artery was evaluated by PWD, using inspiratory cough as a provocative maneuver. The response to head-up tilt was studied by a tilt table with simultaneous heart rate and blood pressure recording. The hemodynamic variables were compared between groups, and were examined by correlation analysis. Regarding SVR, MSA patients exhibited a prolonged latency and less heart rate acceleration following inspiratory cough. Compared with the tilt table test, the elevation of heart rate upon SVR was positively correlated to the increase of heart rate after head-up tilt. The correlation analysis indicated that the magnitude of blood pressure drop from supine to upright was positively associated with the SVR latency but negatively correlated with the heart rate changes upon SVR. The present study demonstrated that blunted heart rate response might explain MSA's vulnerability to postural challenge. PWD may be used to predict cardiovascular response to orthostatic stress upon head-up tilt in MSA patients.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1100/2012/548529
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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  • 4
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    No. 18 Benefits of Cardiac Rehabilitation in Heart Failure Patients Receiving Continuous‐Flow Left Ventricular Assist Device in Early Postoperative Period
    Wiley ; 2014
    In:  PM&R Vol. 6, No. 8S2 ( 2014-08)
    Details
    In: PM&R, Wiley, Vol. 6, No. 8S2 ( 2014-08)
    Type of Medium: Online Resource
    ISSN: 1934-1482 , 1934-1563
    URL: Article
    DOI: 10.1016/j.pmrj.2014.08.296
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2480906-8
    detail.hit.zdb_id: 2608988-9
    SSG: 31
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  • 5
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    Tai Chi Chuan Training is Associated with Enhanced Endothelium‐Dependent Dilation in Skin Vasculature of Healthy Older Men
    Wiley ; 2002
    In:  Journal of the American Geriatrics Society Vol. 50, No. 6 ( 2002-06), p. 1024-1030
    Details
    In: Journal of the American Geriatrics Society, Wiley, Vol. 50, No. 6 ( 2002-06), p. 1024-1030
    Abstract: OBJECTIVES: The vascular endothelium modulates vascular tone by synthesizing and metabolizing vasoactive substances. Endothelium‐dependent vasodilation declines with age. This study investigated whether Tai Chi Chuan (TCC) training could enhance endothelial function in the skin vasculature of older men. SETTING: Community setting. DESIGN: Basic hemodynamic characteristics and skin vascular response to endothelium‐dependent and ‐independent vasodilators were studied. PARTICIPANTS: Ten older men who practiced TCC, 10 older healthy sedentary men, and 12 younger healthy sedentary men. The older TCC subjects had practiced classical Yang TCC for a mean ± standard deviation of 11.2 ± 3.4 years; mean attendance was 5.1 ± 1.8 times weekly. Sedentary subjects had not participated in any regular exercise training for at least 5 years. MEASUREMENTS: Different doses of 1% acetylcholine (ACh) and 1% sodium nitroprusside (SNP) were iontophoretically applied to the skin of subjects' lower legs, and cutaneous microvascular perfusion responses were determined by laser doppler measurements. Additionally, arterial and venous hemodynamic variables were measured by impedance plethysmograph. RESULTS: The older TCC group had higher lower leg arterial blood flow (LABF); LABF in response to reactive hyperemia; and lower leg venous capacity, tone and blood flow than their sedentary counterparts, but the older TCC group displayed similar arterial and venous hemodynamic variables to the younger sedentary group. The younger sedentary group had a higher ACh‐induced cutaneous perfusion and a higher ratio of ACh‐ to SNP‐induced cutaneous perfusion than the two older groups. The older TCC group showed a higher ACh‐induced cutaneous perfusion and a higher ratio of ACh‐ to SNP‐induced cutaneous perfusion than the older sedentary group. Skin vascular responses to SNP did not differ significantly between the three groups. CONCLUSIONS: Regular practice of TCC is associated with enhanced endothelium‐dependent dilation in skin vasculature of older individuals. Moreover, TCC training may delay the age‐related decline of venous compliance and hyperemic arterial response.
    Type of Medium: Online Resource
    ISSN: 0002-8614 , 1532-5415
    URL: Article
    DOI: 10.1046/j.1532-5415.2002.50256.x
    Language: English
    Publisher: Wiley
    Publication Date: 2002
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    detail.hit.zdb_id: 80363-7
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  • 6
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    Tai Chi Chuan in Medicine and Health Promotion
    Wiley ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-17
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Wiley, Vol. 2013 ( 2013), p. 1-17
    Abstract: Tai Chi Chuan (Tai Chi) is a Chinese traditional mind-body exercise and recently, it becomes popular worldwide. During the practice of Tai Chi, deep diaphragmatic breathing is integrated into body motions to achieve a harmonious balance between body and mind and to facilitate the flow of internal energy (Qi). Participants can choose to perform a complete set of Tai Chi or selected movements according to their needs. Previous research substantiates that Tai Chi has significant benefits to health promotion, and regularly practicing Tai Chi improves aerobic capacity, muscular strength, balance, health-related quality of life, and psychological well-being. Recent studies also prove that Tai Chi is safe and effective for patients with neurological diseases (e.g., stroke, Parkinson's disease, traumatic brain injury, multiple sclerosis, cognitive dysfunction), rheumatological disease (e.g., rheumatoid arthritis, ankylosing spondylitis, and fibromyalgia), orthopedic diseases (e.g., osteoarthritis, osteoporosis, low-back pain, and musculoskeletal disorder), cardiovascular diseases (e.g., acute myocardial infarction, coronary artery bypass grafting surgery, and heart failure), chronic obstructive pulmonary diseases, and breast cancers. Tai Chi is an aerobic exercise with mild-to-moderate intensity and is appropriate for implementation in the community. This paper reviews the existing literature on Tai Chi and introduces its health-promotion effect and the potential clinical applications.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/502131
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2171158-6
    detail.hit.zdb_id: 2148302-4
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  • 7
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    Tai Chi Chuan Exercise for Patients with Cardiovascular Disease
    Wiley ; 2013
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2013 ( 2013), p. 1-9
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Wiley, Vol. 2013 ( 2013), p. 1-9
    Abstract: Exercise training is the cornerstone of rehabilitation for patients with cardiovascular disease (CVD). Although high-intensity exercise has significant cardiovascular benefits, light-to-moderate intensity aerobic exercise also offers health benefits. With lower-intensity workouts, patients may be able to exercise for longer periods of time and increase the acceptance of exercise, particularly in unfit and elderly patients. Tai Chi Chuan (Tai Chi) is a traditional Chinese mind-body exercise. The exercise intensity of Tai Chi is light to moderate, depending on its training style, posture, and duration. Previous research has shown that Tai Chi enhances aerobic capacity, muscular strength, balance, and psychological well-being. Additionally, Tai Chi training has significant benefits for common cardiovascular risk factors, such as hypertension, diabetes mellitus, dyslipidemia, poor exercise capacity, endothelial dysfunction, and depression. Tai Chi is safe and effective in patients with acute myocardial infarction (AMI), coronary artery bypass grafting (CABG) surgery, congestive heart failure (HF), and stroke. In conclusion, Tai Chi has significant benefits to patients with cardiovascular disease, and it may be prescribed as an alternative exercise program for selected patients with CVD.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2013/983208
    Language: English
    Publisher: Wiley
    Publication Date: 2013
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    detail.hit.zdb_id: 2148302-4
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  • 8
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    Work‐related upper limb amputations in Taiwan, 1999–2001
    Wiley ; 2004
    In:  American Journal of Industrial Medicine Vol. 46, No. 6 ( 2004-12), p. 649-655
    Details
    In: American Journal of Industrial Medicine, Wiley, Vol. 46, No. 6 ( 2004-12), p. 649-655
    Abstract: Work‐related upper limb amputations account for a significant number of occupational injuries. This study analyzes the nationwide incidence of work‐related amputations of upper limbs in Taiwan by using the workers' compensation database. Methods A total of 2,950 cases were retrieved and analyzed from the database of workers' compensatory disability claims between the years 1999 and 2001. Results The cases were workers with an average age of 39.1 years, of whom 23.0% were female, the highest percentage of cases was in the 30–49 age group, but the incidence based on insured population was the highest for those under 20 years old. About 96% of the cases involved finger amputation, and 85% of all amputations were related to common powered machines. The average annual incidence of disability claims due to occupational amputation of upper extremities was 12.5 per 100,000 workers. Claims were most prevalent among manufacturing workers and male workers. The male to female risk ratios ranged from 2.62 for manufacturing workers to 9.05 for transport, storage and communication workers by the Poisson regression analysis. Conclusions Young male manufacturing workers were at high risk of occupational amputation of upper extremities in Taiwan. These results provide an epidemiological base for developing a prevention strategy. Am. J. Ind. Med. 46:649–655, 2004. © 2004 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0271-3586 , 1097-0274
    URL: Issue
    URL: Article
    DOI: 10.1002/ajim.v46:6
    DOI: 10.1002/ajim.20098
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 604538-8
    detail.hit.zdb_id: 1491156-5
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  • 9
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    Self‐Healable Spider Dragline Silk Materials
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 44 ( 2023-10)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 44 ( 2023-10)
    Abstract: Developing materials with structural flexibility that permits self‐repair in response to external disturbances remains challenging. Spider silk, which combines an exceptional blend of strength and pliability in nature, serves as an ideal dynamic model for adaptive performance design. In this work, a novel self‐healing material is generated using spider silk. Dragline silk from spider Nephila pilipes is demonstrated with extraordinary in situ self‐repair property through a constructed thin film format, surpassing that of two other silks from spider Cyrtophora moluccensis and silkworm Bombyx mori . Subsequently, R2, a key spidroin associated with self‐healing, is biosynthesized, with validated cohesiveness. R2 is further programmed with tunable healability (permanent and reversible) and conductivity (graphene doping; R2G) for electronics applications. In the first demonstration, film strips from R2 and R2G are woven manually into multidimensional (1D‐3D) conductive fabrics for creating repairable logic gate circuits. In the second example, a reversibly‐healable R2/R2G strip is fabricated as a re‐configurable wearable ring probe to fit fingertips of varying widths while retaining its detecting capabilities. Such a prototype displays a unique conformable wearable technology. Last, the remarkable finding of self‐healing in spider silk can offer a new material paradigm for developing future adaptive biomaterials with tailored performance and environmental sustainability.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.44
    DOI: 10.1002/adfm.202303571
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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    detail.hit.zdb_id: 2039420-2
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  • 10
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    Self‐Healable Spider Dragline Silk Materials (Adv. Funct. Mater. 44/2023)
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 44 ( 2023-10)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 44 ( 2023-10)
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.44
    DOI: 10.1002/adfm.202370262
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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